GPCR CLASS (FAMILY)
SPECIES
G PROTEIN FAMILY
DATE
3D VIEW
Tertiary structure confidence
(pLDDT score) avg.: 79.5
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered
PTM Score: 0.5
iPTM Score: 0.2
PAE mean: 25.9
GPCR - G protein interface interactions
The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle
(Gα residues)
and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid,
hydrophobic - dashed,
ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.
GPCR-G protein backbone (bb) or sidechain (sc):
Structures
0 structures selected.
Sequence Color
Interaction frequency filter (%)
Gα,
GPCR
Interaction cut-off: strict (stick), loose (line)
Interaction type |
GPCR Segment |
AA |
Number |
Generic number |
Gα segment |
AA |
Number |
Generic number |
---|---|---|---|---|---|---|---|---|
Hydrophobic | TM6 | Q | 234 | 6x28 | G.h4s6 | Q | 339 | G.h4s6.13 |
Van-der-waals | TM6 | Q | 234 | 6x28 | G.h4s6 | Q | 339 | G.h4s6.13 |
Hydrophobic | H8 | T | 298 | 8x47 | G.H5 | Q | 377 | G.H5.26 |
Van-der-waals | H8 | T | 298 | 8x47 | G.H5 | Q | 377 | G.H5.26 |
Hydrophobic | ICL2 | P | 131 | 34x50 | G.H5 | H | 368 | G.H5.17 |
Hydrophobic | ICL1 | H | 58 | 12x51 | G.hns1 | K | 46 | G.hns1.02 |
Van-der-waals | ICL1 | H | 58 | 12x51 | G.hns1 | K | 46 | G.hns1.02 |
Hydrophobic | ICL2 | P | 131 | 34x50 | G.H5 | L | 371 | G.H5.20 |
Van-der-waals | ICL2 | P | 131 | 34x50 | G.H5 | L | 371 | G.H5.20 |
Polar | TM6 | Q | 234 | 6x28 | G.h4s6 | Q | 338 | G.h4s6.12 |
Van-der-waals | TM6 | Q | 234 | 6x28 | G.h4s6 | Q | 338 | G.h4s6.12 |
Hydrophobic | TM2 | P | 60 | 2x38 | G.hns1 | R | 47 | G.hns1.03 |
Van-der-waals | TM2 | P | 60 | 2x38 | G.hns1 | R | 47 | G.hns1.03 |
Hydrophobic | TM3 | V | 128 | 3x54 | G.H5 | M | 375 | G.H5.24 |
Van-der-waals | TM3 | V | 128 | 3x54 | G.H5 | M | 375 | G.H5.24 |
Hydrophobic | ICL2 | L | 132 | 34x51 | G.H5 | L | 367 | G.H5.16 |
Van-der-waals | ICL2 | L | 132 | 34x51 | G.H5 | L | 367 | G.H5.16 |
Polar | TM6 | T | 242 | 6x36 | G.H5 | L | 376 | G.H5.25 |
Hydrophobic | TM3 | N | 130 | 3x56 | G.H5 | L | 371 | G.H5.20 |
Hydrophobic | ICL2 | S | 135 | 34x54 | G.S3 | P | 217 | G.S3.02 |
Van-der-waals | ICL2 | S | 135 | 34x54 | G.S3 | P | 217 | G.S3.02 |
Ionic | TM6 | E | 235 | 6x29 | G.H5 | K | 372 | G.H5.21 |
Polar | TM6 | E | 235 | 6x29 | G.H5 | K | 372 | G.H5.21 |
Hydrophobic | TM6 | E | 235 | 6x29 | G.H5 | K | 372 | G.H5.21 |
