GPCR CLASS (FAMILY)
SPECIES
G PROTEIN FAMILY
DATE
3D VIEW
Tertiary structure confidence
(pLDDT score) avg.: 75.7
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered
PTM Score: 0.7
iPTM Score: 0.7
PAE mean: 12.2
GPCR - G protein interface interactions
The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle
(Gα residues)
and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid,
hydrophobic - dashed,
ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.
GPCR-G protein backbone (bb) or sidechain (sc):
Structures
0 structures selected.
Sequence Color
Interaction frequency filter (%)
Gα,
GPCR
Interaction cut-off: strict (stick), loose (line)
Interaction type |
GPCR Segment |
AA |
Number |
Generic number |
Gα segment |
AA |
Number |
Generic number |
---|---|---|---|---|---|---|---|---|
Ionic | C-term | H | 389 | - | G.hns1 | E | 30 | G.hns1.01 |
Polar | C-term | H | 389 | - | G.hns1 | E | 30 | G.hns1.01 |
Hydrophobic | C-term | H | 389 | - | G.hns1 | E | 30 | G.hns1.01 |
Van-der-waals | C-term | H | 389 | - | G.hns1 | E | 30 | G.hns1.01 |
Polar | TM7 | T | 353 | 7x56 | G.H5 | G | 352 | G.H5.24 |
Hydrophobic | TM7 | T | 353 | 7x56 | G.H5 | G | 352 | G.H5.24 |
Van-der-waals | TM7 | T | 353 | 7x56 | G.H5 | G | 352 | G.H5.24 |
Hydrophobic | C-term | V | 418 | - | G.H2 | K | 209 | G.H2.05 |
Hydrophobic | TM5 | L | 269 | 5x72 | G.H5 | D | 337 | G.H5.09 |
Hydrophobic | C-term | A | 427 | - | G.H2 | I | 212 | G.H2.08 |
Hydrophobic | TM5 | A | 268 | 5x71 | G.H5 | D | 337 | G.H5.09 |
Hydrophobic | C-term | M | 423 | - | G.h2s4 | F | 215 | G.h2s4.01 |
Van-der-waals | C-term | M | 423 | - | G.h2s4 | F | 215 | G.h2s4.01 |
Polar | C-term | Y | 385 | - | G.h2s4 | T | 219 | G.h2s4.05 |
Hydrophobic | C-term | Y | 385 | - | G.h2s4 | T | 219 | G.h2s4.05 |
Van-der-waals | C-term | Y | 385 | - | G.h2s4 | T | 219 | G.h2s4.05 |
Ionic | H8 | K | 356 | 8x49 | G.H5 | E | 346 | G.H5.18 |
Polar | H8 | K | 356 | 8x49 | G.H5 | E | 346 | G.H5.18 |
Hydrophobic | H8 | K | 356 | 8x49 | G.H5 | E | 346 | G.H5.18 |
Van-der-waals | H8 | K | 356 | 8x49 | G.H5 | E | 346 | G.H5.18 |
Ionic | C-term | E | 415 | - | G.H2 | K | 209 | G.H2.05 |
Hydrophobic | ICL2 | L | 176 | 34x51 | G.H5 | I | 343 | G.H5.15 |
Hydrophobic | TM3 | I | 172 | 3x54 | G.H5 | L | 348 | G.H5.20 |
Van-der-waals | TM3 | I | 172 | 3x54 | G.H5 | L | 348 | G.H5.20 |
Hydrophobic | TM5 | T | 265 | 5x68 | G.H5 | T | 340 | G.H5.12 |
Hydrophobic | TM5 | C | 275 | 5x78 | G.S6 | M | 323 | G.S6.05 |
Polar | ICL3 | W | 283 | - | G.h4s6 | E | 318 | G.h4s6.12 |
Van-der-waals | ICL3 | W | 283 | - | G.h4s6 | E | 318 | G.h4s6.12 |
Hydrophobic | C-term | W | 420 | - | G.H2 | W | 211 | G.H2.07 |
Van-der-waals | C-term | W | 420 | - | G.H2 | W | 211 | G.H2.07 |
Hydrophobic | C-term | I | 403 | - | H.HA | E | 68 | H.HA.06 |
Hydrophobic | ICL2 | F | 179 | 34x54 | G.hns1 | A | 31 | G.hns1.02 |
