GPCR CLASS (FAMILY)
SPECIES
G PROTEIN FAMILY
DATE
3D VIEW
Tertiary structure confidence
(pLDDT score) avg.: 77.5
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered
PTM Score: 0.7
iPTM Score: 0.5
PAE mean: 17.1
GPCR - G protein interface interactions
The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle
(Gα residues)
and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid,
hydrophobic - dashed,
ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.
GPCR-G protein backbone (bb) or sidechain (sc):
Structures
0 structures selected.
Sequence Color
Interaction frequency filter (%)
Gα,
GPCR
Interaction cut-off: strict (stick), loose (line)
Interaction type |
GPCR Segment |
AA |
Number |
Generic number |
Gα segment |
AA |
Number |
Generic number |
---|---|---|---|---|---|---|---|---|
Hydrophobic | C-term | V | 337 | - | G.H2 | H | 221 | G.H2.09 |
Hydrophobic | H8 | F | 313 | 8x50 | G.H5 | N | 372 | G.H5.24 |
Van-der-waals | H8 | F | 313 | 8x50 | G.H5 | N | 372 | G.H5.24 |
Polar | TM5 | S | 229 | 5x68 | G.H5 | R | 360 | G.H5.12 |
Hydrophobic | TM5 | S | 229 | 5x68 | G.H5 | R | 360 | G.H5.12 |
Van-der-waals | TM5 | S | 229 | 5x68 | G.H5 | R | 360 | G.H5.12 |
Hydrophobic | ICL2 | V | 142 | 34x54 | G.hns1 | R | 40 | G.hns1.02 |
Van-der-waals | ICL2 | V | 142 | 34x54 | G.hns1 | R | 40 | G.hns1.02 |
Hydrophobic | TM3 | R | 131 | 3x50 | G.H5 | I | 371 | G.H5.23 |
Hydrophobic | ICL2 | L | 138 | 34x50 | G.H5 | R | 360 | G.H5.12 |
Van-der-waals | ICL2 | L | 138 | 34x50 | G.H5 | R | 360 | G.H5.12 |
Hydrophobic | C-term | F | 332 | - | G.H2 | K | 217 | G.H2.05 |
Polar | ICL2 | G | 141 | 34x53 | G.H5 | Y | 367 | G.H5.19 |
Hydrophobic | ICL2 | G | 141 | 34x53 | G.H5 | Y | 367 | G.H5.19 |
Van-der-waals | ICL2 | G | 141 | 34x53 | G.H5 | Y | 367 | G.H5.19 |
Hydrophobic | TM5 | V | 233 | 5x72 | G.H5 | D | 361 | G.H5.13 |
Van-der-waals | TM5 | V | 233 | 5x72 | G.H5 | D | 361 | G.H5.13 |
Polar | ICL2 | V | 142 | 34x54 | G.H5 | Y | 367 | G.H5.19 |
Van-der-waals | ICL3 | F | 236 | - | G.H5 | K | 357 | G.H5.09 |
Hydrophobic | ICL2 | V | 142 | 34x54 | G.S1 | L | 43 | G.S1.02 |
Van-der-waals | ICL2 | V | 142 | 34x54 | G.S1 | L | 43 | G.S1.02 |
Hydrophobic | TM3 | I | 135 | 3x54 | G.H5 | L | 368 | G.H5.20 |
Hydrophobic | ICL2 | L | 138 | 34x50 | G.S3 | T | 202 | G.S3.01 |
Hydrophobic | TM6 | L | 246 | 6x29 | G.h4s6 | R | 338 | G.h4s6.20 |
Van-der-waals | TM6 | L | 246 | 6x29 | G.h4s6 | R | 338 | G.h4s6.20 |
Polar | H8 | D | 310 | 8x47 | G.H5 | N | 372 | G.H5.24 |
Hydrophobic | H8 | D | 310 | 8x47 | G.H5 | N | 372 | G.H5.24 |
Van-der-waals | H8 | D | 310 | 8x47 | G.H5 | N | 372 | G.H5.24 |
Hydrophobic | C-term | L | 329 | - | G.H3 | P | 265 | G.H3.16 |
Polar | C-term | H | 335 | - | G.H2 | H | 221 | G.H2.09 |
Hydrophobic | C-term | H | 335 | - | G.H2 | H | 221 | G.H2.09 |
Van-der-waals | C-term | H | 335 | - | G.H2 | H | 221 | G.H2.09 |
Hydrophobic | TM3 | K | 134 | 3x53 | G.H5 | Y | 367 | G.H5.19 |
