GPCR CLASS (FAMILY)
SPECIES
G PROTEIN FAMILY
DATE
3D VIEW
Tertiary structure confidence
(pLDDT score) avg.: 85.4
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered
PTM Score: 0.6
iPTM Score: 0.3
PAE mean: 20.7
GPCR - G protein interface interactions
The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle
(Gα residues)
and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid,
hydrophobic - dashed,
ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.
GPCR-G protein backbone (bb) or sidechain (sc):
Structures
0 structures selected.
Sequence Color
Interaction frequency filter (%)
Gα,
GPCR
Interaction cut-off: strict (stick), loose (line)
Interaction type |
GPCR Segment |
AA |
Number |
Generic number |
Gα segment |
AA |
Number |
Generic number |
---|---|---|---|---|---|---|---|---|
Hydrophobic | TM6 | T | 237 | 6x36 | G.H5 | L | 344 | G.H5.20 |
Hydrophobic | ICL2 | V | 131 | 34x55 | G.hns1 | A | 27 | G.hns1.02 |
Van-der-waals | ICL2 | V | 131 | 34x55 | G.hns1 | A | 27 | G.hns1.02 |
Hydrophobic | ICL2 | L | 127 | 34x51 | G.H5 | T | 336 | G.H5.12 |
Van-der-waals | ICL2 | L | 127 | 34x51 | G.H5 | T | 336 | G.H5.12 |
Polar | H8 | K | 292 | 8x48 | G.H5 | F | 350 | G.H5.26 |
Hydrophobic | H8 | K | 292 | 8x48 | G.H5 | F | 350 | G.H5.26 |
Van-der-waals | H8 | K | 292 | 8x48 | G.H5 | F | 350 | G.H5.26 |
Hydrophobic | H8 | N | 291 | 8x47 | G.H5 | L | 349 | G.H5.25 |
Hydrophobic | TM2 | M | 56 | 2x39 | G.H5 | G | 348 | G.H5.24 |
Hydrophobic | H8 | N | 291 | 8x47 | G.H5 | F | 350 | G.H5.26 |
Van-der-waals | H8 | N | 291 | 8x47 | G.H5 | F | 350 | G.H5.26 |
Polar | ICL2 | Y | 129 | 34x53 | G.H5 | C | 347 | G.H5.23 |
Hydrophobic | ICL2 | Y | 129 | 34x53 | G.H5 | C | 347 | G.H5.23 |
Van-der-waals | ICL2 | Y | 129 | 34x53 | G.H5 | C | 347 | G.H5.23 |
Hydrophobic | TM2 | M | 56 | 2x39 | G.H5 | C | 347 | G.H5.23 |
Van-der-waals | TM2 | M | 56 | 2x39 | G.H5 | C | 347 | G.H5.23 |
Polar | TM2 | T | 54 | 2x37 | G.H5 | G | 348 | G.H5.24 |
Hydrophobic | ICL2 | L | 127 | 34x51 | G.H5 | I | 340 | G.H5.16 |
Van-der-waals | ICL2 | L | 127 | 34x51 | G.H5 | I | 340 | G.H5.16 |
Hydrophobic | TM6 | S | 240 | 6x39 | G.H5 | L | 349 | G.H5.25 |
Van-der-waals | TM6 | S | 240 | 6x39 | G.H5 | L | 349 | G.H5.25 |
Hydrophobic | TM7 | Y | 287 | 7x53 | G.H5 | L | 349 | G.H5.25 |
Polar | ICL2 | L | 127 | 34x51 | G.H5 | N | 343 | G.H5.19 |
