GPCR CLASS (FAMILY)
SPECIES
G PROTEIN FAMILY
DATE
3D VIEW
Tertiary structure confidence
(pLDDT score) avg.: 71.5
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered
PTM Score: 0.6
iPTM Score: 0.4
PAE mean: 19.7
GPCR - G protein interface interactions
The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle
(Gα residues)
and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid,
hydrophobic - dashed,
ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.
GPCR-G protein backbone (bb) or sidechain (sc):
Structures
0 structures selected.
Sequence Color
Interaction frequency filter (%)
Gα,
GPCR
Interaction cut-off: strict (stick), loose (line)
Interaction type |
GPCR Segment |
AA |
Number |
Generic number |
Gα segment |
AA |
Number |
Generic number |
---|---|---|---|---|---|---|---|---|
Hydrophobic | TM5 | I | 223 | 5x61 | G.H5 | L | 368 | G.H5.20 |
Ionic | TM4 | D | 140 | 4x40 | G.hns1 | R | 40 | G.hns1.02 |
Polar | TM4 | D | 140 | 4x40 | G.hns1 | R | 40 | G.hns1.02 |
Hydrophobic | TM4 | D | 140 | 4x40 | G.hns1 | R | 40 | G.hns1.02 |
Van-der-waals | TM4 | D | 140 | 4x40 | G.hns1 | R | 40 | G.hns1.02 |
Hydrophobic | TM5 | I | 223 | 5x61 | G.H5 | L | 373 | G.H5.25 |
Hydrophobic | TM4 | P | 139 | 4x39 | G.HN | K | 37 | G.HN.52 |
Van-der-waals | TM4 | P | 139 | 4x39 | G.HN | K | 37 | G.HN.52 |
Hydrophobic | ICL2 | S | 137 | 34x55 | G.hns1 | G | 41 | G.hns1.03 |
Van-der-waals | ICL2 | S | 137 | 34x55 | G.hns1 | G | 41 | G.hns1.03 |
Polar | C-term | R | 315 | - | G.HN | R | 8 | G.HN.08 |
Hydrophobic | C-term | R | 315 | - | G.HN | R | 8 | G.HN.08 |
Van-der-waals | C-term | R | 315 | - | G.HN | R | 8 | G.HN.08 |
Hydrophobic | ICL2 | P | 132 | 34x50 | G.H5 | R | 360 | G.H5.12 |
Van-der-waals | ICL2 | P | 132 | 34x50 | G.H5 | R | 360 | G.H5.12 |
Ionic | ICL2 | E | 134 | 34x52 | G.s2s3 | K | 201 | G.s2s3.02 |
Polar | ICL2 | E | 134 | 34x52 | G.s2s3 | K | 201 | G.s2s3.02 |
Hydrophobic | ICL2 | E | 134 | 34x52 | G.s2s3 | K | 201 | G.s2s3.02 |
Van-der-waals | ICL2 | E | 134 | 34x52 | G.s2s3 | K | 201 | G.s2s3.02 |
Polar | TM5 | I | 230 | 5x68 | G.h4s6 | R | 338 | G.h4s6.20 |
Hydrophobic | TM5 | I | 230 | 5x68 | G.h4s6 | R | 338 | G.h4s6.20 |
Van-der-waals | TM5 | I | 230 | 5x68 | G.h4s6 | R | 338 | G.h4s6.20 |
Hydrophobic | ICL3 | A | 231 | - | G.H5 | L | 374 | G.H5.26 |
Van-der-waals | ICL3 | A | 231 | - | G.H5 | L | 374 | G.H5.26 |
Hydrophobic | TM6 | C | 243 | 6x37 | G.H5 | L | 373 | G.H5.25 |
Van-der-waals | TM6 | C | 243 | 6x37 | G.H5 | L | 373 | G.H5.25 |
Hydrophobic | TM2 | M | 62 | 2x39 | G.H5 | I | 371 | G.H5.23 |
Van-der-waals | TM2 | M | 62 | 2x39 | G.H5 | I | 371 | G.H5.23 |
Polar | TM6 | A | 239 | 6x33 | G.H5 | L | 373 | G.H5.25 |
