G13 - OR51I2 complex model

GPCR CLASS (FAMILY)

O1 (fish-like odorant)

SPECIES

Homo sapiens

G PROTEIN FAMILY

G12/13

DATE

2023-09-15

3D VIEW

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Tertiary structure confidence

(pLDDT score) avg.: 81.8

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.6
iPTM Score: 0.3
PAE mean: 22.5


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic TM3 R 122 3x50 G.H5 L 374 G.H5.23
Van-der-waals TM3 R 122 3x50 G.H5 L 374 G.H5.23
Hydrophobic ICL2 L 130 34x51 G.S1 V 49 G.S1.02
Van-der-waals ICL2 L 130 34x51 G.S1 V 49 G.S1.02
Polar H8 E 298 8x49 G.H5 Q 377 G.H5.26
Hydrophobic H8 E 298 8x49 G.H5 Q 377 G.H5.26
Van-der-waals H8 E 298 8x49 G.H5 Q 377 G.H5.26
Hydrophobic ICL2 P 129 34x50 G.H5 L 367 G.H5.16
Van-der-waals ICL2 P 129 34x50 G.H5 L 367 G.H5.16
Hydrophobic TM3 D 128 3x56 G.S3 V 216 G.S3.01
Van-der-waals TM3 D 128 3x56 G.S3 V 216 G.S3.01
Hydrophobic TM2 M 59 2x39 G.H5 L 374 G.H5.23
Van-der-waals TM2 M 59 2x39 G.H5 L 374 G.H5.23
Polar ICL2 R 131 34x52 G.hns1 R 47 G.hns1.03
Hydrophobic ICL2 R 131 34x52 G.hns1 R 47 G.hns1.03
Van-der-waals ICL2 R 131 34x52 G.hns1 R 47 G.hns1.03
Polar ICL2 T 134 34x55 G.S1 L 48 G.S1.01
Hydrophobic ICL2 Y 132 34x53 G.H5 L 374 G.H5.23
Van-der-waals ICL2 Y 132 34x53 G.H5 L 374 G.H5.23
Hydrophobic TM3 A 125 3x53 G.H5 L 371 G.H5.20
Van-der-waals TM3 A 125 3x53 G.H5 L 371 G.H5.20
Hydrophobic TM6 K 236 6x32 G.H5 M 375 G.H5.24
Hydrophobic TM2 M 59 2x39 G.H5 M 375 G.H5.24
Hydrophobic TM6 K 236 6x32 G.H5 Q 377 G.H5.26
Hydrophobic TM6 S 243 6x39 G.H5 L 376 G.H5.25
Van-der-waals TM6 S 243 6x39 G.H5 L 376 G.H5.25
Hydrophobic ICL2 L 130 34x51 G.S3 F 218 G.S3.03
Van-der-waals ICL2 L 130 34x51 G.S3 F 218 G.S3.03
Hydrophobic H8 I 299 8x50 G.H5 L 376 G.H5.25
Hydrophobic TM6 A 237 6x33 G.H5 L 371 G.H5.20
Hydrophobic TM3 A 125 3x53 G.H5 L 374 G.H5.23
Van-der-waals TM3 A 125 3x53 G.H5 L 374 G.H5.23
Polar ICL2 T 134 34x55 G.hns1 R 47 G.hns1.03
Hydrophobic ICL2 T 134 34x55 G.hns1 R 47 G.hns1.03
Hydrophobic ICL2 L 130 34x51 G.S3 V 216 G.S3.01
Hydrophobic TM7 K 295 7x56 G.H5 L 376 G.H5.25
Van-der-waals TM7 K 295 7x56 G.H5 L 376 G.H5.25
Hydrophobic TM3 A 125 3x53 G.H5 N 370 G.H5.19
Hydrophobic ICL2 L 130 34x51 G.H5 I 366 G.H5.15
Van-der-waals ICL2 L 130 34x51 G.H5 I 366 G.H5.15
Hydrophobic TM4 V 140 4x41 G.hns1 K 46 G.hns1.02
Van-der-waals TM4 V 140 4x41 G.hns1 K 46 G.hns1.02
