Golf - NPFF1 receptor complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gs

DATE

2023-09-15

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

(pLDDT score) avg.: 75.6

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.6
iPTM Score: 0.4
PAE mean: 19.6


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic TM3 I 145 3x54 G.H5 L 375 G.H5.20
Polar ICL2 P 148 - G.H5 Q 371 G.H5.16
Hydrophobic ICL2 P 148 - G.H5 Q 371 G.H5.16
Van-der-waals ICL2 P 148 - G.H5 Q 371 G.H5.16
Hydrophobic ICL3 G 253 - G.H4 F 326 G.H4.08
Van-der-waals ICL3 G 253 - G.H4 F 326 G.H4.08
Hydrophobic ICL3 G 253 - G.hgh4 A 311 G.hgh4.14
Hydrophobic ICL2 K 152 - G.H5 Y 378 G.H5.23
Van-der-waals ICL2 K 152 - G.H5 Y 378 G.H5.23
Polar TM2 T 76 2x37 G.H5 Q 377 G.H5.22
Hydrophobic TM2 T 76 2x37 G.H5 Q 377 G.H5.22
Van-der-waals TM2 T 76 2x37 G.H5 Q 377 G.H5.22
Polar ICL3 G 252 - G.hgh4 D 310 G.hgh4.13
Hydrophobic ICL3 G 252 - G.hgh4 D 310 G.hgh4.13
Van-der-waals ICL3 G 252 - G.hgh4 D 310 G.hgh4.13
Polar TM6 A 257 6x22 G.hgh4 D 310 G.hgh4.13
Van-der-waals TM6 A 257 6x22 G.hgh4 D 310 G.hgh4.13
Hydrophobic ICL1 M 74 12x50 G.H5 E 379 G.H5.24
Van-der-waals ICL1 M 74 12x50 G.H5 E 379 G.H5.24
Hydrophobic TM3 C 144 3x53 G.H5 Y 378 G.H5.23
Van-der-waals TM3 C 144 3x53 G.H5 Y 378 G.H5.23
Polar ICL3 G 253 - G.H4 R 329 G.H4.12
Hydrophobic ICL3 G 253 - G.H4 R 329 G.H4.12
Van-der-waals ICL3 G 253 - G.H4 R 329 G.H4.12
Ionic C-term H 408 - G.hgh4 D 310 G.hgh4.13
Polar C-term H 408 - G.hgh4 D 310 G.hgh4.13
Hydrophobic C-term H 408 - G.hgh4 D 310 G.hgh4.13
Van-der-waals C-term H 408 - G.hgh4 D 310 G.hgh4.13
Polar TM5 P 251 5x73 G.hgh4 D 310 G.hgh4.13
Hydrophobic TM5 P 251 5x73 G.hgh4 D 310 G.hgh4.13
Van-der-waals TM5 P 251 5x73 G.hgh4 D 310 G.hgh4.13
Hydrophobic TM2 T 78 2x39 G.H5 L 380 G.H5.25
Polar ICL2 L 153 - G.H5 Y 378 G.H5.23
Hydrophobic TM2 T 76 2x37 G.H5 Y 378 G.H5.23
Van-der-waals TM2 T 76 2x37 G.H5 Y 378 G.H5.23
Polar ICL3 E 254 - G.hgh4 D 310 G.hgh4.13
Hydrophobic ICL3 E 254 - G.hgh4 D 310 G.hgh4.13
Van-der-waals ICL3 E 254 - G.hgh4 D 310 G.hgh4.13
Hydrophobic TM3 R 141 3x50 G.H5 L 380 G.H5.25
Van-der-waals TM3 R 141 3x50 G.H5 L 380 G.H5.25
Hydrophobic TM5 P 251 5x73 G.hgh4 A 311 G.hgh4.14
Van-der-waals TM5 P 251 5x73 G.hgh4 A 311 G.hgh4.14
Polar ICL2 K 152 - G.H5 I 370 G.H5.15
Van-der-waals ICL2 K 152 - G.H5 I 370 G.H5.15
Hydrophobic TM3 C 144 3x53 G.H5 L 375 G.H5.20
Van-der-waals TM3 C 144 3x53 G.H5 L 375 G.H5.20
Hydrophobic ICL2 P 148 - G.H5 R 367 G.H5.12
Van-der-waals ICL2 P 148 - G.H5 R 367 G.H5.12
Hydrophobic ICL3 G 252 - G.H4 F 326 G.H4.08