Van-der-waals | ICL2 | F | 179 | 34x54 | G.hns1 | A | 31 | G.hns1.02 |
Hydrophobic | C-term | M | 423 | - | G.H2 | I | 212 | G.H2.08 |
Hydrophobic | H8 | K | 356 | 8x49 | G.H5 | K | 349 | G.H5.21 |
Hydrophobic | C-term | W | 420 | - | G.H3 | L | 249 | G.H3.08 |
Van-der-waals | C-term | W | 420 | - | G.H3 | L | 249 | G.H3.08 |
Ionic | ICL3 | E | 280 | - | G.H4 | K | 304 | G.H4.12 |
Polar | ICL3 | E | 280 | - | G.H4 | K | 304 | G.H4.12 |
Van-der-waals | ICL3 | E | 280 | - | G.H4 | K | 304 | G.H4.12 |
Hydrophobic | TM3 | R | 168 | 3x50 | G.H5 | L | 353 | G.H5.25 |
Van-der-waals | TM3 | R | 168 | 3x50 | G.H5 | L | 353 | G.H5.25 |
Hydrophobic | TM6 | M | 298 | 6x37 | G.H5 | L | 353 | G.H5.25 |
Hydrophobic | ICL2 | F | 179 | 34x54 | G.hns1 | K | 32 | G.hns1.03 |
Van-der-waals | ICL2 | F | 179 | 34x54 | G.hns1 | K | 32 | G.hns1.03 |
Hydrophobic | ICL2 | F | 179 | 34x54 | G.S1 | V | 34 | G.S1.02 |
Van-der-waals | ICL2 | F | 179 | 34x54 | G.S1 | V | 34 | G.S1.02 |
Hydrophobic | TM3 | I | 172 | 3x54 | G.H5 | L | 353 | G.H5.25 |
Hydrophobic | C-term | W | 420 | - | G.H3 | S | 252 | G.H3.11 |
Van-der-waals | C-term | W | 420 | - | G.H3 | S | 252 | G.H3.11 |
Hydrophobic | TM5 | I | 262 | 5x65 | G.H5 | L | 348 | G.H5.20 |
Hydrophobic | TM5 | T | 265 | 5x68 | G.H5 | I | 344 | G.H5.16 |
Van-der-waals | TM5 | T | 265 | 5x68 | G.H5 | I | 344 | G.H5.16 |
Polar | TM6 | K | 293 | 6x32 | G.H5 | F | 354 | G.H5.26 |
Hydrophobic | TM6 | K | 293 | 6x32 | G.H5 | F | 354 | G.H5.26 |
Van-der-waals | TM6 | K | 293 | 6x32 | G.H5 | F | 354 | G.H5.26 |
Hydrophobic | TM3 | I | 172 | 3x54 | G.H5 | I | 344 | G.H5.16 |
Polar | C-term | Y | 385 | - | G.h3s5 | T | 262 | G.h3s5.03 |
Van-der-waals | C-term | Y | 385 | - | G.h3s5 | T | 262 | G.h3s5.03 |
Hydrophobic | C-term | W | 420 | - | G.H2 | R | 208 | G.H2.04 |
Hydrophobic | TM5 | T | 265 | 5x68 | G.H5 | D | 341 | G.H5.13 |
Van-der-waals | TM5 | T | 265 | 5x68 | G.H5 | D | 341 | G.H5.13 |
Polar | TM5 | G | 273 | 5x76 | G.H4 | K | 304 | G.H4.12 |
Van-der-waals | TM5 | G | 273 | 5x76 | G.H4 | K | 304 | G.H4.12 |
Hydrophobic | TM6 | M | 294 | 6x33 | G.H5 | L | 348 | G.H5.20 |
Van-der-waals | TM6 | M | 294 | 6x33 | G.H5 | L | 348 | G.H5.20 |
Polar | C-term | T | 388 | - | G.h2s4 | E | 216 | G.h2s4.02 |
Hydrophobic | C-term | T | 388 | - | G.h2s4 | E | 216 | G.h2s4.02 |
Van-der-waals | C-term | T | 388 | - | G.h2s4 | E | 216 | G.h2s4.02 |
Polar | C-term | H | 389 | - | G.HN | D | 26 | G.HN.50 |
Hydrophobic | C-term | H | 389 | - | G.HN | D | 26 | G.HN.50 |
Ionic | C-term | E | 424 | - | G.H3 | K | 257 | G.H3.16 |
Polar | C-term | E | 424 | - | G.H3 | K | 257 | G.H3.16 |
Hydrophobic | C-term | E | 424 | - | G.H3 | K | 257 | G.H3.16 |
Van-der-waals | C-term | E | 424 | - | G.H3 | K | 257 | G.H3.16 |
Hydrophobic | H8 | P | 355 | 8x48 | G.H5 | K | 349 | G.H5.21 |
