GPCR CLASS (FAMILY)
SPECIES
G PROTEIN FAMILY
DATE
3D VIEW
Tertiary structure confidence
(pLDDT score) avg.: 74.8
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered
PTM Score: 0.7
iPTM Score: 0.7
PAE mean: 13.9
GPCR - G protein interface interactions
The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle
(Gα residues)
and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid,
hydrophobic - dashed,
ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.
GPCR-G protein backbone (bb) or sidechain (sc):
Structures
0 structures selected.
Sequence Color
Interaction frequency filter (%)
Gα,
GPCR
Interaction cut-off: strict (stick), loose (line)
Interaction type |
GPCR Segment |
AA |
Number |
Generic number |
Gα segment |
AA |
Number |
Generic number |
---|---|---|---|---|---|---|---|---|
Polar | C-term | T | 388 | - | G.h2s4 | D | 227 | G.h2s4.03 |
Hydrophobic | C-term | T | 388 | - | G.h2s4 | D | 227 | G.h2s4.03 |
Van-der-waals | C-term | T | 388 | - | G.h2s4 | D | 227 | G.h2s4.03 |
Ionic | H8 | H | 354 | 8x47 | G.H5 | E | 379 | G.H5.24 |
Polar | H8 | H | 354 | 8x47 | G.H5 | E | 379 | G.H5.24 |
Hydrophobic | H8 | H | 354 | 8x47 | G.H5 | E | 379 | G.H5.24 |
Van-der-waals | H8 | H | 354 | 8x47 | G.H5 | E | 379 | G.H5.24 |
Hydrophobic | TM5 | L | 269 | 5x72 | G.H5 | D | 365 | G.H5.10 |
Van-der-waals | TM5 | L | 269 | 5x72 | G.H5 | D | 365 | G.H5.10 |
Hydrophobic | TM5 | I | 262 | 5x65 | G.H5 | L | 375 | G.H5.20 |
Hydrophobic | TM5 | F | 272 | 5x75 | G.H5 | N | 364 | G.H5.09 |
Hydrophobic | TM6 | K | 293 | 6x32 | G.H5 | L | 380 | G.H5.25 |
Van-der-waals | TM6 | K | 293 | 6x32 | G.H5 | L | 380 | G.H5.25 |
Aromatic | C-term | H | 389 | - | G.hns1 | Y | 39 | G.hns1.01 |
Hydrophobic | C-term | H | 389 | - | G.hns1 | Y | 39 | G.hns1.01 |
Van-der-waals | C-term | H | 389 | - | G.hns1 | Y | 39 | G.hns1.01 |
Polar | H8 | P | 355 | 8x48 | G.H5 | E | 379 | G.H5.24 |
Hydrophobic | H8 | P | 355 | 8x48 | G.H5 | E | 379 | G.H5.24 |
Van-der-waals | H8 | P | 355 | 8x48 | G.H5 | E | 379 | G.H5.24 |
Ionic | TM6 | R | 287 | 6x26 | G.H5 | D | 368 | G.H5.13 |
Polar | TM6 | R | 287 | 6x26 | G.H5 | D | 368 | G.H5.13 |
Van-der-waals | TM6 | R | 287 | 6x26 | G.H5 | D | 368 | G.H5.13 |
Hydrophobic | TM5 | F | 272 | 5x75 | G.H5 | R | 361 | G.H5.06 |
Hydrophobic | TM6 | M | 294 | 6x33 | G.H5 | L | 380 | G.H5.25 |
Van-der-waals | TM6 | M | 294 | 6x33 | G.H5 | L | 380 | G.H5.25 |
