G13 -
NPS receptor complex model
GPCR CLASS (FAMILY)
SPECIES
G PROTEIN FAMILY
DATE
3D VIEW
Tertiary structure confidence
(pLDDT score) avg.: 78.2
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered
PTM Score: 0.7
iPTM Score: 0.6
PAE mean: 15.1
GPCR - G protein interface interactions
The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle
(Gα residues)
and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid,
hydrophobic - dashed,
ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.
GPCR-G protein backbone (bb) or sidechain (sc):
Structures
0 structures selected.
Sequence Color
Interaction frequency filter (%)
Gα,
GPCR
Interaction cut-off: strict (stick), loose (line)
Interaction type |
GPCR Segment |
AA |
Number |
Generic number |
Gα segment |
AA |
Number |
Generic number |
---|---|---|---|---|---|---|---|---|
Ionic | TM4 | E | 160 | 4x39 | G.hns1 | K | 46 | G.hns1.02 |
Polar | TM4 | E | 160 | 4x39 | G.hns1 | K | 46 | G.hns1.02 |
Hydrophobic | TM4 | E | 160 | 4x39 | G.hns1 | K | 46 | G.hns1.02 |
Van-der-waals | TM4 | E | 160 | 4x39 | G.hns1 | K | 46 | G.hns1.02 |
Polar | ICL3 | L | 256 | - | G.S6 | H | 344 | G.S6.03 |
Hydrophobic | H8 | S | 335 | 8x48 | G.H5 | Q | 377 | G.H5.26 |
Van-der-waals | H8 | S | 335 | 8x48 | G.H5 | Q | 377 | G.H5.26 |
Polar | TM5 | Y | 244 | 5x72 | G.S6 | Y | 343 | G.S6.02 |
Van-der-waals | TM5 | Y | 244 | 5x72 | G.S6 | Y | 343 | G.S6.02 |
Hydrophobic | ICL2 | P | 153 | 34x50 | G.H5 | K | 363 | G.H5.12 |
Hydrophobic | ICL2 | L | 157 | - | G.H5 | I | 366 | G.H5.15 |
Hydrophobic | TM6 | A | 272 | 6x33 | G.H5 | M | 375 | G.H5.24 |
Van-der-waals | TM6 | A | 272 | 6x33 | G.H5 | M | 375 | G.H5.24 |
Hydrophobic | TM6 | L | 264 | 6x25 | G.H5 | H | 368 | G.H5.17 |
Hydrophobic | ICL2 | M | 154 | 34x51 | G.H5 | F | 359 | G.H5.08 |
Hydrophobic | ICL3 | L | 256 | - | G.H4 | Q | 323 | G.H4.08 |
Van-der-waals | ICL3 | L | 256 | - | G.H4 | Q | 323 | G.H4.08 |
Van-der-waals | ICL1 | K | 79 | - | G.h3s5 | N | 283 | G.h3s5.02 |
Polar | TM3 | A | 149 | 3x53 | G.H5 | N | 370 | G.H5.19 |
Hydrophobic | TM3 | A | 149 | 3x53 | G.H5 | N | 370 | G.H5.19 |
Van-der-waals | TM3 | A | 149 | 3x53 | G.H5 | N | 370 | G.H5.19 |
Hydrophobic | ICL2 | P | 153 | 34x50 | G.H5 | L | 367 | G.H5.16 |
Polar | TM5 | S | 252 | 5x80 | G.H4 | R | 320 | G.H4.05 |
Van-der-waals | TM5 | S | 252 | 5x80 | G.H4 | R | 320 | G.H4.05 |
Polar | H8 | S | 336 | 8x49 | G.H5 | L | 376 | G.H5.25 |
Hydrophobic | TM5 | K | 240 | 5x68 | G.H5 | L | 367 | G.H5.16 |
Van-der-waals | TM5 | K | 240 | 5x68 | G.H5 | L | 367 | G.H5.16 |
Polar | ICL3 | Y | 260 | - | G.S6 | Y | 343 | G.S6.02 |
Aromatic | ICL3 | Y | 260 | - | G.S6 | Y | 343 | G.S6.02 |
Hydrophobic | ICL3 | Y | 260 | - | G.S6 | Y | 343 | G.S6.02 |
Van-der-waals | ICL3 | Y | 260 | - | G.S6 | Y | 343 | G.S6.02 |
Hydrophobic | TM6 | A | 272 | 6x33 | G.H5 | L | 371 | G.H5.20 |
Hydrophobic | TM7 | Y | 330 | 7x53 | G.H5 | L | 376 | G.H5.25 |
