Go - OR51B4 complex model

GPCR CLASS (FAMILY)

O1 (fish-like odorant)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gi/o

DATE

2023-09-15

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

(pLDDT score) avg.: 83.2

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.6
iPTM Score: 0.5
PAE mean: 19.2


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic ICL2 P 126 34x50 G.H5 I 343 G.H5.15
Van-der-waals ICL2 P 126 34x50 G.H5 I 343 G.H5.15
Hydrophobic TM6 T 237 6x36 G.H5 L 353 G.H5.25
Van-der-waals TM6 T 237 6x36 G.H5 L 353 G.H5.25
Hydrophobic TM2 M 57 2x39 G.H5 G 350 G.H5.22
Van-der-waals TM2 M 57 2x39 G.H5 G 350 G.H5.22
Hydrophobic TM5 I 218 5x61 G.H5 L 353 G.H5.25
Hydrophobic ICL2 L 127 34x51 G.H5 F 336 G.H5.08
Van-der-waals ICL2 L 127 34x51 G.H5 F 336 G.H5.08
Hydrophobic ICL2 L 127 34x51 G.S3 L 195 G.S3.01
Van-der-waals ICL2 L 127 34x51 G.S3 L 195 G.S3.01
Hydrophobic TM5 I 225 5x68 G.H5 I 344 G.H5.16
Van-der-waals TM5 I 225 5x68 G.H5 I 344 G.H5.16
Hydrophobic TM3 A 122 3x53 G.H5 C 351 G.H5.23
Polar H8 T 293 8x47 G.H5 G 350 G.H5.22
Hydrophobic H8 T 293 8x47 G.H5 G 350 G.H5.22
Van-der-waals H8 T 293 8x47 G.H5 G 350 G.H5.22
Polar H8 T 293 8x47 G.H5 G 352 G.H5.24
Hydrophobic H8 T 293 8x47 G.H5 G 352 G.H5.24
Polar ICL2 N 130 34x54 G.hns1 A 31 G.hns1.02
Hydrophobic ICL2 N 130 34x54 G.hns1 A 31 G.hns1.02
Van-der-waals ICL2 N 130 34x54 G.hns1 A 31 G.hns1.02
Polar ICL2 R 128 34x52 G.s2s3 N 194 G.s2s3.02
Hydrophobic ICL2 R 128 34x52 G.s2s3 N 194 G.s2s3.02
Van-der-waals ICL2 R 128 34x52 G.s2s3 N 194 G.s2s3.02
Hydrophobic TM4 N 135 4x39 G.HN K 24 G.HN.48
Hydrophobic ICL2 P 126 34x50 G.H5 I 344 G.H5.16
Van-der-waals ICL2 P 126 34x50 G.H5 I 344 G.H5.16
Hydrophobic TM3 C 119 3x50 G.H5 L 353 G.H5.25
Hydrophobic TM3 I 123 3x54 G.H5 L 353 G.H5.25
Van-der-waals TM3 I 123 3x54 G.H5 L 353 G.H5.25
Hydrophobic TM5 V 222 5x65 G.H5 L 348 G.H5.20
Van-der-waals TM5 V 222 5x65 G.H5 L 348 G.H5.20
Polar ICL2 R 128 34x52 G.s2s3 K 193 G.s2s3.01
Hydrophobic ICL2 L 127 34x51 G.H5 I 343 G.H5.15
Van-der-waals ICL2 L 127 34x51 G.H5 I 343 G.H5.15
Polar TM3 C 119 3x50 G.H5 C 351 G.H5.23
Hydrophobic TM3 C 119 3x50 G.H5 C 351 G.H5.23
Van-der-waals TM3 C 119 3x50 G.H5 C 351 G.H5.23
Hydrophobic TM2 M 57 2x39 G.H5 C 351 G.H5.23
Van-der-waals TM2 M 57 2x39 G.H5 C 351 G.H5.23
Hydrophobic TM4 T 134 4x38 G.HN I 28 G.HN.52
Polar H8 K 294 8x48 G.h4s6 N 316 G.h4s6.10
Van-der-waals H8 K 294 8x48 G.h4s6 N 316 G.h4s6.10
Polar TM6 T 237 6x36 G.H5 G 352 G.H5.24
Hydrophobic TM6 T 237 6x36 G.H5 G 352 G.H5.24
Van-der-waals TM6 T 237 6x36 G.H5 G 352 G.H5.24
Hydrophobic ICL2 P 126 34x50 G.H5 T 340 G.H5.12
Hydrophobic ICL2 L 127 34x51 G.H5 T 340 G.H5.12
Van-der-waals ICL2 L 127 34x51 G.H5 T 340 G.H5.12
Polar ICL2 C 131 34x55 G.hns1 K 32 G.hns1.03
Hydrophobic ICL2 C 131 34x55 G.hns1 K 32 G.hns1.03
Van-der-waals ICL2 C 131 34x55 G.hns1 K 32 G.hns1.03
Polar TM6 S 234 6x33 G.H5 L 353 G.H5.25
Hydrophobic TM6 S 234 6x33 G.H5 L 353 G.H5.25
Van-der-waals TM6 S 234 6x33 G.H5 L 353 G.H5.25
Polar TM3 A 122 3x53 G.H5 N 347 G.H5.19
Hydrophobic TM3 A 122 3x53 G.H5 N 347 G.H5.19
Van-der-waals TM3 A 122 3x53 G.H5 N 347 G.H5.19
Hydrophobic TM3 I 123 3x54 G.H5 L 348 G.H5.20
Van-der-waals TM3 I 123 3x54 G.H5 L 348 G.H5.20
Hydrophobic TM6 C 238 6x37 G.H5 L 353 G.H5.25
Van-der-waals TM6 C 238 6x37 G.H5 L 353 G.H5.25
Polar TM6 E 230 6x29 G.H5 Y 354 G.H5.26
Hydrophobic TM6 E 230 6x29 G.H5 Y 354 G.H5.26
Van-der-waals TM6 E 230 6x29 G.H5 Y 354 G.H5.26
Polar ICL2 P 126 34x50 G.H5 N 347 G.H5.19
Van-der-waals ICL2 P 126 34x50 G.H5 N 347 G.H5.19
Polar TM6 K 233 6x32 G.H5 Y 354 G.H5.26
Hydrophobic TM6 K 233 6x32 G.H5 Y 354 G.H5.26
Van-der-waals TM6 K 233 6x32 G.H5 Y 354 G.H5.26
Hydrophobic TM5 I 225 5x68 G.H5 D 341 G.H5.13
Van-der-waals TM5 I 225 5x68 G.H5 D 341 G.H5.13
Ionic H8 R 298 8x52 G.h3s5 D 262 G.h3s5.02
Polar H8 R 298 8x52 G.h3s5 D 262 G.h3s5.02
Hydrophobic H8 R 298 8x52 G.h3s5 D 262 G.h3s5.02
Van-der-waals H8 R 298 8x52 G.h3s5 D 262 G.h3s5.02