Gi1 -
NPFF1 receptor complex model
GPCR CLASS (FAMILY)
SPECIES
G PROTEIN FAMILY
DATE
3D VIEW
Tertiary structure confidence
(pLDDT score) avg.: 83.5
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered
PTM Score: 0.7
iPTM Score: 0.7
PAE mean: 11.9
GPCR - G protein interface interactions
The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle
(Gα residues)
and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid,
hydrophobic - dashed,
ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.
GPCR-G protein backbone (bb) or sidechain (sc):
Structures
0 structures selected.
Sequence Color
Interaction frequency filter (%)
Gα,
Gβ,
Gγ,
GPCR
Interaction cut-off: strict (stick), loose (line)
Interaction type |
GPCR Segment |
AA |
Number |
Generic number |
Gα segment |
AA |
Number |
Generic number |
---|---|---|---|---|---|---|---|---|
Hydrophobic | C-term | V | 406 | - | H.HA | A | 71 | H.HA.09 |
Aromatic | TM6 | R | 264 | 6x29 | G.H5 | F | 354 | G.H5.26 |
Hydrophobic | TM6 | R | 264 | 6x29 | G.H5 | F | 354 | G.H5.26 |
Van-der-waals | TM6 | R | 264 | 6x29 | G.H5 | F | 354 | G.H5.26 |
Polar | TM6 | R | 260 | 6x25 | G.h4s6 | K | 314 | G.h4s6.08 |
Van-der-waals | TM6 | R | 260 | 6x25 | G.h4s6 | K | 314 | G.h4s6.08 |
Hydrophobic | TM5 | L | 243 | 5x65 | G.H5 | L | 348 | G.H5.20 |
Hydrophobic | ICL2 | P | 148 | - | G.H5 | I | 344 | G.H5.16 |
Hydrophobic | C-term | P | 364 | - | G.H3 | W | 258 | G.H3.17 |
Hydrophobic | C-term | R | 363 | - | G.H3 | F | 259 | G.H3.18 |
Hydrophobic | H8 | N | 333 | 8x47 | G.H5 | G | 352 | G.H5.24 |
Van-der-waals | H8 | N | 333 | 8x47 | G.H5 | G | 352 | G.H5.24 |
Polar | TM2 | T | 78 | 2x39 | G.H5 | C | 351 | G.H5.23 |
Hydrophobic | TM2 | T | 78 | 2x39 | G.H5 | C | 351 | G.H5.23 |
Hydrophobic | TM3 | I | 145 | 3x54 | G.H5 | I | 344 | G.H5.16 |
Polar | C-term | N | 403 | - | H.HA | Q | 68 | H.HA.06 |
Van-der-waals | C-term | N | 403 | - | H.HA | Q | 68 | H.HA.06 |
Ionic | C-term | R | 405 | - | H.hbhc | E | 116 | H.hbhc.04 |
Hydrophobic | C-term | W | 428 | - | G.H2 | R | 208 | G.H2.04 |
Hydrophobic | ICL2 | F | 149 | - | G.H5 | F | 336 | G.H5.08 |
Van-der-waals | ICL2 | F | 149 | - | G.H5 | F | 336 | G.H5.08 |
Hydrophobic | TM6 | L | 272 | 6x37 | G.H5 | L | 353 | G.H5.25 |
Polar | ICL2 | K | 152 | - | G.H5 | N | 347 | G.H5.19 |
Hydrophobic | ICL2 | K | 152 | - | G.H5 | N | 347 | G.H5.19 |
Van-der-waals | ICL2 | K | 152 | - | G.H5 | N | 347 | G.H5.19 |
Hydrophobic | TM6 | A | 261 | 6x26 | G.h4s6 | E | 318 | G.h4s6.12 |
Van-der-waals | TM6 | A | 261 | 6x26 | G.h4s6 | E | 318 | G.h4s6.12 |
Ionic | TM6 | R | 265 | 6x30 | G.H5 | D | 341 | G.H5.13 |
Polar | TM6 | R | 265 | 6x30 | G.H5 | D | 341 | G.H5.13 |
Van-der-waals | TM6 | R | 265 | 6x30 | G.H5 | D | 341 | G.H5.13 |
