GPCR CLASS (FAMILY)
SPECIES
G PROTEIN FAMILY
DATE
3D VIEW
Tertiary structure confidence
(pLDDT score) avg.: 80.4
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered
PTM Score: 0.5
iPTM Score: 0.2
PAE mean: 25.4
GPCR - G protein interface interactions
The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle
(Gα residues)
and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid,
hydrophobic - dashed,
ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.
GPCR-G protein backbone (bb) or sidechain (sc):
Structures
0 structures selected.
Sequence Color
Interaction frequency filter (%)
Gα,
GPCR
Interaction cut-off: strict (stick), loose (line)
Interaction type |
GPCR Segment |
AA |
Number |
Generic number |
Gα segment |
AA |
Number |
Generic number |
---|---|---|---|---|---|---|---|---|
Hydrophobic | TM3 | C | 130 | 3x56 | G.hns1 | K | 46 | G.hns1.02 |
Van-der-waals | TM3 | C | 130 | 3x56 | G.hns1 | K | 46 | G.hns1.02 |
Polar | ICL2 | A | 135 | 34x54 | G.H5 | Q | 373 | G.H5.22 |
Hydrophobic | ICL2 | A | 135 | 34x54 | G.H5 | Q | 373 | G.H5.22 |
Hydrophobic | TM2 | M | 61 | 2x39 | G.H5 | Q | 377 | G.H5.26 |
Van-der-waals | TM2 | M | 61 | 2x39 | G.H5 | Q | 377 | G.H5.26 |
Hydrophobic | TM2 | M | 61 | 2x39 | G.H5 | M | 375 | G.H5.24 |
Polar | ICL2 | P | 131 | 34x50 | G.hns1 | K | 46 | G.hns1.02 |
Hydrophobic | ICL2 | A | 135 | 34x54 | G.h3s5 | N | 283 | G.h3s5.02 |
Polar | TM2 | Q | 59 | 2x37 | G.H5 | Q | 373 | G.H5.22 |
Hydrophobic | TM2 | Q | 59 | 2x37 | G.H5 | Q | 373 | G.H5.22 |
Polar | TM5 | T | 230 | 5x68 | G.s2s3 | N | 215 | G.s2s3.02 |
Hydrophobic | TM5 | T | 230 | 5x68 | G.s2s3 | N | 215 | G.s2s3.02 |
Van-der-waals | TM5 | T | 230 | 5x68 | G.s2s3 | N | 215 | G.s2s3.02 |
Polar | H8 | N | 298 | 8x47 | G.H5 | L | 376 | G.H5.25 |
Hydrophobic | H8 | N | 298 | 8x47 | G.H5 | L | 376 | G.H5.25 |
Van-der-waals | H8 | N | 298 | 8x47 | G.H5 | L | 376 | G.H5.25 |
Hydrophobic | TM2 | M | 61 | 2x39 | G.H5 | L | 376 | G.H5.25 |
Van-der-waals | TM2 | M | 61 | 2x39 | G.H5 | L | 376 | G.H5.25 |
Polar | ICL2 | H | 133 | 34x52 | G.hns1 | K | 46 | G.hns1.02 |
Hydrophobic | ICL2 | H | 133 | 34x52 | G.hns1 | K | 46 | G.hns1.02 |
Van-der-waals | ICL2 | H | 133 | 34x52 | G.hns1 | K | 46 | G.hns1.02 |
Hydrophobic | ICL2 | P | 131 | 34x50 | G.hns1 | R | 47 | G.hns1.03 |
Hydrophobic | ICL2 | L | 132 | 34x51 | G.S1 | L | 48 | G.S1.01 |
Van-der-waals | ICL2 | L | 132 | 34x51 | G.S1 | L | 48 | G.S1.01 |