Van-der-waals | TM3 | K | 134 | 3x53 | G.H5 | Y | 367 | G.H5.19 |
Polar | TM5 | E | 232 | 5x71 | G.H5 | K | 357 | G.H5.09 |
Hydrophobic | TM5 | E | 232 | 5x71 | G.H5 | K | 357 | G.H5.09 |
Van-der-waals | TM5 | E | 232 | 5x71 | G.H5 | K | 357 | G.H5.09 |
Polar | TM5 | S | 229 | 5x68 | G.H5 | D | 361 | G.H5.13 |
Van-der-waals | TM5 | S | 229 | 5x68 | G.H5 | D | 361 | G.H5.13 |
Hydrophobic | C-term | L | 334 | - | G.H2 | H | 221 | G.H2.09 |
Van-der-waals | C-term | L | 334 | - | G.H2 | H | 221 | G.H2.09 |
Polar | C-term | S | 344 | - | G.S2 | C | 196 | G.S2.05 |
Van-der-waals | C-term | S | 344 | - | G.S2 | C | 196 | G.S2.05 |
Polar | C-term | V | 340 | - | G.S2 | I | 192 | G.S2.01 |
Hydrophobic | ICL2 | L | 138 | 34x50 | G.H5 | V | 363 | G.H5.15 |
Van-der-waals | ICL2 | L | 138 | 34x50 | G.H5 | V | 363 | G.H5.15 |
Polar | C-term | V | 340 | - | G.S2 | E | 194 | G.S2.03 |
Van-der-waals | C-term | V | 340 | - | G.S2 | E | 194 | G.S2.03 |
Hydrophobic | TM7 | I | 309 | 7x56 | G.H5 | L | 373 | G.H5.25 |
Ionic | C-term | R | 341 | - | G.S2 | E | 194 | G.S2.03 |
Polar | C-term | R | 341 | - | G.S2 | E | 194 | G.S2.03 |
Hydrophobic | C-term | R | 341 | - | G.S2 | E | 194 | G.S2.03 |
Van-der-waals | C-term | R | 341 | - | G.S2 | E | 194 | G.S2.03 |
Polar | C-term | K | 342 | - | G.S2 | E | 194 | G.S2.03 |
Van-der-waals | C-term | K | 342 | - | G.S2 | E | 194 | G.S2.03 |
Hydrophobic | C-term | F | 332 | - | G.H2 | I | 220 | G.H2.08 |
Van-der-waals | C-term | F | 332 | - | G.H2 | I | 220 | G.H2.08 |
Polar | ICL2 | W | 143 | 34x55 | G.hns1 | R | 40 | G.hns1.02 |
Aromatic | ICL2 | W | 143 | 34x55 | G.hns1 | R | 40 | G.hns1.02 |
Hydrophobic | ICL2 | W | 143 | 34x55 | G.hns1 | R | 40 | G.hns1.02 |
Van-der-waals | ICL2 | W | 143 | 34x55 | G.hns1 | R | 40 | G.hns1.02 |
Hydrophobic | C-term | T | 339 | - | G.S2 | I | 192 | G.S2.01 |
Hydrophobic | ICL1 | R | 66 | 12x51 | G.H5 | E | 370 | G.H5.22 |
Van-der-waals | ICL1 | R | 66 | 12x51 | G.H5 | E | 370 | G.H5.22 |
Hydrophobic | C-term | T | 339 | - | G.S2 | E | 194 | G.S2.03 |
Hydrophobic | ICL2 | L | 138 | 34x50 | G.S1 | L | 43 | G.S1.02 |
Polar | TM4 | K | 145 | 4x38 | G.HN | K | 36 | G.HN.51 |
Hydrophobic | TM5 | K | 225 | 5x64 | G.H5 | R | 360 | G.H5.12 |
Hydrophobic | TM5 | V | 233 | 5x72 | G.H5 | K | 357 | G.H5.09 |
Hydrophobic | C-term | V | 346 | - | G.H1 | H | 66 | G.H1.12 |
Van-der-waals | C-term | V | 346 | - | G.H1 | H | 66 | G.H1.12 |
Hydrophobic | TM7 | I | 309 | 7x56 | G.H5 | I | 371 | G.H5.23 |
Van-der-waals | TM7 | I | 309 | 7x56 | G.H5 | I | 371 | G.H5.23 |
Hydrophobic | TM3 | I | 135 | 3x54 | G.H5 | L | 364 | G.H5.16 |
Van-der-waals | TM3 | I | 135 | 3x54 | G.H5 | L | 364 | G.H5.16 |
Hydrophobic | C-term | K | 342 | - | G.S2 | Y | 195 | G.S2.04 |
Hydrophobic | TM4 | K | 145 | 4x38 | G.hns1 | R | 40 | G.hns1.02 |
Van-der-waals | TM4 | K | 145 | 4x38 | G.hns1 | R | 40 | G.hns1.02 |
Hydrophobic | TM2 | A | 68 | 2x39 | G.H5 | I | 371 | G.H5.23 |