Van-der-waals | TM7 | Y | 330 | 7x53 | G.H5 | L | 376 | G.H5.25 |
Hydrophobic | TM6 | A | 268 | 6x29 | G.H5 | M | 375 | G.H5.24 |
Van-der-waals | TM6 | A | 268 | 6x29 | G.H5 | M | 375 | G.H5.24 |
Hydrophobic | ICL3 | L | 256 | - | G.H4 | V | 327 | G.H4.12 |
Hydrophobic | ICL3 | S | 259 | - | G.H4 | R | 331 | G.H4.16 |
Van-der-waals | ICL3 | S | 259 | - | G.H4 | R | 331 | G.H4.16 |
Polar | ICL2 | P | 153 | 34x50 | G.H5 | N | 370 | G.H5.19 |
Hydrophobic | TM2 | M | 83 | 2x39 | G.H5 | L | 376 | G.H5.25 |
Van-der-waals | TM2 | M | 83 | 2x39 | G.H5 | L | 376 | G.H5.25 |
Hydrophobic | H8 | S | 334 | 8x47 | G.H5 | L | 376 | G.H5.25 |
Van-der-waals | H8 | S | 334 | 8x47 | G.H5 | L | 376 | G.H5.25 |
Polar | TM4 | K | 161 | 4x40 | G.HN | T | 43 | G.HN.52 |
Hydrophobic | TM4 | K | 161 | 4x40 | G.HN | T | 43 | G.HN.52 |
Van-der-waals | TM4 | K | 161 | 4x40 | G.HN | T | 43 | G.HN.52 |
Polar | ICL3 | N | 261 | - | G.h4s6 | Q | 337 | G.h4s6.11 |
Van-der-waals | ICL3 | N | 261 | - | G.h4s6 | Q | 337 | G.h4s6.11 |
Hydrophobic | ICL3 | Y | 260 | - | G.h4s6 | P | 341 | G.h4s6.20 |
Van-der-waals | ICL3 | Y | 260 | - | G.h4s6 | P | 341 | G.h4s6.20 |
Hydrophobic | TM2 | S | 81 | 2x37 | G.H5 | Q | 373 | G.H5.22 |
Van-der-waals | TM2 | S | 81 | 2x37 | G.H5 | Q | 373 | G.H5.22 |
Polar | TM3 | R | 146 | 3x50 | G.H5 | L | 374 | G.H5.23 |
Hydrophobic | TM3 | R | 146 | 3x50 | G.H5 | L | 374 | G.H5.23 |
Van-der-waals | TM3 | R | 146 | 3x50 | G.H5 | L | 374 | G.H5.23 |
Hydrophobic | TM2 | M | 83 | 2x39 | G.H5 | Q | 373 | G.H5.22 |
Van-der-waals | TM2 | M | 83 | 2x39 | G.H5 | Q | 373 | G.H5.22 |
Hydrophobic | ICL2 | M | 154 | 34x51 | G.S3 | F | 218 | G.S3.03 |
Van-der-waals | ICL2 | M | 154 | 34x51 | G.S3 | F | 218 | G.S3.03 |
Hydrophobic | TM2 | M | 83 | 2x39 | G.H5 | L | 374 | G.H5.23 |
Van-der-waals | TM2 | M | 83 | 2x39 | G.H5 | L | 374 | G.H5.23 |
Hydrophobic | C-term | M | 362 | - | G.h4s6 | R | 335 | G.h4s6.09 |
Van-der-waals | C-term | M | 362 | - | G.h4s6 | R | 335 | G.h4s6.09 |
Polar | TM1 | R | 77 | 1x60 | G.H5 | L | 376 | G.H5.25 |
Hydrophobic | TM1 | R | 77 | 1x60 | G.H5 | L | 376 | G.H5.25 |
Van-der-waals | TM1 | R | 77 | 1x60 | G.H5 | L | 376 | G.H5.25 |
Hydrophobic | TM3 | I | 150 | 3x54 | G.H5 | L | 367 | G.H5.16 |
Van-der-waals | TM3 | I | 150 | 3x54 | G.H5 | L | 367 | G.H5.16 |
Polar | TM6 | K | 271 | 6x32 | G.H5 | M | 375 | G.H5.24 |
Hydrophobic | TM6 | K | 271 | 6x32 | G.H5 | M | 375 | G.H5.24 |
Van-der-waals | TM6 | K | 271 | 6x32 | G.H5 | M | 375 | G.H5.24 |
Hydrophobic | TM6 | L | 264 | 6x25 | G.h4s6 | Q | 339 | G.h4s6.13 |
Hydrophobic | ICL2 | F | 156 | 34x53 | G.H5 | N | 370 | G.H5.19 |
Hydrophobic | ICL3 | L | 256 | - | G.S6 | F | 346 | G.S6.05 |
Hydrophobic | ICL2 | M | 154 | 34x51 | G.H5 | K | 363 | G.H5.12 |
Van-der-waals | ICL2 | M | 154 | 34x51 | G.H5 | K | 363 | G.H5.12 |
Polar | ICL3 | S | 258 | - | G.S6 | H | 344 | G.S6.03 |