Polar | TM5 | T | 265 | 5x68 | G.H5 | R | 367 | G.H5.12 |
Hydrophobic | TM5 | T | 265 | 5x68 | G.H5 | R | 367 | G.H5.12 |
Hydrophobic | TM5 | A | 274 | 5x77 | G.S6 | P | 348 | G.S6.03 |
Van-der-waals | TM5 | A | 274 | 5x77 | G.S6 | P | 348 | G.S6.03 |
Van-der-waals | TM6 | R | 287 | 6x26 | G.H5 | R | 372 | G.H5.17 |
Aromatic | ICL2 | F | 179 | 34x54 | G.S1 | H | 43 | G.S1.02 |
Hydrophobic | ICL2 | F | 179 | 34x54 | G.S1 | H | 43 | G.S1.02 |
Van-der-waals | ICL2 | F | 179 | 34x54 | G.S1 | H | 43 | G.S1.02 |
Hydrophobic | TM3 | I | 172 | 3x54 | G.H5 | L | 375 | G.H5.20 |
Van-der-waals | TM5 | A | 268 | 5x71 | G.H5 | R | 367 | G.H5.12 |
Hydrophobic | ICL2 | L | 176 | 34x51 | G.S3 | F | 206 | G.S3.03 |
Hydrophobic | TM3 | R | 168 | 3x50 | G.H5 | L | 380 | G.H5.25 |
Ionic | TM5 | E | 264 | 5x67 | G.H5 | R | 367 | G.H5.12 |
Polar | TM5 | E | 264 | 5x67 | G.H5 | R | 367 | G.H5.12 |
Van-der-waals | TM5 | E | 264 | 5x67 | G.H5 | R | 367 | G.H5.12 |
Hydrophobic | TM6 | S | 290 | 6x29 | G.H5 | L | 381 | G.H5.26 |
Van-der-waals | TM6 | S | 290 | 6x29 | G.H5 | L | 381 | G.H5.26 |
Hydrophobic | ICL2 | L | 176 | 34x51 | G.H5 | F | 363 | G.H5.08 |
Van-der-waals | ICL2 | L | 176 | 34x51 | G.H5 | F | 363 | G.H5.08 |
Hydrophobic | ICL2 | P | 175 | 34x50 | G.H5 | Q | 371 | G.H5.16 |
Polar | TM5 | A | 261 | 5x64 | G.H5 | Q | 371 | G.H5.16 |
Hydrophobic | TM5 | A | 261 | 5x64 | G.H5 | Q | 371 | G.H5.16 |
Hydrophobic | C-term | W | 420 | - | G.H3 | N | 266 | G.H3.15 |
Hydrophobic | ICL3 | W | 283 | - | G.H5 | R | 372 | G.H5.17 |
Van-der-waals | ICL3 | W | 283 | - | G.H5 | R | 372 | G.H5.17 |
Polar | TM3 | D | 167 | 3x49 | G.H5 | Y | 378 | G.H5.23 |
Hydrophobic | TM3 | D | 167 | 3x49 | G.H5 | Y | 378 | G.H5.23 |
Van-der-waals | TM3 | D | 167 | 3x49 | G.H5 | Y | 378 | G.H5.23 |
Hydrophobic | TM5 | A | 274 | 5x77 | G.S6 | H | 349 | G.S6.04 |
Van-der-waals | TM5 | A | 274 | 5x77 | G.S6 | H | 349 | G.S6.04 |
Polar | TM5 | G | 277 | 5x80 | G.hgh4 | D | 310 | G.hgh4.13 |
Hydrophobic | TM5 | G | 277 | 5x80 | G.hgh4 | D | 310 | G.hgh4.13 |
Van-der-waals | TM5 | G | 277 | 5x80 | G.hgh4 | D | 310 | G.hgh4.13 |
Hydrophobic | C-term | W | 420 | - | G.H3 | L | 259 | G.H3.08 |
Hydrophobic | TM5 | I | 262 | 5x65 | G.H5 | Q | 371 | G.H5.16 |
Van-der-waals | TM5 | I | 262 | 5x65 | G.H5 | Q | 371 | G.H5.16 |
Polar | TM5 | K | 276 | 5x79 | G.hgh4 | T | 312 | G.hgh4.15 |
