Go - GPR68 complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gi/o

DATE

2023-09-15

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

(pLDDT score) avg.: 86.7

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.8
iPTM Score: 0.8
PAE mean: 12.7


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic TM6 I 226 6x33 G.H5 Y 354 G.H5.26
Hydrophobic ICL2 P 126 34x50 G.H5 I 343 G.H5.15
Hydrophobic TM3 V 123 3x54 G.H5 I 344 G.H5.16
Hydrophobic TM5 V 212 5x65 G.H5 L 348 G.H5.20
Hydrophobic TM6 I 226 6x33 G.H5 L 348 G.H5.20
Hydrophobic TM6 L 229 6x36 G.H5 L 353 G.H5.25
Van-der-waals TM6 L 229 6x36 G.H5 L 353 G.H5.25
Hydrophobic C-term L 344 - G.s4h3 E 237 G.s4h3.10
Van-der-waals C-term L 344 - G.s4h3 E 237 G.s4h3.10
Hydrophobic ICL2 F 127 34x51 G.S3 L 195 G.S3.01
Van-der-waals ICL2 F 127 34x51 G.S3 L 195 G.S3.01
Polar TM3 R 119 3x50 G.H5 G 352 G.H5.24
Polar H8 E 291 8x48 G.h4s6 N 316 G.h4s6.10
Polar TM6 R 222 6x29 G.h4s6 N 316 G.h4s6.10
Van-der-waals TM6 R 222 6x29 G.h4s6 N 316 G.h4s6.10
Polar TM6 Q 219 6x26 G.h4s6 E 318 G.h4s6.12
Hydrophobic TM6 Q 219 6x26 G.h4s6 E 318 G.h4s6.12
Van-der-waals TM6 Q 219 6x26 G.h4s6 E 318 G.h4s6.12
Polar ICL3 G 217 - G.H5 D 341 G.H5.13
Hydrophobic ICL3 G 217 - G.H5 D 341 G.H5.13
Van-der-waals ICL3 G 217 - G.H5 D 341 G.H5.13
Hydrophobic TM3 A 122 3x53 G.H5 C 351 G.H5.23
Van-der-waals TM3 A 122 3x53 G.H5 C 351 G.H5.23
Hydrophobic ICL3 G 217 - G.S6 Y 320 G.S6.02
Van-der-waals ICL3 G 217 - G.S6 Y 320 G.S6.02
Polar TM2 N 54 2x37 G.H5 G 350 G.H5.22
Hydrophobic TM6 I 226 6x33 G.H5 L 353 G.H5.25
Van-der-waals TM6 I 226 6x33 G.H5 L 353 G.H5.25
Hydrophobic TM5 I 208 5x61 G.H5 L 353 G.H5.25
Hydrophobic C-term L 340 - G.s4h3 T 241 G.s4h3.14
Van-der-waals C-term L 340 - G.s4h3 T 241 G.s4h3.14
Hydrophobic TM3 R 119 3x50 G.H5 L 353 G.H5.25
Van-der-waals TM3 R 119 3x50 G.H5 L 353 G.H5.25
Hydrophobic C-term L 341 - G.H3 M 249 G.H3.07
Polar TM6 R 222 6x29 G.H5 Y 354 G.H5.26
Hydrophobic TM6 R 222 6x29 G.H5 Y 354 G.H5.26
Van-der-waals TM6 R 222 6x29 G.H5 Y 354 G.H5.26
Polar TM6 Q 225 6x32 G.H5 Y 354 G.H5.26
Van-der-waals TM6 Q 225 6x32 G.H5 Y 354 G.H5.26
Hydrophobic ICL2 F 127 34x51 G.H5 I 343 G.H5.15
Van-der-waals ICL2 F 127 34x51 G.H5 I 343 G.H5.15
Polar TM3 R 119 3x50 G.H5 C 351 G.H5.23
Hydrophobic TM3 R 119 3x50 G.H5 C 351 G.H5.23
Van-der-waals TM3 R 119 3x50 G.H5 C 351 G.H5.23
Hydrophobic TM2 L 56 2x39 G.H5 C 351 G.H5.23
Van-der-waals TM2 L 56 2x39 G.H5 C 351 G.H5.23
Polar ICL3 T 218 - G.h4s6 E 318 G.h4s6.12
Hydrophobic ICL3 T 218 - G.h4s6 E 318 G.h4s6.12
Van-der-waals ICL3 T 218 - G.h4s6 E 318 G.h4s6.12
Hydrophobic ICL3 G 217 - G.h4s6 E 318 G.h4s6.12
Van-der-waals ICL3 G 217 - G.h4s6 E 318 G.h4s6.12
Van-der-waals H8 R 295 8x52 G.h4s6 N 316 G.h4s6.10
Polar ICL3 H 216 - G.H5 D 341 G.H5.13
Hydrophobic ICL3 H 216 - G.H5 D 341 G.H5.13
Van-der-waals ICL3 H 216 - G.H5 D 341 G.H5.13
Polar TM3 A 122 3x53 G.H5 N 347 G.H5.19
Hydrophobic TM3 A 122 3x53 G.H5 N 347 G.H5.19
Van-der-waals TM3 A 122 3x53 G.H5 N 347 G.H5.19
Polar ICL3 S 215 - G.H5 D 341 G.H5.13
Hydrophobic ICL3 S 215 - G.H5 D 341 G.H5.13
Van-der-waals ICL3 S 215 - G.H5 D 341 G.H5.13
Hydrophobic TM6 L 229 6x36 G.H5 G 352 G.H5.24
Hydrophobic TM3 V 123 3x54 G.H5 L 348 G.H5.20
Van-der-waals TM3 V 123 3x54 G.H5 L 348 G.H5.20
Van-der-waals ICL2 P 126 34x50 G.H5 N 347 G.H5.19
Polar TM6 R 222 6x29 G.h4s6 P 315 G.h4s6.09
Van-der-waals TM6 R 222 6x29 G.h4s6 P 315 G.h4s6.09
Hydrophobic H8 S 290 8x47 G.H5 G 352 G.H5.24
Hydrophobic TM6 V 230 6x37 G.H5 L 353 G.H5.25
Hydrophobic TM5 I 208 5x61 G.H5 L 348 G.H5.20
Hydrophobic C-term L 344 - G.s4h3 D 238 G.s4h3.11
Van-der-waals C-term L 344 - G.s4h3 D 238 G.s4h3.11
Ionic H8 R 295 8x52 G.h3s5 D 262 G.h3s5.02
Polar H8 R 295 8x52 G.h3s5 D 262 G.h3s5.02