Hydrophobic | ICL3 | S | 258 | - | G.S6 | H | 344 | G.S6.03 |
Van-der-waals | ICL3 | S | 258 | - | G.S6 | H | 344 | G.S6.03 |
Hydrophobic | TM3 | I | 150 | 3x54 | G.H5 | L | 371 | G.H5.20 |
Hydrophobic | ICL3 | L | 256 | - | G.H4 | K | 324 | G.H4.09 |
Van-der-waals | ICL3 | L | 256 | - | G.H4 | K | 324 | G.H4.09 |
Hydrophobic | C-term | I | 371 | - | G.H3 | T | 274 | G.H3.11 |
Hydrophobic | TM2 | T | 84 | 2x40 | G.H5 | L | 376 | G.H5.25 |
Van-der-waals | TM7 | F | 333 | 7x56 | G.H5 | M | 375 | G.H5.24 |
Hydrophobic | ICL2 | L | 157 | - | G.S1 | V | 49 | G.S1.02 |
Van-der-waals | ICL2 | L | 157 | - | G.S1 | V | 49 | G.S1.02 |
Polar | ICL3 | C | 257 | - | G.S6 | H | 344 | G.S6.03 |
Hydrophobic | ICL3 | C | 257 | - | G.S6 | H | 344 | G.S6.03 |
Van-der-waals | ICL3 | C | 257 | - | G.S6 | H | 344 | G.S6.03 |
Hydrophobic | TM6 | A | 268 | 6x29 | G.H5 | H | 368 | G.H5.17 |
Polar | ICL3 | G | 254 | - | G.H4 | R | 320 | G.H4.05 |
Hydrophobic | ICL3 | G | 254 | - | G.H4 | R | 320 | G.H4.05 |
Van-der-waals | ICL3 | G | 254 | - | G.H4 | R | 320 | G.H4.05 |
Hydrophobic | ICL2 | L | 157 | - | G.hns1 | K | 46 | G.hns1.02 |
Van-der-waals | ICL2 | L | 157 | - | G.hns1 | K | 46 | G.hns1.02 |
Hydrophobic | TM3 | A | 149 | 3x53 | G.H5 | L | 374 | G.H5.23 |
Hydrophobic | TM6 | I | 265 | 6x26 | G.H5 | H | 368 | G.H5.17 |
Van-der-waals | TM6 | I | 265 | 6x26 | G.H5 | H | 368 | G.H5.17 |
Hydrophobic | TM6 | L | 264 | 6x25 | G.h4s6 | Q | 338 | G.h4s6.12 |
Van-der-waals | TM6 | L | 264 | 6x25 | G.h4s6 | Q | 338 | G.h4s6.12 |
Polar | ICL2 | Q | 158 | - | G.hns1 | R | 47 | G.hns1.03 |
Hydrophobic | ICL2 | Q | 158 | - | G.hns1 | R | 47 | G.hns1.03 |
Van-der-waals | ICL2 | Q | 158 | - | G.hns1 | R | 47 | G.hns1.03 |
Polar | TM5 | Y | 244 | 5x72 | G.H5 | D | 364 | G.H5.13 |
Hydrophobic | TM5 | Y | 244 | 5x72 | G.H5 | D | 364 | G.H5.13 |
Van-der-waals | TM5 | Y | 244 | 5x72 | G.H5 | D | 364 | G.H5.13 |
Hydrophobic | ICL2 | M | 154 | 34x51 | G.S1 | V | 49 | G.S1.02 |
Polar | H8 | S | 335 | 8x48 | G.H5 | L | 376 | G.H5.25 |
Polar | TM5 | C | 251 | 5x79 | G.H4 | R | 320 | G.H4.05 |
Hydrophobic | ICL2 | M | 154 | 34x51 | G.H5 | V | 362 | G.H5.11 |
Hydrophobic | TM3 | I | 150 | 3x54 | G.H5 | L | 374 | G.H5.23 |
Van-der-waals | TM3 | I | 150 | 3x54 | G.H5 | L | 374 | G.H5.23 |
Hydrophobic | C-term | I | 371 | - | G.H2 | R | 230 | G.H2.04 |
Hydrophobic | TM5 | I | 237 | 5x65 | G.H5 | L | 371 | G.H5.20 |
Hydrophobic | ICL2 | P | 153 | 34x50 | G.H5 | I | 366 | G.H5.15 |
Van-der-waals | ICL2 | P | 153 | 34x50 | G.H5 | I | 366 | G.H5.15 |
Hydrophobic | TM6 | K | 269 | 6x30 | G.H5 | L | 371 | G.H5.20 |
Hydrophobic | ICL2 | M | 154 | 34x51 | G.H5 | I | 366 | G.H5.15 |
Van-der-waals | ICL2 | M | 154 | 34x51 | G.H5 | I | 366 | G.H5.15 |
Hydrophobic | ICL2 | L | 157 | - | G.hns1 | R | 47 | G.hns1.03 |
Hydrophobic | ICL2 | M | 154 | 34x51 | G.S3 | V | 216 | G.S3.01 |
Van-der-waals | ICL2 | M | 154 | 34x51 | G.S3 | V | 216 | G.S3.01 |