Go - OR51B2 complex model

GPCR CLASS (FAMILY)

O1 (fish-like odorant)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gi/o

DATE

2023-09-15

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

(pLDDT score) avg.: 83.5

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.6
iPTM Score: 0.4
PAE mean: 20.1


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic TM6 E 231 6x29 G.H5 D 341 G.H5.13
Van-der-waals TM6 E 231 6x29 G.H5 D 341 G.H5.13
Hydrophobic ICL2 Y 130 34x53 G.H5 N 347 G.H5.19
Van-der-waals ICL2 Y 130 34x53 G.H5 N 347 G.H5.19
Polar H8 Q 296 8x49 G.H5 G 352 G.H5.24
Polar H8 K 295 8x48 G.H5 Y 354 G.H5.26
Hydrophobic H8 K 295 8x48 G.H5 Y 354 G.H5.26
Van-der-waals H8 K 295 8x48 G.H5 Y 354 G.H5.26
Hydrophobic ICL2 S 132 34x55 G.hns1 K 32 G.hns1.03
Van-der-waals ICL2 S 132 34x55 G.hns1 K 32 G.hns1.03
Hydrophobic TM5 I 226 5x68 G.H5 D 341 G.H5.13
Hydrophobic TM2 M 57 2x39 G.H5 C 351 G.H5.23
Van-der-waals TM2 M 57 2x39 G.H5 C 351 G.H5.23
Polar TM3 D 119 3x49 G.H5 C 351 G.H5.23
Hydrophobic TM3 D 119 3x49 G.H5 C 351 G.H5.23
Van-der-waals TM3 D 119 3x49 G.H5 C 351 G.H5.23
Hydrophobic TM5 I 226 5x68 G.H5 I 344 G.H5.16
Ionic TM6 K 234 6x32 G.h4s6 E 318 G.h4s6.12
Polar TM6 K 234 6x32 G.h4s6 E 318 G.h4s6.12
Hydrophobic TM6 K 234 6x32 G.h4s6 E 318 G.h4s6.12
Van-der-waals TM6 K 234 6x32 G.h4s6 E 318 G.h4s6.12
Hydrophobic TM2 M 57 2x39 G.H5 G 352 G.H5.24
Hydrophobic TM3 A 123 3x53 G.H5 C 351 G.H5.23
Hydrophobic ICL2 P 127 34x50 G.H5 T 340 G.H5.12
Van-der-waals ICL2 P 127 34x50 G.H5 T 340 G.H5.12
Hydrophobic ICL2 L 128 34x51 G.H5 V 339 G.H5.11
Hydrophobic ICL2 P 127 34x50 G.H5 I 343 G.H5.15
Van-der-waals ICL2 P 127 34x50 G.H5 I 343 G.H5.15
Hydrophobic TM2 M 57 2x39 G.H5 L 353 G.H5.25
Van-der-waals TM2 M 57 2x39 G.H5 L 353 G.H5.25
Polar TM6 K 234 6x32 G.H5 Y 354 G.H5.26
Hydrophobic TM6 K 234 6x32 G.H5 Y 354 G.H5.26
Van-der-waals TM6 K 234 6x32 G.H5 Y 354 G.H5.26
Hydrophobic TM6 S 241 6x39 G.H5 L 353 G.H5.25
Hydrophobic TM3 A 123 3x53 G.H5 L 348 G.H5.20
Hydrophobic TM7 Y 290 7x53 G.H5 L 353 G.H5.25
Hydrophobic ICL2 P 127 34x50 G.H5 I 344 G.H5.16
Van-der-waals ICL2 P 127 34x50 G.H5 I 344 G.H5.16
