G12 - NPFF1 receptor complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

G12/13

DATE

2023-09-15

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

(pLDDT score) avg.: 82.2

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.7
iPTM Score: 0.7
PAE mean: 13.5


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic TM3 I 145 3x54 G.H5 L 375 G.H5.20
Van-der-waals TM3 I 145 3x54 G.H5 L 375 G.H5.20
Hydrophobic ICL2 E 151 - G.hns1 R 56 G.hns1.03
Ionic ICL2 K 152 - G.H5 D 377 G.H5.22
Polar ICL2 K 152 - G.H5 D 377 G.H5.22
Van-der-waals ICL2 K 152 - G.H5 D 377 G.H5.22
Hydrophobic TM6 A 261 6x26 G.H5 Q 372 G.H5.17
Hydrophobic ICL3 E 255 - G.H4 V 332 G.H4.12
Hydrophobic TM6 V 268 6x33 G.H5 L 375 G.H5.20
Polar H8 E 334 8x48 G.H5 Q 381 G.H5.26
Hydrophobic H8 E 334 8x48 G.H5 Q 381 G.H5.26
Van-der-waals H8 E 334 8x48 G.H5 Q 381 G.H5.26
Hydrophobic TM3 C 144 3x53 G.H5 I 378 G.H5.23
Polar H8 E 334 8x48 G.H5 L 380 G.H5.25
Van-der-waals H8 E 334 8x48 G.H5 L 380 G.H5.25
Hydrophobic C-term V 374 - G.H3 T 279 G.H3.11
Hydrophobic ICL2 F 149 - G.S3 I 221 G.S3.01
Van-der-waals ICL2 F 149 - G.S3 I 221 G.S3.01
Hydrophobic TM6 V 268 6x33 G.H5 M 379 G.H5.24
Van-der-waals TM6 V 268 6x33 G.H5 M 379 G.H5.24
Hydrophobic TM3 I 145 3x54 G.H5 I 378 G.H5.23
Van-der-waals TM3 I 145 3x54 G.H5 I 378 G.H5.23
Hydrophobic TM5 A 250 5x72 G.H5 F 361 G.H5.06
Hydrophobic TM2 N 79 2x40 G.H5 L 380 G.H5.25
Van-der-waals TM2 N 79 2x40 G.H5 L 380 G.H5.25
Polar H8 N 335 8x49 G.H5 L 380 G.H5.25
Hydrophobic H8 N 335 8x49 G.H5 L 380 G.H5.25
Van-der-waals H8 N 335 8x49 G.H5 L 380 G.H5.25
Hydrophobic TM6 M 271 6x36 G.H5 M 379 G.H5.24
Polar H8 E 334 8x48 G.H5 M 379 G.H5.24
Polar TM3 R 141 3x50 G.H5 I 378 G.H5.23
Hydrophobic TM3 R 141 3x50 G.H5 I 378 G.H5.23
Hydrophobic H8 N 333 8x47 G.H5 M 379 G.H5.24
Van-der-waals H8 N 333 8x47 G.H5 M 379 G.H5.24
Polar C-term W 428 - G.s4h3 R 265 G.s4h3.12
Van-der-waals C-term W 428 - G.s4h3 R 265 G.s4h3.12
Hydrophobic C-term A 427 - H.HB M 132 H.HB.10
Hydrophobic ICL2 R 150 - G.hns1 R 56 G.hns1.03
Hydrophobic ICL2 F 149 - G.S3 F 223 G.S3.03
Hydrophobic H8 F 336 8x50 G.H5 L 380 G.H5.25
Hydrophobic TM6 R 264 6x29 G.H5 M 379 G.H5.24
Aromatic ICL2 F 149 - G.H5 F 363 G.H5.08
Hydrophobic ICL2 F 149 - G.H5 F 363 G.H5.08
Van-der-waals ICL2 F 149 - G.H5 F 363 G.H5.08
Polar H8 N 335 8x49 G.H5 Q 381 G.H5.26
Hydrophobic H8 N 335 8x49 G.H5 Q 381 G.H5.26
Van-der-waals H8 N 335 8x49 G.H5 Q 381 G.H5.26
