Gi1 -
NTS2 receptor complex model
GPCR CLASS (FAMILY)
SPECIES
G PROTEIN FAMILY
DATE
3D VIEW
Tertiary structure confidence
(pLDDT score) avg.: 83.5
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered
PTM Score: 0.7
iPTM Score: 0.7
PAE mean: 12.2
GPCR - G protein interface interactions
The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle
(Gα residues)
and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid,
hydrophobic - dashed,
ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.
GPCR-G protein backbone (bb) or sidechain (sc):
Structures
0 structures selected.
Sequence Color
Interaction frequency filter (%)
Gα,
GPCR
Interaction cut-off: strict (stick), loose (line)
Interaction type |
GPCR Segment |
AA |
Number |
Generic number |
Gα segment |
AA |
Number |
Generic number |
---|---|---|---|---|---|---|---|---|
Hydrophobic | TM6 | L | 299 | 6x37 | G.H5 | L | 353 | G.H5.25 |
Hydrophobic | TM3 | R | 133 | 3x50 | G.H5 | L | 353 | G.H5.25 |
Hydrophobic | TM6 | L | 292 | 6x30 | G.H5 | L | 348 | G.H5.20 |
Hydrophobic | TM3 | A | 136 | 3x53 | G.H5 | C | 351 | G.H5.23 |
Van-der-waals | TM3 | A | 136 | 3x53 | G.H5 | C | 351 | G.H5.23 |
Hydrophobic | ICL2 | L | 147 | 34x57 | G.H5 | C | 351 | G.H5.23 |
Hydrophobic | TM4 | T | 148 | 4x38 | G.hns1 | A | 31 | G.hns1.02 |
Van-der-waals | TM4 | T | 148 | 4x38 | G.hns1 | A | 31 | G.hns1.02 |
Hydrophobic | C-term | P | 405 | - | G.H3 | W | 258 | G.H3.17 |
Van-der-waals | C-term | P | 405 | - | G.H3 | W | 258 | G.H3.17 |
Polar | ICL2 | R | 144 | 34x54 | G.hns1 | A | 31 | G.hns1.02 |
Hydrophobic | ICL2 | R | 144 | 34x54 | G.hns1 | A | 31 | G.hns1.02 |
Van-der-waals | ICL2 | R | 144 | 34x54 | G.hns1 | A | 31 | G.hns1.02 |
Aromatic | C-term | F | 402 | - | G.h2s4 | F | 215 | G.h2s4.01 |
Hydrophobic | C-term | F | 402 | - | G.h2s4 | F | 215 | G.h2s4.01 |
Van-der-waals | C-term | F | 402 | - | G.h2s4 | F | 215 | G.h2s4.01 |
Polar | TM2 | L | 68 | 2x39 | G.H5 | D | 350 | G.H5.22 |
Hydrophobic | TM2 | L | 68 | 2x39 | G.H5 | D | 350 | G.H5.22 |
Van-der-waals | TM2 | L | 68 | 2x39 | G.H5 | D | 350 | G.H5.22 |
Hydrophobic | ICL2 | L | 141 | 34x51 | G.s2s3 | K | 192 | G.s2s3.01 |
Van-der-waals | ICL2 | L | 141 | 34x51 | G.s2s3 | K | 192 | G.s2s3.01 |
Ionic | TM2 | R | 67 | 2x38 | G.H5 | D | 350 | G.H5.22 |
Polar | TM2 | R | 67 | 2x38 | G.H5 | D | 350 | G.H5.22 |
Hydrophobic | TM2 | R | 67 | 2x38 | G.H5 | D | 350 | G.H5.22 |
Ionic | TM6 | R | 287 | 6x25 | G.h4s6 | D | 315 | G.h4s6.09 |
Polar | TM6 | R | 287 | 6x25 | G.h4s6 | D | 315 | G.h4s6.09 |
Hydrophobic | TM6 | R | 287 | 6x25 | G.h4s6 | D | 315 | G.h4s6.09 |
