Gi3 - OR51A4 complex model

GPCR CLASS (FAMILY)

O1 (fish-like odorant)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gi/o

DATE

2023-09-15

3D VIEW

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Tertiary structure confidence

(pLDDT score) avg.: 84.3

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.6
iPTM Score: 0.3
PAE mean: 25.1


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, GPCR
Interaction cut-off: strict (stick), loose (line)

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Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic ICL2 R 133 34x52 G.hns1 K 32 G.hns1.03
Van-der-waals ICL2 R 133 34x52 G.hns1 K 32 G.hns1.03
Hydrophobic ICL2 R 133 34x52 G.hns1 A 30 G.hns1.01
Van-der-waals ICL2 R 133 34x52 G.hns1 A 30 G.hns1.01
Hydrophobic TM6 C 242 6x37 G.H5 L 353 G.H5.25
Van-der-waals TM6 C 242 6x37 G.H5 L 353 G.H5.25
Polar TM6 A 238 6x33 G.H5 Y 354 G.H5.26
Hydrophobic TM6 A 238 6x33 G.H5 Y 354 G.H5.26
Van-der-waals TM6 A 238 6x33 G.H5 Y 354 G.H5.26
Hydrophobic TM2 E 59 2x37 G.H5 E 350 G.H5.22
Van-der-waals TM2 E 59 2x37 G.H5 E 350 G.H5.22
Hydrophobic TM3 R 124 3x50 G.H5 L 353 G.H5.25
Van-der-waals TM3 R 124 3x50 G.H5 L 353 G.H5.25
Hydrophobic ICL2 L 132 34x51 G.S3 L 194 G.S3.01
Van-der-waals ICL2 L 132 34x51 G.S3 L 194 G.S3.01
Hydrophobic TM3 I 128 3x54 G.H5 L 353 G.H5.25
Van-der-waals TM3 I 128 3x54 G.H5 L 353 G.H5.25
Hydrophobic ICL2 L 132 34x51 G.hns1 A 31 G.hns1.02
Van-der-waals ICL2 L 132 34x51 G.hns1 A 31 G.hns1.02
Polar ICL2 Y 134 34x53 G.H5 C 351 G.H5.23
Hydrophobic ICL2 Y 134 34x53 G.H5 C 351 G.H5.23
Van-der-waals ICL2 Y 134 34x53 G.H5 C 351 G.H5.23
Ionic TM6 E 234 6x29 G.H5 K 345 G.H5.17
Polar TM6 E 234 6x29 G.H5 K 345 G.H5.17
Hydrophobic TM6 E 234 6x29 G.H5 K 345 G.H5.17
Van-der-waals TM6 E 234 6x29 G.H5 K 345 G.H5.17
Hydrophobic TM6 T 241 6x36 G.H5 Y 354 G.H5.26
Van-der-waals TM6 T 241 6x36 G.H5 Y 354 G.H5.26
Polar TM6 E 234 6x29 G.H5 Y 354 G.H5.26
Polar TM6 T 241 6x36 G.H5 L 353 G.H5.25
Hydrophobic TM6 T 241 6x36 G.H5 L 353 G.H5.25
Van-der-waals TM6 T 241 6x36 G.H5 L 353 G.H5.25
Hydrophobic ICL2 L 132 34x51 G.H5 N 347 G.H5.19
Van-der-waals ICL2 L 132 34x51 G.H5 N 347 G.H5.19
Hydrophobic ICL2 L 132 34x51 G.h2s4 T 219 G.h2s4.05
Van-der-waals ICL2 L 132 34x51 G.h2s4 T 219 G.h2s4.05
Polar ICL2 R 133 34x52 G.HN D 26 G.HN.50
Hydrophobic ICL2 I 137 34x56 G.hns1 A 31 G.hns1.02
