Gi3 - OR51A2 complex model

GPCR CLASS (FAMILY)

O1 (fish-like odorant)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gi/o

DATE

2023-09-15

3D VIEW

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Tertiary structure confidence

(pLDDT score) avg.: 84.4

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.6
iPTM Score: 0.3
PAE mean: 21.4


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, GPCR
Interaction cut-off: strict (stick), loose (line)

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Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic ICL3 A 230 - G.hns1 A 31 G.hns1.02
Hydrophobic TM6 E 235 6x30 G.HN E 28 G.HN.52
Van-der-waals TM6 E 235 6x30 G.HN E 28 G.HN.52
Hydrophobic ICL2 P 131 34x50 G.H5 C 351 G.H5.23
Van-der-waals ICL2 P 131 34x50 G.H5 C 351 G.H5.23
Polar H8 Q 299 8x49 G.H5 L 353 G.H5.25
Hydrophobic ICL2 Y 134 34x53 G.H5 G 352 G.H5.24
Van-der-waals ICL2 Y 134 34x53 G.H5 G 352 G.H5.24
Hydrophobic TM3 I 128 3x54 G.H5 L 353 G.H5.25
Polar TM6 S 231 6x26 G.hns1 K 32 G.hns1.03
Hydrophobic TM6 S 231 6x26 G.hns1 K 32 G.hns1.03
Van-der-waals TM6 S 231 6x26 G.hns1 K 32 G.hns1.03
Hydrophobic TM5 P 227 5x66 G.HN R 24 G.HN.48
Van-der-waals TM5 P 227 5x66 G.HN R 24 G.HN.48
Hydrophobic ICL2 T 135 34x54 G.H5 E 350 G.H5.22
Polar TM6 S 231 6x26 G.HN E 28 G.HN.52
Van-der-waals TM6 S 231 6x26 G.HN E 28 G.HN.52
Polar TM6 K 232 6x27 G.HN E 28 G.HN.52
Polar TM5 I 229 5x68 G.hns1 K 32 G.hns1.03
Van-der-waals TM5 I 229 5x68 G.hns1 K 32 G.hns1.03
Hydrophobic ICL2 Y 134 34x53 G.H5 C 351 G.H5.23
Polar ICL2 L 132 34x51 G.H5 E 350 G.H5.22
Hydrophobic ICL2 L 132 34x51 G.H5 E 350 G.H5.22
Van-der-waals ICL2 L 132 34x51 G.H5 E 350 G.H5.22
Ionic ICL2 R 133 34x52 G.h3s5 E 261 G.h3s5.02
Hydrophobic ICL2 R 133 34x52 G.h3s5 E 261 G.h3s5.02
Van-der-waals ICL2 R 133 34x52 G.h3s5 E 261 G.h3s5.02
Polar TM5 G 228 5x67 G.HN E 28 G.HN.52
Hydrophobic TM5 G 228 5x67 G.HN E 28 G.HN.52
Polar ICL3 A 230 - G.HN E 28 G.HN.52
Hydrophobic ICL3 A 230 - G.HN E 28 G.HN.52
Van-der-waals ICL3 A 230 - G.HN E 28 G.HN.52
Hydrophobic TM6 T 241 6x36 G.H5 L 353 G.H5.25
Van-der-waals TM6 T 241 6x36 G.H5 L 353 G.H5.25
Polar TM5 I 229 5x68 G.HN G 27 G.HN.51
Hydrophobic TM5 I 229 5x68 G.HN G 27 G.HN.51
Van-der-waals TM5 I 229 5x68 G.HN G 27 G.HN.51
Hydrophobic ICL2 P 131 34x50 G.H5 E 350 G.H5.22
Van-der-waals ICL2 P 131 34x50 G.H5 E 350 G.H5.22
Hydrophobic ICL2 L 132 34x51 G.H5 N 347 G.H5.19
Van-der-waals ICL2 L 132 34x51 G.H5 N 347 G.H5.19
Polar TM5 I 229 5x68 G.HN E 28 G.HN.52
Hydrophobic TM5 I 229 5x68 G.HN E 28 G.HN.52
Van-der-waals TM5 I 229 5x68 G.HN E 28 G.HN.52
Van-der-waals TM6 K 237 6x32 G.H5 Y 354 G.H5.26
Hydrophobic ICL2 P 131 34x50 G.H5 N 347 G.H5.19
Van-der-waals ICL2 P 131 34x50 G.H5 N 347 G.H5.19
Hydrophobic ICL2 L 132 34x51 G.h3s5 E 261 G.h3s5.02
Van-der-waals ICL2 L 132 34x51 G.h3s5 E 261 G.h3s5.02
Polar ICL2 S 136 34x55 G.h3s5 E 261 G.h3s5.02
Van-der-waals ICL2 S 136 34x55 G.h3s5 E 261 G.h3s5.02
Ionic TM6 E 235 6x30 G.HN R 24 G.HN.48
Polar TM6 E 235 6x30 G.HN R 24 G.HN.48
Hydrophobic TM6 A 238 6x33 G.H5 L 353 G.H5.25
Hydrophobic H8 Q 299 8x49 G.H5 Y 354 G.H5.26
Van-der-waals H8 Q 299 8x49 G.H5 Y 354 G.H5.26
Hydrophobic TM5 G 228 5x67 G.HN G 27 G.HN.51
Van-der-waals TM5 G 228 5x67 G.HN G 27 G.HN.51
Polar TM3 A 127 3x53 G.H5 C 351 G.H5.23
Hydrophobic TM3 A 127 3x53 G.H5 C 351 G.H5.23
Van-der-waals TM3 A 127 3x53 G.H5 C 351 G.H5.23
Hydrophobic TM5 G 228 5x67 G.HN R 24 G.HN.48
Hydrophobic ICL3 A 230 - G.hns1 K 32 G.hns1.03
Hydrophobic ICL2 Y 134 34x53 G.H5 E 350 G.H5.22
Van-der-waals ICL2 Y 134 34x53 G.H5 E 350 G.H5.22
Polar TM5 I 229 5x68 G.hns1 A 31 G.hns1.02
Hydrophobic TM5 I 229 5x68 G.hns1 A 31 G.hns1.02
Van-der-waals TM5 I 229 5x68 G.hns1 A 31 G.hns1.02
Ionic TM6 K 233 6x28 G.s2s3 D 193 G.s2s3.02
Polar TM6 K 233 6x28 G.s2s3 D 193 G.s2s3.02
Ionic TM6 E 234 6x29 G.hns1 K 32 G.hns1.03
Polar TM6 E 234 6x29 G.hns1 K 32 G.hns1.03
Hydrophobic TM6 E 234 6x29 G.hns1 K 32 G.hns1.03
Van-der-waals TM6 E 234 6x29 G.hns1 K 32 G.hns1.03
Hydrophobic TM2 M 61 2x39 G.H5 G 352 G.H5.24
Van-der-waals TM2 M 61 2x39 G.H5 G 352 G.H5.24
Polar TM5 P 227 5x66 G.HN E 28 G.HN.52
Hydrophobic TM5 P 227 5x66 G.HN E 28 G.HN.52
Van-der-waals TM5 P 227 5x66 G.HN E 28 G.HN.52