Van-der-waals | ICL2 | L | 127 | 34x51 | G.H5 | N | 343 | G.H5.19 |
Polar | H8 | D | 293 | 8x49 | G.H5 | F | 350 | G.H5.26 |
Polar | ICL2 | L | 127 | 34x51 | G.H5 | I | 339 | G.H5.15 |
Hydrophobic | ICL2 | L | 127 | 34x51 | G.H5 | I | 339 | G.H5.15 |
Van-der-waals | ICL2 | L | 127 | 34x51 | G.H5 | I | 339 | G.H5.15 |
Hydrophobic | ICL2 | L | 127 | 34x51 | G.S1 | V | 30 | G.S1.02 |
Van-der-waals | ICL2 | L | 127 | 34x51 | G.S1 | V | 30 | G.S1.02 |
Polar | ICL2 | P | 126 | 34x50 | G.H5 | N | 343 | G.H5.19 |
Hydrophobic | ICL2 | P | 126 | 34x50 | G.H5 | N | 343 | G.H5.19 |
Van-der-waals | ICL2 | P | 126 | 34x50 | G.H5 | N | 343 | G.H5.19 |
Hydrophobic | TM3 | C | 119 | 3x50 | G.H5 | C | 347 | G.H5.23 |
Hydrophobic | ICL2 | P | 126 | 34x50 | G.H5 | I | 339 | G.H5.15 |
Hydrophobic | ICL2 | R | 128 | 34x52 | G.hns1 | R | 28 | G.hns1.03 |
Van-der-waals | ICL2 | R | 128 | 34x52 | G.hns1 | R | 28 | G.hns1.03 |
Aromatic | TM6 | K | 233 | 6x32 | G.H5 | F | 350 | G.H5.26 |
Hydrophobic | TM6 | K | 233 | 6x32 | G.H5 | F | 350 | G.H5.26 |
Van-der-waals | TM6 | K | 233 | 6x32 | G.H5 | F | 350 | G.H5.26 |
Polar | TM2 | Y | 57 | 2x40 | G.H5 | G | 348 | G.H5.24 |
Hydrophobic | TM2 | Y | 57 | 2x40 | G.H5 | G | 348 | G.H5.24 |
Van-der-waals | TM2 | Y | 57 | 2x40 | G.H5 | G | 348 | G.H5.24 |
Hydrophobic | ICL2 | V | 131 | 34x55 | G.hns1 | D | 26 | G.hns1.01 |
Van-der-waals | ICL2 | V | 131 | 34x55 | G.hns1 | D | 26 | G.hns1.01 |
Hydrophobic | TM6 | K | 233 | 6x32 | G.H5 | K | 341 | G.H5.17 |
Van-der-waals | TM6 | K | 233 | 6x32 | G.H5 | K | 341 | G.H5.17 |
Van-der-waals | TM6 | T | 237 | 6x36 | G.H5 | F | 350 | G.H5.26 |
Polar | H8 | N | 291 | 8x47 | G.H5 | G | 348 | G.H5.24 |
Hydrophobic | H8 | N | 291 | 8x47 | G.H5 | G | 348 | G.H5.24 |
Van-der-waals | H8 | N | 291 | 8x47 | G.H5 | G | 348 | G.H5.24 |
Hydrophobic | ICL2 | P | 130 | 34x54 | G.H5 | N | 343 | G.H5.19 |
Van-der-waals | ICL2 | P | 130 | 34x54 | G.H5 | N | 343 | G.H5.19 |
Polar | TM2 | T | 54 | 2x37 | G.H5 | D | 346 | G.H5.22 |
Hydrophobic | TM2 | T | 54 | 2x37 | G.H5 | D | 346 | G.H5.22 |
Van-der-waals | TM2 | T | 54 | 2x37 | G.H5 | D | 346 | G.H5.22 |
Hydrophobic | ICL2 | L | 127 | 34x51 | G.S3 | L | 190 | G.S3.01 |
Van-der-waals | ICL2 | L | 127 | 34x51 | G.S3 | L | 190 | G.S3.01 |
Hydrophobic | ICL2 | Y | 129 | 34x53 | G.H5 | N | 343 | G.H5.19 |
Van-der-waals | ICL2 | Y | 129 | 34x53 | G.H5 | N | 343 | G.H5.19 |