Van-der-waals | TM6 | R | 287 | 6x25 | G.h4s6 | D | 315 | G.h4s6.09 |
Hydrophobic | TM5 | T | 229 | 5x61 | G.H5 | L | 353 | G.H5.25 |
Hydrophobic | TM2 | L | 68 | 2x39 | G.H5 | G | 352 | G.H5.24 |
Van-der-waals | TM2 | L | 68 | 2x39 | G.H5 | G | 352 | G.H5.24 |
Ionic | ICL2 | R | 142 | 34x52 | G.s2s3 | D | 193 | G.s2s3.02 |
Polar | ICL2 | R | 142 | 34x52 | G.s2s3 | D | 193 | G.s2s3.02 |
Van-der-waals | ICL2 | R | 142 | 34x52 | G.s2s3 | D | 193 | G.s2s3.02 |
Hydrophobic | TM5 | L | 233 | 5x65 | G.H5 | L | 348 | G.H5.20 |
Hydrophobic | TM6 | L | 292 | 6x30 | G.H5 | F | 354 | G.H5.26 |
Polar | TM3 | R | 133 | 3x50 | G.H5 | C | 351 | G.H5.23 |
Hydrophobic | TM3 | R | 133 | 3x50 | G.H5 | C | 351 | G.H5.23 |
Van-der-waals | TM3 | R | 133 | 3x50 | G.H5 | C | 351 | G.H5.23 |
Hydrophobic | TM7 | V | 361 | 7x56 | G.H5 | L | 353 | G.H5.25 |
Hydrophobic | TM4 | R | 150 | 4x40 | G.HN | R | 24 | G.HN.48 |
Van-der-waals | TM4 | R | 150 | 4x40 | G.HN | R | 24 | G.HN.48 |
Polar | ICL2 | R | 144 | 34x54 | G.S1 | E | 33 | G.S1.01 |
Hydrophobic | ICL2 | R | 144 | 34x54 | G.S1 | E | 33 | G.S1.01 |
Van-der-waals | ICL2 | R | 144 | 34x54 | G.S1 | E | 33 | G.S1.01 |
Hydrophobic | TM6 | R | 288 | 6x26 | G.H5 | F | 354 | G.H5.26 |
Hydrophobic | TM3 | A | 136 | 3x53 | G.H5 | N | 347 | G.H5.19 |
Ionic | TM4 | R | 151 | 4x41 | G.HN | E | 28 | G.HN.52 |
Polar | TM4 | R | 151 | 4x41 | G.HN | E | 28 | G.HN.52 |
Hydrophobic | TM4 | R | 151 | 4x41 | G.HN | E | 28 | G.HN.52 |
Van-der-waals | TM4 | R | 151 | 4x41 | G.HN | E | 28 | G.HN.52 |
Hydrophobic | TM3 | V | 137 | 3x54 | G.H5 | L | 353 | G.H5.25 |
Polar | ICL2 | P | 140 | 34x50 | G.H5 | N | 347 | G.H5.19 |
Van-der-waals | ICL2 | P | 140 | 34x50 | G.H5 | N | 347 | G.H5.19 |
Polar | TM6 | S | 295 | 6x33 | G.H5 | L | 353 | G.H5.25 |
Hydrophobic | TM6 | S | 295 | 6x33 | G.H5 | L | 353 | G.H5.25 |
Van-der-waals | TM6 | S | 295 | 6x33 | G.H5 | L | 353 | G.H5.25 |
Hydrophobic | TM3 | E | 132 | 3x49 | G.H5 | C | 351 | G.H5.23 |
Hydrophobic | ICL3 | S | 248 | - | G.H4 | A | 301 | G.H4.08 |
Van-der-waals | ICL3 | S | 248 | - | G.H4 | A | 301 | G.H4.08 |
Polar | TM4 | R | 150 | 4x40 | G.HN | D | 20 | G.HN.44 |
Polar | ICL2 | R | 144 | 34x54 | G.h2s4 | T | 219 | G.h2s4.05 |
Hydrophobic | ICL2 | R | 144 | 34x54 | G.h2s4 | T | 219 | G.h2s4.05 |
Van-der-waals | ICL2 | R | 144 | 34x54 | G.h2s4 | T | 219 | G.h2s4.05 |
Hydrophobic | TM6 | S | 291 | 6x29 | G.H5 | F | 354 | G.H5.26 |
Ionic | ICL3 | K | 284 | - | G.H4 | E | 308 | G.H4.16 |
Polar | ICL3 | K | 284 | - | G.H4 | E | 308 | G.H4.16 |
Van-der-waals | ICL3 | K | 284 | - | G.H4 | E | 308 | G.H4.16 |
Hydrophobic | TM2 | G | 66 | 2x37 | G.H5 | D | 350 | G.H5.22 |
