Gi2 -
Y2 receptor complex model
GPCR CLASS (FAMILY)
SPECIES
G PROTEIN FAMILY
DATE
3D VIEW
Tertiary structure confidence
(pLDDT score) avg.: 82.7
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered
PTM Score: 0.7
iPTM Score: 0.7
PAE mean: 12.8
GPCR - G protein interface interactions
The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle
(Gα residues)
and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid,
hydrophobic - dashed,
ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.
GPCR-G protein backbone (bb) or sidechain (sc):
Structures
0 structures selected.
Sequence Color
Interaction frequency filter (%)
Gα,
GPCR
Interaction cut-off: strict (stick), loose (line)
Interaction type |
GPCR Segment |
AA |
Number |
Generic number |
Gα segment |
AA |
Number |
Generic number |
---|---|---|---|---|---|---|---|---|
Hydrophobic | TM6 | T | 266 | 6x33 | G.H5 | L | 349 | G.H5.20 |
Hydrophobic | ICL2 | H | 155 | - | G.H5 | T | 341 | G.H5.12 |
Van-der-waals | ICL2 | H | 155 | - | G.H5 | T | 341 | G.H5.12 |
Polar | TM6 | T | 266 | 6x33 | G.H5 | L | 354 | G.H5.25 |
Hydrophobic | TM6 | T | 266 | 6x33 | G.H5 | L | 354 | G.H5.25 |
Van-der-waals | TM6 | T | 266 | 6x33 | G.H5 | L | 354 | G.H5.25 |
Hydrophobic | TM5 | L | 246 | 5x65 | G.H5 | I | 345 | G.H5.16 |
Polar | ICL2 | S | 158 | - | G.HN | E | 28 | G.HN.52 |
Hydrophobic | ICL2 | S | 158 | - | G.HN | E | 28 | G.HN.52 |
Van-der-waals | ICL2 | S | 158 | - | G.HN | E | 28 | G.HN.52 |
Polar | C-term | R | 366 | - | G.S2 | I | 185 | G.S2.01 |
Polar | TM3 | C | 151 | 3x53 | G.H5 | C | 352 | G.H5.23 |
Hydrophobic | TM3 | C | 151 | 3x53 | G.H5 | C | 352 | G.H5.23 |
Van-der-waals | TM3 | C | 151 | 3x53 | G.H5 | C | 352 | G.H5.23 |
Hydrophobic | ICL2 | E | 157 | - | G.hns1 | A | 31 | G.hns1.02 |
Polar | TM5 | S | 251 | 5x70 | G.H5 | D | 342 | G.H5.13 |
Hydrophobic | TM5 | S | 251 | 5x70 | G.H5 | D | 342 | G.H5.13 |
Van-der-waals | TM6 | M | 269 | 6x36 | G.H5 | G | 353 | G.H5.24 |
Ionic | C-term | H | 350 | - | G.H5 | D | 351 | G.H5.22 |
Polar | C-term | H | 350 | - | G.H5 | D | 351 | G.H5.22 |
Hydrophobic | C-term | H | 350 | - | G.H5 | D | 351 | G.H5.22 |
Van-der-waals | C-term | H | 350 | - | G.H5 | D | 351 | G.H5.22 |
Hydrophobic | TM5 | P | 252 | 5x71 | G.H5 | F | 335 | G.H5.06 |
Van-der-waals | TM5 | P | 252 | 5x71 | G.H5 | F | 335 | G.H5.06 |
Ionic | TM6 | R | 262 | 6x29 | G.h4s6 | E | 319 | G.h4s6.12 |
Polar | C-term | R | 366 | - | G.S2 | E | 187 | G.S2.03 |
Hydrophobic | TM5 | H | 249 | 5x68 | G.H5 | T | 341 | G.H5.12 |
Hydrophobic | C-term | V | 365 | - | G.S2 | E | 187 | G.S2.03 |
Van-der-waals | C-term | V | 365 | - | G.S2 | E | 187 | G.S2.03 |
Polar | ICL2 | L | 156 | - | G.hns1 | R | 32 | G.hns1.03 |
Hydrophobic | ICL2 | L | 156 | - | G.hns1 | R | 32 | G.hns1.03 |
Van-der-waals | ICL2 | L | 156 | - | G.hns1 | R | 32 | G.hns1.03 |
Polar | C-term | N | 372 | - | H.HA | Q | 68 | H.HA.06 |
Van-der-waals | C-term | N | 372 | - | H.HA | Q | 68 | H.HA.06 |
Hydrophobic | TM6 | L | 270 | 6x37 | G.H5 | L | 354 | G.H5.25 |