Hydrophobic TM2 Y 58 2x40 G.H5 C 351 G.H5.23
Polar ICL2 R 129 34x52 G.s2s3 N 194 G.s2s3.02
Hydrophobic ICL2 R 129 34x52 G.s2s3 N 194 G.s2s3.02
Van-der-waals ICL2 R 129 34x52 G.s2s3 N 194 G.s2s3.02
Polar ICL2 P 127 34x50 G.H5 N 347 G.H5.19
Van-der-waals ICL2 P 127 34x50 G.H5 N 347 G.H5.19
Hydrophobic TM4 T 135 4x38 G.HN I 28 G.HN.52
Hydrophobic ICL2 L 128 34x51 G.H5 I 343 G.H5.15
Van-der-waals ICL2 L 128 34x51 G.H5 I 343 G.H5.15
Hydrophobic TM6 A 235 6x33 G.H5 L 348 G.H5.20
Van-der-waals TM6 A 235 6x33 G.H5 L 348 G.H5.20
Polar TM2 Y 58 2x40 G.H5 G 352 G.H5.24
Hydrophobic TM2 Y 58 2x40 G.H5 G 352 G.H5.24
Van-der-waals TM2 Y 58 2x40 G.H5 G 352 G.H5.24
Hydrophobic ICL2 A 131 34x54 G.hns1 A 31 G.hns1.02
Van-der-waals ICL2 A 131 34x54 G.hns1 A 31 G.hns1.02
Hydrophobic TM3 I 124 3x54 G.H5 I 344 G.H5.16
Hydrophobic ICL2 L 128 34x51 G.S3 L 195 G.S3.01
Van-der-waals ICL2 L 128 34x51 G.S3 L 195 G.S3.01
Hydrophobic ICL2 L 128 34x51 G.H5 T 340 G.H5.12
Van-der-waals ICL2 L 128 34x51 G.H5 T 340 G.H5.12
Polar TM6 T 238 6x36 G.H5 L 353 G.H5.25
Hydrophobic TM6 T 238 6x36 G.H5 L 353 G.H5.25
Van-der-waals TM6 T 238 6x36 G.H5 L 353 G.H5.25
Hydrophobic TM6 T 238 6x36 G.H5 L 348 G.H5.20
Van-der-waals TM6 T 238 6x36 G.H5 L 348 G.H5.20
Polar TM6 E 231 6x29 G.S6 Y 320 G.S6.02
Hydrophobic TM6 E 231 6x29 G.S6 Y 320 G.S6.02
Van-der-waals TM6 E 231 6x29 G.S6 Y 320 G.S6.02
Hydrophobic TM3 I 124 3x54 G.H5 L 348 G.H5.20
Polar ICL2 Y 130 34x53 G.H5 C 351 G.H5.23
Hydrophobic ICL2 Y 130 34x53 G.H5 C 351 G.H5.23
Van-der-waals ICL2 Y 130 34x53 G.H5 C 351 G.H5.23
Hydrophobic TM2 Y 58 2x40 G.H5 G 350 G.H5.22
Van-der-waals TM2 Y 58 2x40 G.H5 G 350 G.H5.22
Hydrophobic TM2 E 55 2x37 G.H5 G 350 G.H5.22
Van-der-waals TM2 E 55 2x37 G.H5 G 350 G.H5.22
Polar H8 T 294 8x47 G.H5 G 352 G.H5.24
Hydrophobic H8 T 294 8x47 G.H5 G 352 G.H5.24
Van-der-waals H8 T 294 8x47 G.H5 G 352 G.H5.24
Polar H8 Q 296 8x49 G.H5 R 349 G.H5.21
Hydrophobic H8 Q 296 8x49 G.H5 R 349 G.H5.21
Van-der-waals H8 Q 296 8x49 G.H5 R 349 G.H5.21
Polar TM3 A 123 3x53 G.H5 N 347 G.H5.19
Hydrophobic TM3 A 123 3x53 G.H5 N 347 G.H5.19
Hydrophobic TM3 C 120 3x50 G.H5 L 353 G.H5.25
Van-der-waals TM3 C 120 3x50 G.H5 L 353 G.H5.25