Gq - OR51B4 complex model

GPCR CLASS (FAMILY)

O1 (fish-like odorant)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gq/11

DATE

2023-09-15

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

(pLDDT score) avg.: 87.7

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.8
iPTM Score: 0.8
PAE mean: 12.2


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Polar TM3 A 122 3x53 G.H5 N 352 G.H5.19
Hydrophobic TM3 A 122 3x53 G.H5 N 352 G.H5.19
Van-der-waals TM3 A 122 3x53 G.H5 N 352 G.H5.19
Hydrophobic ICL2 L 127 34x51 G.H5 F 341 G.H5.08
Van-der-waals ICL2 L 127 34x51 G.H5 F 341 G.H5.08
Hydrophobic TM4 T 134 4x38 G.hns1 R 38 G.hns1.03
Van-der-waals TM4 T 134 4x38 G.hns1 R 38 G.hns1.03
Hydrophobic TM6 K 233 6x32 G.H5 L 358 G.H5.25
Hydrophobic ICL2 L 127 34x51 G.S3 V 199 G.S3.01
Van-der-waals ICL2 L 127 34x51 G.S3 V 199 G.S3.01
Hydrophobic TM6 K 233 6x32 G.H5 N 357 G.H5.24
Polar ICL2 R 128 34x52 G.s2s3 Q 197 G.s2s3.01
Hydrophobic ICL2 R 128 34x52 G.s2s3 Q 197 G.s2s3.01
Van-der-waals ICL2 R 128 34x52 G.s2s3 Q 197 G.s2s3.01
Hydrophobic TM3 I 123 3x54 G.H5 L 353 G.H5.20
Van-der-waals TM3 I 123 3x54 G.H5 L 353 G.H5.20
Hydrophobic TM2 M 57 2x39 G.H5 Y 356 G.H5.23
Van-der-waals TM2 M 57 2x39 G.H5 Y 356 G.H5.23
Polar ICL2 R 128 34x52 G.s2s3 S 198 G.s2s3.02
Hydrophobic ICL2 R 128 34x52 G.s2s3 S 198 G.s2s3.02
Hydrophobic TM6 E 230 6x29 G.H5 V 359 G.H5.26
Van-der-waals TM6 E 230 6x29 G.H5 V 359 G.H5.26
Polar TM6 T 237 6x36 G.H5 N 357 G.H5.24
Hydrophobic TM6 T 237 6x36 G.H5 N 357 G.H5.24
Van-der-waals TM6 T 237 6x36 G.H5 N 357 G.H5.24
Ionic TM2 E 55 2x37 G.hns1 R 37 G.hns1.02
Polar TM2 E 55 2x37 G.hns1 R 37 G.hns1.02
Hydrophobic TM2 E 55 2x37 G.hns1 R 37 G.hns1.02
Van-der-waals TM2 E 55 2x37 G.hns1 R 37 G.hns1.02
Polar TM2 Y 58 2x40 G.H5 E 355 G.H5.22
Hydrophobic ICL2 L 127 34x51 G.H5 K 345 G.H5.12
Polar ICL1 H 54 12x51 G.hns1 R 37 G.hns1.02
Hydrophobic ICL1 H 54 12x51 G.hns1 R 37 G.hns1.02
Van-der-waals ICL1 H 54 12x51 G.hns1 R 37 G.hns1.02
Hydrophobic TM3 I 123 3x54 G.H5 L 358 G.H5.25
Hydrophobic TM6 C 238 6x37 G.H5 L 358 G.H5.25
Van-der-waals TM6 C 238 6x37 G.H5 L 358 G.H5.25
Polar H8 T 293 8x47 G.H5 N 357 G.H5.24
Hydrophobic H8 T 293 8x47 G.H5 N 357 G.H5.24
Van-der-waals H8 T 293 8x47 G.H5 N 357 G.H5.24
Hydrophobic ICL2 R 128 34x52 G.S3 V 199 G.S3.01
Hydrophobic TM5 I 225 5x68 G.H5 L 349 G.H5.16
Van-der-waals TM5 I 225 5x68 G.H5 L 349 G.H5.16
