Gz -
Y4 receptor complex model
GPCR CLASS (FAMILY)
SPECIES
G PROTEIN FAMILY
DATE
3D VIEW
Tertiary structure confidence
(pLDDT score) avg.: 82.6
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered
PTM Score: 0.8
iPTM Score: 0.8
PAE mean: 13.2
GPCR - G protein interface interactions
The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle
(Gα residues)
and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid,
hydrophobic - dashed,
ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.
GPCR-G protein backbone (bb) or sidechain (sc):
Structures
0 structures selected.
Sequence Color
Interaction frequency filter (%)
Gα,
GPCR
Interaction cut-off: strict (stick), loose (line)
Interaction type |
GPCR Segment |
AA |
Number |
Generic number |
Gα segment |
AA |
Number |
Generic number |
---|---|---|---|---|---|---|---|---|
Ionic | TM6 | R | 256 | 6x26 | G.h4s6 | E | 319 | G.h4s6.12 |
Polar | TM6 | R | 256 | 6x26 | G.h4s6 | E | 319 | G.h4s6.12 |
Hydrophobic | TM6 | R | 256 | 6x26 | G.h4s6 | E | 319 | G.h4s6.12 |
Van-der-waals | TM6 | R | 256 | 6x26 | G.h4s6 | E | 319 | G.h4s6.12 |
Hydrophobic | TM6 | V | 266 | 6x36 | G.H5 | L | 354 | G.H5.25 |
Van-der-waals | TM6 | V | 266 | 6x36 | G.H5 | L | 354 | G.H5.25 |
Hydrophobic | C-term | L | 354 | - | G.h2s4 | F | 216 | G.h2s4.01 |
Van-der-waals | C-term | L | 354 | - | G.h2s4 | F | 216 | G.h2s4.01 |
Van-der-waals | TM5 | R | 240 | 5x64 | G.H5 | T | 341 | G.H5.12 |
Hydrophobic | TM6 | V | 263 | 6x33 | G.H5 | L | 349 | G.H5.20 |
Polar | TM6 | R | 256 | 6x26 | G.S6 | Y | 321 | G.S6.02 |
Polar | ICL1 | A | 73 | 12x51 | G.H5 | Y | 351 | G.H5.22 |
Hydrophobic | ICL2 | T | 147 | - | G.H5 | I | 344 | G.H5.15 |
Hydrophobic | ICL3 | Y | 253 | - | G.h4s6 | K | 315 | G.h4s6.08 |
Hydrophobic | TM6 | M | 270 | 6x40 | G.H5 | L | 354 | G.H5.25 |
Hydrophobic | TM3 | R | 139 | 3x50 | G.H5 | L | 354 | G.H5.25 |
Polar | TM3 | L | 142 | 3x53 | G.H5 | N | 348 | G.H5.19 |
Hydrophobic | TM3 | L | 142 | 3x53 | G.H5 | N | 348 | G.H5.19 |
Van-der-waals | TM3 | L | 142 | 3x53 | G.H5 | N | 348 | G.H5.19 |
Hydrophobic | ICL2 | P | 146 | - | G.H5 | T | 341 | G.H5.12 |
Hydrophobic | TM6 | M | 260 | 6x30 | G.H5 | L | 349 | G.H5.20 |
Hydrophobic | H8 | N | 328 | 8x49 | G.H5 | G | 353 | G.H5.24 |
Van-der-waals | H8 | N | 328 | 8x49 | G.H5 | G | 353 | G.H5.24 |
Polar | TM2 | V | 75 | 2x38 | G.H5 | Y | 351 | G.H5.22 |
Van-der-waals | TM2 | V | 75 | 2x38 | G.H5 | Y | 351 | G.H5.22 |
Polar | ICL3 | Y | 253 | - | G.h4s6 | N | 312 | G.h4s6.02 |
Hydrophobic | ICL2 | K | 150 | - | G.hns1 | R | 31 | G.hns1.02 |
