G12 - OR51E2 complex model

GPCR CLASS (FAMILY)

O1 (fish-like odorant)

SPECIES

Homo sapiens

G PROTEIN FAMILY

G12/13

DATE

2023-09-15

3D VIEW

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Tertiary structure confidence

(pLDDT score) avg.: 84.3

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.7
iPTM Score: 0.7
PAE mean: 15.9


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Polar H8 K 296 8x48 G.H5 L 380 G.H5.25
Van-der-waals H8 K 296 8x48 G.H5 L 380 G.H5.25
Polar ICL2 R 130 34x52 G.s2s3 K 219 G.s2s3.01
Van-der-waals ICL2 R 130 34x52 G.s2s3 K 219 G.s2s3.01
Hydrophobic TM7 K 294 7x56 G.H5 M 379 G.H5.24
Hydrophobic ICL2 L 129 34x51 G.H5 K 367 G.H5.12
Hydrophobic TM6 K 235 6x32 G.H5 M 379 G.H5.24
Van-der-waals TM6 K 235 6x32 G.H5 M 379 G.H5.24
Ionic ICL1 R 52 12x48 G.HN D 44 G.HN.44
Polar ICL1 R 52 12x48 G.HN D 44 G.HN.44
Hydrophobic ICL1 R 52 12x48 G.HN D 44 G.HN.44
Van-der-waals ICL1 R 52 12x48 G.HN D 44 G.HN.44
Hydrophobic TM3 A 124 3x53 G.H5 I 378 G.H5.23
Van-der-waals TM3 A 124 3x53 G.H5 I 378 G.H5.23
Polar TM2 Y 59 2x40 G.H5 L 380 G.H5.25
Hydrophobic TM2 Y 59 2x40 G.H5 L 380 G.H5.25
Van-der-waals TM2 Y 59 2x40 G.H5 L 380 G.H5.25
Hydrophobic TM2 M 58 2x39 G.H5 D 377 G.H5.22
Van-der-waals TM2 M 58 2x39 G.H5 D 377 G.H5.22
Hydrophobic TM3 A 124 3x53 G.H5 L 371 G.H5.16
Hydrophobic TM7 Y 291 7x53 G.H5 L 380 G.H5.25
Van-der-waals TM7 Y 291 7x53 G.H5 L 380 G.H5.25
Hydrophobic TM3 I 125 3x54 G.H5 L 371 G.H5.16
Van-der-waals TM3 I 125 3x54 G.H5 L 371 G.H5.16
Hydrophobic ICL2 A 132 34x54 G.hns1 R 56 G.hns1.03
Hydrophobic TM6 A 236 6x33 G.H5 L 375 G.H5.20
Van-der-waals TM6 A 236 6x33 G.H5 L 375 G.H5.20
Hydrophobic TM2 L 62 2x43 G.H5 L 380 G.H5.25
Van-der-waals TM2 L 62 2x43 G.H5 L 380 G.H5.25
Hydrophobic TM3 D 120 3x49 G.H5 I 378 G.H5.23
Polar TM4 T 138 4x40 G.HN R 52 G.HN.52
Van-der-waals TM4 T 138 4x40 G.HN R 52 G.HN.52
Polar TM6 K 235 6x32 G.H5 Q 372 G.H5.17
Hydrophobic ICL2 L 129 34x51 G.H5 F 363 G.H5.08
Van-der-waals ICL2 L 129 34x51 G.H5 F 363 G.H5.08
Polar ICL2 H 131 34x53 G.H5 N 374 G.H5.19
Hydrophobic ICL2 H 131 34x53 G.H5 N 374 G.H5.19
Hydrophobic ICL2 P 128 34x50 G.H5 K 367 G.H5.12
Van-der-waals ICL2 P 128 34x50 G.H5 K 367 G.H5.12
Hydrophobic TM3 R 121 3x50 G.H5 I 378 G.H5.23
Van-der-waals TM3 R 121 3x50 G.H5 I 378 G.H5.23
Hydrophobic ICL2 R 130 34x52 G.S3 I 221 G.S3.01
Hydrophobic TM3 I 125 3x54 G.H5 L 375 G.H5.20
Polar TM3 A 124 3x53 G.H5 N 374 G.H5.19
Hydrophobic TM3 A 124 3x53 G.H5 N 374 G.H5.19
Van-der-waals TM3 A 124 3x53 G.H5 N 374 G.H5.19
Polar TM6 E 232 6x29 G.H5 Q 372 G.H5.17
Hydrophobic TM6 E 232 6x29 G.H5 Q 372 G.H5.17
Van-der-waals TM6 E 232 6x29 G.H5 Q 372 G.H5.17
Polar ICL2 P 128 34x50 G.H5 N 374 G.H5.19
Van-der-waals ICL2 P 128 34x50 G.H5 N 374 G.H5.19
Polar ICL2 A 133 34x55 G.hns1 R 56 G.hns1.03
Hydrophobic ICL2 A 133 34x55 G.hns1 R 56 G.hns1.03
Van-der-waals ICL2 A 133 34x55 G.hns1 R 56 G.hns1.03
Hydrophobic ICL2 A 132 34x54 G.hns1 R 55 G.hns1.02
Van-der-waals ICL2 A 132 34x54 G.hns1 R 55 G.hns1.02
Hydrophobic TM6 T 239 6x36 G.H5 M 379 G.H5.24
Van-der-waals TM6 T 239 6x36 G.H5 M 379 G.H5.24
Hydrophobic ICL2 L 129 34x51 G.S3 I 221 G.S3.01
Van-der-waals ICL2 L 129 34x51 G.S3 I 221 G.S3.01
Hydrophobic ICL2 L 129 34x51 G.S1 V 58 G.S1.02
Hydrophobic TM6 T 239 6x36 G.H5 I 378 G.H5.23
Van-der-waals TM6 T 239 6x36 G.H5 I 378 G.H5.23
Hydrophobic ICL2 P 128 34x50 G.H5 I 370 G.H5.15
Van-der-waals ICL2 P 128 34x50 G.H5 I 370 G.H5.15
Hydrophobic TM6 K 235 6x32 G.H5 L 375 G.H5.20
Hydrophobic H8 K 296 8x48 G.H5 Q 381 G.H5.26
Van-der-waals H8 K 296 8x48 G.H5 Q 381 G.H5.26
Hydrophobic TM4 N 137 4x39 G.HN R 52 G.HN.52
Van-der-waals TM4 N 137 4x39 G.HN R 52 G.HN.52
Hydrophobic ICL2 L 129 34x51 G.H5 V 366 G.H5.11
Hydrophobic ICL2 H 131 34x53 G.H5 I 378 G.H5.23
Hydrophobic TM2 M 58 2x39 G.H5 L 380 G.H5.25
Van-der-waals TM2 M 58 2x39 G.H5 L 380 G.H5.25
Hydrophobic ICL2 L 129 34x51 G.H5 I 370 G.H5.15
Van-der-waals ICL2 L 129 34x51 G.H5 I 370 G.H5.15
Hydrophobic TM2 M 58 2x39 G.H5 I 378 G.H5.23
Van-der-waals TM2 M 58 2x39 G.H5 I 378 G.H5.23
Hydrophobic TM5 L 227 5x68 G.H5 L 371 G.H5.16
Van-der-waals TM5 L 227 5x68 G.H5 L 371 G.H5.16
Hydrophobic ICL2 P 128 34x50 G.H5 L 371 G.H5.16
Hydrophobic H8 T 295 8x47 G.H5 L 380 G.H5.25
Van-der-waals H8 T 295 8x47 G.H5 L 380 G.H5.25