G12 - OR51G2 complex model

GPCR CLASS (FAMILY)

O1 (fish-like odorant)

SPECIES

Homo sapiens

G PROTEIN FAMILY

G12/13

DATE

2023-09-15

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

(pLDDT score) avg.: 82.7

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.7
iPTM Score: 0.7
PAE mean: 16.0


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic H8 T 301 8x47 G.H5 L 380 G.H5.25
Van-der-waals H8 T 301 8x47 G.H5 L 380 G.H5.25
Hydrophobic TM2 Y 65 2x40 G.H5 L 380 G.H5.25
Van-der-waals TM2 Y 65 2x40 G.H5 L 380 G.H5.25
Hydrophobic ICL2 L 135 34x51 G.H5 V 366 G.H5.11
Van-der-waals ICL2 L 135 34x51 G.H5 V 366 G.H5.11
Hydrophobic ICL2 Y 137 34x53 G.H5 I 378 G.H5.23
Hydrophobic TM3 A 130 3x53 G.H5 I 378 G.H5.23
Van-der-waals TM3 A 130 3x53 G.H5 I 378 G.H5.23
Polar ICL1 H 61 12x51 G.HN R 52 G.HN.52
Van-der-waals ICL1 H 61 12x51 G.HN R 52 G.HN.52
Polar ICL1 R 58 12x48 G.HN S 40 G.HN.40
Polar ICL2 S 139 34x55 G.hns1 R 56 G.hns1.03
Hydrophobic ICL2 S 139 34x55 G.hns1 R 56 G.hns1.03
Van-der-waals ICL2 S 139 34x55 G.hns1 R 56 G.hns1.03
Hydrophobic ICL2 P 134 34x50 G.H5 I 370 G.H5.15
Van-der-waals ICL2 P 134 34x50 G.H5 I 370 G.H5.15
Polar TM4 N 143 4x39 G.HN R 52 G.HN.52
Hydrophobic TM4 N 143 4x39 G.HN R 52 G.HN.52
Van-der-waals TM4 N 143 4x39 G.HN R 52 G.HN.52
Hydrophobic TM5 I 233 5x68 G.H5 L 371 G.H5.16
Van-der-waals TM5 I 233 5x68 G.H5 L 371 G.H5.16
Polar TM6 K 241 6x32 G.H5 Q 372 G.H5.17
Hydrophobic ICL2 L 135 34x51 G.H5 I 370 G.H5.15
Van-der-waals ICL2 L 135 34x51 G.H5 I 370 G.H5.15
Hydrophobic TM2 M 64 2x39 G.H5 L 380 G.H5.25
Van-der-waals TM2 M 64 2x39 G.H5 L 380 G.H5.25
Hydrophobic TM3 I 131 3x54 G.H5 L 371 G.H5.16
Van-der-waals TM3 I 131 3x54 G.H5 L 371 G.H5.16
Polar ICL2 P 134 34x50 G.H5 N 374 G.H5.19
Hydrophobic ICL2 P 134 34x50 G.H5 N 374 G.H5.19
Van-der-waals ICL2 P 134 34x50 G.H5 N 374 G.H5.19
Polar ICL1 R 58 12x48 G.HN R 41 G.HN.41
Hydrophobic ICL1 R 58 12x48 G.HN R 41 G.HN.41
Van-der-waals ICL1 R 58 12x48 G.HN R 41 G.HN.41
Polar TM3 C 132 3x55 G.H5 K 367 G.H5.12
Hydrophobic ICL2 V 138 34x54 G.hns1 R 55 G.hns1.02
Van-der-waals ICL2 V 138 34x54 G.hns1 R 55 G.hns1.02
Hydrophobic ICL2 L 135 34x51 G.S3 I 221 G.S3.01
Van-der-waals ICL2 L 135 34x51 G.S3 I 221 G.S3.01
Hydrophobic H8 K 302 8x48 G.H5 Q 381 G.H5.26
Van-der-waals H8 K 302 8x48 G.H5 Q 381 G.H5.26
Hydrophobic TM3 A 130 3x53 G.H5 L 371 G.H5.16
Hydrophobic TM6 T 245 6x36 G.H5 L 375 G.H5.20
