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Y1 receptor complex model
GPCR CLASS (FAMILY)
SPECIES
G PROTEIN FAMILY
DATE
3D VIEW
Tertiary structure confidence
(pLDDT score) avg.: 85.9
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered
PTM Score: 0.8
iPTM Score: 0.8
PAE mean: 11.9
GPCR - G protein interface interactions
The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle
(Gα residues)
and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid,
hydrophobic - dashed,
ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.
GPCR-G protein backbone (bb) or sidechain (sc):
Structures
0 structures selected.
Sequence Color
Interaction frequency filter (%)
Gα,
Gβ,
Gγ,
GPCR
Interaction cut-off: strict (stick), loose (line)
Interaction type |
GPCR Segment |
AA |
Number |
Generic number |
Gα segment |
AA |
Number |
Generic number |
---|---|---|---|---|---|---|---|---|
Hydrophobic | TM5 | R | 237 | 5x64 | G.H5 | I | 344 | G.H5.16 |
Ionic | ICL3 | R | 249 | - | G.h4s6 | E | 318 | G.h4s6.12 |
Polar | ICL3 | R | 249 | - | G.h4s6 | E | 318 | G.h4s6.12 |
Hydrophobic | ICL3 | R | 249 | - | G.h4s6 | E | 318 | G.h4s6.12 |
Van-der-waals | ICL3 | R | 249 | - | G.h4s6 | E | 318 | G.h4s6.12 |
Hydrophobic | H8 | N | 324 | 8x47 | G.H5 | G | 352 | G.H5.24 |
Van-der-waals | H8 | N | 324 | 8x47 | G.H5 | G | 352 | G.H5.24 |
Hydrophobic | C-term | M | 352 | - | G.H2 | I | 213 | G.H2.08 |
Van-der-waals | C-term | M | 352 | - | G.H2 | I | 213 | G.H2.08 |
Hydrophobic | TM5 | L | 238 | 5x65 | G.H5 | I | 344 | G.H5.16 |
Ionic | TM6 | R | 254 | 6x26 | G.H5 | D | 341 | G.H5.13 |
Polar | TM6 | R | 254 | 6x26 | G.H5 | D | 341 | G.H5.13 |
Hydrophobic | TM6 | R | 254 | 6x26 | G.H5 | D | 341 | G.H5.13 |
Van-der-waals | TM6 | R | 254 | 6x26 | G.H5 | D | 341 | G.H5.13 |
Hydrophobic | TM2 | T | 75 | 2x39 | G.H5 | C | 351 | G.H5.23 |
Van-der-waals | C-term | M | 352 | - | G.H3 | N | 257 | G.H3.15 |
Polar | C-term | T | 354 | - | G.H2 | S | 207 | G.H2.02 |
Hydrophobic | TM6 | I | 261 | 6x33 | G.H5 | L | 348 | G.H5.20 |
Hydrophobic | ICL2 | P | 145 | - | G.H5 | I | 343 | G.H5.15 |
Van-der-waals | ICL2 | P | 145 | - | G.H5 | I | 343 | G.H5.15 |
Hydrophobic | TM5 | M | 245 | 5x72 | G.H5 | D | 337 | G.H5.09 |
Hydrophobic | TM6 | I | 261 | 6x33 | G.H5 | L | 353 | G.H5.25 |
Van-der-waals | TM6 | I | 261 | 6x33 | G.H5 | L | 353 | G.H5.25 |
Hydrophobic | C-term | M | 352 | - | G.H2 | R | 209 | G.H2.04 |
Van-der-waals | C-term | M | 352 | - | G.H2 | R | 209 | G.H2.04 |