Hydrophobic | ICL2 | F | 149 | - | G.H5 | I | 343 | G.H5.15 |
Van-der-waals | ICL2 | F | 149 | - | G.H5 | I | 343 | G.H5.15 |
Polar | C-term | R | 371 | - | G.HN | G | 27 | G.HN.51 |
Van-der-waals | C-term | R | 371 | - | G.HN | G | 27 | G.HN.51 |
Ionic | ICL2 | E | 151 | - | G.hns1 | R | 32 | G.hns1.03 |
Polar | ICL2 | E | 151 | - | G.hns1 | R | 32 | G.hns1.03 |
Hydrophobic | ICL2 | E | 151 | - | G.hns1 | R | 32 | G.hns1.03 |
Van-der-waals | ICL2 | E | 151 | - | G.hns1 | R | 32 | G.hns1.03 |
Hydrophobic | C-term | L | 401 | - | H.HA | E | 65 | H.HA.03 |
Hydrophobic | ICL2 | F | 149 | - | G.H5 | T | 340 | G.H5.12 |
Van-der-waals | ICL2 | F | 149 | - | G.H5 | T | 340 | G.H5.12 |
Aromatic | C-term | F | 373 | - | G.HN | R | 24 | G.HN.48 |
Hydrophobic | C-term | F | 373 | - | G.HN | R | 24 | G.HN.48 |
Van-der-waals | C-term | F | 373 | - | G.HN | R | 24 | G.HN.48 |
Polar | TM3 | R | 141 | 3x50 | G.H5 | C | 351 | G.H5.23 |
Hydrophobic | TM3 | R | 141 | 3x50 | G.H5 | C | 351 | G.H5.23 |
Hydrophobic | ICL2 | F | 149 | - | G.S3 | L | 194 | G.S3.01 |
Van-der-waals | ICL2 | F | 149 | - | G.S3 | L | 194 | G.S3.01 |
Polar | C-term | R | 371 | - | G.HN | R | 24 | G.HN.48 |
Hydrophobic | C-term | R | 371 | - | G.HN | R | 24 | G.HN.48 |
Van-der-waals | C-term | R | 371 | - | G.HN | R | 24 | G.HN.48 |
Polar | C-term | H | 408 | - | H.HA | S | 75 | H.HA.13 |
Ionic | TM6 | R | 260 | 6x25 | G.h4s6 | D | 315 | G.h4s6.09 |
Polar | TM6 | R | 260 | 6x25 | G.h4s6 | D | 315 | G.h4s6.09 |
Hydrophobic | TM6 | R | 260 | 6x25 | G.h4s6 | D | 315 | G.h4s6.09 |
Van-der-waals | TM6 | R | 260 | 6x25 | G.h4s6 | D | 315 | G.h4s6.09 |
Polar | TM2 | T | 78 | 2x39 | G.H5 | D | 350 | G.H5.22 |
Ionic | C-term | H | 408 | - | H.hbhc | E | 115 | H.hbhc.03 |
Polar | C-term | H | 408 | - | H.hbhc | E | 115 | H.hbhc.03 |
Hydrophobic | C-term | H | 408 | - | H.hbhc | E | 115 | H.hbhc.03 |
Van-der-waals | C-term | H | 408 | - | H.hbhc | E | 115 | H.hbhc.03 |
Hydrophobic | C-term | V | 406 | - | H.HA | S | 75 | H.HA.13 |
Hydrophobic | C-term | R | 363 | - | G.H3 | K | 257 | G.H3.16 |
Polar | C-term | S | 361 | - | G.H3 | K | 257 | G.H3.16 |
Hydrophobic | C-term | S | 361 | - | G.H3 | K | 257 | G.H3.16 |
Van-der-waals | C-term | S | 361 | - | G.H3 | K | 257 | G.H3.16 |
Hydrophobic | ICL2 | P | 148 | - | G.H5 | I | 343 | G.H5.15 |
Van-der-waals | ICL2 | P | 148 | - | G.H5 | I | 343 | G.H5.15 |
Hydrophobic | TM5 | L | 243 | 5x65 | G.H5 | I | 344 | G.H5.16 |
Ionic | ICL2 | K | 152 | - | G.H5 | D | 350 | G.H5.22 |
Polar | ICL2 | K | 152 | - | G.H5 | D | 350 | G.H5.22 |
Van-der-waals | ICL2 | K | 152 | - | G.H5 | D | 350 | G.H5.22 |
Hydrophobic | TM3 | I | 145 | 3x54 | G.H5 | L | 353 | G.H5.25 |
Van-der-waals | TM3 | I | 145 | 3x54 | G.H5 | L | 353 | G.H5.25 |
Hydrophobic | C-term | I | 430 | - | G.H3 | N | 256 | G.H3.15 |