Van-der-waals | ICL2 | K | 150 | - | G.hns1 | R | 31 | G.hns1.02 |
Hydrophobic | H8 | N | 326 | 8x47 | G.H5 | G | 353 | G.H5.24 |
Van-der-waals | H8 | N | 326 | 8x47 | G.H5 | G | 353 | G.H5.24 |
Hydrophobic | TM6 | V | 263 | 6x33 | G.H5 | L | 354 | G.H5.25 |
Van-der-waals | TM6 | V | 263 | 6x33 | G.H5 | L | 354 | G.H5.25 |
Hydrophobic | TM5 | L | 241 | 5x65 | G.H5 | I | 345 | G.H5.16 |
Hydrophobic | TM5 | Q | 244 | 5x68 | G.H5 | D | 342 | G.H5.13 |
Van-der-waals | TM5 | Q | 244 | 5x68 | G.H5 | D | 342 | G.H5.13 |
Hydrophobic | TM6 | L | 255 | 6x25 | G.h4s6 | E | 316 | G.h4s6.09 |
Van-der-waals | TM6 | L | 255 | 6x25 | G.h4s6 | E | 316 | G.h4s6.09 |
Polar | TM4 | S | 154 | 4x40 | G.HN | R | 24 | G.HN.48 |
Hydrophobic | TM4 | S | 154 | 4x40 | G.HN | R | 24 | G.HN.48 |
Van-der-waals | TM4 | S | 154 | 4x40 | G.HN | R | 24 | G.HN.48 |
Polar | TM6 | H | 259 | 6x29 | G.H5 | C | 355 | G.H5.26 |
Hydrophobic | TM6 | H | 259 | 6x29 | G.H5 | C | 355 | G.H5.26 |
Hydrophobic | TM6 | M | 260 | 6x30 | G.H5 | Q | 346 | G.H5.17 |
Polar | H8 | T | 327 | 8x48 | G.H5 | C | 355 | G.H5.26 |
Hydrophobic | H8 | T | 327 | 8x48 | G.H5 | C | 355 | G.H5.26 |
Van-der-waals | H8 | T | 327 | 8x48 | G.H5 | C | 355 | G.H5.26 |
Hydrophobic | TM5 | Q | 244 | 5x68 | G.H5 | I | 345 | G.H5.16 |
Van-der-waals | TM5 | Q | 244 | 5x68 | G.H5 | I | 345 | G.H5.16 |
Ionic | ICL3 | H | 249 | - | G.h4s6 | E | 319 | G.h4s6.12 |
Polar | ICL3 | H | 249 | - | G.h4s6 | E | 319 | G.h4s6.12 |
Hydrophobic | ICL3 | H | 249 | - | G.h4s6 | E | 319 | G.h4s6.12 |
Van-der-waals | ICL3 | H | 249 | - | G.h4s6 | E | 319 | G.h4s6.12 |
Hydrophobic | TM6 | L | 267 | 6x37 | G.H5 | L | 354 | G.H5.25 |
Polar | H8 | T | 327 | 8x48 | G.H5 | G | 353 | G.H5.24 |
Van-der-waals | H8 | T | 327 | 8x48 | G.H5 | G | 353 | G.H5.24 |
Polar | ICL2 | K | 150 | - | G.H5 | N | 348 | G.H5.19 |
Hydrophobic | TM3 | R | 139 | 3x50 | G.H5 | I | 352 | G.H5.23 |
Hydrophobic | TM3 | I | 143 | 3x54 | G.H5 | N | 348 | G.H5.19 |
Hydrophobic | TM3 | L | 142 | 3x53 | G.H5 | Y | 351 | G.H5.22 |
Hydrophobic | TM6 | R | 256 | 6x26 | G.H5 | Q | 346 | G.H5.17 |
Van-der-waals | TM6 | R | 256 | 6x26 | G.H5 | Q | 346 | G.H5.17 |
Hydrophobic | TM5 | F | 248 | 5x72 | G.H5 | D | 338 | G.H5.09 |
Van-der-waals | TM5 | F | 248 | 5x72 | G.H5 | D | 338 | G.H5.09 |
Polar | C-term | H | 351 | - | G.H3 | W | 259 | G.H3.17 |
Aromatic | C-term | H | 351 | - | G.H3 | W | 259 | G.H3.17 |
Hydrophobic | C-term | H | 351 | - | G.H3 | W | 259 | G.H3.17 |
Van-der-waals | C-term | H | 351 | - | G.H3 | W | 259 | G.H3.17 |
