Gi3 - OR51B4 complex model

GPCR CLASS (FAMILY)

O1 (fish-like odorant)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gi/o

DATE

2023-09-15

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

(pLDDT score) avg.: 83.7

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.5
iPTM Score: 0.2
PAE mean: 24.8


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type
GPCR
Segment

AA

Number
Generic
number

segment

AA

Number
Generic
number
Polar ICL2 L 127 34x51 G.H5 D 341 G.H5.13
Hydrophobic ICL2 L 127 34x51 G.H5 D 341 G.H5.13
Van-der-waals ICL2 L 127 34x51 G.H5 D 341 G.H5.13
Hydrophobic TM3 D 118 3x49 G.H5 L 353 G.H5.25
Van-der-waals TM3 D 118 3x49 G.H5 L 353 G.H5.25
Polar TM2 E 55 2x37 G.H5 L 348 G.H5.20
Hydrophobic TM2 E 55 2x37 G.H5 L 348 G.H5.20
Van-der-waals TM2 E 55 2x37 G.H5 L 348 G.H5.20
Hydrophobic ICL2 R 128 34x52 G.H5 I 344 G.H5.16
Hydrophobic TM6 T 237 6x36 G.H5 L 353 G.H5.25
Van-der-waals TM6 T 237 6x36 G.H5 L 353 G.H5.25
Polar TM3 A 122 3x53 G.H5 Y 354 G.H5.26
Hydrophobic TM3 A 122 3x53 G.H5 Y 354 G.H5.26
Van-der-waals TM3 A 122 3x53 G.H5 Y 354 G.H5.26
Hydrophobic TM2 M 57 2x39 G.H5 G 352 G.H5.24
Van-der-waals TM2 M 57 2x39 G.H5 G 352 G.H5.24
Van-der-waals H8 T 293 8x47 G.H5 G 352 G.H5.24
Hydrophobic TM2 M 57 2x39 G.H5 L 353 G.H5.25
Van-der-waals TM2 M 57 2x39 G.H5 L 353 G.H5.25
Hydrophobic ICL2 Y 129 34x53 G.H5 L 348 G.H5.20
Van-der-waals ICL2 Y 129 34x53 G.H5 L 348 G.H5.20
Polar ICL2 N 130 34x54 G.H5 I 344 G.H5.16
Hydrophobic ICL2 N 130 34x54 G.H5 I 344 G.H5.16
Van-der-waals ICL2 N 130 34x54 G.H5 I 344 G.H5.16
Hydrophobic TM6 K 233 6x32 G.H5 K 349 G.H5.21
Hydrophobic TM2 P 56 2x38 G.H5 L 353 G.H5.25
Van-der-waals TM2 P 56 2x38 G.H5 L 353 G.H5.25
Hydrophobic ICL2 L 127 34x51 G.H5 I 344 G.H5.16
Van-der-waals ICL2 L 127 34x51 G.H5 I 344 G.H5.16
Hydrophobic TM6 T 237 6x36 G.H5 Y 354 G.H5.26
Van-der-waals TM6 T 237 6x36 G.H5 Y 354 G.H5.26
Polar TM3 I 123 3x54 G.H5 Y 354 G.H5.26
Hydrophobic TM3 I 123 3x54 G.H5 Y 354 G.H5.26
Van-der-waals TM3 I 123 3x54 G.H5 Y 354 G.H5.26
Ionic ICL2 R 128 34x52 G.H5 D 337 G.H5.09
Polar ICL2 R 128 34x52 G.H5 D 337 G.H5.09
Polar TM2 Y 58 2x40 G.H5 G 352 G.H5.24
Hydrophobic TM2 Y 58 2x40 G.H5 G 352 G.H5.24
Van-der-waals TM2 Y 58 2x40 G.H5 G 352 G.H5.24