Van-der-waals | TM6 | E | 235 | 6x29 | G.H5 | K | 372 | G.H5.21 |
Hydrophobic | TM6 | R | 238 | 6x32 | G.H5 | L | 376 | G.H5.25 |
Hydrophobic | TM6 | A | 239 | 6x33 | G.H5 | M | 375 | G.H5.24 |
Van-der-waals | TM6 | A | 239 | 6x33 | G.H5 | M | 375 | G.H5.24 |
Ionic | ICL2 | D | 134 | 34x53 | G.hns1 | R | 47 | G.hns1.03 |
Polar | ICL2 | D | 134 | 34x53 | G.hns1 | R | 47 | G.hns1.03 |
Hydrophobic | ICL2 | D | 134 | 34x53 | G.hns1 | R | 47 | G.hns1.03 |
Van-der-waals | ICL2 | D | 134 | 34x53 | G.hns1 | R | 47 | G.hns1.03 |
Polar | TM3 | R | 124 | 3x50 | G.H5 | M | 375 | G.H5.24 |
Hydrophobic | TM3 | R | 124 | 3x50 | G.H5 | M | 375 | G.H5.24 |
Van-der-waals | TM3 | R | 124 | 3x50 | G.H5 | M | 375 | G.H5.24 |
Hydrophobic | ICL1 | T | 56 | 12x49 | G.HN | K | 42 | G.HN.51 |
Polar | TM2 | Y | 62 | 2x40 | G.H5 | Q | 377 | G.H5.26 |
Hydrophobic | TM2 | Y | 62 | 2x40 | G.H5 | Q | 377 | G.H5.26 |
Van-der-waals | TM2 | Y | 62 | 2x40 | G.H5 | Q | 377 | G.H5.26 |
Hydrophobic | TM5 | I | 230 | 5x68 | G.H5 | H | 368 | G.H5.17 |
Van-der-waals | TM5 | I | 230 | 5x68 | G.H5 | H | 368 | G.H5.17 |
Hydrophobic | TM2 | G | 59 | 2x37 | G.hns1 | K | 46 | G.hns1.02 |
Van-der-waals | TM2 | G | 59 | 2x37 | G.hns1 | K | 46 | G.hns1.02 |
Polar | ICL2 | L | 138 | 34x57 | G.hns1 | R | 47 | G.hns1.03 |
Hydrophobic | ICL2 | L | 138 | 34x57 | G.hns1 | R | 47 | G.hns1.03 |
Van-der-waals | ICL2 | L | 138 | 34x57 | G.hns1 | R | 47 | G.hns1.03 |
Hydrophobic | ICL2 | L | 132 | 34x51 | G.S3 | V | 216 | G.S3.01 |
Van-der-waals | ICL2 | L | 132 | 34x51 | G.S3 | V | 216 | G.S3.01 |
Hydrophobic | TM3 | A | 127 | 3x53 | G.H5 | M | 375 | G.H5.24 |
Van-der-waals | TM3 | A | 127 | 3x53 | G.H5 | M | 375 | G.H5.24 |
Hydrophobic | TM3 | A | 127 | 3x53 | G.H5 | L | 371 | G.H5.20 |
Van-der-waals | TM3 | A | 127 | 3x53 | G.H5 | L | 371 | G.H5.20 |
Polar | TM6 | R | 238 | 6x32 | G.h4s6 | Q | 339 | G.h4s6.13 |
Van-der-waals | TM6 | R | 238 | 6x32 | G.h4s6 | Q | 339 | G.h4s6.13 |
Hydrophobic | ICL2 | L | 132 | 34x51 | G.H5 | K | 363 | G.H5.12 |
Van-der-waals | ICL2 | L | 132 | 34x51 | G.H5 | K | 363 | G.H5.12 |
Hydrophobic | ICL2 | L | 132 | 34x51 | G.S3 | F | 218 | G.S3.03 |
Polar | ICL2 | H | 133 | 34x52 | G.s2s3 | K | 214 | G.s2s3.01 |
Hydrophobic | ICL2 | H | 133 | 34x52 | G.s2s3 | K | 214 | G.s2s3.01 |
Van-der-waals | ICL2 | H | 133 | 34x52 | G.s2s3 | K | 214 | G.s2s3.01 |
