GPCR CLASS (FAMILY)
SPECIES
G PROTEIN FAMILY
DATE
3D VIEW
Tertiary structure confidence
(pLDDT score) avg.: 71.7
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered
PTM Score: 0.6
iPTM Score: 0.6
PAE mean: 16.1
GPCR - G protein interface interactions
The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle
(Gα residues)
and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid,
hydrophobic - dashed,
ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.
GPCR-G protein backbone (bb) or sidechain (sc):
Structures
0 structures selected.
Sequence Color
Interaction frequency filter (%)
Gα,
GPCR
Interaction cut-off: strict (stick), loose (line)
Interaction type |
GPCR Segment |
AA |
Number |
Generic number |
Gα segment |
AA |
Number |
Generic number |
---|---|---|---|---|---|---|---|---|
Van-der-waals | TM5 | F | 272 | 5x75 | G.S6 | H | 344 | G.S6.03 |
Hydrophobic | TM5 | T | 265 | 5x68 | G.H5 | D | 364 | G.H5.13 |
Polar | H8 | H | 354 | 8x47 | G.H5 | Q | 377 | G.H5.26 |
Hydrophobic | H8 | H | 354 | 8x47 | G.H5 | Q | 377 | G.H5.26 |
Van-der-waals | H8 | H | 354 | 8x47 | G.H5 | Q | 377 | G.H5.26 |
Hydrophobic | ICL3 | W | 283 | - | G.h4s6 | P | 341 | G.h4s6.20 |
Hydrophobic | C-term | Y | 382 | - | G.H5 | L | 376 | G.H5.25 |
Van-der-waals | C-term | Y | 382 | - | G.H5 | L | 376 | G.H5.25 |
Hydrophobic | ICL2 | F | 179 | 34x54 | G.h2s4 | T | 241 | G.h2s4.05 |
Polar | TM2 | N | 106 | 2x40 | G.H5 | Q | 377 | G.H5.26 |
Hydrophobic | TM2 | N | 106 | 2x40 | G.H5 | Q | 377 | G.H5.26 |
Van-der-waals | TM2 | N | 106 | 2x40 | G.H5 | Q | 377 | G.H5.26 |
Hydrophobic | TM5 | L | 269 | 5x72 | G.S6 | Y | 343 | G.S6.02 |
Van-der-waals | TM5 | L | 269 | 5x72 | G.S6 | Y | 343 | G.S6.02 |
Polar | H8 | H | 354 | 8x47 | G.H5 | L | 376 | G.H5.25 |
Hydrophobic | H8 | H | 354 | 8x47 | G.H5 | L | 376 | G.H5.25 |
Van-der-waals | H8 | H | 354 | 8x47 | G.H5 | L | 376 | G.H5.25 |
Polar | TM3 | V | 171 | 3x53 | G.H5 | N | 370 | G.H5.19 |
Hydrophobic | TM3 | V | 171 | 3x53 | G.H5 | N | 370 | G.H5.19 |
Van-der-waals | TM3 | V | 171 | 3x53 | G.H5 | N | 370 | G.H5.19 |
Hydrophobic | TM5 | I | 262 | 5x65 | G.H5 | L | 371 | G.H5.20 |
Van-der-waals | TM5 | I | 262 | 5x65 | G.H5 | L | 371 | G.H5.20 |
Hydrophobic | H8 | P | 355 | 8x48 | G.H5 | L | 376 | G.H5.25 |
Hydrophobic | TM3 | V | 171 | 3x53 | G.H5 | L | 374 | G.H5.23 |
Hydrophobic | ICL2 | L | 176 | 34x51 | G.S3 | V | 216 | G.S3.01 |