Hydrophobic | TM5 | K | 276 | 5x79 | G.hgh4 | T | 312 | G.hgh4.15 |
Van-der-waals | TM5 | K | 276 | 5x79 | G.hgh4 | T | 312 | G.hgh4.15 |
Hydrophobic | ICL2 | F | 179 | 34x54 | G.H5 | M | 373 | G.H5.18 |
Hydrophobic | ICL2 | L | 176 | 34x51 | G.S3 | V | 204 | G.S3.01 |
Van-der-waals | ICL2 | L | 176 | 34x51 | G.S3 | V | 204 | G.S3.01 |
Polar | TM5 | K | 276 | 5x79 | G.hgh4 | A | 311 | G.hgh4.14 |
Hydrophobic | TM5 | K | 276 | 5x79 | G.hgh4 | A | 311 | G.hgh4.14 |
Van-der-waals | TM5 | K | 276 | 5x79 | G.hgh4 | A | 311 | G.hgh4.14 |
Hydrophobic | C-term | M | 423 | - | G.H2 | R | 219 | G.H2.05 |
Polar | TM3 | I | 172 | 3x54 | G.H5 | Q | 371 | G.H5.16 |
Hydrophobic | TM3 | I | 172 | 3x54 | G.H5 | Q | 371 | G.H5.16 |
Van-der-waals | TM3 | I | 172 | 3x54 | G.H5 | Q | 371 | G.H5.16 |
Hydrophobic | ICL3 | W | 283 | - | G.H5 | D | 368 | G.H5.13 |
Ionic | C-term | H | 389 | - | G.h2s4 | D | 227 | G.h2s4.03 |
Polar | C-term | H | 389 | - | G.h2s4 | D | 227 | G.h2s4.03 |
Hydrophobic | C-term | H | 389 | - | G.h2s4 | D | 227 | G.h2s4.03 |
Van-der-waals | C-term | H | 389 | - | G.h2s4 | D | 227 | G.h2s4.03 |
Hydrophobic | C-term | V | 428 | - | G.H3 | R | 267 | G.H3.16 |
Hydrophobic | ICL2 | F | 179 | 34x54 | G.H5 | H | 374 | G.H5.19 |
Hydrophobic | TM5 | K | 276 | 5x79 | G.H4 | F | 326 | G.H4.08 |
Van-der-waals | TM5 | K | 276 | 5x79 | G.H4 | F | 326 | G.H4.08 |
Polar | C-term | Y | 385 | - | G.h3s5 | T | 271 | G.h3s5.02 |
Hydrophobic | C-term | Y | 385 | - | G.h3s5 | T | 271 | G.h3s5.02 |
Van-der-waals | C-term | Y | 385 | - | G.h3s5 | T | 271 | G.h3s5.02 |
Hydrophobic | ICL2 | F | 179 | 34x54 | G.H5 | I | 370 | G.H5.15 |
Van-der-waals | ICL2 | F | 179 | 34x54 | G.H5 | I | 370 | G.H5.15 |
Hydrophobic | TM2 | A | 105 | 2x39 | G.H5 | Y | 378 | G.H5.23 |
Van-der-waals | TM2 | A | 105 | 2x39 | G.H5 | Y | 378 | G.H5.23 |
Polar | TM5 | T | 265 | 5x68 | G.H5 | Q | 371 | G.H5.16 |
Hydrophobic | TM5 | T | 265 | 5x68 | G.H5 | Q | 371 | G.H5.16 |
Aromatic | C-term | H | 389 | - | G.HN | R | 36 | G.HN.51 |
Hydrophobic | TM3 | V | 171 | 3x53 | G.H5 | Y | 378 | G.H5.23 |
Van-der-waals | TM3 | V | 171 | 3x53 | G.H5 | Y | 378 | G.H5.23 |
Hydrophobic | TM5 | L | 269 | 5x72 | G.H5 | D | 368 | G.H5.13 |
Polar | TM5 | F | 272 | 5x75 | G.S6 | H | 349 | G.S6.04 |
Hydrophobic | TM5 | F | 272 | 5x75 | G.S6 | H | 349 | G.S6.04 |
Polar | ICL2 | G | 180 | 34x55 | G.hns1 | K | 40 | G.hns1.02 |