Polar | H8 | S | 363 | 8x48 | G.H5 | F | 354 | G.H5.26 |
Hydrophobic | H8 | S | 363 | 8x48 | G.H5 | F | 354 | G.H5.26 |
Van-der-waals | H8 | S | 363 | 8x48 | G.H5 | F | 354 | G.H5.26 |
Ionic | TM6 | R | 288 | 6x26 | G.h4s6 | E | 318 | G.h4s6.12 |
Hydrophobic | TM2 | L | 68 | 2x39 | G.H5 | C | 351 | G.H5.23 |
Hydrophobic | TM3 | V | 137 | 3x54 | G.H5 | L | 348 | G.H5.20 |
Van-der-waals | TM3 | V | 137 | 3x54 | G.H5 | L | 348 | G.H5.20 |
Hydrophobic | C-term | F | 402 | - | G.H2 | W | 211 | G.H2.07 |
Hydrophobic | TM4 | T | 148 | 4x38 | G.HN | E | 28 | G.HN.52 |
Hydrophobic | TM7 | V | 361 | 7x56 | G.H5 | G | 352 | G.H5.24 |
Van-der-waals | TM7 | V | 361 | 7x56 | G.H5 | G | 352 | G.H5.24 |
Hydrophobic | ICL2 | L | 141 | 34x51 | G.H5 | I | 343 | G.H5.15 |
Hydrophobic | ICL3 | L | 280 | - | G.H4 | C | 305 | G.H4.13 |
Van-der-waals | ICL3 | L | 280 | - | G.H4 | C | 305 | G.H4.13 |
Polar | ICL3 | K | 284 | - | G.S6 | I | 319 | G.S6.01 |
Polar | ICL2 | S | 145 | 34x55 | G.hns1 | R | 32 | G.hns1.03 |
Hydrophobic | ICL2 | S | 145 | 34x55 | G.hns1 | R | 32 | G.hns1.03 |
Van-der-waals | ICL2 | S | 145 | 34x55 | G.hns1 | R | 32 | G.hns1.03 |
Hydrophobic | ICL2 | R | 144 | 34x54 | G.S1 | V | 34 | G.S1.02 |
Van-der-waals | ICL2 | R | 144 | 34x54 | G.S1 | V | 34 | G.S1.02 |
Polar | H8 | S | 362 | 8x47 | G.H5 | G | 352 | G.H5.24 |
Hydrophobic | H8 | S | 362 | 8x47 | G.H5 | G | 352 | G.H5.24 |
Polar | TM3 | R | 133 | 3x50 | G.H5 | G | 352 | G.H5.24 |
Polar | TM2 | R | 67 | 2x38 | G.H5 | C | 351 | G.H5.23 |
Hydrophobic | TM2 | R | 67 | 2x38 | G.H5 | C | 351 | G.H5.23 |
Van-der-waals | TM2 | R | 67 | 2x38 | G.H5 | C | 351 | G.H5.23 |
Ionic | TM6 | R | 288 | 6x26 | G.H5 | D | 341 | G.H5.13 |
Polar | TM6 | R | 288 | 6x26 | G.H5 | D | 341 | G.H5.13 |
Hydrophobic | TM6 | R | 288 | 6x26 | G.H5 | D | 341 | G.H5.13 |
Van-der-waals | TM6 | R | 288 | 6x26 | G.H5 | D | 341 | G.H5.13 |
Hydrophobic | ICL2 | R | 144 | 34x54 | G.S3 | L | 194 | G.S3.01 |
Hydrophobic | TM5 | L | 236 | 5x68 | G.H5 | I | 344 | G.H5.16 |
Hydrophobic | C-term | M | 396 | - | G.H3 | K | 248 | G.H3.07 |
Van-der-waals | C-term | M | 396 | - | G.H3 | K | 248 | G.H3.07 |
Hydrophobic | C-term | F | 402 | - | G.H2 | I | 212 | G.H2.08 |
Van-der-waals | C-term | F | 402 | - | G.H2 | I | 212 | G.H2.08 |
Hydrophobic | ICL2 | P | 140 | 34x50 | G.H5 | I | 344 | G.H5.16 |
Van-der-waals | ICL2 | P | 140 | 34x50 | G.H5 | I | 344 | G.H5.16 |
Hydrophobic | ICL2 | L | 141 | 34x51 | G.H5 | T | 340 | G.H5.12 |
Hydrophobic | ICL2 | L | 141 | 34x51 | G.S3 | L | 194 | G.S3.01 |
Van-der-waals | ICL2 | L | 141 | 34x51 | G.S3 | L | 194 | G.S3.01 |