Hydrophobic | ICL2 | T | 147 | - | G.S3 | L | 195 | G.S3.01 |
Van-der-waals | ICL2 | T | 147 | - | G.S3 | L | 195 | G.S3.01 |
Polar | H8 | N | 326 | 8x47 | G.H5 | I | 352 | G.H5.23 |
Hydrophobic | TM3 | L | 142 | 3x53 | G.H5 | I | 352 | G.H5.23 |
Van-der-waals | TM3 | L | 142 | 3x53 | G.H5 | I | 352 | G.H5.23 |
Hydrophobic | TM5 | F | 248 | 5x72 | G.H5 | D | 342 | G.H5.13 |
Aromatic | TM5 | F | 248 | 5x72 | G.S6 | Y | 321 | G.S6.02 |
Hydrophobic | TM5 | F | 248 | 5x72 | G.S6 | Y | 321 | G.S6.02 |
Van-der-waals | TM5 | F | 248 | 5x72 | G.S6 | Y | 321 | G.S6.02 |
Hydrophobic | TM5 | F | 248 | 5x72 | G.H5 | A | 339 | G.H5.10 |
Van-der-waals | TM5 | F | 248 | 5x72 | G.H5 | A | 339 | G.H5.10 |
Polar | H8 | N | 328 | 8x49 | G.H5 | Y | 351 | G.H5.22 |
Van-der-waals | H8 | N | 328 | 8x49 | G.H5 | Y | 351 | G.H5.22 |
Hydrophobic | C-term | T | 356 | - | G.H2 | K | 210 | G.H2.05 |
Hydrophobic | C-term | L | 354 | - | G.H3 | I | 254 | G.H3.12 |
Hydrophobic | TM5 | F | 248 | 5x72 | G.H5 | F | 335 | G.H5.06 |
Van-der-waals | C-term | L | 354 | - | G.H3 | N | 257 | G.H3.15 |
Polar | ICL3 | Y | 253 | - | G.H4 | E | 309 | G.H4.16 |
Hydrophobic | TM5 | L | 241 | 5x65 | G.H5 | L | 349 | G.H5.20 |
Hydrophobic | ICL2 | P | 146 | - | G.H5 | I | 344 | G.H5.15 |
Van-der-waals | ICL2 | P | 146 | - | G.H5 | I | 344 | G.H5.15 |
Hydrophobic | ICL2 | P | 146 | - | G.H5 | I | 345 | G.H5.16 |
Hydrophobic | TM3 | I | 143 | 3x54 | G.H5 | L | 349 | G.H5.20 |
Van-der-waals | TM3 | I | 143 | 3x54 | G.H5 | L | 349 | G.H5.20 |
Hydrophobic | TM2 | T | 76 | 2x39 | G.H5 | I | 352 | G.H5.23 |
Aromatic | ICL2 | K | 150 | - | G.H5 | Y | 351 | G.H5.22 |
Hydrophobic | ICL2 | K | 150 | - | G.H5 | Y | 351 | G.H5.22 |
Polar | H8 | N | 328 | 8x49 | G.H5 | K | 350 | G.H5.21 |
Van-der-waals | H8 | N | 328 | 8x49 | G.H5 | K | 350 | G.H5.21 |
Hydrophobic | TM3 | I | 143 | 3x54 | G.H5 | I | 352 | G.H5.23 |
Ionic | TM6 | R | 256 | 6x26 | G.H5 | D | 342 | G.H5.13 |
Polar | TM6 | R | 256 | 6x26 | G.H5 | D | 342 | G.H5.13 |
Hydrophobic | TM6 | R | 256 | 6x26 | G.H5 | D | 342 | G.H5.13 |
Van-der-waals | TM6 | R | 256 | 6x26 | G.H5 | D | 342 | G.H5.13 |
Polar | TM2 | N | 74 | 2x37 | G.H5 | Y | 351 | G.H5.22 |
Hydrophobic | TM2 | N | 74 | 2x37 | G.H5 | Y | 351 | G.H5.22 |
Van-der-waals | TM2 | N | 74 | 2x37 | G.H5 | Y | 351 | G.H5.22 |
Hydrophobic | TM3 | I | 143 | 3x54 | G.H5 | I | 345 | G.H5.16 |
Polar | C-term | E | 350 | - | G.H3 | N | 258 | G.H3.16 |
Van-der-waals | C-term | E | 350 | - | G.H3 | N | 258 | G.H3.16 |
Hydrophobic | TM5 | R | 240 | 5x64 | G.H5 | I | 345 | G.H5.16 |