Gt1 - GPR68 complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gi/o

DATE

2023-09-15

3D VIEW

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Tertiary structure confidence

(pLDDT score) avg.: 83.2

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.7
iPTM Score: 0.7
PAE mean: 13.0


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic ICL2 F 127 34x51 G.H5 T 336 G.H5.12
Hydrophobic ICL2 F 127 34x51 G.H5 F 332 G.H5.08
Hydrophobic H8 S 290 8x47 G.H5 G 348 G.H5.24
Van-der-waals H8 S 290 8x47 G.H5 G 348 G.H5.24
Hydrophobic TM6 R 222 6x29 G.H5 F 350 G.H5.26
Van-der-waals TM6 R 222 6x29 G.H5 F 350 G.H5.26
Hydrophobic TM6 L 229 6x36 G.H5 L 349 G.H5.25
Van-der-waals TM6 L 229 6x36 G.H5 L 349 G.H5.25
Polar ICL3 T 218 - G.h4s6 E 314 G.h4s6.12
Hydrophobic ICL3 T 218 - G.h4s6 E 314 G.h4s6.12
Polar H8 E 291 8x48 G.H5 F 350 G.H5.26
Polar ICL3 G 217 - G.H5 D 337 G.H5.13
Hydrophobic ICL3 G 217 - G.H5 D 337 G.H5.13
Van-der-waals ICL3 G 217 - G.H5 D 337 G.H5.13
Hydrophobic TM6 I 226 6x33 G.H5 L 344 G.H5.20
Hydrophobic ICL3 G 217 - G.h4s6 E 314 G.h4s6.12
Van-der-waals ICL3 G 217 - G.h4s6 E 314 G.h4s6.12
Hydrophobic C-term L 340 - G.H3 H 252 G.H3.15
Van-der-waals C-term L 340 - G.H3 H 252 G.H3.15
Hydrophobic TM2 L 56 2x39 G.H5 C 347 G.H5.23
Hydrophobic C-term L 341 - G.H2 R 204 G.H2.04
Van-der-waals C-term L 341 - G.H2 R 204 G.H2.04
Hydrophobic TM6 I 226 6x33 G.H5 L 349 G.H5.25
Van-der-waals TM6 I 226 6x33 G.H5 L 349 G.H5.25
Hydrophobic ICL2 F 127 34x51 G.H5 I 339 G.H5.15
Van-der-waals ICL2 F 127 34x51 G.H5 I 339 G.H5.15
Polar ICL3 H 216 - G.H5 D 337 G.H5.13
Hydrophobic ICL3 H 216 - G.H5 D 337 G.H5.13
Van-der-waals ICL3 H 216 - G.H5 D 337 G.H5.13
Van-der-waals ICL2 P 126 34x50 G.H5 N 343 G.H5.19
Polar ICL3 S 215 - G.H5 D 337 G.H5.13
Hydrophobic ICL3 S 215 - G.H5 D 337 G.H5.13
Van-der-waals ICL3 S 215 - G.H5 D 337 G.H5.13
Polar TM6 Q 219 6x26 G.h4s6 R 310 G.h4s6.08
Van-der-waals TM6 Q 219 6x26 G.h4s6 R 310 G.h4s6.08
Polar TM3 R 119 3x50 G.H5 C 347 G.H5.23
Hydrophobic TM3 R 119 3x50 G.H5 C 347 G.H5.23
Van-der-waals TM3 R 119 3x50 G.H5 C 347 G.H5.23
Hydrophobic ICL2 P 126 34x50 G.H5 I 339 G.H5.15
Hydrophobic C-term P 346 - G.H3 H 244 G.H3.07
Polar C-term L 344 - G.H3 H 244 G.H3.07
Hydrophobic C-term L 344 - G.H3 H 244 G.H3.07
Van-der-waals C-term L 344 - G.H3 H 244 G.H3.07
Hydrophobic ICL3 G 217 - G.S6 Y 316 G.S6.02
Van-der-waals ICL3 G 217 - G.S6 Y 316 G.S6.02
Hydrophobic ICL2 H 130 34x54 G.hns1 A 27 G.hns1.02
Polar TM2 N 54 2x37 G.H5 D 346 G.H5.22
Van-der-waals TM2 N 54 2x37 G.H5 D 346 G.H5.22
Hydrophobic ICL2 F 127 34x51 G.S3 L 190 G.S3.01
Van-der-waals ICL2 F 127 34x51 G.S3 L 190 G.S3.01
Ionic TM4 K 136 4x40 G.HN E 16 G.HN.44
Hydrophobic TM4 T 134 4x38 G.HN K 20 G.HN.48
Hydrophobic TM3 V 123 3x54 G.H5 I 340 G.H5.16
Van-der-waals TM3 V 123 3x54 G.H5 I 340 G.H5.16
Hydrophobic TM3 A 122 3x53 G.H5 C 347 G.H5.23
Van-der-waals TM3 A 122 3x53 G.H5 C 347 G.H5.23
Hydrophobic ICL2 P 126 34x50 G.H5 I 340 G.H5.16
Hydrophobic TM6 V 230 6x37 G.H5 L 349 G.H5.25
Hydrophobic C-term L 344 - G.H3 S 248 G.H3.11
Van-der-waals C-term L 344 - G.H3 S 248 G.H3.11
Polar C-term H 345 - G.H2 R 201 G.H2.01
Hydrophobic C-term H 345 - G.H2 R 201 G.H2.01
Van-der-waals C-term H 345 - G.H2 R 201 G.H2.01
Hydrophobic C-term L 341 - G.H3 L 245 G.H3.08
Ionic ICL2 R 128 34x52 G.s2s3 D 189 G.s2s3.02
Polar ICL2 R 128 34x52 G.s2s3 D 189 G.s2s3.02
Hydrophobic TM5 I 208 5x61 G.H5 L 349 G.H5.25
Hydrophobic TM5 V 212 5x65 G.H5 L 344 G.H5.20
Hydrophobic TM6 Q 225 6x32 G.H5 F 350 G.H5.26
Van-der-waals TM6 Q 225 6x32 G.H5 F 350 G.H5.26
Hydrophobic TM6 I 226 6x33 G.H5 F 350 G.H5.26
Ionic ICL2 H 130 34x54 G.HN E 24 G.HN.52
Polar ICL2 H 130 34x54 G.HN E 24 G.HN.52
Hydrophobic ICL2 H 130 34x54 G.HN E 24 G.HN.52
Van-der-waals ICL2 H 130 34x54 G.HN E 24 G.HN.52
Polar TM3 A 122 3x53 G.H5 N 343 G.H5.19
Hydrophobic TM3 A 122 3x53 G.H5 N 343 G.H5.19
Van-der-waals TM3 A 122 3x53 G.H5 N 343 G.H5.19
Hydrophobic TM3 R 119 3x50 G.H5 L 349 G.H5.25
Hydrophobic TM6 L 229 6x36 G.H5 G 348 G.H5.24
Hydrophobic TM3 V 123 3x54 G.H5 L 344 G.H5.20
Van-der-waals TM3 V 123 3x54 G.H5 L 344 G.H5.20