G12 - Y2 receptor complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

G12/13

DATE

2023-09-15

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

(pLDDT score) avg.: 79.8

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.7
iPTM Score: 0.7
PAE mean: 15.4


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic TM3 I 152 3x54 G.H5 I 378 G.H5.23
Van-der-waals TM3 I 152 3x54 G.H5 I 378 G.H5.23
Hydrophobic C-term V 355 - G.H3 L 285 G.H3.17
Polar TM6 T 266 6x33 G.H5 L 380 G.H5.25
Hydrophobic TM6 T 266 6x33 G.H5 L 380 G.H5.25
Van-der-waals TM6 T 266 6x33 G.H5 L 380 G.H5.25
Hydrophobic TM6 M 269 6x36 G.H5 L 380 G.H5.25
Van-der-waals TM6 M 269 6x36 G.H5 L 380 G.H5.25
Hydrophobic ICL2 H 155 - G.H5 K 367 G.H5.12
Van-der-waals ICL2 H 155 - G.H5 K 367 G.H5.12
Hydrophobic TM5 P 252 5x71 G.H5 D 368 G.H5.13
Hydrophobic TM5 L 246 5x65 G.H5 L 375 G.H5.20
Hydrophobic ICL2 L 156 - G.H5 F 363 G.H5.08
Hydrophobic TM5 P 252 5x71 G.S6 F 347 G.S6.02
Hydrophobic ICL2 S 158 - G.hns1 R 55 G.hns1.02
Polar TM6 R 262 6x29 G.H5 Q 372 G.H5.17
Van-der-waals C-term V 355 - G.h2s4 D 243 G.h2s4.02
Polar TM3 C 151 3x53 G.H5 N 374 G.H5.19
Hydrophobic TM3 C 151 3x53 G.H5 N 374 G.H5.19
Van-der-waals TM3 C 151 3x53 G.H5 N 374 G.H5.19
Polar C-term P 371 - G.h1ha R 83 G.h1ha.02
Ionic TM4 R 163 4x40 G.HN D 44 G.HN.44
Hydrophobic ICL2 H 155 - G.H5 I 370 G.H5.15
Van-der-waals ICL2 H 155 - G.H5 I 370 G.H5.15
Polar TM6 Y 259 6x26 G.H5 Q 372 G.H5.17
Hydrophobic TM6 Y 259 6x26 G.H5 Q 372 G.H5.17
Van-der-waals TM6 Y 259 6x26 G.H5 Q 372 G.H5.17
Hydrophobic TM5 P 252 5x71 G.H5 H 364 G.H5.09
Hydrophobic TM5 L 246 5x65 G.H5 L 371 G.H5.16
Hydrophobic TM5 P 252 5x71 G.H5 F 361 G.H5.06
Hydrophobic TM3 I 152 3x54 G.H5 L 380 G.H5.25
Van-der-waals TM3 I 152 3x54 G.H5 L 380 G.H5.25
Hydrophobic H8 Y 332 8x50 G.H5 M 379 G.H5.24
Van-der-waals H8 Y 332 8x50 G.H5 M 379 G.H5.24
Polar ICL2 K 159 - G.hns1 R 55 G.hns1.02
Van-der-waals ICL2 K 159 - G.hns1 R 55 G.hns1.02
Hydrophobic TM6 T 266 6x33 G.H5 L 375 G.H5.20
Polar TM3 R 148 3x50 G.H5 M 379 G.H5.24
Ionic ICL2 E 157 - G.hns1 R 56 G.hns1.03
Polar ICL2 E 157 - G.hns1 R 56 G.hns1.03
Hydrophobic ICL2 E 157 - G.hns1 R 56 G.hns1.03
Polar C-term S 351 - G.h3s5 N 288 G.h3s5.02
Van-der-waals C-term S 351 - G.h3s5 N 288 G.h3s5.02
Hydrophobic C-term L 363 - G.H2 Q 240 G.H2.09
Van-der-waals C-term L 363 - G.H2 Q 240 G.H2.09
Hydrophobic TM2 N 86 2x40 G.H5 M 379 G.H5.24
Van-der-waals TM2 N 86 2x40 G.H5 M 379 G.H5.24
Hydrophobic TM6 Y 259 6x26 G.H5 D 368 G.H5.13
Van-der-waals TM6 Y 259 6x26 G.H5 D 368 G.H5.13
Polar H8 N 331 8x49 G.H5 K 376 G.H5.21
Van-der-waals H8 N 331 8x49 G.H5 K 376 G.H5.21
Hydrophobic ICL2 L 156 - G.H5 I 370 G.H5.15
Hydrophobic TM4 I 164 4x41 G.HN R 52 G.HN.52
Van-der-waals TM4 I 164 4x41 G.HN R 52 G.HN.52
Hydrophobic TM3 I 152 3x54 G.H5 L 371 G.H5.16
Polar H8 S 330 8x48 G.H5 Q 381 G.H5.26