Hydrophobic | TM6 | A | 239 | 6x33 | G.H5 | L | 373 | G.H5.25 |
Van-der-waals | TM6 | A | 239 | 6x33 | G.H5 | L | 373 | G.H5.25 |
Polar | TM4 | D | 140 | 4x40 | G.HN | K | 37 | G.HN.52 |
Hydrophobic | TM4 | D | 140 | 4x40 | G.HN | K | 37 | G.HN.52 |
Van-der-waals | TM4 | D | 140 | 4x40 | G.HN | K | 37 | G.HN.52 |
Hydrophobic | TM5 | T | 226 | 5x64 | G.H5 | L | 364 | G.H5.16 |
Van-der-waals | TM5 | T | 226 | 5x64 | G.H5 | L | 364 | G.H5.16 |
Polar | ICL2 | H | 136 | 34x54 | G.hns1 | G | 41 | G.hns1.03 |
Hydrophobic | ICL2 | H | 136 | 34x54 | G.hns1 | G | 41 | G.hns1.03 |
Polar | TM6 | T | 242 | 6x36 | G.H5 | N | 372 | G.H5.24 |
Hydrophobic | TM6 | T | 242 | 6x36 | G.H5 | N | 372 | G.H5.24 |
Van-der-waals | TM6 | T | 242 | 6x36 | G.H5 | N | 372 | G.H5.24 |
Hydrophobic | ICL2 | H | 136 | 34x54 | G.h2s4 | I | 227 | G.h2s4.05 |
Polar | ICL2 | S | 137 | 34x55 | G.hns1 | R | 40 | G.hns1.02 |
Hydrophobic | ICL2 | S | 137 | 34x55 | G.hns1 | R | 40 | G.hns1.02 |
Polar | C-term | R | 314 | - | G.HN | R | 8 | G.HN.08 |
Hydrophobic | C-term | R | 314 | - | G.HN | R | 8 | G.HN.08 |
Van-der-waals | C-term | R | 314 | - | G.HN | R | 8 | G.HN.08 |
Hydrophobic | ICL2 | L | 135 | 34x53 | G.H5 | Y | 367 | G.H5.19 |
Hydrophobic | TM3 | S | 128 | 3x53 | G.H5 | Y | 367 | G.H5.19 |
Van-der-waals | TM3 | S | 128 | 3x53 | G.H5 | Y | 367 | G.H5.19 |
Hydrophobic | ICL2 | T | 133 | 34x51 | G.H5 | R | 360 | G.H5.12 |
Ionic | TM6 | E | 234 | 6x28 | G.h4s6 | K | 331 | G.h4s6.13 |
Polar | TM6 | E | 234 | 6x28 | G.h4s6 | K | 331 | G.h4s6.13 |
Hydrophobic | TM6 | E | 234 | 6x28 | G.h4s6 | K | 331 | G.h4s6.13 |
Van-der-waals | TM6 | E | 234 | 6x28 | G.h4s6 | K | 331 | G.h4s6.13 |
Hydrophobic | ICL2 | H | 136 | 34x54 | G.H5 | V | 363 | G.H5.15 |
Van-der-waals | ICL2 | H | 136 | 34x54 | G.H5 | V | 363 | G.H5.15 |
Hydrophobic | TM5 | I | 230 | 5x68 | G.H5 | L | 364 | G.H5.16 |
Hydrophobic | TM6 | K | 238 | 6x32 | G.h4s6 | R | 335 | G.h4s6.17 |
Van-der-waals | TM6 | K | 238 | 6x32 | G.h4s6 | R | 335 | G.h4s6.17 |
Hydrophobic | TM6 | T | 242 | 6x36 | G.H5 | L | 373 | G.H5.25 |
Van-der-waals | TM6 | T | 242 | 6x36 | G.H5 | L | 373 | G.H5.25 |
Polar | TM7 | K | 297 | 7x56 | G.H5 | N | 372 | G.H5.24 |
Van-der-waals | TM7 | K | 297 | 7x56 | G.H5 | N | 372 | G.H5.24 |
Hydrophobic | TM6 | G | 235 | 6x29 | G.H5 | L | 374 | G.H5.26 |
Hydrophobic | TM3 | S | 128 | 3x53 | G.H5 | L | 364 | G.H5.16 |
Van-der-waals | TM3 | S | 128 | 3x53 | G.H5 | L | 364 | G.H5.16 |
Hydrophobic | ICL2 | P | 132 | 34x50 | G.H5 | V | 363 | G.H5.15 |
Van-der-waals | ICL2 | P | 132 | 34x50 | G.H5 | V | 363 | G.H5.15 |
Hydrophobic | TM5 | V | 227 | 5x65 | G.H5 | L | 374 | G.H5.26 |