Hydrophobic | TM5 | M | 244 | 5x71 | G.H5 | D | 337 | G.H5.09 |
Hydrophobic | TM3 | I | 142 | 3x54 | G.H5 | I | 344 | G.H5.16 |
Van-der-waals | TM3 | I | 142 | 3x54 | G.H5 | I | 344 | G.H5.16 |
Hydrophobic | TM5 | R | 241 | 5x68 | G.H5 | I | 344 | G.H5.16 |
Van-der-waals | TM5 | R | 241 | 5x68 | G.H5 | I | 344 | G.H5.16 |
Hydrophobic | ICL2 | R | 146 | - | G.H5 | F | 336 | G.H5.08 |
Van-der-waals | ICL2 | R | 146 | - | G.H5 | F | 336 | G.H5.08 |
Polar | TM3 | R | 138 | 3x50 | G.H5 | C | 351 | G.H5.23 |
Hydrophobic | TM3 | R | 138 | 3x50 | G.H5 | C | 351 | G.H5.23 |
Van-der-waals | TM3 | R | 138 | 3x50 | G.H5 | C | 351 | G.H5.23 |
Hydrophobic | C-term | T | 354 | - | G.H3 | L | 250 | G.H3.08 |
Hydrophobic | ICL3 | M | 248 | - | G.S6 | Y | 320 | G.S6.02 |
Hydrophobic | TM6 | L | 265 | 6x37 | G.H5 | L | 353 | G.H5.25 |
Hydrophobic | TM6 | I | 261 | 6x33 | G.H5 | Y | 354 | G.H5.26 |
Hydrophobic | ICL3 | M | 248 | - | G.H5 | V | 334 | G.H5.06 |
Van-der-waals | ICL3 | M | 248 | - | G.H5 | V | 334 | G.H5.06 |
Hydrophobic | ICL3 | M | 248 | - | G.S6 | H | 322 | G.S6.04 |
Polar | H8 | N | 326 | 8x49 | G.H5 | R | 349 | G.H5.21 |
Van-der-waals | H8 | N | 326 | 8x49 | G.H5 | R | 349 | G.H5.21 |
Hydrophobic | C-term | Y | 347 | - | G.H3 | K | 258 | G.H3.16 |
Polar | ICL2 | R | 146 | - | G.s2s3 | K | 193 | G.s2s3.01 |
Van-der-waals | ICL2 | R | 146 | - | G.s2s3 | K | 193 | G.s2s3.01 |
Polar | C-term | T | 354 | - | G.H2 | R | 209 | G.H2.04 |
Hydrophobic | C-term | T | 354 | - | G.H2 | R | 209 | G.H2.04 |
Van-der-waals | C-term | T | 354 | - | G.H2 | R | 209 | G.H2.04 |
Polar | ICL3 | R | 249 | - | G.h4s6 | K | 317 | G.h4s6.11 |
Van-der-waals | ICL3 | R | 249 | - | G.h4s6 | K | 317 | G.h4s6.11 |
Hydrophobic | TM6 | M | 264 | 6x36 | G.H5 | L | 353 | G.H5.25 |
Van-der-waals | TM6 | M | 264 | 6x36 | G.H5 | L | 353 | G.H5.25 |
Ionic | TM6 | R | 254 | 6x26 | G.h4s6 | E | 318 | G.h4s6.12 |
Polar | TM6 | R | 254 | 6x26 | G.h4s6 | E | 318 | G.h4s6.12 |
Van-der-waals | TM6 | R | 254 | 6x26 | G.h4s6 | E | 318 | G.h4s6.12 |
Hydrophobic | TM3 | R | 138 | 3x50 | G.H5 | L | 353 | G.H5.25 |
Van-der-waals | TM3 | R | 138 | 3x50 | G.H5 | L | 353 | G.H5.25 |
Hydrophobic | ICL2 | P | 145 | - | G.H5 | I | 344 | G.H5.16 |
Van-der-waals | C-term | M | 352 | - | G.H3 | S | 253 | G.H3.11 |
Hydrophobic | C-term | M | 355 | - | G.H2 | E | 208 | G.H2.03 |
Hydrophobic | ICL2 | P | 145 | - | G.H5 | T | 340 | G.H5.12 |
