G12 -
Y4 receptor complex model
GPCR CLASS (FAMILY)
SPECIES
G PROTEIN FAMILY
DATE
3D VIEW
Tertiary structure confidence
(pLDDT score) avg.: 79.0
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered
PTM Score: 0.7
iPTM Score: 0.7
PAE mean: 16.0
GPCR - G protein interface interactions
The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle
(Gα residues)
and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid,
hydrophobic - dashed,
ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.
GPCR-G protein backbone (bb) or sidechain (sc):
Structures
0 structures selected.
Sequence Color
Interaction frequency filter (%)
Gα,
GPCR
Interaction cut-off: strict (stick), loose (line)
Interaction type |
GPCR Segment |
AA |
Number |
Generic number |
Gα segment |
AA |
Number |
Generic number |
---|---|---|---|---|---|---|---|---|
Hydrophobic | TM3 | L | 142 | 3x53 | G.H5 | I | 378 | G.H5.23 |
Van-der-waals | TM3 | L | 142 | 3x53 | G.H5 | I | 378 | G.H5.23 |
Aromatic | TM5 | F | 248 | 5x72 | G.H5 | H | 364 | G.H5.09 |
Hydrophobic | TM5 | F | 248 | 5x72 | G.H5 | H | 364 | G.H5.09 |
Van-der-waals | TM5 | F | 248 | 5x72 | G.H5 | H | 364 | G.H5.09 |
Hydrophobic | TM5 | F | 248 | 5x72 | G.H5 | D | 368 | G.H5.13 |
Van-der-waals | TM5 | F | 248 | 5x72 | G.H5 | D | 368 | G.H5.13 |
Polar | ICL3 | Y | 253 | - | G.S6 | L | 346 | G.S6.01 |
Polar | H8 | T | 327 | 8x48 | G.H5 | Q | 381 | G.H5.26 |
Hydrophobic | H8 | T | 327 | 8x48 | G.H5 | Q | 381 | G.H5.26 |
Van-der-waals | H8 | T | 327 | 8x48 | G.H5 | Q | 381 | G.H5.26 |
Hydrophobic | TM6 | M | 260 | 6x30 | G.H5 | L | 375 | G.H5.20 |
Ionic | ICL2 | K | 150 | - | G.H5 | D | 377 | G.H5.22 |
Polar | ICL2 | K | 150 | - | G.H5 | D | 377 | G.H5.22 |
Hydrophobic | TM3 | I | 143 | 3x54 | G.H5 | L | 375 | G.H5.20 |
Van-der-waals | TM3 | I | 143 | 3x54 | G.H5 | L | 375 | G.H5.20 |
Polar | TM6 | H | 259 | 6x29 | G.H5 | Q | 372 | G.H5.17 |
Hydrophobic | C-term | L | 352 | - | G.H3 | K | 284 | G.H3.16 |
Hydrophobic | TM6 | V | 263 | 6x33 | G.H5 | L | 375 | G.H5.20 |
Hydrophobic | ICL2 | P | 146 | - | G.H5 | L | 371 | G.H5.16 |
Hydrophobic | TM5 | V | 247 | 5x71 | G.H5 | H | 364 | G.H5.09 |
Van-der-waals | TM5 | V | 247 | 5x71 | G.H5 | H | 364 | G.H5.09 |
Hydrophobic | TM5 | L | 241 | 5x65 | G.H5 | L | 375 | G.H5.20 |
Van-der-waals | TM5 | L | 241 | 5x65 | G.H5 | L | 375 | G.H5.20 |
Hydrophobic | C-term | L | 354 | - | G.H3 | N | 283 | G.H3.15 |
Van-der-waals | C-term | L | 354 | - | G.H3 | N | 283 | G.H3.15 |
Hydrophobic | ICL2 | P | 146 | - | G.H5 | K | 367 | G.H5.12 |
Van-der-waals | ICL2 | P | 146 | - | G.H5 | K | 367 | G.H5.12 |
Polar | TM5 | Q | 244 | 5x68 | G.H5 | D | 368 | G.H5.13 |
Van-der-waals | TM5 | Q | 244 | 5x68 | G.H5 | D | 368 | G.H5.13 |
