Gi2 - OR51G2 complex model

GPCR CLASS (FAMILY)

O1 (fish-like odorant)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gi/o

DATE

2023-09-15

3D VIEW

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Tertiary structure confidence

(pLDDT score) avg.: 84.7

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.6
iPTM Score: 0.3
PAE mean: 22.2


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Ionic TM6 E 238 6x29 G.H5 K 346 G.H5.17
Polar TM6 E 238 6x29 G.H5 K 346 G.H5.17
Van-der-waals TM6 E 238 6x29 G.H5 K 346 G.H5.17
Hydrophobic TM2 M 64 2x39 G.H5 L 354 G.H5.25
Polar TM6 T 245 6x36 G.H5 L 354 G.H5.25
Hydrophobic TM6 T 245 6x36 G.H5 L 354 G.H5.25
Van-der-waals TM6 T 245 6x36 G.H5 L 354 G.H5.25
Hydrophobic ICL2 P 134 34x50 G.H5 K 346 G.H5.17
Van-der-waals ICL2 P 134 34x50 G.H5 K 346 G.H5.17
Hydrophobic TM6 E 238 6x29 G.h4s6 E 319 G.h4s6.12
Van-der-waals TM6 E 238 6x29 G.h4s6 E 319 G.h4s6.12
Hydrophobic H8 Q 303 8x49 G.H5 G 353 G.H5.24
Van-der-waals H8 Q 303 8x49 G.H5 G 353 G.H5.24
Hydrophobic TM4 T 142 4x38 G.hns1 R 32 G.hns1.03
Van-der-waals TM4 T 142 4x38 G.hns1 R 32 G.hns1.03
Hydrophobic ICL2 V 138 34x54 G.S3 L 195 G.S3.01
Hydrophobic ICL2 L 135 34x51 G.s2s3 K 193 G.s2s3.01
Van-der-waals ICL2 L 135 34x51 G.s2s3 K 193 G.s2s3.01
Polar TM6 K 241 6x32 G.H5 F 355 G.H5.26
Hydrophobic TM6 K 241 6x32 G.H5 F 355 G.H5.26
Van-der-waals TM6 K 241 6x32 G.H5 F 355 G.H5.26
Hydrophobic TM6 K 241 6x32 G.H5 K 350 G.H5.21
Hydrophobic ICL2 Y 137 34x53 G.H5 L 354 G.H5.25
Van-der-waals ICL2 Y 137 34x53 G.H5 L 354 G.H5.25
Polar TM2 Y 65 2x40 G.H5 C 352 G.H5.23
Hydrophobic TM2 Y 65 2x40 G.H5 C 352 G.H5.23
Van-der-waals TM2 Y 65 2x40 G.H5 C 352 G.H5.23
Polar TM3 R 127 3x50 G.H5 L 354 G.H5.25
Hydrophobic TM3 R 127 3x50 G.H5 L 354 G.H5.25
Van-der-waals TM3 R 127 3x50 G.H5 L 354 G.H5.25
Polar H8 Q 303 8x49 G.H5 D 351 G.H5.22
Van-der-waals H8 Q 303 8x49 G.H5 D 351 G.H5.22
Hydrophobic ICL2 H 136 34x52 G.s2s3 K 193 G.s2s3.01
Hydrophobic ICL2 L 135 34x51 G.H5 I 345 G.H5.16
Van-der-waals ICL2 L 135 34x51 G.H5 I 345 G.H5.16
Hydrophobic TM6 T 245 6x36 G.H5 F 355 G.H5.26
Van-der-waals TM6 T 245 6x36 G.H5 F 355 G.H5.26
Hydrophobic TM3 A 130 3x53 G.H5 F 355 G.H5.26
Van-der-waals TM3 A 130 3x53 G.H5 F 355 G.H5.26
Hydrophobic TM3 A 130 3x53 G.H5 L 349 G.H5.20
Polar TM2 E 62 2x37 G.H5 C 352 G.H5.23
Hydrophobic TM2 E 62 2x37 G.H5 C 352 G.H5.23
Van-der-waals TM2 E 62 2x37 G.H5 C 352 G.H5.23
Polar H8 Q 303 8x49 G.H5 C 352 G.H5.23
Hydrophobic H8 Q 303 8x49 G.H5 C 352 G.H5.23
Van-der-waals H8 Q 303 8x49 G.H5 C 352 G.H5.23
Hydrophobic TM3 A 130 3x53 G.H5 L 354 G.H5.25
Van-der-waals TM3 A 130 3x53 G.H5 L 354 G.H5.25
Polar TM4 N 143 4x39 G.HN E 28 G.HN.52
Van-der-waals TM4 N 143 4x39 G.HN E 28 G.HN.52
Hydrophobic TM3 I 131 3x54 G.H5 F 355 G.H5.26
Hydrophobic ICL2 L 135 34x51 G.H5 D 342 G.H5.13
Van-der-waals ICL2 L 135 34x51 G.H5 D 342 G.H5.13
Polar ICL2 S 139 34x55 G.s2s3 D 194 G.s2s3.02
Hydrophobic ICL2 S 139 34x55 G.s2s3 D 194 G.s2s3.02
Van-der-waals ICL2 S 139 34x55 G.s2s3 D 194 G.s2s3.02
Hydrophobic TM2 M 64 2x39 G.H5 G 353 G.H5.24
Hydrophobic ICL2 V 138 34x54 G.hns1 R 32 G.hns1.03
Van-der-waals ICL2 V 138 34x54 G.hns1 R 32 G.hns1.03
Hydrophobic ICL2 Y 137 34x53 G.H5 L 349 G.H5.20
Van-der-waals ICL2 Y 137 34x53 G.H5 L 349 G.H5.20
Polar TM3 R 127 3x50 G.H5 G 353 G.H5.24
Hydrophobic ICL2 L 135 34x51 G.H5 T 341 G.H5.12
Van-der-waals ICL2 L 135 34x51 G.H5 T 341 G.H5.12
Hydrophobic ICL2 P 134 34x50 G.H5 I 345 G.H5.16
Van-der-waals ICL2 P 134 34x50 G.H5 I 345 G.H5.16
Hydrophobic TM6 A 242 6x33 G.H5 F 355 G.H5.26
Van-der-waals TM6 A 242 6x33 G.H5 F 355 G.H5.26
Hydrophobic TM3 D 126 3x49 G.H5 L 354 G.H5.25
Van-der-waals TM3 D 126 3x49 G.H5 L 354 G.H5.25
Ionic ICL1 R 58 12x48 G.HN D 20 G.HN.44
Polar ICL1 R 58 12x48 G.HN D 20 G.HN.44
Van-der-waals ICL1 R 58 12x48 G.HN D 20 G.HN.44
Ionic TM6 E 238 6x29 G.H5 K 350 G.H5.21
Polar TM6 E 238 6x29 G.H5 K 350 G.H5.21
Van-der-waals TM6 E 238 6x29 G.H5 K 350 G.H5.21
Hydrophobic ICL2 P 134 34x50 G.H5 L 349 G.H5.20
Van-der-waals ICL2 P 134 34x50 G.H5 L 349 G.H5.20