Hydrophobic | ICL2 | G | 180 | 34x55 | G.hns1 | K | 40 | G.hns1.02 |
Polar | ICL2 | L | 176 | 34x51 | G.S1 | H | 43 | G.S1.02 |
Hydrophobic | ICL2 | L | 176 | 34x51 | G.S1 | H | 43 | G.S1.02 |
Van-der-waals | ICL2 | L | 176 | 34x51 | G.S1 | H | 43 | G.S1.02 |
Hydrophobic | ICL2 | L | 176 | 34x51 | G.H5 | I | 370 | G.H5.15 |
Van-der-waals | ICL2 | L | 176 | 34x51 | G.H5 | I | 370 | G.H5.15 |
Hydrophobic | C-term | Y | 385 | - | G.H5 | M | 373 | G.H5.18 |
Van-der-waals | C-term | Y | 385 | - | G.H5 | M | 373 | G.H5.18 |
Hydrophobic | ICL2 | L | 176 | 34x51 | G.H5 | C | 366 | G.H5.11 |
Polar | TM3 | R | 168 | 3x50 | G.H5 | Y | 378 | G.H5.23 |
Hydrophobic | TM3 | R | 168 | 3x50 | G.H5 | Y | 378 | G.H5.23 |
Van-der-waals | TM3 | R | 168 | 3x50 | G.H5 | Y | 378 | G.H5.23 |
Hydrophobic | TM5 | L | 269 | 5x72 | G.S6 | Y | 347 | G.S6.02 |
Van-der-waals | TM5 | L | 269 | 5x72 | G.S6 | Y | 347 | G.S6.02 |
Hydrophobic | ICL2 | P | 175 | 34x50 | G.H5 | R | 367 | G.H5.12 |
Hydrophobic | TM5 | A | 268 | 5x71 | G.H5 | N | 364 | G.H5.09 |
Van-der-waals | TM5 | A | 268 | 5x71 | G.H5 | N | 364 | G.H5.09 |
Hydrophobic | TM6 | M | 294 | 6x33 | G.H5 | L | 375 | G.H5.20 |
Hydrophobic | TM5 | K | 276 | 5x79 | G.hgh4 | D | 310 | G.hgh4.13 |
Ionic | H8 | K | 356 | 8x49 | G.H5 | E | 379 | G.H5.24 |
Polar | H8 | K | 356 | 8x49 | G.H5 | E | 379 | G.H5.24 |
Hydrophobic | H8 | K | 356 | 8x49 | G.H5 | E | 379 | G.H5.24 |
Van-der-waals | H8 | K | 356 | 8x49 | G.H5 | E | 379 | G.H5.24 |
Hydrophobic | TM5 | T | 265 | 5x68 | G.H5 | D | 368 | G.H5.13 |
Ionic | C-term | E | 424 | - | G.H3 | R | 267 | G.H3.16 |
Polar | C-term | E | 424 | - | G.H3 | R | 267 | G.H3.16 |
Hydrophobic | C-term | E | 424 | - | G.H3 | R | 267 | G.H3.16 |
Van-der-waals | C-term | E | 424 | - | G.H3 | R | 267 | G.H3.16 |
Polar | H8 | K | 356 | 8x49 | G.H5 | K | 376 | G.H5.21 |
Van-der-waals | H8 | K | 356 | 8x49 | G.H5 | K | 376 | G.H5.21 |
Polar | TM3 | V | 171 | 3x53 | G.H5 | H | 374 | G.H5.19 |
Hydrophobic | TM3 | V | 171 | 3x53 | G.H5 | H | 374 | G.H5.19 |
Van-der-waals | TM3 | V | 171 | 3x53 | G.H5 | H | 374 | G.H5.19 |
Hydrophobic | ICL3 | N | 278 | - | G.hgh4 | P | 308 | G.hgh4.11 |
Polar | C-term | W | 420 | - | G.H3 | S | 262 | G.H3.11 |
Hydrophobic | C-term | W | 420 | - | G.H3 | S | 262 | G.H3.11 |
Van-der-waals | C-term | W | 420 | - | G.H3 | S | 262 | G.H3.11 |
