Gi1 - OPN5 complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gi/o

DATE

2023-09-15

3D VIEW

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Tertiary structure confidence

(pLDDT score) avg.: 81.6

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.7
iPTM Score: 0.7
PAE mean: 12.5


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Polar TM3 R 131 3x50 G.H5 C 351 G.H5.23
Hydrophobic TM3 R 131 3x50 G.H5 C 351 G.H5.23
Van-der-waals TM3 R 131 3x50 G.H5 C 351 G.H5.23
Hydrophobic ICL2 L 138 34x50 G.H5 I 343 G.H5.15
Hydrophobic ICL2 L 138 34x50 G.H5 T 340 G.H5.12
Ionic TM4 K 147 4x40 G.HN E 28 G.HN.52
Polar TM4 K 147 4x40 G.HN E 28 G.HN.52
Polar TM4 K 145 4x38 G.HN R 24 G.HN.48
Van-der-waals TM4 K 145 4x38 G.HN R 24 G.HN.48
Ionic ICL1 R 66 12x51 G.H5 D 350 G.H5.22
Polar ICL1 R 66 12x51 G.H5 D 350 G.H5.22
Hydrophobic ICL1 R 66 12x51 G.H5 D 350 G.H5.22
Van-der-waals ICL1 R 66 12x51 G.H5 D 350 G.H5.22
Hydrophobic TM6 L 246 6x29 G.H5 K 345 G.H5.17
Van-der-waals TM6 L 246 6x29 G.H5 K 345 G.H5.17
Hydrophobic ICL2 V 142 34x54 G.hns1 R 32 G.hns1.03
Van-der-waals ICL2 V 142 34x54 G.hns1 R 32 G.hns1.03
Hydrophobic TM7 I 309 7x56 G.H5 L 353 G.H5.25
Hydrophobic TM5 V 226 5x65 G.H5 I 344 G.H5.16
Hydrophobic TM6 S 243 6x26 G.H5 K 345 G.H5.17
Hydrophobic TM3 K 134 3x53 G.H5 C 351 G.H5.23
Hydrophobic ICL2 W 143 34x55 G.hns1 R 32 G.hns1.03
Van-der-waals ICL2 W 143 34x55 G.hns1 R 32 G.hns1.03
Hydrophobic TM5 I 222 5x61 G.H5 L 348 G.H5.20
Hydrophobic TM4 K 147 4x40 G.HN R 24 G.HN.48
Van-der-waals TM4 K 147 4x40 G.HN R 24 G.HN.48
Hydrophobic TM6 V 253 6x36 G.H5 L 353 G.H5.25
Van-der-waals TM6 V 253 6x36 G.H5 L 353 G.H5.25
Hydrophobic ICL2 L 138 34x50 G.S3 L 194 G.S3.01
Van-der-waals ICL2 L 138 34x50 G.S3 L 194 G.S3.01
Hydrophobic TM4 K 145 4x38 G.HN G 27 G.HN.51
Hydrophobic TM5 V 233 5x72 G.S6 Y 320 G.S6.02
Hydrophobic TM6 I 240 6x23 G.S6 Y 320 G.S6.02
Hydrophobic TM3 R 131 3x50 G.H5 L 353 G.H5.25
Hydrophobic TM7 I 309 7x56 G.H5 G 352 G.H5.24
Van-der-waals TM7 I 309 7x56 G.H5 G 352 G.H5.24
Hydrophobic TM3 I 135 3x54 G.H5 I 344 G.H5.16
Hydrophobic TM3 I 135 3x54 G.H5 L 353 G.H5.25
Hydrophobic TM5 V 233 5x72 G.H5 A 338 G.H5.10
Hydrophobic H8 F 313 8x50 G.H5 F 354 G.H5.26
Hydrophobic TM5 K 225 5x64 G.H5 I 344 G.H5.16
Van-der-waals TM5 K 225 5x64 G.H5 I 344 G.H5.16
Hydrophobic TM6 L 250 6x33 G.H5 L 353 G.H5.25
Van-der-waals TM6 L 250 6x33 G.H5 L 353 G.H5.25
Polar TM6 S 242 6x25 G.h4s6 E 318 G.h4s6.12
Hydrophobic TM6 S 242 6x25 G.h4s6 E 318 G.h4s6.12