Hydrophobic ICL2 P 148 - G.H5 I 370 G.H5.15
Van-der-waals ICL2 P 148 - G.H5 I 370 G.H5.15
Polar ICL2 K 152 - G.H5 N 374 G.H5.19
Hydrophobic ICL2 K 152 - G.H5 N 374 G.H5.19
Van-der-waals ICL2 K 152 - G.H5 N 374 G.H5.19
Polar ICL3 G 253 - G.S6 H 348 G.S6.03
Hydrophobic ICL3 G 253 - G.S6 H 348 G.S6.03
Hydrophobic C-term V 372 - G.H2 F 239 G.H2.08
Hydrophobic ICL2 F 149 - G.H5 I 370 G.H5.15
Van-der-waals ICL2 F 149 - G.H5 I 370 G.H5.15
Ionic ICL3 E 255 - G.S6 H 348 G.S6.03
Polar ICL3 E 255 - G.S6 H 348 G.S6.03
Hydrophobic ICL3 E 255 - G.S6 H 348 G.S6.03
Van-der-waals ICL3 E 255 - G.S6 H 348 G.S6.03
Polar TM3 C 144 3x53 G.H5 N 374 G.H5.19
Hydrophobic TM3 C 144 3x53 G.H5 N 374 G.H5.19
Van-der-waals TM3 C 144 3x53 G.H5 N 374 G.H5.19
Polar C-term W 428 - H.HA D 110 H.HA.24
Van-der-waals C-term W 428 - H.HA D 110 H.HA.24
Van-der-waals C-term A 427 - H.HA K 114 H.HA.28
Hydrophobic ICL2 F 149 - G.H5 V 366 G.H5.11
Hydrophobic TM3 I 145 3x54 G.H5 L 371 G.H5.16
Van-der-waals TM3 I 145 3x54 G.H5 L 371 G.H5.16
Hydrophobic H8 N 333 8x47 G.H5 L 380 G.H5.25
Van-der-waals H8 N 333 8x47 G.H5 L 380 G.H5.25
Hydrophobic ICL2 E 151 - G.HN R 52 G.HN.52
Hydrophobic TM6 R 265 6x30 G.H5 L 375 G.H5.20
Ionic ICL2 E 151 - G.hns1 R 55 G.hns1.02
Polar ICL2 E 151 - G.hns1 R 55 G.hns1.02
Hydrophobic ICL2 E 151 - G.hns1 R 55 G.hns1.02
Van-der-waals ICL2 E 151 - G.hns1 R 55 G.hns1.02
Hydrophobic TM6 R 267 6x32 G.H5 M 379 G.H5.24
Aromatic C-term W 428 - H.HA K 114 H.HA.28
Hydrophobic C-term W 428 - H.HA K 114 H.HA.28
Van-der-waals C-term W 428 - H.HA K 114 H.HA.28
Hydrophobic TM5 L 243 5x65 G.H5 L 375 G.H5.20
Hydrophobic ICL2 F 149 - G.S1 V 58 G.S1.02
Polar C-term A 427 - H.HA D 110 H.HA.24
Hydrophobic C-term A 427 - H.HA D 110 H.HA.24
Van-der-waals C-term A 427 - H.HA D 110 H.HA.24
Hydrophobic C-term I 430 - H.HA R 106 H.HA.20
Van-der-waals C-term I 430 - H.HA R 106 H.HA.20
Hydrophobic ICL2 F 149 - G.H5 K 367 G.H5.12
Hydrophobic TM4 T 154 4x38 G.hns1 R 55 G.hns1.02
Van-der-waals TM4 T 154 4x38 G.hns1 R 55 G.hns1.02
Hydrophobic TM2 I 82 2x43 G.H5 L 380 G.H5.25
Polar C-term P 426 - H.HA K 114 H.HA.28
Hydrophobic C-term P 426 - H.HA K 114 H.HA.28
Van-der-waals C-term P 426 - H.HA K 114 H.HA.28
Ionic TM6 R 265 6x30 G.H5 D 368 G.H5.13
Polar TM6 R 265 6x30 G.H5 D 368 G.H5.13
Van-der-waals TM6 R 265 6x30 G.H5 D 368 G.H5.13
Polar TM6 R 264 6x29 G.H5 Q 381 G.H5.26
Van-der-waals TM6 R 264 6x29 G.H5 Q 381 G.H5.26