Polar ICL2 H 136 34x52 G.s2s3 K 219 G.s2s3.01
Van-der-waals ICL2 H 136 34x52 G.s2s3 K 219 G.s2s3.01
Hydrophobic ICL2 L 135 34x51 G.H5 K 367 G.H5.12
Polar H8 K 302 8x48 G.H5 L 380 G.H5.25
Van-der-waals H8 K 302 8x48 G.H5 L 380 G.H5.25
Hydrophobic TM2 E 62 2x37 G.H5 D 377 G.H5.22
Van-der-waals TM2 E 62 2x37 G.H5 D 377 G.H5.22
Hydrophobic TM3 I 131 3x54 G.H5 L 375 G.H5.20
Hydrophobic TM2 M 64 2x39 G.H5 I 378 G.H5.23
Van-der-waals TM2 M 64 2x39 G.H5 I 378 G.H5.23
Hydrophobic ICL2 Y 137 34x53 G.H5 N 374 G.H5.19
Polar H8 Q 303 8x49 G.H5 L 380 G.H5.25
Hydrophobic TM4 T 142 4x38 G.hns1 R 56 G.hns1.03
Van-der-waals TM4 T 142 4x38 G.hns1 R 56 G.hns1.03
Hydrophobic TM6 K 241 6x32 G.H5 K 376 G.H5.21
Van-der-waals TM6 K 241 6x32 G.H5 K 376 G.H5.21
Hydrophobic ICL2 P 134 34x50 G.H5 L 371 G.H5.16
Hydrophobic TM6 T 245 6x36 G.H5 I 378 G.H5.23
Van-der-waals TM6 T 245 6x36 G.H5 I 378 G.H5.23
Ionic TM2 E 62 2x37 G.hns1 R 55 G.hns1.02
Polar TM2 E 62 2x37 G.hns1 R 55 G.hns1.02
Hydrophobic TM2 E 62 2x37 G.hns1 R 55 G.hns1.02
Van-der-waals TM2 E 62 2x37 G.hns1 R 55 G.hns1.02
Hydrophobic TM7 K 300 7x56 G.H5 L 380 G.H5.25
Hydrophobic ICL2 H 136 34x52 G.S3 I 221 G.S3.01
Van-der-waals ICL2 H 136 34x52 G.S3 I 221 G.S3.01
Polar TM3 A 130 3x53 G.H5 N 374 G.H5.19
Hydrophobic TM3 A 130 3x53 G.H5 N 374 G.H5.19
Van-der-waals TM3 A 130 3x53 G.H5 N 374 G.H5.19
Hydrophobic TM6 A 242 6x33 G.H5 L 375 G.H5.20
Van-der-waals TM6 A 242 6x33 G.H5 L 375 G.H5.20
Hydrophobic TM6 T 245 6x36 G.H5 M 379 G.H5.24
Van-der-waals TM6 T 245 6x36 G.H5 M 379 G.H5.24
Hydrophobic TM3 R 127 3x50 G.H5 I 378 G.H5.23
Hydrophobic TM6 K 241 6x32 G.H5 M 379 G.H5.24
Van-der-waals TM6 K 241 6x32 G.H5 M 379 G.H5.24
Polar ICL2 V 138 34x54 G.hns1 R 56 G.hns1.03
Hydrophobic ICL2 V 138 34x54 G.hns1 R 56 G.hns1.03
Van-der-waals ICL2 V 138 34x54 G.hns1 R 56 G.hns1.03
Polar TM6 E 238 6x29 G.H5 Q 372 G.H5.17
Hydrophobic TM6 E 238 6x29 G.H5 Q 372 G.H5.17
Van-der-waals TM6 E 238 6x29 G.H5 Q 372 G.H5.17
Hydrophobic TM7 Y 297 7x53 G.H5 L 380 G.H5.25
Van-der-waals TM7 Y 297 7x53 G.H5 L 380 G.H5.25
Ionic ICL1 R 58 12x48 G.HN D 44 G.HN.44
Polar ICL1 R 58 12x48 G.HN D 44 G.HN.44
Hydrophobic ICL1 R 58 12x48 G.HN D 44 G.HN.44
Van-der-waals ICL1 R 58 12x48 G.HN D 44 G.HN.44
Hydrophobic ICL2 P 134 34x50 G.H5 K 367 G.H5.12
Van-der-waals ICL2 P 134 34x50 G.H5 K 367 G.H5.12
Hydrophobic ICL2 L 135 34x51 G.H5 F 363 G.H5.08
Van-der-waals ICL2 L 135 34x51 G.H5 F 363 G.H5.08