Hydrophobic | ICL2 | V | 181 | 34x56 | G.hns1 | R | 47 | G.hns1.03 |
Van-der-waals | ICL2 | V | 181 | 34x56 | G.hns1 | R | 47 | G.hns1.03 |
Polar | TM5 | K | 276 | 5x79 | G.H4 | K | 324 | G.H4.09 |
Hydrophobic | TM5 | K | 276 | 5x79 | G.H4 | K | 324 | G.H4.09 |
Van-der-waals | TM5 | K | 276 | 5x79 | G.H4 | K | 324 | G.H4.09 |
Polar | C-term | R | 380 | - | G.h4s6 | Q | 337 | G.h4s6.11 |
Hydrophobic | TM3 | I | 172 | 3x54 | G.H5 | L | 374 | G.H5.23 |
Van-der-waals | TM3 | I | 172 | 3x54 | G.H5 | L | 374 | G.H5.23 |
Hydrophobic | ICL2 | L | 176 | 34x51 | G.H5 | K | 363 | G.H5.12 |
Van-der-waals | ICL2 | L | 176 | 34x51 | G.H5 | K | 363 | G.H5.12 |
Polar | TM2 | T | 103 | 2x37 | G.H5 | Q | 377 | G.H5.26 |
Polar | TM3 | R | 168 | 3x50 | G.H5 | Q | 377 | G.H5.26 |
Hydrophobic | TM3 | R | 168 | 3x50 | G.H5 | Q | 377 | G.H5.26 |
Van-der-waals | TM3 | R | 168 | 3x50 | G.H5 | Q | 377 | G.H5.26 |
Polar | C-term | E | 417 | - | H.hbhc | R | 128 | H.hbhc.01 |
Hydrophobic | TM6 | S | 290 | 6x29 | G.H5 | M | 375 | G.H5.24 |
Van-der-waals | TM6 | S | 290 | 6x29 | G.H5 | M | 375 | G.H5.24 |
Hydrophobic | TM3 | I | 172 | 3x54 | G.H5 | L | 367 | G.H5.16 |
Van-der-waals | TM3 | I | 172 | 3x54 | G.H5 | L | 367 | G.H5.16 |
Hydrophobic | ICL2 | F | 179 | 34x54 | G.hns1 | K | 46 | G.hns1.02 |
Van-der-waals | ICL2 | F | 179 | 34x54 | G.hns1 | K | 46 | G.hns1.02 |
Hydrophobic | TM5 | F | 272 | 5x75 | G.H5 | R | 360 | G.H5.09 |
Van-der-waals | TM5 | F | 272 | 5x75 | G.H5 | R | 360 | G.H5.09 |
Ionic | ICL3 | E | 280 | - | G.H4 | R | 331 | G.H4.16 |
Polar | ICL3 | E | 280 | - | G.H4 | R | 331 | G.H4.16 |
Hydrophobic | ICL3 | E | 280 | - | G.H4 | R | 331 | G.H4.16 |
Van-der-waals | ICL3 | E | 280 | - | G.H4 | R | 331 | G.H4.16 |
Hydrophobic | TM6 | M | 294 | 6x33 | G.H5 | L | 374 | G.H5.23 |
Hydrophobic | TM5 | T | 265 | 5x68 | G.H5 | L | 367 | G.H5.16 |
Van-der-waals | TM5 | T | 265 | 5x68 | G.H5 | L | 367 | G.H5.16 |
Hydrophobic | ICL2 | F | 179 | 34x54 | G.hns1 | R | 47 | G.hns1.03 |
Van-der-waals | ICL2 | F | 179 | 34x54 | G.hns1 | R | 47 | G.hns1.03 |
Hydrophobic | TM6 | M | 294 | 6x33 | G.H5 | L | 371 | G.H5.20 |
Hydrophobic | ICL2 | P | 175 | 34x50 | G.H5 | K | 363 | G.H5.12 |
Van-der-waals | ICL2 | P | 175 | 34x50 | G.H5 | K | 363 | G.H5.12 |
Hydrophobic | H8 | P | 355 | 8x48 | G.H5 | M | 375 | G.H5.24 |
Van-der-waals | H8 | P | 355 | 8x48 | G.H5 | M | 375 | G.H5.24 |
Hydrophobic | ICL2 | F | 179 | 34x54 | G.S1 | V | 49 | G.S1.02 |