Hydrophobic ICL2 P 131 34x50 G.H5 N 347 G.H5.19
Van-der-waals ICL2 P 131 34x50 G.H5 N 347 G.H5.19
Polar TM6 K 237 6x32 G.H5 Y 354 G.H5.26
Aromatic TM6 K 237 6x32 G.H5 Y 354 G.H5.26
Hydrophobic TM6 K 237 6x32 G.H5 Y 354 G.H5.26
Van-der-waals TM6 K 237 6x32 G.H5 Y 354 G.H5.26
Hydrophobic TM2 M 61 2x39 G.H5 C 351 G.H5.23
Van-der-waals TM2 M 61 2x39 G.H5 C 351 G.H5.23
Polar ICL2 R 133 34x52 G.HN G 27 G.HN.51
Hydrophobic ICL2 R 133 34x52 G.HN G 27 G.HN.51
Van-der-waals ICL2 R 133 34x52 G.HN G 27 G.HN.51
Polar H8 Q 299 8x49 G.H5 Y 354 G.H5.26
Van-der-waals H8 Q 299 8x49 G.H5 Y 354 G.H5.26
Hydrophobic TM6 K 237 6x32 G.H5 K 345 G.H5.17
Van-der-waals TM6 K 237 6x32 G.H5 K 345 G.H5.17
Polar ICL2 R 133 34x52 G.hns1 A 31 G.hns1.02
Hydrophobic ICL2 R 133 34x52 G.hns1 A 31 G.hns1.02
Van-der-waals ICL2 R 133 34x52 G.hns1 A 31 G.hns1.02
Hydrophobic TM6 A 238 6x33 G.H5 L 348 G.H5.20
Hydrophobic TM3 A 127 3x53 G.H5 L 348 G.H5.20
Van-der-waals TM3 A 127 3x53 G.H5 L 348 G.H5.20
Hydrophobic TM3 A 127 3x53 G.H5 C 351 G.H5.23
Van-der-waals TM3 A 127 3x53 G.H5 C 351 G.H5.23
Hydrophobic ICL2 P 131 34x50 G.H5 L 348 G.H5.20
Van-der-waals ICL2 P 131 34x50 G.H5 L 348 G.H5.20
Hydrophobic TM3 A 127 3x53 G.H5 L 353 G.H5.25
Van-der-waals TM3 A 127 3x53 G.H5 L 353 G.H5.25
Polar ICL2 R 133 34x52 G.HN E 28 G.HN.52
Hydrophobic ICL2 R 133 34x52 G.HN E 28 G.HN.52
Van-der-waals ICL2 R 133 34x52 G.HN E 28 G.HN.52
Polar ICL2 S 136 34x55 G.hns1 A 30 G.hns1.01
Hydrophobic ICL2 L 132 34x51 G.H5 I 343 G.H5.15
Van-der-waals ICL2 L 132 34x51 G.H5 I 343 G.H5.15
Hydrophobic TM3 N 130 3x56 G.hns1 K 32 G.hns1.03
Van-der-waals TM3 N 130 3x56 G.hns1 K 32 G.hns1.03
Polar ICL2 R 133 34x52 G.HN K 29 G.HN.53
Hydrophobic ICL2 R 133 34x52 G.HN K 29 G.HN.53
Van-der-waals ICL2 R 133 34x52 G.HN K 29 G.HN.53
Hydrophobic ICL2 S 136 34x55 G.hns1 A 31 G.hns1.02
Van-der-waals ICL2 S 136 34x55 G.hns1 A 31 G.hns1.02
Hydrophobic ICL2 L 132 34x51 G.S1 V 34 G.S1.02
Van-der-waals ICL2 L 132 34x51 G.S1 V 34 G.S1.02
Hydrophobic ICL2 Y 134 34x53 G.H5 E 350 G.H5.22
Van-der-waals TM6 K 237 6x32 G.H5 K 349 G.H5.21
Hydrophobic ICL2 P 131 34x50 G.H5 I 344 G.H5.16
Van-der-waals ICL2 P 131 34x50 G.H5 I 344 G.H5.16
Hydrophobic TM3 I 128 3x54 G.H5 L 348 G.H5.20
Van-der-waals TM3 I 128 3x54 G.H5 L 348 G.H5.20
Hydrophobic TM2 M 61 2x39 G.H5 G 352 G.H5.24
Van-der-waals TM2 M 61 2x39 G.H5 G 352 G.H5.24