Hydrophobic | TM6 | Q | 262 | 6x32 | G.H5 | M | 379 | G.H5.24 |
Polar | H8 | N | 326 | 8x47 | G.H5 | I | 378 | G.H5.23 |
Polar | H8 | T | 327 | 8x48 | G.H5 | M | 379 | G.H5.24 |
Polar | ICL2 | K | 150 | - | G.H5 | N | 374 | G.H5.19 |
Ionic | TM6 | R | 256 | 6x26 | G.H5 | D | 368 | G.H5.13 |
Polar | TM6 | R | 256 | 6x26 | G.H5 | D | 368 | G.H5.13 |
Hydrophobic | TM6 | R | 256 | 6x26 | G.H5 | D | 368 | G.H5.13 |
Van-der-waals | TM6 | R | 256 | 6x26 | G.H5 | D | 368 | G.H5.13 |
Polar | H8 | N | 326 | 8x47 | G.H5 | L | 380 | G.H5.25 |
Hydrophobic | H8 | N | 326 | 8x47 | G.H5 | L | 380 | G.H5.25 |
Van-der-waals | H8 | N | 326 | 8x47 | G.H5 | L | 380 | G.H5.25 |
Hydrophobic | TM6 | R | 256 | 6x26 | G.H5 | Q | 372 | G.H5.17 |
Van-der-waals | TM6 | R | 256 | 6x26 | G.H5 | Q | 372 | G.H5.17 |
Polar | TM3 | L | 142 | 3x53 | G.H5 | N | 374 | G.H5.19 |
Hydrophobic | TM3 | L | 142 | 3x53 | G.H5 | N | 374 | G.H5.19 |
Van-der-waals | TM3 | L | 142 | 3x53 | G.H5 | N | 374 | G.H5.19 |
Hydrophobic | TM3 | I | 143 | 3x54 | G.H5 | I | 378 | G.H5.23 |
Polar | H8 | N | 328 | 8x49 | G.H5 | Q | 381 | G.H5.26 |
Hydrophobic | H8 | N | 328 | 8x49 | G.H5 | Q | 381 | G.H5.26 |
Van-der-waals | H8 | N | 328 | 8x49 | G.H5 | Q | 381 | G.H5.26 |
Polar | ICL3 | Y | 253 | - | G.h4s6 | R | 339 | G.h4s6.08 |
Van-der-waals | ICL3 | Y | 253 | - | G.h4s6 | R | 339 | G.h4s6.08 |
Hydrophobic | ICL2 | P | 146 | - | G.H5 | I | 370 | G.H5.15 |
Van-der-waals | ICL2 | P | 146 | - | G.H5 | I | 370 | G.H5.15 |
Hydrophobic | TM5 | L | 241 | 5x65 | G.H5 | L | 371 | G.H5.16 |
Hydrophobic | TM6 | M | 260 | 6x30 | G.H5 | Q | 372 | G.H5.17 |
Hydrophobic | ICL2 | T | 147 | - | G.H5 | I | 370 | G.H5.15 |
Hydrophobic | TM6 | V | 266 | 6x36 | G.H5 | M | 379 | G.H5.24 |
Polar | TM6 | H | 259 | 6x29 | G.H5 | Q | 381 | G.H5.26 |
Hydrophobic | TM6 | H | 259 | 6x29 | G.H5 | Q | 381 | G.H5.26 |
Van-der-waals | TM6 | H | 259 | 6x29 | G.H5 | Q | 381 | G.H5.26 |
Polar | ICL2 | G | 148 | - | G.hns1 | R | 56 | G.hns1.03 |
Hydrophobic | ICL2 | G | 148 | - | G.hns1 | R | 56 | G.hns1.03 |
Van-der-waals | ICL2 | G | 148 | - | G.hns1 | R | 56 | G.hns1.03 |
Hydrophobic | H8 | F | 329 | 8x50 | G.H5 | L | 380 | G.H5.25 |
Polar | ICL3 | Y | 253 | - | G.h4s6 | R | 342 | G.h4s6.11 |
Van-der-waals | ICL3 | Y | 253 | - | G.h4s6 | R | 342 | G.h4s6.11 |
Van-der-waals | H8 | K | 331 | 8x52 | G.H5 | Q | 381 | G.H5.26 |
Hydrophobic | C-term | L | 354 | - | G.h2s4 | F | 242 | G.h2s4.01 |
Polar | TM3 | R | 139 | 3x50 | G.H5 | I | 378 | G.H5.23 |
Hydrophobic | TM3 | R | 139 | 3x50 | G.H5 | I | 378 | G.H5.23 |
Van-der-waals | TM3 | R | 139 | 3x50 | G.H5 | I | 378 | G.H5.23 |
Hydrophobic | ICL2 | T | 147 | - | G.S3 | I | 221 | G.S3.01 |