Van-der-waals | C-term | I | 430 | - | G.H3 | N | 256 | G.H3.15 |
Hydrophobic | C-term | L | 411 | - | H.HA | R | 86 | H.HA.24 |
Van-der-waals | C-term | L | 411 | - | H.HA | R | 86 | H.HA.24 |
Hydrophobic | TM6 | M | 271 | 6x36 | G.H5 | L | 353 | G.H5.25 |
Van-der-waals | TM6 | M | 271 | 6x36 | G.H5 | L | 353 | G.H5.25 |
Polar | TM3 | C | 144 | 3x53 | G.H5 | N | 347 | G.H5.19 |
Hydrophobic | TM3 | C | 144 | 3x53 | G.H5 | N | 347 | G.H5.19 |
Van-der-waals | TM3 | C | 144 | 3x53 | G.H5 | N | 347 | G.H5.19 |
Hydrophobic | TM5 | K | 242 | 5x64 | G.H5 | I | 344 | G.H5.16 |
Hydrophobic | TM5 | P | 249 | 5x71 | G.h4s6 | E | 318 | G.h4s6.12 |
Van-der-waals | TM5 | P | 249 | 5x71 | G.h4s6 | E | 318 | G.h4s6.12 |
Polar | ICL2 | P | 148 | - | G.H5 | N | 347 | G.H5.19 |
Ionic | C-term | R | 363 | - | G.h3s5 | D | 261 | G.h3s5.02 |
Polar | C-term | R | 363 | - | G.h3s5 | D | 261 | G.h3s5.02 |
Hydrophobic | C-term | R | 363 | - | G.h3s5 | D | 261 | G.h3s5.02 |
Van-der-waals | C-term | R | 363 | - | G.h3s5 | D | 261 | G.h3s5.02 |
Van-der-waals | TM5 | P | 247 | 5x69 | G.H5 | D | 341 | G.H5.13 |
Hydrophobic | TM6 | V | 268 | 6x33 | G.H5 | L | 348 | G.H5.20 |
Hydrophobic | C-term | L | 401 | - | H.HA | E | 64 | H.HA.02 |
Hydrophobic | TM3 | I | 145 | 3x54 | G.H5 | L | 348 | G.H5.20 |
Van-der-waals | TM3 | I | 145 | 3x54 | G.H5 | L | 348 | G.H5.20 |
Polar | TM3 | C | 144 | 3x53 | G.H5 | C | 351 | G.H5.23 |
Hydrophobic | TM3 | C | 144 | 3x53 | G.H5 | C | 351 | G.H5.23 |
Van-der-waals | TM3 | C | 144 | 3x53 | G.H5 | C | 351 | G.H5.23 |
Polar | H8 | E | 334 | 8x48 | G.H5 | F | 354 | G.H5.26 |
Hydrophobic | TM3 | R | 141 | 3x50 | G.H5 | L | 353 | G.H5.25 |
Van-der-waals | TM3 | R | 141 | 3x50 | G.H5 | L | 353 | G.H5.25 |
Polar | C-term | R | 363 | - | G.h3s5 | T | 262 | G.h3s5.03 |
Van-der-waals | C-term | R | 363 | - | G.h3s5 | T | 262 | G.h3s5.03 |
Hydrophobic | TM6 | V | 268 | 6x33 | G.H5 | L | 353 | G.H5.25 |
Van-der-waals | TM6 | V | 268 | 6x33 | G.H5 | L | 353 | G.H5.25 |
Ionic | C-term | R | 371 | - | G.HN | E | 28 | G.HN.52 |
Polar | C-term | R | 371 | - | G.HN | E | 28 | G.HN.52 |
Hydrophobic | C-term | R | 371 | - | G.HN | E | 28 | G.HN.52 |
Van-der-waals | C-term | R | 371 | - | G.HN | E | 28 | G.HN.52 |
Polar | H8 | N | 335 | 8x49 | G.H5 | K | 349 | G.H5.21 |
Van-der-waals | H8 | N | 335 | 8x49 | G.H5 | K | 349 | G.H5.21 |
Polar | C-term | R | 363 | - | G.H3 | W | 258 | G.H3.17 |
Aromatic | C-term | R | 363 | - | G.H3 | W | 258 | G.H3.17 |
Hydrophobic | C-term | R | 363 | - | G.H3 | W | 258 | G.H3.17 |
Van-der-waals | C-term | R | 363 | - | G.H3 | W | 258 | G.H3.17 |
Hydrophobic | TM5 | P | 249 | 5x71 | G.S6 | Y | 320 | G.S6.02 |
Van-der-waals | TM5 | P | 249 | 5x71 | G.S6 | Y | 320 | G.S6.02 |