Van-der-waals | TM6 | L | 270 | 6x37 | G.H5 | L | 354 | G.H5.25 |
Hydrophobic | ICL2 | L | 156 | - | G.S3 | L | 195 | G.S3.01 |
Van-der-waals | ICL2 | L | 156 | - | G.S3 | L | 195 | G.S3.01 |
Hydrophobic | C-term | N | 368 | - | G.S2 | V | 186 | G.S2.02 |
Van-der-waals | C-term | N | 368 | - | G.S2 | V | 186 | G.S2.02 |
Polar | C-term | N | 368 | - | G.S2 | E | 187 | G.S2.03 |
Polar | C-term | V | 381 | - | H.HA | Q | 79 | H.HA.17 |
Hydrophobic | C-term | P | 371 | - | H.HA | E | 65 | H.HA.03 |
Hydrophobic | C-term | P | 371 | - | H.HA | Y | 69 | H.HA.07 |
Hydrophobic | C-term | V | 355 | - | G.h2s4 | E | 217 | G.h2s4.02 |
Van-der-waals | C-term | V | 355 | - | G.h2s4 | E | 217 | G.h2s4.02 |
Hydrophobic | TM5 | K | 245 | 5x64 | G.H5 | I | 345 | G.H5.16 |
Hydrophobic | TM6 | M | 269 | 6x36 | G.H5 | L | 354 | G.H5.25 |
Van-der-waals | TM6 | M | 269 | 6x36 | G.H5 | L | 354 | G.H5.25 |
Hydrophobic | TM5 | P | 252 | 5x71 | G.S6 | Y | 321 | G.S6.02 |
Polar | H8 | S | 330 | 8x48 | G.H5 | F | 355 | G.H5.26 |
Van-der-waals | H8 | S | 330 | 8x48 | G.H5 | F | 355 | G.H5.26 |
Hydrophobic | TM5 | P | 252 | 5x71 | G.H5 | A | 339 | G.H5.10 |
Van-der-waals | TM5 | P | 252 | 5x71 | G.H5 | A | 339 | G.H5.10 |
Polar | C-term | N | 380 | - | H.HA | Q | 79 | H.HA.17 |
Hydrophobic | TM5 | L | 246 | 5x65 | G.H5 | L | 349 | G.H5.20 |
Polar | C-term | E | 352 | - | G.h3s5 | T | 263 | G.h3s5.03 |
Polar | TM3 | R | 148 | 3x50 | G.H5 | C | 352 | G.H5.23 |
Hydrophobic | TM3 | R | 148 | 3x50 | G.H5 | C | 352 | G.H5.23 |
Van-der-waals | TM3 | R | 148 | 3x50 | G.H5 | C | 352 | G.H5.23 |
Hydrophobic | C-term | V | 381 | - | H.hdhe | Q | 148 | H.hdhe.02 |
Polar | TM5 | S | 251 | 5x70 | G.h4s6 | E | 319 | G.h4s6.12 |
Van-der-waals | TM5 | S | 251 | 5x70 | G.h4s6 | E | 319 | G.h4s6.12 |
Hydrophobic | TM6 | R | 262 | 6x29 | G.H5 | F | 355 | G.H5.26 |
Van-der-waals | TM6 | R | 262 | 6x29 | G.H5 | F | 355 | G.H5.26 |
Hydrophobic | C-term | T | 379 | - | G.hfs2 | K | 181 | G.hfs2.04 |
Van-der-waals | C-term | T | 379 | - | G.hfs2 | K | 181 | G.hfs2.04 |
Ionic | TM5 | H | 249 | 5x68 | G.H5 | D | 342 | G.H5.13 |
Polar | TM5 | H | 249 | 5x68 | G.H5 | D | 342 | G.H5.13 |
Hydrophobic | TM5 | H | 249 | 5x68 | G.H5 | D | 342 | G.H5.13 |
Van-der-waals | TM5 | H | 249 | 5x68 | G.H5 | D | 342 | G.H5.13 |
Hydrophobic | TM2 | T | 85 | 2x39 | G.H5 | C | 352 | G.H5.23 |
Polar | TM6 | R | 262 | 6x29 | G.h4s6 | D | 316 | G.h4s6.09 |
Van-der-waals | TM6 | R | 262 | 6x29 | G.h4s6 | D | 316 | G.h4s6.09 |
Ionic | ICL2 | K | 159 | - | G.H5 | D | 351 | G.H5.22 |
Polar | ICL2 | K | 159 | - | G.H5 | D | 351 | G.H5.22 |
Van-der-waals | ICL2 | K | 159 | - | G.H5 | D | 351 | G.H5.22 |
Hydrophobic | C-term | E | 352 | - | G.h3s5 | D | 262 | G.h3s5.02 |
Van-der-waals | C-term | E | 352 | - | G.h3s5 | D | 262 | G.h3s5.02 |
Hydrophobic | ICL2 | H | 155 | - | G.H5 | I | 345 | G.H5.16 |
Polar | TM4 | R | 163 | 4x40 | G.HN | S | 16 | G.HN.40 |
Ionic | TM4 | R | 163 | 4x40 | G.HN | D | 20 | G.HN.44 |