Hydrophobic | TM5 | I | 230 | 5x68 | G.H5 | D | 361 | G.H5.13 |
Van-der-waals | TM5 | I | 230 | 5x68 | G.H5 | D | 361 | G.H5.13 |
Polar | TM6 | K | 238 | 6x32 | G.H5 | L | 374 | G.H5.26 |
Hydrophobic | TM6 | K | 238 | 6x32 | G.H5 | L | 374 | G.H5.26 |
Van-der-waals | TM6 | K | 238 | 6x32 | G.H5 | L | 374 | G.H5.26 |
Hydrophobic | ICL3 | A | 231 | - | G.h4s6 | R | 338 | G.h4s6.20 |
Van-der-waals | ICL3 | A | 231 | - | G.h4s6 | R | 338 | G.h4s6.20 |
Polar | C-term | R | 315 | - | G.HN | W | 7 | G.HN.07 |
Van-der-waals | C-term | R | 315 | - | G.HN | W | 7 | G.HN.07 |
Hydrophobic | H8 | E | 311 | 8x60 | G.HN | W | 7 | G.HN.07 |
Van-der-waals | H8 | E | 311 | 8x60 | G.HN | W | 7 | G.HN.07 |
Hydrophobic | ICL2 | P | 132 | 34x50 | G.H5 | L | 364 | G.H5.16 |
Hydrophobic | TM3 | P | 125 | 3x50 | G.H5 | Y | 367 | G.H5.19 |
Polar | ICL2 | H | 136 | 34x54 | G.hns1 | R | 40 | G.hns1.02 |
Hydrophobic | ICL2 | H | 136 | 34x54 | G.hns1 | R | 40 | G.hns1.02 |
Van-der-waals | ICL2 | H | 136 | 34x54 | G.hns1 | R | 40 | G.hns1.02 |
Hydrophobic | ICL2 | T | 133 | 34x51 | G.S1 | L | 43 | G.S1.02 |
Van-der-waals | ICL2 | T | 133 | 34x51 | G.S1 | L | 43 | G.S1.02 |
Hydrophobic | TM1 | T | 54 | 1x59 | G.HN | W | 7 | G.HN.07 |
Van-der-waals | TM1 | T | 54 | 1x59 | G.HN | W | 7 | G.HN.07 |
Hydrophobic | TM5 | I | 230 | 5x68 | G.H5 | A | 365 | G.H5.17 |
Polar | ICL2 | T | 133 | 34x51 | G.S3 | T | 202 | G.S3.01 |
Hydrophobic | ICL2 | T | 133 | 34x51 | G.S3 | T | 202 | G.S3.01 |
Van-der-waals | ICL2 | T | 133 | 34x51 | G.S3 | T | 202 | G.S3.01 |
Hydrophobic | TM5 | V | 227 | 5x65 | G.H5 | L | 368 | G.H5.20 |
Van-der-waals | TM5 | V | 227 | 5x65 | G.H5 | L | 368 | G.H5.20 |
Polar | TM6 | K | 238 | 6x32 | G.H5 | N | 372 | G.H5.24 |
Hydrophobic | TM6 | K | 238 | 6x32 | G.H5 | N | 372 | G.H5.24 |
Van-der-waals | TM6 | K | 238 | 6x32 | G.H5 | N | 372 | G.H5.24 |
Hydrophobic | TM3 | H | 129 | 3x54 | G.H5 | L | 368 | G.H5.20 |
Van-der-waals | TM3 | H | 129 | 3x54 | G.H5 | L | 368 | G.H5.20 |
Hydrophobic | ICL2 | T | 133 | 34x51 | G.H5 | F | 356 | G.H5.08 |
Van-der-waals | ICL2 | T | 133 | 34x51 | G.H5 | F | 356 | G.H5.08 |
Van-der-waals | TM2 | Q | 60 | 2x37 | G.hns1 | R | 40 | G.hns1.02 |
Hydrophobic | TM3 | H | 129 | 3x54 | G.H5 | L | 364 | G.H5.16 |
Van-der-waals | TM3 | H | 129 | 3x54 | G.H5 | L | 364 | G.H5.16 |
Hydrophobic | ICL1 | I | 56 | 12x48 | G.HN | L | 33 | G.HN.48 |
Van-der-waals | ICL1 | I | 56 | 12x48 | G.HN | L | 33 | G.HN.48 |
Hydrophobic | ICL2 | H | 136 | 34x54 | G.S1 | L | 43 | G.S1.02 |
Van-der-waals | ICL2 | H | 136 | 34x54 | G.S1 | L | 43 | G.S1.02 |
Hydrophobic | TM4 | T | 141 | 4x41 | G.HN | K | 37 | G.HN.52 |
Van-der-waals | TM4 | T | 141 | 4x41 | G.HN | K | 37 | G.HN.52 |