Hydrophobic | TM3 | A | 127 | 3x53 | G.H5 | L | 374 | G.H5.23 |
Van-der-waals | TM3 | A | 127 | 3x53 | G.H5 | L | 374 | G.H5.23 |
Hydrophobic | TM3 | C | 129 | 3x55 | G.hns1 | K | 46 | G.hns1.02 |
Polar | ICL2 | Y | 134 | 34x53 | G.H5 | Q | 373 | G.H5.22 |
Hydrophobic | ICL2 | Y | 134 | 34x53 | G.H5 | Q | 373 | G.H5.22 |
Van-der-waals | ICL2 | Y | 134 | 34x53 | G.H5 | Q | 373 | G.H5.22 |
Hydrophobic | ICL2 | P | 131 | 34x50 | G.H5 | L | 374 | G.H5.23 |
Hydrophobic | ICL1 | H | 58 | 12x51 | G.h4s6 | Q | 339 | G.h4s6.13 |
Van-der-waals | TM5 | I | 227 | 5x65 | G.hns1 | R | 47 | G.hns1.03 |
Hydrophobic | ICL2 | L | 132 | 34x51 | G.S1 | V | 49 | G.S1.02 |
Van-der-waals | ICL2 | L | 132 | 34x51 | G.S1 | V | 49 | G.S1.02 |
Hydrophobic | ICL2 | P | 131 | 34x50 | G.H5 | N | 370 | G.H5.19 |
Van-der-waals | ICL2 | P | 131 | 34x50 | G.H5 | N | 370 | G.H5.19 |
Polar | TM6 | S | 245 | 6x39 | G.H5 | Q | 377 | G.H5.26 |
Hydrophobic | TM6 | S | 245 | 6x39 | G.H5 | Q | 377 | G.H5.26 |
Van-der-waals | TM6 | S | 245 | 6x39 | G.H5 | Q | 377 | G.H5.26 |
Hydrophobic | TM2 | Q | 59 | 2x37 | G.H5 | K | 372 | G.H5.21 |
Van-der-waals | TM2 | Q | 59 | 2x37 | G.H5 | K | 372 | G.H5.21 |
Polar | TM7 | K | 297 | 7x56 | G.H5 | Q | 377 | G.H5.26 |
Hydrophobic | TM7 | K | 297 | 7x56 | G.H5 | Q | 377 | G.H5.26 |
Van-der-waals | TM7 | K | 297 | 7x56 | G.H5 | Q | 377 | G.H5.26 |
Hydrophobic | ICL2 | L | 132 | 34x51 | G.H5 | N | 370 | G.H5.19 |
Van-der-waals | ICL2 | L | 132 | 34x51 | G.H5 | N | 370 | G.H5.19 |
Polar | TM3 | C | 129 | 3x55 | G.hns1 | R | 47 | G.hns1.03 |
Hydrophobic | TM3 | C | 129 | 3x55 | G.hns1 | R | 47 | G.hns1.03 |
Van-der-waals | TM3 | C | 129 | 3x55 | G.hns1 | R | 47 | G.hns1.03 |
Hydrophobic | TM3 | I | 128 | 3x54 | G.H5 | L | 374 | G.H5.23 |
Van-der-waals | TM3 | I | 128 | 3x54 | G.H5 | L | 374 | G.H5.23 |
Polar | TM5 | N | 226 | 5x64 | G.hns1 | R | 47 | G.hns1.03 |
Hydrophobic | TM5 | N | 226 | 5x64 | G.hns1 | R | 47 | G.hns1.03 |
Van-der-waals | TM5 | N | 226 | 5x64 | G.hns1 | R | 47 | G.hns1.03 |
Hydrophobic | TM5 | N | 226 | 5x64 | G.HN | T | 43 | G.HN.52 |
Van-der-waals | TM5 | N | 226 | 5x64 | G.HN | T | 43 | G.HN.52 |
Polar | TM5 | T | 230 | 5x68 | G.hns1 | R | 47 | G.hns1.03 |
Hydrophobic | TM5 | T | 230 | 5x68 | G.hns1 | R | 47 | G.hns1.03 |
Van-der-waals | TM5 | T | 230 | 5x68 | G.hns1 | R | 47 | G.hns1.03 |
Hydrophobic | TM3 | C | 130 | 3x56 | G.hns1 | R | 47 | G.hns1.03 |