Van-der-waals TM6 S 242 6x25 G.h4s6 E 318 G.h4s6.12
Hydrophobic TM5 V 233 5x72 G.H5 D 341 G.H5.13
Van-der-waals TM5 V 233 5x72 G.H5 D 341 G.H5.13
Hydrophobic TM6 I 240 6x23 G.h4s6 E 318 G.h4s6.12
Van-der-waals TM6 I 240 6x23 G.h4s6 E 318 G.h4s6.12
Hydrophobic TM6 L 250 6x33 G.H5 L 348 G.H5.20
Van-der-waals TM6 L 250 6x33 G.H5 L 348 G.H5.20
Hydrophobic TM3 I 135 3x54 G.H5 N 347 G.H5.19
Polar TM3 K 134 3x53 G.H5 N 347 G.H5.19
Van-der-waals TM3 K 134 3x53 G.H5 N 347 G.H5.19
Hydrophobic ICL2 S 139 34x51 G.s2s3 D 193 G.s2s3.02
Van-der-waals ICL2 S 139 34x51 G.s2s3 D 193 G.s2s3.02
Polar ICL2 S 139 34x51 G.hns1 R 32 G.hns1.03
Hydrophobic ICL2 W 143 34x55 G.HN E 28 G.HN.52
Hydrophobic ICL2 V 142 34x54 G.hns1 A 31 G.hns1.02
Van-der-waals ICL2 V 142 34x54 G.hns1 A 31 G.hns1.02
Hydrophobic TM5 V 226 5x65 G.H5 L 348 G.H5.20
Hydrophobic TM5 S 229 5x68 G.H5 I 344 G.H5.16
Van-der-waals TM5 S 229 5x68 G.H5 I 344 G.H5.16
Hydrophobic ICL2 L 138 34x50 G.H5 I 344 G.H5.16
Hydrophobic TM5 V 233 5x72 G.H5 D 337 G.H5.09
Hydrophobic TM6 L 246 6x29 G.H5 F 354 G.H5.26
Van-der-waals TM6 L 246 6x29 G.H5 F 354 G.H5.26
Hydrophobic ICL2 S 139 34x51 G.S3 L 194 G.S3.01
Ionic C-term E 352 - G.hfs2 K 180 G.hfs2.04
Polar TM5 S 229 5x68 G.H5 D 341 G.H5.13
Hydrophobic TM5 S 229 5x68 G.H5 D 341 G.H5.13
Van-der-waals TM5 S 229 5x68 G.H5 D 341 G.H5.13
Ionic TM4 K 145 4x38 G.HN E 28 G.HN.52
Polar TM4 K 145 4x38 G.HN E 28 G.HN.52
Hydrophobic TM4 K 145 4x38 G.HN E 28 G.HN.52
Van-der-waals TM4 K 145 4x38 G.HN E 28 G.HN.52
Polar ICL3 D 237 - G.H4 Q 304 G.H4.12
Van-der-waals ICL3 D 237 - G.H4 Q 304 G.H4.12
Hydrophobic TM5 E 232 5x71 G.H5 D 337 G.H5.09
Hydrophobic C-term F 332 - G.H2 I 212 G.H2.08
Hydrophobic TM6 L 246 6x29 G.H5 L 348 G.H5.20
Ionic TM5 E 232 5x71 G.s2s3 K 192 G.s2s3.01
Polar TM5 E 232 5x71 G.s2s3 K 192 G.s2s3.01
Polar TM5 S 230 5x69 G.H5 D 341 G.H5.13
Hydrophobic H8 F 313 8x50 G.H5 K 349 G.H5.21
Van-der-waals H8 F 313 8x50 G.H5 K 349 G.H5.21
Van-der-waals H8 D 310 8x47 G.H5 G 352 G.H5.24
Hydrophobic C-term L 334 - G.H2 I 212 G.H2.08
Polar TM6 R 239 6x22 G.H4 Q 304 G.H4.12
Polar TM6 K 249 6x32 G.H5 F 354 G.H5.26
Hydrophobic TM6 K 249 6x32 G.H5 F 354 G.H5.26
Van-der-waals TM6 K 249 6x32 G.H5 F 354 G.H5.26
Hydrophobic ICL3 F 236 - G.S6 H 322 G.S6.04
Van-der-waals ICL3 F 236 - G.S6 H 322 G.S6.04
Aromatic ICL3 F 236 - G.H5 F 334 G.H5.06
Hydrophobic ICL3 F 236 - G.H5 F 334 G.H5.06
Van-der-waals ICL3 F 236 - G.H5 F 334 G.H5.06
Hydrophobic TM3 I 135 3x54 G.H5 L 348 G.H5.20
Van-der-waals TM3 I 135 3x54 G.H5 L 348 G.H5.20