Gt2 - OR51B5 complex model

GPCR CLASS (FAMILY)

O1 (fish-like odorant)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gi/o

DATE

2023-09-15

3D VIEW

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Tertiary structure confidence

(pLDDT score) avg.: 84.6

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.6
iPTM Score: 0.3
PAE mean: 25.3


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic ICL2 L 128 34x51 G.S1 V 34 G.S1.02
Van-der-waals ICL2 L 128 34x51 G.S1 V 34 G.S1.02
Polar TM6 T 238 6x36 G.H5 F 354 G.H5.26
Hydrophobic TM3 I 124 3x54 G.H5 L 353 G.H5.25
Van-der-waals TM3 I 124 3x54 G.H5 L 353 G.H5.25
Ionic ICL2 R 129 34x52 G.hns1 E 30 G.hns1.01
Polar ICL2 R 129 34x52 G.hns1 E 30 G.hns1.01
Hydrophobic ICL2 R 129 34x52 G.hns1 E 30 G.hns1.01
Van-der-waals ICL2 R 129 34x52 G.hns1 E 30 G.hns1.01
Hydrophobic TM6 A 235 6x33 G.H5 F 354 G.H5.26
Van-der-waals TM6 A 235 6x33 G.H5 F 354 G.H5.26
Hydrophobic TM5 I 226 5x68 G.H5 I 344 G.H5.16
Hydrophobic TM3 A 123 3x53 G.H5 L 353 G.H5.25
Hydrophobic ICL2 L 128 34x51 G.hns1 K 32 G.hns1.03
Hydrophobic TM2 M 57 2x39 G.H5 G 352 G.H5.24
Van-der-waals TM2 M 57 2x39 G.H5 G 352 G.H5.24
Polar TM3 A 123 3x53 G.H5 C 351 G.H5.23
Hydrophobic TM3 A 123 3x53 G.H5 C 351 G.H5.23
Van-der-waals TM3 A 123 3x53 G.H5 C 351 G.H5.23
Hydrophobic ICL2 S 132 34x55 G.h2s4 G 217 G.h2s4.03
Polar ICL2 L 128 34x51 G.H5 N 347 G.H5.19
Hydrophobic ICL2 L 128 34x51 G.H5 N 347 G.H5.19
Van-der-waals ICL2 L 128 34x51 G.H5 N 347 G.H5.19
Polar ICL2 L 128 34x51 G.h2s4 T 219 G.h2s4.05
Hydrophobic ICL2 L 128 34x51 G.h2s4 T 219 G.h2s4.05
Van-der-waals ICL2 L 128 34x51 G.h2s4 T 219 G.h2s4.05
Hydrophobic TM6 K 234 6x32 G.H5 F 354 G.H5.26
Van-der-waals TM6 K 234 6x32 G.H5 F 354 G.H5.26
Van-der-waals TM6 K 234 6x32 G.H5 L 353 G.H5.25
Hydrophobic ICL2 P 127 34x50 G.H5 N 347 G.H5.19
Van-der-waals ICL2 P 127 34x50 G.H5 N 347 G.H5.19
Polar ICL2 R 129 34x52 G.S1 T 33 G.S1.01
Hydrophobic ICL2 R 129 34x52 G.S1 T 33 G.S1.01
Van-der-waals ICL2 R 129 34x52 G.S1 T 33 G.S1.01
Hydrophobic ICL2 L 128 34x51 G.H5 I 343 G.H5.15
Van-der-waals ICL2 L 128 34x51 G.H5 I 343 G.H5.15
Hydrophobic TM6 A 235 6x33 G.H5 L 348 G.H5.20
Hydrophobic TM6 E 231 6x29 G.H5 F 354 G.H5.26
Van-der-waals TM6 E 231 6x29 G.H5 F 354 G.H5.26
Polar TM6 A 235 6x33 G.H5 L 353 G.H5.25
Hydrophobic TM6 A 235 6x33 G.H5 L 353 G.H5.25
Van-der-waals TM6 A 235 6x33 G.H5 L 353 G.H5.25
Hydrophobic TM5 I 226 5x68 G.H5 L 348 G.H5.20
Van-der-waals TM5 I 226 5x68 G.H5 L 348 G.H5.20
Hydrophobic TM6 E 231 6x29 G.H5 K 345 G.H5.17
Hydrophobic TM6 C 239 6x37 G.H5 L 353 G.H5.25
Van-der-waals TM6 C 239 6x37 G.H5 L 353 G.H5.25
Polar ICL2 Y 130 34x53 G.H5 D 350 G.H5.22
Hydrophobic ICL2 Y 130 34x53 G.H5 D 350 G.H5.22
Van-der-waals ICL2 Y 130 34x53 G.H5 D 350 G.H5.22
Polar TM6 T 238 6x36 G.H5 L 353 G.H5.25
Hydrophobic TM6 T 238 6x36 G.H5 L 353 G.H5.25
Van-der-waals TM6 T 238 6x36 G.H5 L 353 G.H5.25
Hydrophobic ICL2 L 128 34x51 G.S1 T 33 G.S1.01
Hydrophobic ICL2 P 127 34x50 G.H5 C 351 G.H5.23
Hydrophobic TM3 N 126 3x56 G.hns1 A 31 G.hns1.02
Van-der-waals TM3 N 126 3x56 G.hns1 A 31 G.hns1.02
Hydrophobic TM3 I 124 3x54 G.H5 L 348 G.H5.20
Van-der-waals TM3 I 124 3x54 G.H5 L 348 G.H5.20
Hydrophobic ICL2 L 128 34x51 G.S3 L 194 G.S3.01
Hydrophobic ICL2 Y 130 34x53 G.H5 C 351 G.H5.23
Van-der-waals ICL2 Y 130 34x53 G.H5 C 351 G.H5.23
Polar H8 Q 296 8x49 G.H5 F 354 G.H5.26
Van-der-waals H8 Q 296 8x49 G.H5 F 354 G.H5.26
Polar TM6 T 238 6x36 G.H5 G 352 G.H5.24
Hydrophobic TM6 T 238 6x36 G.H5 G 352 G.H5.24
Van-der-waals TM6 T 238 6x36 G.H5 G 352 G.H5.24
Hydrophobic ICL2 T 131 34x54 G.h3s5 A 261 G.h3s5.02
Hydrophobic ICL2 R 129 34x52 G.hns1 A 31 G.hns1.02
Van-der-waals ICL2 R 129 34x52 G.hns1 A 31 G.hns1.02
Van-der-waals TM3 A 123 3x53 G.H5 N 347 G.H5.19
Hydrophobic ICL1 N 52 12x49 G.h4s6 V 316 G.h4s6.10