Aromatic | TM5 | F | 272 | 5x75 | G.S6 | H | 345 | G.S6.04 |
Hydrophobic | TM5 | F | 272 | 5x75 | G.S6 | H | 345 | G.S6.04 |
Van-der-waals | TM5 | F | 272 | 5x75 | G.S6 | H | 345 | G.S6.04 |
Hydrophobic | TM3 | R | 168 | 3x50 | G.H5 | L | 374 | G.H5.23 |
Van-der-waals | TM3 | R | 168 | 3x50 | G.H5 | L | 374 | G.H5.23 |
Hydrophobic | ICL2 | F | 179 | 34x54 | G.S1 | L | 48 | G.S1.01 |
Hydrophobic | TM5 | L | 269 | 5x72 | G.h4s6 | P | 341 | G.h4s6.20 |
Van-der-waals | TM5 | L | 269 | 5x72 | G.h4s6 | P | 341 | G.h4s6.20 |
Hydrophobic | ICL2 | G | 180 | 34x55 | G.hns1 | R | 47 | G.hns1.03 |
Hydrophobic | TM6 | K | 293 | 6x32 | G.H5 | M | 375 | G.H5.24 |
Hydrophobic | TM6 | M | 294 | 6x33 | G.H5 | M | 375 | G.H5.24 |
Van-der-waals | TM6 | M | 294 | 6x33 | G.H5 | M | 375 | G.H5.24 |
Polar | ICL2 | G | 180 | 34x55 | G.hns1 | K | 46 | G.hns1.02 |
Hydrophobic | ICL2 | G | 180 | 34x55 | G.hns1 | K | 46 | G.hns1.02 |
Van-der-waals | ICL2 | G | 180 | 34x55 | G.hns1 | K | 46 | G.hns1.02 |
Hydrophobic | TM3 | I | 172 | 3x54 | G.H5 | L | 371 | G.H5.20 |
Van-der-waals | TM3 | I | 172 | 3x54 | G.H5 | L | 371 | G.H5.20 |
Polar | H8 | K | 356 | 8x49 | G.H5 | L | 376 | G.H5.25 |
Hydrophobic | H8 | K | 356 | 8x49 | G.H5 | L | 376 | G.H5.25 |
Van-der-waals | H8 | K | 356 | 8x49 | G.H5 | L | 376 | G.H5.25 |
Hydrophobic | ICL2 | P | 175 | 34x50 | G.H5 | L | 367 | G.H5.16 |
Hydrophobic | ICL2 | L | 176 | 34x51 | G.H5 | I | 366 | G.H5.15 |
Van-der-waals | ICL2 | L | 176 | 34x51 | G.H5 | I | 366 | G.H5.15 |
Hydrophobic | ICL2 | P | 175 | 34x50 | G.H5 | I | 366 | G.H5.15 |
Hydrophobic | ICL2 | L | 176 | 34x51 | G.H5 | V | 362 | G.H5.11 |
Hydrophobic | ICL2 | F | 179 | 34x54 | G.H5 | I | 366 | G.H5.15 |
Van-der-waals | ICL2 | F | 179 | 34x54 | G.H5 | I | 366 | G.H5.15 |
Polar | TM7 | T | 353 | 7x56 | G.H5 | Q | 377 | G.H5.26 |
Polar | C-term | Y | 385 | - | G.H3 | V | 280 | G.H3.17 |
Van-der-waals | C-term | Y | 385 | - | G.H3 | V | 280 | G.H3.17 |
Hydrophobic | ICL2 | L | 176 | 34x51 | G.H5 | F | 359 | G.H5.08 |
Van-der-waals | ICL2 | L | 176 | 34x51 | G.H5 | F | 359 | G.H5.08 |
Hydrophobic | ICL2 | L | 176 | 34x51 | G.S1 | V | 49 | G.S1.02 |
Ionic | TM5 | K | 276 | 5x79 | G.H4 | E | 328 | G.H4.13 |
Hydrophobic | TM5 | K | 276 | 5x79 | G.H4 | E | 328 | G.H4.13 |
Van-der-waals | TM5 | K | 276 | 5x79 | G.H4 | E | 328 | G.H4.13 |
Hydrophobic | ICL2 | L | 176 | 34x51 | G.S3 | F | 218 | G.S3.03 |