Polar | TM6 | K | 293 | 6x32 | G.H5 | E | 379 | G.H5.24 |
Hydrophobic | TM5 | G | 277 | 5x80 | G.hgh4 | P | 308 | G.hgh4.11 |
Hydrophobic | ICL3 | W | 283 | - | G.S6 | Y | 347 | G.S6.02 |
Van-der-waals | C-term | A | 427 | - | G.H3 | R | 267 | G.H3.16 |
Hydrophobic | C-term | P | 383 | - | G.h4s6 | K | 343 | G.h4s6.12 |
Hydrophobic | ICL2 | L | 176 | 34x51 | G.H5 | R | 367 | G.H5.12 |
Polar | TM6 | K | 293 | 6x32 | G.H5 | L | 381 | G.H5.26 |
Hydrophobic | TM6 | K | 293 | 6x32 | G.H5 | L | 381 | G.H5.26 |
Van-der-waals | TM6 | K | 293 | 6x32 | G.H5 | L | 381 | G.H5.26 |
Hydrophobic | TM5 | F | 272 | 5x75 | G.H5 | R | 360 | G.H5.05 |
Polar | TM6 | Q | 286 | 6x25 | G.h4s6 | Y | 345 | G.h4s6.20 |
Van-der-waals | TM6 | Q | 286 | 6x25 | G.h4s6 | Y | 345 | G.h4s6.20 |
Hydrophobic | ICL2 | P | 175 | 34x50 | G.H5 | I | 370 | G.H5.15 |
Hydrophobic | C-term | W | 420 | - | G.H3 | I | 263 | G.H3.12 |
Hydrophobic | ICL3 | W | 283 | - | G.h4s6 | Y | 345 | G.h4s6.20 |
Polar | TM5 | C | 275 | 5x78 | G.H4 | R | 329 | G.H4.12 |
Van-der-waals | TM5 | C | 275 | 5x78 | G.H4 | R | 329 | G.H4.12 |
Hydrophobic | ICL2 | P | 175 | 34x50 | G.H5 | H | 374 | G.H5.19 |
Van-der-waals | ICL2 | P | 175 | 34x50 | G.H5 | H | 374 | G.H5.19 |
Polar | TM5 | G | 277 | 5x80 | G.H4 | R | 329 | G.H4.12 |
Hydrophobic | TM5 | G | 277 | 5x80 | G.H4 | R | 329 | G.H4.12 |
Van-der-waals | TM5 | G | 277 | 5x80 | G.H4 | R | 329 | G.H4.12 |
Hydrophobic | C-term | S | 387 | - | G.h2s4 | D | 227 | G.h2s4.03 |
Van-der-waals | C-term | S | 387 | - | G.h2s4 | D | 227 | G.h2s4.03 |
Hydrophobic | TM3 | I | 172 | 3x54 | G.H5 | L | 380 | G.H5.25 |
Van-der-waals | TM3 | I | 172 | 3x54 | G.H5 | L | 380 | G.H5.25 |
Hydrophobic | TM5 | F | 272 | 5x75 | G.H5 | E | 357 | G.H5.02 |
Van-der-waals | TM5 | F | 272 | 5x75 | G.H5 | E | 357 | G.H5.02 |
Polar | ICL3 | N | 278 | - | G.hgh4 | D | 310 | G.hgh4.13 |
Hydrophobic | ICL3 | N | 278 | - | G.hgh4 | D | 310 | G.hgh4.13 |
Van-der-waals | ICL3 | N | 278 | - | G.hgh4 | D | 310 | G.hgh4.13 |
Hydrophobic | TM6 | I | 297 | 6x36 | G.H5 | L | 380 | G.H5.25 |
Van-der-waals | ICL2 | F | 179 | 34x54 | G.hns1 | K | 40 | G.hns1.02 |
Hydrophobic | C-term | H | 389 | - | G.hns1 | K | 40 | G.hns1.02 |
Polar | TM5 | K | 276 | 5x79 | G.H4 | R | 329 | G.H4.12 |
Hydrophobic | TM5 | K | 276 | 5x79 | G.H4 | R | 329 | G.H4.12 |
Van-der-waals | TM5 | K | 276 | 5x79 | G.H4 | R | 329 | G.H4.12 |