Polar | TM5 | G | 277 | 5x80 | G.H4 | N | 301 | G.H4.08 |
Hydrophobic | TM5 | G | 277 | 5x80 | G.H4 | N | 301 | G.H4.08 |
Van-der-waals | TM5 | G | 277 | 5x80 | G.H4 | N | 301 | G.H4.08 |
Hydrophobic | ICL2 | P | 175 | 34x50 | G.H5 | T | 340 | G.H5.12 |
Polar | C-term | H | 389 | - | G.HN | A | 27 | G.HN.51 |
Hydrophobic | C-term | H | 389 | - | G.HN | A | 27 | G.HN.51 |
Van-der-waals | C-term | H | 389 | - | G.HN | A | 27 | G.HN.51 |
Hydrophobic | ICL2 | P | 175 | 34x50 | G.H5 | I | 343 | G.H5.15 |
Polar | TM5 | F | 272 | 5x75 | G.S6 | H | 322 | G.S6.04 |
Aromatic | TM5 | F | 272 | 5x75 | G.S6 | H | 322 | G.S6.04 |
Hydrophobic | TM5 | F | 272 | 5x75 | G.S6 | H | 322 | G.S6.04 |
Van-der-waals | TM5 | F | 272 | 5x75 | G.S6 | H | 322 | G.S6.04 |
Hydrophobic | ICL2 | L | 176 | 34x51 | G.H5 | F | 336 | G.H5.08 |
Van-der-waals | ICL2 | L | 176 | 34x51 | G.H5 | F | 336 | G.H5.08 |
Hydrophobic | TM5 | Y | 255 | 5x58 | G.H5 | L | 353 | G.H5.25 |
Polar | TM3 | V | 171 | 3x53 | G.H5 | N | 347 | G.H5.19 |
Hydrophobic | TM3 | V | 171 | 3x53 | G.H5 | N | 347 | G.H5.19 |
Van-der-waals | TM3 | V | 171 | 3x53 | G.H5 | N | 347 | G.H5.19 |
Hydrophobic | C-term | L | 400 | - | H.HA | E | 68 | H.HA.06 |
Van-der-waals | C-term | L | 400 | - | H.HA | E | 68 | H.HA.06 |
Hydrophobic | TM5 | I | 262 | 5x65 | G.H5 | I | 344 | G.H5.16 |
Polar | C-term | Y | 385 | - | G.h2s4 | V | 218 | G.h2s4.04 |
Hydrophobic | C-term | Y | 385 | - | G.h2s4 | V | 218 | G.h2s4.04 |
Van-der-waals | C-term | Y | 385 | - | G.h2s4 | V | 218 | G.h2s4.04 |
Hydrophobic | C-term | S | 387 | - | G.hns1 | E | 30 | G.hns1.01 |
Van-der-waals | C-term | S | 387 | - | G.hns1 | E | 30 | G.hns1.01 |
Hydrophobic | ICL2 | G | 180 | 34x55 | G.hns1 | K | 32 | G.hns1.03 |
Hydrophobic | TM6 | M | 294 | 6x33 | G.H5 | L | 353 | G.H5.25 |
Van-der-waals | TM6 | M | 294 | 6x33 | G.H5 | L | 353 | G.H5.25 |
Hydrophobic | TM5 | F | 272 | 5x75 | G.H5 | Q | 330 | G.H5.02 |
Van-der-waals | TM5 | F | 272 | 5x75 | G.H5 | Q | 330 | G.H5.02 |
Hydrophobic | C-term | W | 420 | - | G.H3 | H | 256 | G.H3.15 |
Hydrophobic | TM5 | F | 272 | 5x75 | G.H5 | K | 333 | G.H5.05 |
Polar | TM3 | R | 168 | 3x50 | G.H5 | C | 351 | G.H5.23 |
Hydrophobic | TM3 | R | 168 | 3x50 | G.H5 | C | 351 | G.H5.23 |
Van-der-waals | TM3 | R | 168 | 3x50 | G.H5 | C | 351 | G.H5.23 |
Polar | ICL2 | G | 180 | 34x55 | G.hns1 | A | 31 | G.hns1.02 |
Hydrophobic | ICL2 | G | 180 | 34x55 | G.hns1 | A | 31 | G.hns1.02 |
Van-der-waals | ICL2 | G | 180 | 34x55 | G.hns1 | A | 31 | G.hns1.02 |
Hydrophobic | ICL2 | L | 176 | 34x51 | G.H5 | T | 340 | G.H5.12 |
Ionic | H8 | K | 356 | 8x49 | G.H5 | D | 350 | G.H5.22 |
Polar | H8 | K | 356 | 8x49 | G.H5 | D | 350 | G.H5.22 |
Hydrophobic | H8 | K | 356 | 8x49 | G.H5 | D | 350 | G.H5.22 |
Van-der-waals | H8 | K | 356 | 8x49 | G.H5 | D | 350 | G.H5.22 |
Polar | H8 | H | 354 | 8x47 | G.H5 | G | 352 | G.H5.24 |