Hydrophobic | TM6 | T | 232 | 6x26 | G.s2s3 | N | 215 | G.s2s3.02 |
Hydrophobic | TM2 | Y | 62 | 2x40 | G.H5 | L | 376 | G.H5.25 |
Van-der-waals | TM2 | Y | 62 | 2x40 | G.H5 | L | 376 | G.H5.25 |
Hydrophobic | ICL3 | A | 231 | - | G.s2s3 | N | 215 | G.s2s3.02 |
Hydrophobic | TM6 | N | 242 | 6x36 | G.H5 | L | 371 | G.H5.20 |
Van-der-waals | TM6 | N | 242 | 6x36 | G.H5 | L | 371 | G.H5.20 |
Hydrophobic | TM2 | Q | 59 | 2x37 | G.H5 | L | 376 | G.H5.25 |
Van-der-waals | TM2 | Q | 59 | 2x37 | G.H5 | L | 376 | G.H5.25 |
Hydrophobic | TM6 | N | 242 | 6x36 | G.H5 | M | 375 | G.H5.24 |
Van-der-waals | TM6 | N | 242 | 6x36 | G.H5 | M | 375 | G.H5.24 |
Polar | TM7 | Y | 294 | 7x53 | G.H5 | Q | 377 | G.H5.26 |
Hydrophobic | TM7 | Y | 294 | 7x53 | G.H5 | Q | 377 | G.H5.26 |
Van-der-waals | TM7 | Y | 294 | 7x53 | G.H5 | Q | 377 | G.H5.26 |
Hydrophobic | TM3 | M | 120 | 3x46 | G.H5 | Q | 377 | G.H5.26 |
Van-der-waals | TM3 | M | 120 | 3x46 | G.H5 | Q | 377 | G.H5.26 |
Polar | ICL2 | H | 133 | 34x52 | G.h2s4 | S | 239 | G.h2s4.03 |
Hydrophobic | ICL2 | H | 133 | 34x52 | G.h2s4 | S | 239 | G.h2s4.03 |
Van-der-waals | ICL2 | H | 133 | 34x52 | G.h2s4 | S | 239 | G.h2s4.03 |
Hydrophobic | ICL2 | L | 132 | 34x51 | G.hns1 | R | 47 | G.hns1.03 |
Van-der-waals | ICL2 | L | 132 | 34x51 | G.hns1 | R | 47 | G.hns1.03 |
Hydrophobic | TM6 | E | 235 | 6x29 | G.s2s3 | K | 214 | G.s2s3.01 |
Van-der-waals | TM6 | E | 235 | 6x29 | G.s2s3 | K | 214 | G.s2s3.01 |
Hydrophobic | ICL2 | I | 137 | 34x56 | G.hns1 | K | 46 | G.hns1.02 |
Hydrophobic | ICL1 | P | 55 | 12x48 | G.h4s6 | Q | 339 | G.h4s6.13 |
Van-der-waals | ICL1 | P | 55 | 12x48 | G.h4s6 | Q | 339 | G.h4s6.13 |
Polar | TM2 | R | 60 | 2x38 | G.h3s5 | N | 283 | G.h3s5.02 |
Polar | TM6 | H | 246 | 6x40 | G.H5 | Q | 377 | G.H5.26 |
Van-der-waals | TM6 | H | 246 | 6x40 | G.H5 | Q | 377 | G.H5.26 |
Hydrophobic | TM2 | M | 61 | 2x39 | G.H5 | L | 374 | G.H5.23 |
Van-der-waals | TM2 | M | 61 | 2x39 | G.H5 | L | 374 | G.H5.23 |
Polar | ICL2 | L | 132 | 34x51 | G.h2s4 | T | 241 | G.h2s4.05 |
Hydrophobic | ICL2 | L | 132 | 34x51 | G.h2s4 | T | 241 | G.h2s4.05 |
Van-der-waals | ICL2 | L | 132 | 34x51 | G.h2s4 | T | 241 | G.h2s4.05 |
Polar | ICL2 | H | 133 | 34x52 | G.hns1 | V | 45 | G.hns1.01 |
Hydrophobic | ICL2 | H | 133 | 34x52 | G.hns1 | V | 45 | G.hns1.01 |
Van-der-waals | ICL2 | H | 133 | 34x52 | G.hns1 | V | 45 | G.hns1.01 |