Hydrophobic H8 S 330 8x48 G.H5 Q 381 G.H5.26
Van-der-waals H8 S 330 8x48 G.H5 Q 381 G.H5.26
Polar ICL2 S 158 - G.hns1 R 56 G.hns1.03
Hydrophobic ICL2 S 158 - G.hns1 R 56 G.hns1.03
Van-der-waals ICL2 S 158 - G.hns1 R 56 G.hns1.03
Polar ICL2 I 160 - G.hns1 R 55 G.hns1.02
Van-der-waals ICL2 I 160 - G.hns1 R 55 G.hns1.02
Hydrophobic TM5 G 253 5x72 G.S6 F 347 G.S6.02
Van-der-waals TM5 G 253 5x72 G.S6 F 347 G.S6.02
Hydrophobic TM3 C 151 3x53 G.H5 I 378 G.H5.23
Van-der-waals TM3 C 151 3x53 G.H5 I 378 G.H5.23
Hydrophobic TM6 L 270 6x37 G.H5 L 380 G.H5.25
Van-der-waals TM6 L 270 6x37 G.H5 L 380 G.H5.25
Polar TM6 R 262 6x29 G.H5 Q 381 G.H5.26
Hydrophobic TM6 R 262 6x29 G.H5 Q 381 G.H5.26
Van-der-waals TM6 R 262 6x29 G.H5 Q 381 G.H5.26
Ionic ICL2 K 159 - G.H5 D 377 G.H5.22
Polar ICL2 K 159 - G.H5 D 377 G.H5.22
Van-der-waals ICL2 K 159 - G.H5 D 377 G.H5.22
Polar TM5 S 251 5x70 G.H5 D 368 G.H5.13
Hydrophobic TM5 S 251 5x70 G.H5 D 368 G.H5.13
Van-der-waals TM5 S 251 5x70 G.H5 D 368 G.H5.13
Hydrophobic C-term V 365 - G.S2 E 213 G.S2.03
Hydrophobic TM7 Y 325 7x53 G.H5 M 379 G.H5.24
Van-der-waals TM7 Y 325 7x53 G.H5 M 379 G.H5.24
Polar ICL2 K 159 - G.H5 N 374 G.H5.19
Hydrophobic ICL2 K 159 - G.H5 N 374 G.H5.19
Van-der-waals ICL2 K 159 - G.H5 N 374 G.H5.19
Polar H8 N 329 8x47 G.H5 Q 381 G.H5.26
Van-der-waals H8 N 329 8x47 G.H5 Q 381 G.H5.26
Hydrophobic TM5 H 249 5x68 G.H5 L 371 G.H5.16
Van-der-waals TM5 H 249 5x68 G.H5 L 371 G.H5.16
Hydrophobic ICL2 L 156 - G.H5 K 367 G.H5.12
Hydrophobic ICL3 A 255 - G.h4s6 P 345 G.h4s6.20
Hydrophobic TM3 I 152 3x54 G.H5 L 375 G.H5.20
Polar ICL2 H 155 - G.H5 N 374 G.H5.19
Van-der-waals ICL2 H 155 - G.H5 N 374 G.H5.19
Hydrophobic ICL2 H 155 - G.H5 L 371 G.H5.16
Hydrophobic TM5 P 252 5x71 G.H5 A 365 G.H5.10
Polar H8 N 329 8x47 G.H5 M 379 G.H5.24
Hydrophobic H8 N 329 8x47 G.H5 M 379 G.H5.24
Van-der-waals H8 N 329 8x47 G.H5 M 379 G.H5.24
Hydrophobic ICL3 A 254 - G.S6 H 348 G.S6.03
Ionic TM5 H 249 5x68 G.H5 D 368 G.H5.13
Polar TM5 H 249 5x68 G.H5 D 368 G.H5.13
Hydrophobic TM5 H 249 5x68 G.H5 D 368 G.H5.13
Van-der-waals TM5 H 249 5x68 G.H5 D 368 G.H5.13
Polar TM3 R 148 3x50 G.H5 I 378 G.H5.23
Hydrophobic TM3 R 148 3x50 G.H5 I 378 G.H5.23
Van-der-waals TM3 R 148 3x50 G.H5 I 378 G.H5.23
Hydrophobic C-term L 363 - G.S2 I 211 G.S2.01
Hydrophobic TM2 I 89 2x43 G.H5 M 379 G.H5.24
Van-der-waals TM2 I 89 2x43 G.H5 M 379 G.H5.24
Ionic C-term H 350 - G.H5 D 377 G.H5.22
Polar C-term H 350 - G.H5 D 377 G.H5.22
Hydrophobic C-term H 350 - G.H5 D 377 G.H5.22
Van-der-waals C-term H 350 - G.H5 D 377 G.H5.22
Hydrophobic TM3 R 148 3x50 G.H5 L 380 G.H5.25
Hydrophobic TM2 T 85 2x39 G.H5 I 378 G.H5.23
Hydrophobic ICL2 L 156 - G.S3 I 221 G.S3.01
Van-der-waals ICL2 L 156 - G.S3 I 221 G.S3.01
Hydrophobic TM6 M 269 6x36 G.H5 M 379 G.H5.24
Van-der-waals TM6 M 269 6x36 G.H5 M 379 G.H5.24
Van-der-waals TM5 S 251 5x70 G.S6 F 347 G.S6.02