Hydrophobic | TM5 | M | 245 | 5x72 | G.S6 | Y | 320 | G.S6.02 |
Hydrophobic | TM5 | L | 238 | 5x65 | G.H5 | L | 348 | G.H5.20 |
Polar | TM2 | N | 73 | 2x37 | G.H5 | G | 350 | G.H5.22 |
Van-der-waals | TM2 | N | 73 | 2x37 | G.H5 | G | 350 | G.H5.22 |
Polar | TM3 | L | 141 | 3x53 | G.H5 | N | 347 | G.H5.19 |
Hydrophobic | TM3 | L | 141 | 3x53 | G.H5 | N | 347 | G.H5.19 |
Van-der-waals | TM3 | L | 141 | 3x53 | G.H5 | N | 347 | G.H5.19 |
Hydrophobic | C-term | M | 352 | - | G.H2 | K | 210 | G.H2.05 |
Ionic | TM5 | R | 241 | 5x68 | G.H5 | D | 341 | G.H5.13 |
Polar | TM5 | R | 241 | 5x68 | G.H5 | D | 341 | G.H5.13 |
Hydrophobic | TM5 | R | 241 | 5x68 | G.H5 | D | 341 | G.H5.13 |
Van-der-waals | TM5 | R | 241 | 5x68 | G.H5 | D | 341 | G.H5.13 |
Polar | ICL3 | M | 248 | - | G.S6 | C | 321 | G.S6.03 |
Hydrophobic | ICL3 | M | 248 | - | G.S6 | C | 321 | G.S6.03 |
Van-der-waals | ICL3 | M | 248 | - | G.S6 | C | 321 | G.S6.03 |
Polar | TM6 | E | 257 | 6x29 | G.H5 | Y | 354 | G.H5.26 |
Hydrophobic | TM6 | E | 257 | 6x29 | G.H5 | Y | 354 | G.H5.26 |
Van-der-waals | TM6 | E | 257 | 6x29 | G.H5 | Y | 354 | G.H5.26 |
Hydrophobic | C-term | Y | 347 | - | G.h3s5 | I | 261 | G.h3s5.01 |
Polar | ICL2 | R | 149 | - | G.H5 | N | 347 | G.H5.19 |
Hydrophobic | TM5 | M | 245 | 5x72 | G.H5 | D | 341 | G.H5.13 |
Hydrophobic | ICL2 | R | 146 | - | G.S3 | L | 195 | G.S3.01 |
Van-der-waals | ICL2 | R | 146 | - | G.S3 | L | 195 | G.S3.01 |
Ionic | C-term | H | 356 | - | G.s4h3 | E | 237 | G.s4h3.10 |
Polar | C-term | H | 356 | - | G.s4h3 | E | 237 | G.s4h3.10 |
Hydrophobic | C-term | H | 356 | - | G.s4h3 | E | 237 | G.s4h3.10 |
Van-der-waals | C-term | H | 356 | - | G.s4h3 | E | 237 | G.s4h3.10 |
Van-der-waals | ICL3 | R | 249 | - | G.S6 | I | 319 | G.S6.01 |
Hydrophobic | TM3 | I | 142 | 3x54 | G.H5 | L | 353 | G.H5.25 |
Polar | TM5 | R | 241 | 5x68 | G.H5 | T | 340 | G.H5.12 |
Hydrophobic | TM5 | R | 241 | 5x68 | G.H5 | T | 340 | G.H5.12 |
Van-der-waals | TM5 | R | 241 | 5x68 | G.H5 | T | 340 | G.H5.12 |
Hydrophobic | C-term | T | 349 | - | G.H3 | K | 258 | G.H3.16 |
Hydrophobic | TM3 | I | 142 | 3x54 | G.H5 | L | 348 | G.H5.20 |
Van-der-waals | TM3 | I | 142 | 3x54 | G.H5 | L | 348 | G.H5.20 |
Polar | H8 | K | 325 | 8x48 | G.H5 | Y | 354 | G.H5.26 |
Hydrophobic | H8 | K | 325 | 8x48 | G.H5 | Y | 354 | G.H5.26 |
Van-der-waals | H8 | K | 325 | 8x48 | G.H5 | Y | 354 | G.H5.26 |
Hydrophobic | TM3 | L | 141 | 3x53 | G.H5 | C | 351 | G.H5.23 |