Van-der-waals ICL3 G 252 - G.H4 F 326 G.H4.08
Polar H8 N 333 8x47 G.H5 E 379 G.H5.24
Hydrophobic H8 N 333 8x47 G.H5 E 379 G.H5.24
Van-der-waals H8 N 333 8x47 G.H5 E 379 G.H5.24
Hydrophobic ICL2 F 149 - G.H5 N 364 G.H5.09
Polar ICL3 E 254 - G.hgh4 P 308 G.hgh4.11
Hydrophobic ICL3 E 254 - G.hgh4 P 308 G.hgh4.11
Van-der-waals ICL3 E 254 - G.hgh4 P 308 G.hgh4.11
Hydrophobic TM2 T 78 2x39 G.H5 Y 378 G.H5.23
Van-der-waals TM2 T 78 2x39 G.H5 Y 378 G.H5.23
Hydrophobic C-term V 406 - G.H4 R 329 G.H4.12
Hydrophobic C-term V 406 - G.H4 L 333 G.H4.16
Van-der-waals C-term V 406 - G.H4 L 333 G.H4.16
Polar ICL3 E 254 - G.hgh4 T 306 G.hgh4.09
Hydrophobic ICL3 G 253 - G.hgh4 P 308 G.hgh4.11
Van-der-waals ICL3 G 253 - G.hgh4 P 308 G.hgh4.11
Aromatic ICL2 F 149 - G.H5 F 363 G.H5.08
Hydrophobic ICL2 F 149 - G.H5 F 363 G.H5.08
Van-der-waals ICL2 F 149 - G.H5 F 363 G.H5.08
Polar ICL2 K 152 - G.H5 H 374 G.H5.19
Aromatic ICL2 K 152 - G.H5 H 374 G.H5.19
Hydrophobic ICL2 K 152 - G.H5 H 374 G.H5.19
Van-der-waals ICL2 K 152 - G.H5 H 374 G.H5.19
Polar ICL3 E 255 - G.hgh4 D 310 G.hgh4.13
Polar TM5 P 251 5x73 G.hgh4 T 312 G.hgh4.15
Hydrophobic TM5 P 251 5x73 G.hgh4 T 312 G.hgh4.15
Van-der-waals TM5 P 251 5x73 G.hgh4 T 312 G.hgh4.15
Polar TM3 E 140 3x49 G.H5 Y 378 G.H5.23
Hydrophobic TM3 E 140 3x49 G.H5 Y 378 G.H5.23
Van-der-waals TM3 E 140 3x49 G.H5 Y 378 G.H5.23
Hydrophobic ICL3 G 252 - G.H4 R 329 G.H4.12
Polar C-term E 362 - G.h4s6 K 343 G.h4s6.12
Van-der-waals C-term E 362 - G.h4s6 K 343 G.h4s6.12
Polar C-term H 409 - G.H5 R 372 G.H5.17
Polar TM3 C 144 3x53 G.H5 Q 371 G.H5.16
Hydrophobic TM3 C 144 3x53 G.H5 Q 371 G.H5.16
Van-der-waals TM3 C 144 3x53 G.H5 Q 371 G.H5.16
Polar TM2 N 79 2x40 G.H5 E 379 G.H5.24
Hydrophobic TM2 N 79 2x40 G.H5 E 379 G.H5.24
Van-der-waals TM2 N 79 2x40 G.H5 E 379 G.H5.24
Hydrophobic ICL3 E 254 - G.hgh4 E 309 G.hgh4.12
Van-der-waals ICL3 E 254 - G.hgh4 E 309 G.hgh4.12
Polar H8 N 335 8x49 G.H5 E 379 G.H5.24
Hydrophobic H8 N 335 8x49 G.H5 E 379 G.H5.24
Van-der-waals H8 N 335 8x49 G.H5 E 379 G.H5.24
Aromatic ICL2 F 149 - G.H5 R 367 G.H5.12
Hydrophobic ICL2 F 149 - G.H5 R 367 G.H5.12
Van-der-waals ICL2 F 149 - G.H5 R 367 G.H5.12
Polar ICL3 G 252 - G.hgh4 A 311 G.hgh4.14
Hydrophobic ICL3 G 252 - G.hgh4 A 311 G.hgh4.14
Van-der-waals ICL3 G 252 - G.hgh4 A 311 G.hgh4.14
Hydrophobic TM2 V 77 2x38 G.H5 Y 378 G.H5.23
Van-der-waals TM2 V 77 2x38 G.H5 Y 378 G.H5.23
Polar C-term H 408 - G.H4 R 329 G.H4.12
Hydrophobic C-term H 408 - G.H4 R 329 G.H4.12
Van-der-waals C-term H 408 - G.H4 R 329 G.H4.12