Hydrophobic | TM3 | A | 122 | 3x53 | G.H5 | C | 347 | G.H5.23 |
Van-der-waals | TM3 | A | 122 | 3x53 | G.H5 | C | 347 | G.H5.23 |
Hydrophobic | TM3 | A | 122 | 3x53 | G.H5 | L | 344 | G.H5.20 |
Van-der-waals | TM3 | A | 122 | 3x53 | G.H5 | L | 344 | G.H5.20 |
Hydrophobic | ICL2 | P | 126 | 34x50 | G.H5 | I | 340 | G.H5.16 |
Van-der-waals | ICL2 | P | 126 | 34x50 | G.H5 | I | 340 | G.H5.16 |
Hydrophobic | TM6 | K | 233 | 6x32 | G.H5 | K | 345 | G.H5.21 |
Van-der-waals | TM6 | K | 233 | 6x32 | G.H5 | K | 345 | G.H5.21 |
Van-der-waals | ICL2 | R | 128 | 34x52 | G.hns1 | A | 27 | G.hns1.02 |
Hydrophobic | TM6 | G | 230 | 6x29 | G.H5 | K | 341 | G.H5.17 |
Hydrophobic | TM2 | M | 56 | 2x39 | G.H5 | L | 349 | G.H5.25 |
Van-der-waals | TM2 | M | 56 | 2x39 | G.H5 | L | 349 | G.H5.25 |
Ionic | TM6 | K | 233 | 6x32 | G.h4s6 | E | 314 | G.h4s6.12 |
Polar | TM6 | K | 233 | 6x32 | G.h4s6 | E | 314 | G.h4s6.12 |
Polar | ICL2 | R | 128 | 34x52 | G.s2s3 | D | 189 | G.s2s3.02 |
Hydrophobic | ICL2 | R | 128 | 34x52 | G.s2s3 | D | 189 | G.s2s3.02 |
Van-der-waals | ICL2 | R | 128 | 34x52 | G.s2s3 | D | 189 | G.s2s3.02 |
Hydrophobic | ICL2 | R | 128 | 34x52 | G.S3 | L | 190 | G.S3.01 |
Van-der-waals | ICL2 | R | 128 | 34x52 | G.S3 | L | 190 | G.S3.01 |
Hydrophobic | ICL2 | L | 127 | 34x51 | G.S3 | F | 192 | G.S3.03 |
Polar | ICL2 | Y | 129 | 34x53 | G.H5 | D | 346 | G.H5.22 |
Hydrophobic | ICL2 | Y | 129 | 34x53 | G.H5 | D | 346 | G.H5.22 |
Van-der-waals | ICL2 | Y | 129 | 34x53 | G.H5 | D | 346 | G.H5.22 |
Polar | TM6 | T | 237 | 6x36 | G.H5 | L | 349 | G.H5.25 |
Hydrophobic | TM6 | T | 237 | 6x36 | G.H5 | L | 349 | G.H5.25 |
Van-der-waals | TM6 | T | 237 | 6x36 | G.H5 | L | 349 | G.H5.25 |
Hydrophobic | TM3 | C | 119 | 3x50 | G.H5 | L | 349 | G.H5.25 |
Van-der-waals | TM3 | C | 119 | 3x50 | G.H5 | L | 349 | G.H5.25 |
Polar | ICL2 | L | 132 | 34x56 | G.hns1 | A | 27 | G.hns1.02 |
Hydrophobic | ICL2 | L | 132 | 34x56 | G.hns1 | A | 27 | G.hns1.02 |
Hydrophobic | ICL2 | P | 126 | 34x50 | G.H5 | L | 344 | G.H5.20 |
Polar | TM3 | D | 118 | 3x49 | G.H5 | C | 347 | G.H5.23 |
Hydrophobic | TM3 | D | 118 | 3x49 | G.H5 | C | 347 | G.H5.23 |
Van-der-waals | TM3 | D | 118 | 3x49 | G.H5 | C | 347 | G.H5.23 |
Hydrophobic | TM3 | V | 123 | 3x54 | G.H5 | L | 344 | G.H5.20 |
Van-der-waals | TM3 | V | 123 | 3x54 | G.H5 | L | 344 | G.H5.20 |