Hydrophobic | ICL2 | T | 136 | 34x55 | G.S3 | V | 216 | G.S3.01 |
Hydrophobic | TM2 | Y | 63 | 2x41 | G.HN | T | 43 | G.HN.52 |
Hydrophobic | ICL2 | D | 134 | 34x53 | G.H5 | L | 371 | G.H5.20 |
Hydrophobic | TM4 | P | 140 | 4x39 | G.HN | T | 43 | G.HN.52 |
Hydrophobic | ICL2 | P | 131 | 34x50 | G.H5 | L | 367 | G.H5.16 |
Van-der-waals | ICL2 | P | 131 | 34x50 | G.H5 | L | 367 | G.H5.16 |
Polar | ICL1 | L | 57 | 12x50 | G.hns1 | K | 46 | G.hns1.02 |
Hydrophobic | ICL1 | L | 57 | 12x50 | G.hns1 | K | 46 | G.hns1.02 |
Van-der-waals | ICL1 | L | 57 | 12x50 | G.hns1 | K | 46 | G.hns1.02 |
Polar | ICL1 | T | 56 | 12x49 | G.hns1 | K | 46 | G.hns1.02 |
Hydrophobic | ICL1 | T | 56 | 12x49 | G.hns1 | K | 46 | G.hns1.02 |
Van-der-waals | ICL1 | T | 56 | 12x49 | G.hns1 | K | 46 | G.hns1.02 |
Polar | ICL1 | A | 55 | 12x48 | G.HN | K | 42 | G.HN.51 |
Hydrophobic | ICL1 | A | 55 | 12x48 | G.HN | K | 42 | G.HN.51 |
Van-der-waals | ICL1 | A | 55 | 12x48 | G.HN | K | 42 | G.HN.51 |
Hydrophobic | TM4 | T | 139 | 4x38 | G.hns1 | R | 47 | G.hns1.03 |
Van-der-waals | TM4 | T | 139 | 4x38 | G.hns1 | R | 47 | G.hns1.03 |
Polar | TM6 | T | 242 | 6x36 | G.H5 | M | 375 | G.H5.24 |
Hydrophobic | TM6 | T | 242 | 6x36 | G.H5 | M | 375 | G.H5.24 |
Van-der-waals | TM6 | T | 242 | 6x36 | G.H5 | M | 375 | G.H5.24 |
Polar | H8 | Q | 300 | 8x49 | G.H5 | Q | 377 | G.H5.26 |
Hydrophobic | H8 | Q | 300 | 8x49 | G.H5 | Q | 377 | G.H5.26 |
Van-der-waals | H8 | Q | 300 | 8x49 | G.H5 | Q | 377 | G.H5.26 |
Hydrophobic | ICL2 | H | 133 | 34x52 | G.S3 | V | 216 | G.S3.01 |
Van-der-waals | ICL2 | H | 133 | 34x52 | G.S3 | V | 216 | G.S3.01 |
Hydrophobic | TM6 | R | 238 | 6x32 | G.H5 | K | 372 | G.H5.21 |
Polar | ICL2 | S | 135 | 34x54 | G.hns1 | R | 47 | G.hns1.03 |
Hydrophobic | ICL2 | S | 135 | 34x54 | G.hns1 | R | 47 | G.hns1.03 |
Van-der-waals | ICL2 | S | 135 | 34x54 | G.hns1 | R | 47 | G.hns1.03 |
Polar | TM6 | E | 235 | 6x29 | G.S6 | Y | 343 | G.S6.02 |
Van-der-waals | TM6 | E | 235 | 6x29 | G.S6 | Y | 343 | G.S6.02 |
Ionic | TM6 | E | 235 | 6x29 | G.H5 | H | 368 | G.H5.17 |
Hydrophobic | ICL2 | T | 136 | 34x55 | G.s2s3 | N | 215 | G.s2s3.02 |
Van-der-waals | ICL2 | T | 136 | 34x55 | G.s2s3 | N | 215 | G.s2s3.02 |
Van-der-waals | TM2 | Y | 62 | 2x40 | G.hns1 | K | 46 | G.hns1.02 |
Hydrophobic | TM3 | V | 128 | 3x54 | G.H5 | L | 371 | G.H5.20 |
Van-der-waals | TM3 | V | 128 | 3x54 | G.H5 | L | 371 | G.H5.20 |