Van-der-waals | ICL2 | T | 147 | - | G.S3 | I | 221 | G.S3.01 |
Hydrophobic | TM5 | F | 248 | 5x72 | G.S6 | F | 347 | G.S6.02 |
Van-der-waals | TM5 | F | 248 | 5x72 | G.S6 | F | 347 | G.S6.02 |
Polar | H8 | T | 327 | 8x48 | G.H5 | L | 380 | G.H5.25 |
Hydrophobic | H8 | T | 327 | 8x48 | G.H5 | L | 380 | G.H5.25 |
Van-der-waals | H8 | T | 327 | 8x48 | G.H5 | L | 380 | G.H5.25 |
Polar | H8 | N | 328 | 8x49 | G.H5 | L | 380 | G.H5.25 |
Hydrophobic | H8 | N | 328 | 8x49 | G.H5 | L | 380 | G.H5.25 |
Van-der-waals | H8 | N | 328 | 8x49 | G.H5 | L | 380 | G.H5.25 |
Hydrophobic | TM5 | Q | 244 | 5x68 | G.H5 | L | 371 | G.H5.16 |
Van-der-waals | TM5 | Q | 244 | 5x68 | G.H5 | L | 371 | G.H5.16 |
Polar | ICL3 | Y | 253 | - | G.h4s6 | P | 345 | G.h4s6.20 |
Hydrophobic | ICL3 | Y | 253 | - | G.h4s6 | P | 345 | G.h4s6.20 |
Van-der-waals | ICL3 | Y | 253 | - | G.h4s6 | P | 345 | G.h4s6.20 |
Hydrophobic | ICL3 | Y | 253 | - | G.h4s6 | S | 343 | G.h4s6.12 |
Van-der-waals | ICL3 | Y | 253 | - | G.h4s6 | S | 343 | G.h4s6.12 |
Hydrophobic | ICL2 | T | 147 | - | G.H5 | K | 367 | G.H5.12 |
Hydrophobic | TM6 | V | 263 | 6x33 | G.H5 | M | 379 | G.H5.24 |
Van-der-waals | TM6 | V | 263 | 6x33 | G.H5 | M | 379 | G.H5.24 |
Polar | ICL1 | A | 73 | 12x51 | G.hns1 | R | 55 | G.hns1.02 |
Polar | ICL2 | P | 146 | - | G.H5 | N | 374 | G.H5.19 |
Van-der-waals | ICL2 | P | 146 | - | G.H5 | N | 374 | G.H5.19 |
Polar | ICL2 | P | 151 | - | G.hns1 | R | 55 | G.hns1.02 |
Van-der-waals | ICL2 | P | 151 | - | G.hns1 | R | 55 | G.hns1.02 |
Hydrophobic | TM4 | S | 152 | 4x38 | G.hns1 | R | 55 | G.hns1.02 |
Van-der-waals | TM4 | S | 152 | 4x38 | G.hns1 | R | 55 | G.hns1.02 |
Hydrophobic | TM5 | R | 240 | 5x64 | G.H5 | K | 367 | G.H5.12 |
Van-der-waals | TM5 | R | 240 | 5x64 | G.H5 | K | 367 | G.H5.12 |
Hydrophobic | H8 | N | 326 | 8x47 | G.H5 | M | 379 | G.H5.24 |
Van-der-waals | H8 | N | 326 | 8x47 | G.H5 | M | 379 | G.H5.24 |
Ionic | C-term | E | 350 | - | G.H3 | K | 284 | G.H3.16 |
Polar | C-term | E | 350 | - | G.H3 | K | 284 | G.H3.16 |
Van-der-waals | C-term | E | 350 | - | G.H3 | K | 284 | G.H3.16 |
Hydrophobic | C-term | L | 354 | - | G.H3 | T | 279 | G.H3.11 |
Van-der-waals | C-term | L | 354 | - | G.H3 | T | 279 | G.H3.11 |
Polar | ICL3 | Y | 253 | - | G.h4s6 | K | 344 | G.h4s6.19 |
Hydrophobic | ICL3 | Y | 253 | - | G.h4s6 | K | 344 | G.h4s6.19 |
Van-der-waals | ICL3 | Y | 253 | - | G.h4s6 | K | 344 | G.h4s6.19 |
Hydrophobic | TM3 | I | 143 | 3x54 | G.H5 | L | 371 | G.H5.16 |
Van-der-waals | TM3 | I | 143 | 3x54 | G.H5 | L | 371 | G.H5.16 |
Hydrophobic | ICL2 | W | 149 | - | G.hns1 | R | 56 | G.hns1.03 |
Van-der-waals | ICL2 | W | 149 | - | G.hns1 | R | 56 | G.hns1.03 |