Polar H8 Q 295 8x49 G.H5 K 349 G.H5.21
Van-der-waals H8 Q 295 8x49 G.H5 K 349 G.H5.21
Polar TM2 E 55 2x37 G.H5 C 351 G.H5.23
Hydrophobic TM2 E 55 2x37 G.H5 C 351 G.H5.23
Van-der-waals TM2 E 55 2x37 G.H5 C 351 G.H5.23
Polar ICL2 P 126 34x50 G.H5 K 345 G.H5.17
Hydrophobic ICL2 P 126 34x50 G.H5 K 345 G.H5.17
Van-der-waals ICL2 P 126 34x50 G.H5 K 345 G.H5.17
Hydrophobic ICL2 Y 129 34x53 G.H5 I 344 G.H5.16
Polar ICL2 C 131 34x55 G.s2s3 K 192 G.s2s3.01
Hydrophobic ICL2 C 131 34x55 G.s2s3 K 192 G.s2s3.01
Van-der-waals ICL2 C 131 34x55 G.s2s3 K 192 G.s2s3.01
Polar H8 Q 295 8x49 G.H5 C 351 G.H5.23
Hydrophobic H8 Q 295 8x49 G.H5 C 351 G.H5.23
Van-der-waals H8 Q 295 8x49 G.H5 C 351 G.H5.23
Hydrophobic TM2 E 55 2x37 G.H5 L 353 G.H5.25
Van-der-waals TM2 E 55 2x37 G.H5 L 353 G.H5.25
Polar ICL1 S 52 12x49 G.H5 C 351 G.H5.23
Hydrophobic ICL1 S 52 12x49 G.H5 C 351 G.H5.23
Van-der-waals ICL1 S 52 12x49 G.H5 C 351 G.H5.23
Ionic ICL2 R 128 34x52 G.H5 D 341 G.H5.13
Polar ICL2 R 128 34x52 G.H5 D 341 G.H5.13
Hydrophobic ICL2 R 128 34x52 G.H5 D 341 G.H5.13
Van-der-waals ICL2 R 128 34x52 G.H5 D 341 G.H5.13
Polar H8 Q 295 8x49 G.H5 E 350 G.H5.22
Hydrophobic H8 Q 295 8x49 G.H5 E 350 G.H5.22
Van-der-waals H8 Q 295 8x49 G.H5 E 350 G.H5.22
Hydrophobic ICL2 N 130 34x54 G.H5 L 348 G.H5.20
Van-der-waals ICL2 N 130 34x54 G.H5 L 348 G.H5.20
Hydrophobic ICL2 L 127 34x51 G.H5 A 338 G.H5.10
Ionic H8 R 298 8x52 G.h3s5 E 261 G.h3s5.02
Hydrophobic TM6 E 230 6x29 G.h4s6 E 318 G.h4s6.12
Hydrophobic ICL2 C 131 34x55 G.H5 I 344 G.H5.16
Van-der-waals ICL2 C 131 34x55 G.H5 I 344 G.H5.16
Hydrophobic ICL2 P 126 34x50 G.H5 Y 354 G.H5.26
Hydrophobic ICL2 L 127 34x51 G.H5 V 342 G.H5.14
Van-der-waals ICL2 L 127 34x51 G.H5 V 342 G.H5.14
Hydrophobic ICL2 P 126 34x50 G.H5 I 344 G.H5.16
Van-der-waals ICL2 P 126 34x50 G.H5 I 344 G.H5.16
Polar H8 Q 295 8x49 G.H5 G 352 G.H5.24
Hydrophobic H8 Q 295 8x49 G.H5 G 352 G.H5.24
Van-der-waals H8 Q 295 8x49 G.H5 G 352 G.H5.24
Hydrophobic ICL2 R 128 34x52 G.s2s3 K 192 G.s2s3.01
Hydrophobic TM2 Y 58 2x40 G.H5 L 353 G.H5.25
Hydrophobic ICL2 Y 129 34x53 G.H5 L 353 G.H5.25
Van-der-waals ICL2 Y 129 34x53 G.H5 L 353 G.H5.25
Polar TM2 Y 58 2x40 G.H5 C 351 G.H5.23
Hydrophobic TM2 Y 58 2x40 G.H5 C 351 G.H5.23
Van-der-waals TM2 Y 58 2x40 G.H5 C 351 G.H5.23