Hydrophobic TM5 V 222 5x65 G.H5 L 358 G.H5.25
Hydrophobic ICL2 P 126 34x50 G.H5 L 349 G.H5.16
Polar TM3 D 118 3x49 G.H5 Y 356 G.H5.23
Hydrophobic TM3 D 118 3x49 G.H5 Y 356 G.H5.23
Van-der-waals TM3 D 118 3x49 G.H5 Y 356 G.H5.23
Hydrophobic TM3 I 123 3x54 G.H5 N 352 G.H5.19
Hydrophobic ICL2 L 127 34x51 G.H5 V 344 G.H5.11
Hydrophobic TM5 V 222 5x65 G.H5 L 353 G.H5.20
Van-der-waals TM5 V 222 5x65 G.H5 L 353 G.H5.20
Polar TM7 K 292 7x56 G.H5 N 357 G.H5.24
Hydrophobic TM7 K 292 7x56 G.H5 N 357 G.H5.24
Van-der-waals TM7 K 292 7x56 G.H5 N 357 G.H5.24
Hydrophobic TM3 I 123 3x54 G.H5 L 349 G.H5.16
Van-der-waals TM3 I 123 3x54 G.H5 L 349 G.H5.16
Hydrophobic ICL2 P 126 34x50 G.H5 I 348 G.H5.15
Van-der-waals ICL2 P 126 34x50 G.H5 I 348 G.H5.15
Hydrophobic ICL2 L 127 34x51 G.S1 L 40 G.S1.02
Van-der-waals ICL2 L 127 34x51 G.S1 L 40 G.S1.02
Hydrophobic TM2 M 57 2x39 G.H5 E 355 G.H5.22
Hydrophobic TM3 C 119 3x50 G.H5 L 358 G.H5.25
Polar ICL2 Y 129 34x53 G.H5 Y 356 G.H5.23
Hydrophobic ICL2 L 127 34x51 G.S3 F 201 G.S3.03
Hydrophobic ICL2 L 127 34x51 G.H5 I 348 G.H5.15
Van-der-waals ICL2 L 127 34x51 G.H5 I 348 G.H5.15
Hydrophobic ICL2 P 126 34x50 G.H5 K 345 G.H5.12
Polar ICL2 N 130 34x54 G.hns1 R 37 G.hns1.02
Hydrophobic ICL2 N 130 34x54 G.hns1 R 37 G.hns1.02
Van-der-waals ICL2 N 130 34x54 G.hns1 R 37 G.hns1.02
Polar TM6 S 234 6x33 G.H5 L 358 G.H5.25
Hydrophobic TM6 S 234 6x33 G.H5 L 358 G.H5.25
Van-der-waals TM6 S 234 6x33 G.H5 L 358 G.H5.25
Hydrophobic TM4 N 135 4x39 G.HN R 34 G.HN.52
Van-der-waals TM4 N 135 4x39 G.HN R 34 G.HN.52
Polar ICL2 N 130 34x54 G.hns1 R 38 G.hns1.03
Hydrophobic ICL2 N 130 34x54 G.hns1 R 38 G.hns1.03
Polar H8 T 293 8x47 G.H5 E 355 G.H5.22
Hydrophobic H8 T 293 8x47 G.H5 E 355 G.H5.22
Van-der-waals H8 T 293 8x47 G.H5 E 355 G.H5.22
Hydrophobic TM3 A 122 3x53 G.H5 Y 356 G.H5.23
Van-der-waals TM3 A 122 3x53 G.H5 Y 356 G.H5.23
Hydrophobic TM5 I 218 5x61 G.H5 L 358 G.H5.25
Hydrophobic TM6 T 237 6x36 G.H5 L 358 G.H5.25
Polar H8 K 294 8x48 G.H5 N 357 G.H5.24
Polar TM3 C 119 3x50 G.H5 Y 356 G.H5.23
Hydrophobic TM3 C 119 3x50 G.H5 Y 356 G.H5.23
Van-der-waals TM3 C 119 3x50 G.H5 Y 356 G.H5.23
Polar TM6 K 233 6x32 G.H5 V 359 G.H5.26
Hydrophobic TM6 K 233 6x32 G.H5 V 359 G.H5.26
Van-der-waals TM6 K 233 6x32 G.H5 V 359 G.H5.26
Polar ICL2 C 131 34x55 G.s2s3 S 198 G.s2s3.02
Van-der-waals ICL2 C 131 34x55 G.s2s3 S 198 G.s2s3.02