Polar | TM4 | R | 163 | 4x40 | G.HN | D | 20 | G.HN.44 |
Hydrophobic | TM4 | R | 163 | 4x40 | G.HN | D | 20 | G.HN.44 |
Van-der-waals | TM4 | R | 163 | 4x40 | G.HN | D | 20 | G.HN.44 |
Polar | TM6 | K | 265 | 6x32 | G.H5 | F | 355 | G.H5.26 |
Hydrophobic | TM6 | K | 265 | 6x32 | G.H5 | F | 355 | G.H5.26 |
Van-der-waals | TM6 | K | 265 | 6x32 | G.H5 | F | 355 | G.H5.26 |
Hydrophobic | ICL2 | S | 158 | - | G.HN | G | 27 | G.HN.51 |
Hydrophobic | ICL2 | L | 156 | - | G.H5 | I | 344 | G.H5.15 |
Hydrophobic | TM5 | H | 249 | 5x68 | G.H5 | I | 345 | G.H5.16 |
Hydrophobic | C-term | L | 363 | - | G.S2 | I | 185 | G.S2.01 |
Hydrophobic | C-term | F | 375 | - | H.HA | V | 72 | H.HA.10 |
Van-der-waals | C-term | F | 375 | - | H.HA | V | 72 | H.HA.10 |
Hydrophobic | TM6 | R | 262 | 6x29 | G.H5 | K | 346 | G.H5.17 |
Van-der-waals | TM6 | R | 262 | 6x29 | G.H5 | K | 346 | G.H5.17 |
Hydrophobic | ICL2 | H | 155 | - | G.H5 | I | 344 | G.H5.15 |
Van-der-waals | ICL2 | H | 155 | - | G.H5 | I | 344 | G.H5.15 |
Hydrophobic | ICL2 | S | 158 | - | G.hns1 | A | 31 | G.hns1.02 |
Van-der-waals | ICL2 | S | 158 | - | G.hns1 | A | 31 | G.hns1.02 |
Polar | H8 | N | 331 | 8x49 | G.H5 | K | 350 | G.H5.21 |
Van-der-waals | H8 | N | 331 | 8x49 | G.H5 | K | 350 | G.H5.21 |
Hydrophobic | TM3 | I | 152 | 3x54 | G.H5 | L | 354 | G.H5.25 |
Van-der-waals | TM3 | I | 152 | 3x54 | G.H5 | L | 354 | G.H5.25 |
Polar | C-term | T | 356 | - | G.h2s4 | E | 217 | G.h2s4.02 |
Hydrophobic | C-term | T | 356 | - | G.h2s4 | E | 217 | G.h2s4.02 |
Van-der-waals | C-term | T | 356 | - | G.h2s4 | E | 217 | G.h2s4.02 |
Hydrophobic | TM3 | I | 152 | 3x54 | G.H5 | L | 349 | G.H5.20 |
Van-der-waals | TM3 | I | 152 | 3x54 | G.H5 | L | 349 | G.H5.20 |
Hydrophobic | TM5 | G | 253 | 5x72 | G.S6 | Y | 321 | G.S6.02 |
Van-der-waals | TM5 | G | 253 | 5x72 | G.S6 | Y | 321 | G.S6.02 |
Polar | ICL2 | H | 155 | - | G.H5 | N | 348 | G.H5.19 |
Hydrophobic | TM5 | P | 252 | 5x71 | G.H5 | D | 338 | G.H5.09 |
Polar | C-term | I | 349 | - | G.H5 | K | 350 | G.H5.21 |
Hydrophobic | TM3 | R | 148 | 3x50 | G.H5 | L | 354 | G.H5.25 |
Van-der-waals | TM3 | R | 148 | 3x50 | G.H5 | L | 354 | G.H5.25 |
Hydrophobic | C-term | L | 363 | - | G.H2 | H | 214 | G.H2.09 |
Van-der-waals | C-term | L | 363 | - | G.H2 | H | 214 | G.H2.09 |
Hydrophobic | TM5 | P | 252 | 5x71 | G.H5 | D | 342 | G.H5.13 |
Polar | TM3 | C | 151 | 3x53 | G.H5 | N | 348 | G.H5.19 |
Hydrophobic | TM3 | C | 151 | 3x53 | G.H5 | N | 348 | G.H5.19 |
Van-der-waals | TM3 | C | 151 | 3x53 | G.H5 | N | 348 | G.H5.19 |
Polar | C-term | P | 371 | - | H.HA | Q | 68 | H.HA.06 |
Hydrophobic | C-term | P | 371 | - | H.HA | Q | 68 | H.HA.06 |
Van-der-waals | C-term | P | 371 | - | H.HA | Q | 68 | H.HA.06 |
Hydrophobic | H8 | N | 329 | 8x47 | G.H5 | G | 353 | G.H5.24 |
Van-der-waals | H8 | N | 329 | 8x47 | G.H5 | G | 353 | G.H5.24 |
Polar | ICL2 | K | 159 | - | G.H5 | N | 348 | G.H5.19 |
Hydrophobic | ICL2 | K | 159 | - | G.H5 | N | 348 | G.H5.19 |
Van-der-waals | ICL2 | K | 159 | - | G.H5 | N | 348 | G.H5.19 |