Hydrophobic | H8 | H | 354 | 8x47 | G.H5 | G | 352 | G.H5.24 |
Van-der-waals | H8 | H | 354 | 8x47 | G.H5 | G | 352 | G.H5.24 |
Hydrophobic | ICL2 | F | 179 | 34x54 | G.H5 | I | 343 | G.H5.15 |
Polar | TM6 | Q | 286 | 6x25 | G.h4s6 | K | 314 | G.h4s6.08 |
Van-der-waals | TM6 | Q | 286 | 6x25 | G.h4s6 | K | 314 | G.h4s6.08 |
Aromatic | TM5 | F | 272 | 5x75 | G.H5 | F | 334 | G.H5.06 |
Hydrophobic | TM5 | F | 272 | 5x75 | G.H5 | F | 334 | G.H5.06 |
Van-der-waals | TM5 | F | 272 | 5x75 | G.H5 | F | 334 | G.H5.06 |
Ionic | TM6 | R | 287 | 6x26 | G.H5 | D | 341 | G.H5.13 |
Polar | TM6 | R | 287 | 6x26 | G.H5 | D | 341 | G.H5.13 |
Hydrophobic | TM6 | R | 287 | 6x26 | G.H5 | D | 341 | G.H5.13 |
Van-der-waals | TM6 | R | 287 | 6x26 | G.H5 | D | 341 | G.H5.13 |
Hydrophobic | TM5 | L | 269 | 5x72 | G.S6 | Y | 320 | G.S6.02 |
Hydrophobic | TM5 | L | 269 | 5x72 | G.H5 | A | 338 | G.H5.10 |
Polar | H8 | H | 354 | 8x47 | G.H5 | D | 350 | G.H5.22 |
Hydrophobic | H8 | H | 354 | 8x47 | G.H5 | D | 350 | G.H5.22 |
Van-der-waals | H8 | H | 354 | 8x47 | G.H5 | D | 350 | G.H5.22 |
Hydrophobic | ICL2 | V | 181 | 34x56 | G.hns1 | K | 32 | G.hns1.03 |
Van-der-waals | ICL2 | V | 181 | 34x56 | G.hns1 | K | 32 | G.hns1.03 |
Hydrophobic | TM5 | L | 269 | 5x72 | G.H5 | F | 334 | G.H5.06 |
Van-der-waals | TM5 | L | 269 | 5x72 | G.H5 | F | 334 | G.H5.06 |
Hydrophobic | ICL2 | P | 175 | 34x50 | G.H5 | I | 344 | G.H5.16 |
Van-der-waals | ICL2 | P | 175 | 34x50 | G.H5 | I | 344 | G.H5.16 |
Hydrophobic | C-term | M | 423 | - | G.H2 | R | 208 | G.H2.04 |
Polar | H8 | H | 354 | 8x47 | G.H5 | K | 349 | G.H5.21 |
Van-der-waals | H8 | H | 354 | 8x47 | G.H5 | K | 349 | G.H5.21 |
Hydrophobic | C-term | L | 393 | - | G.H2 | H | 213 | G.H2.09 |
Van-der-waals | C-term | L | 393 | - | G.H2 | H | 213 | G.H2.09 |
Hydrophobic | C-term | Y | 382 | - | G.h4s6 | V | 316 | G.h4s6.10 |
Ionic | C-term | R | 407 | - | H.hbhc | E | 116 | H.hbhc.04 |
Polar | C-term | R | 407 | - | H.hbhc | E | 116 | H.hbhc.04 |
Van-der-waals | C-term | R | 407 | - | H.hbhc | E | 116 | H.hbhc.04 |
Hydrophobic | TM5 | L | 269 | 5x72 | G.H5 | D | 341 | G.H5.13 |
Van-der-waals | TM5 | L | 269 | 5x72 | G.H5 | D | 341 | G.H5.13 |
Hydrophobic | TM6 | I | 297 | 6x36 | G.H5 | L | 353 | G.H5.25 |
Van-der-waals | TM6 | I | 297 | 6x36 | G.H5 | L | 353 | G.H5.25 |
Hydrophobic | ICL2 | F | 179 | 34x54 | G.S3 | L | 194 | G.S3.01 |
Hydrophobic | H8 | P | 355 | 8x48 | G.H5 | G | 352 | G.H5.24 |
Hydrophobic | ICL2 | F | 179 | 34x54 | G.S1 | T | 33 | G.S1.01 |
Hydrophobic | ICL2 | L | 176 | 34x51 | G.S3 | L | 194 | G.S3.01 |
Van-der-waals | ICL2 | L | 176 | 34x51 | G.S3 | L | 194 | G.S3.01 |
Hydrophobic | C-term | Y | 385 | - | G.h2s4 | G | 217 | G.h2s4.03 |
Hydrophobic | C-term | P | 383 | - | G.h3s5 | A | 261 | G.h3s5.02 |
Hydrophobic | C-term | W | 420 | - | G.H3 | I | 253 | G.H3.12 |