Hydrophobic | TM6 | L | 250 | 6x33 | G.H5 | I | 371 | G.H5.23 |
Hydrophobic | TM6 | L | 246 | 6x29 | G.H5 | L | 373 | G.H5.25 |
Van-der-waals | TM6 | L | 246 | 6x29 | G.H5 | L | 373 | G.H5.25 |
Van-der-waals | TM4 | K | 147 | 4x40 | G.hns1 | R | 40 | G.hns1.02 |
Hydrophobic | ICL2 | L | 138 | 34x50 | G.H5 | F | 356 | G.H5.08 |
Aromatic | H8 | F | 313 | 8x50 | G.h4s6 | R | 335 | G.h4s6.17 |
Hydrophobic | H8 | F | 313 | 8x50 | G.h4s6 | R | 335 | G.h4s6.17 |
Hydrophobic | TM6 | L | 250 | 6x33 | G.H5 | L | 373 | G.H5.25 |
Van-der-waals | TM6 | L | 250 | 6x33 | G.H5 | L | 373 | G.H5.25 |
Polar | H8 | C | 316 | 8x53 | G.h4s6 | K | 332 | G.h4s6.14 |
Hydrophobic | H8 | C | 316 | 8x53 | G.h4s6 | K | 332 | G.h4s6.14 |
Van-der-waals | H8 | C | 316 | 8x53 | G.h4s6 | K | 332 | G.h4s6.14 |
Polar | C-term | K | 342 | - | G.S2 | C | 196 | G.S2.05 |
Hydrophobic | C-term | T | 336 | - | G.H2 | H | 221 | G.H2.09 |
Hydrophobic | C-term | V | 337 | - | G.H2 | K | 218 | G.H2.06 |
Hydrophobic | ICL2 | V | 142 | 34x54 | G.h2s4 | I | 227 | G.h2s4.05 |
Hydrophobic | C-term | R | 341 | - | G.HN | Q | 35 | G.HN.50 |
Van-der-waals | C-term | R | 341 | - | G.HN | Q | 35 | G.HN.50 |
Ionic | C-term | R | 341 | - | G.hns1 | D | 39 | G.hns1.01 |
Polar | C-term | R | 341 | - | G.hns1 | D | 39 | G.hns1.01 |
Van-der-waals | C-term | R | 341 | - | G.hns1 | D | 39 | G.hns1.01 |
Polar | ICL2 | S | 139 | 34x51 | G.S3 | T | 202 | G.S3.01 |
Hydrophobic | TM6 | L | 246 | 6x29 | G.H5 | L | 368 | G.H5.20 |
Van-der-waals | TM6 | L | 246 | 6x29 | G.H5 | L | 368 | G.H5.20 |
Ionic | C-term | R | 341 | - | G.S1 | E | 42 | G.S1.01 |
Polar | C-term | R | 341 | - | G.HN | Q | 38 | G.HN.53 |
Van-der-waals | C-term | R | 341 | - | G.HN | Q | 38 | G.HN.53 |
Hydrophobic | TM6 | L | 246 | 6x29 | G.H5 | L | 374 | G.H5.26 |
Van-der-waals | TM6 | L | 246 | 6x29 | G.H5 | L | 374 | G.H5.26 |
Van-der-waals | C-term | V | 346 | - | G.S2 | S | 198 | G.S2.07 |
Hydrophobic | C-term | V | 337 | - | G.S2 | I | 192 | G.S2.01 |
Hydrophobic | TM6 | V | 253 | 6x36 | G.H5 | L | 373 | G.H5.25 |
Van-der-waals | TM6 | V | 253 | 6x36 | G.H5 | L | 373 | G.H5.25 |
Polar | ICL2 | S | 139 | 34x51 | G.s2s3 | K | 201 | G.s2s3.02 |
Hydrophobic | C-term | V | 346 | - | G.h1ha | G | 67 | G.h1ha.01 |
Van-der-waals | C-term | V | 346 | - | G.h1ha | G | 67 | G.h1ha.01 |
Hydrophobic | C-term | R | 341 | - | G.S3 | R | 205 | G.S3.04 |
Van-der-waals | C-term | R | 341 | - | G.S3 | R | 205 | G.S3.04 |
Hydrophobic | TM7 | I | 309 | 7x56 | G.H5 | N | 372 | G.H5.24 |
Van-der-waals | TM7 | I | 309 | 7x56 | G.H5 | N | 372 | G.H5.24 |
Hydrophobic | TM6 | L | 250 | 6x33 | G.H5 | L | 368 | G.H5.20 |
Van-der-waals | TM6 | L | 250 | 6x33 | G.H5 | L | 368 | G.H5.20 |
Ionic | TM5 | E | 232 | 5x71 | G.H5 | R | 360 | G.H5.12 |
Polar | TM5 | E | 232 | 5x71 | G.H5 | R | 360 | G.H5.12 |
Hydrophobic | TM5 | E | 232 | 5x71 | G.H5 | R | 360 | G.H5.12 |
Van-der-waals | TM5 | E | 232 | 5x71 | G.H5 | R | 360 | G.H5.12 |