Hydrophobic ICL2 Y 132 34x53 G.H5 N 370 G.H5.19
Polar TM6 K 236 6x32 G.H5 H 368 G.H5.17
Hydrophobic TM6 K 236 6x32 G.H5 H 368 G.H5.17
Van-der-waals TM6 K 236 6x32 G.H5 H 368 G.H5.17
Polar ICL2 T 134 34x55 G.hns1 K 46 G.hns1.02
Hydrophobic ICL2 T 134 34x55 G.hns1 K 46 G.hns1.02
Van-der-waals ICL2 T 134 34x55 G.hns1 K 46 G.hns1.02
Hydrophobic TM7 Y 292 7x53 G.H5 L 376 G.H5.25
Van-der-waals TM7 Y 292 7x53 G.H5 L 376 G.H5.25
Polar H8 K 297 8x48 G.H5 Q 377 G.H5.26
Hydrophobic H8 K 297 8x48 G.H5 Q 377 G.H5.26
Van-der-waals H8 K 297 8x48 G.H5 Q 377 G.H5.26
Polar ICL2 V 135 34x56 G.hns1 K 46 G.hns1.02
Hydrophobic ICL2 V 135 34x56 G.hns1 K 46 G.hns1.02
Van-der-waals ICL2 V 135 34x56 G.hns1 K 46 G.hns1.02
Hydrophobic H8 T 296 8x47 G.H5 L 376 G.H5.25
Van-der-waals H8 T 296 8x47 G.H5 L 376 G.H5.25
Hydrophobic ICL2 T 134 34x55 G.hns1 V 45 G.hns1.01
Ionic TM4 E 139 4x40 G.hns1 K 46 G.hns1.02
Hydrophobic TM6 T 240 6x36 G.H5 M 375 G.H5.24
Van-der-waals TM6 T 240 6x36 G.H5 M 375 G.H5.24
Hydrophobic TM3 I 126 3x54 G.H5 L 371 G.H5.20
Van-der-waals TM3 I 126 3x54 G.H5 L 371 G.H5.20
Polar ICL2 R 131 34x52 G.s2s3 N 215 G.s2s3.02
Hydrophobic TM2 M 59 2x39 G.H5 L 376 G.H5.25
Van-der-waals TM2 M 59 2x39 G.H5 L 376 G.H5.25
Hydrophobic TM3 I 126 3x54 G.H5 L 374 G.H5.23
Polar TM4 T 137 4x38 G.hns1 K 46 G.hns1.02
Hydrophobic TM4 T 137 4x38 G.hns1 K 46 G.hns1.02
Van-der-waals TM4 T 137 4x38 G.hns1 K 46 G.hns1.02
Hydrophobic TM2 Y 60 2x40 G.H5 L 376 G.H5.25
Hydrophobic ICL2 R 131 34x52 G.S3 P 217 G.S3.02
Van-der-waals ICL2 R 131 34x52 G.S3 P 217 G.S3.02
Hydrophobic TM3 I 126 3x54 G.H5 L 367 G.H5.16
Van-der-waals TM3 I 126 3x54 G.H5 L 367 G.H5.16
Polar ICL2 P 129 34x50 G.H5 N 370 G.H5.19
Hydrophobic ICL2 P 129 34x50 G.H5 N 370 G.H5.19
Van-der-waals ICL2 P 129 34x50 G.H5 N 370 G.H5.19
Polar TM7 K 295 7x56 G.H5 Q 377 G.H5.26
Hydrophobic TM3 D 121 3x49 G.H5 L 374 G.H5.23
Van-der-waals TM3 D 121 3x49 G.H5 L 374 G.H5.23
Polar TM2 E 57 2x37 G.H5 Q 373 G.H5.22
Hydrophobic TM2 E 57 2x37 G.H5 Q 373 G.H5.22
Van-der-waals TM2 E 57 2x37 G.H5 Q 373 G.H5.22
Hydrophobic ICL2 L 130 34x51 G.H5 K 363 G.H5.12
Van-der-waals ICL2 L 130 34x51 G.H5 K 363 G.H5.12
Hydrophobic ICL2 Y 132 34x53 G.H5 Q 373 G.H5.22
Hydrophobic ICL2 V 135 34x56 G.hns1 R 47 G.hns1.03
Hydrophobic ICL2 R 131 34x52 G.S3 V 216 G.S3.01
Hydrophobic TM6 T 240 6x36 G.H5 L 374 G.H5.23
Van-der-waals TM6 T 240 6x36 G.H5 L 374 G.H5.23