Gq - OPN5 complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gq/11

DATE

2023-09-15

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

(pLDDT score) avg.: 82.5

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.7
iPTM Score: 0.7
PAE mean: 12.7


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic TM5 E 232 5x71 G.H5 A 342 G.H5.09
Polar TM3 R 131 3x50 G.H5 Y 356 G.H5.23
Hydrophobic TM3 R 131 3x50 G.H5 Y 356 G.H5.23
Van-der-waals TM3 R 131 3x50 G.H5 Y 356 G.H5.23
Hydrophobic ICL2 L 138 34x50 G.H5 K 345 G.H5.12
Aromatic ICL3 F 236 - G.H5 F 339 G.H5.06
Hydrophobic ICL3 F 236 - G.H5 F 339 G.H5.06
Van-der-waals ICL3 F 236 - G.H5 F 339 G.H5.06
Polar TM3 K 134 3x53 G.H5 N 352 G.H5.19
Hydrophobic TM3 K 134 3x53 G.H5 N 352 G.H5.19
Van-der-waals TM3 K 134 3x53 G.H5 N 352 G.H5.19
Hydrophobic TM5 V 233 5x72 G.H5 D 346 G.H5.13
Hydrophobic ICL3 F 236 - G.H5 R 338 G.H5.05
Hydrophobic TM6 L 246 6x29 G.H5 L 353 G.H5.20
Van-der-waals TM6 L 246 6x29 G.H5 L 353 G.H5.20
Hydrophobic TM5 S 229 5x68 G.H5 L 349 G.H5.16
Hydrophobic TM6 I 240 6x23 G.S6 I 324 G.S6.01
Polar ICL3 D 237 - G.S6 S 326 G.S6.03
Hydrophobic ICL3 D 237 - G.S6 S 326 G.S6.03
Van-der-waals ICL3 D 237 - G.S6 S 326 G.S6.03
Hydrophobic C-term L 334 - G.H2 R 214 G.H2.05
Hydrophobic TM5 K 225 5x64 G.H5 K 345 G.H5.12
Van-der-waals TM5 K 225 5x64 G.H5 K 345 G.H5.12
Hydrophobic ICL3 F 236 - G.H5 A 342 G.H5.09
Ionic TM6 R 239 6x22 G.H4 E 307 G.H4.09
Polar TM6 R 239 6x22 G.H4 E 307 G.H4.09
Polar TM7 I 309 7x56 G.H5 N 357 G.H5.24
Hydrophobic TM7 I 309 7x56 G.H5 N 357 G.H5.24
Van-der-waals TM7 I 309 7x56 G.H5 N 357 G.H5.24
Hydrophobic TM3 I 135 3x54 G.H5 N 352 G.H5.19
Hydrophobic TM5 V 226 5x65 G.H5 L 349 G.H5.16
Hydrophobic TM3 I 135 3x54 G.H5 L 349 G.H5.16
Hydrophobic TM6 K 249 6x32 G.H5 V 359 G.H5.26
Hydrophobic ICL2 L 138 34x50 G.H5 I 348 G.H5.15
Van-der-waals ICL2 L 138 34x50 G.H5 I 348 G.H5.15
Hydrophobic TM5 K 225 5x64 G.H5 L 349 G.H5.16
Hydrophobic TM3 I 135 3x54 G.H5 L 353 G.H5.20
Ionic TM5 E 232 5x71 G.H5 K 345 G.H5.12
Polar TM5 E 232 5x71 G.H5 K 345 G.H5.12
Van-der-waals TM5 E 232 5x71 G.H5 K 345 G.H5.12
Polar C-term V 337 - G.H2 R 214 G.H2.05
Van-der-waals C-term V 337 - G.H2 R 214 G.H2.05
Polar TM6 R 239 6x22 G.S6 S 326 G.S6.03
Van-der-waals TM6 R 239 6x22 G.S6 S 326 G.S6.03
Hydrophobic TM6 I 257 6x40 G.H5 L 358 G.H5.25
Hydrophobic TM6 L 250 6x33 G.H5 L 353 G.H5.20
Hydrophobic TM5 V 233 5x72 G.H5 A 342 G.H5.09
Hydrophobic TM3 I 135 3x54 G.H5 L 358 G.H5.25
Polar TM3 D 130 3x49 G.H5 Y 356 G.H5.23
Van-der-waals TM3 D 130 3x49 G.H5 Y 356 G.H5.23
Hydrophobic TM5 I 222 5x61 G.H5 L 353 G.H5.20
Hydrophobic ICL2 V 142 34x54 G.hns1 R 38 G.hns1.03
Van-der-waals ICL2 V 142 34x54 G.hns1 R 38 G.hns1.03
Hydrophobic TM5 Y 219 5x58 G.H5 L 358 G.H5.25
Hydrophobic TM6 L 246 6x29 G.H5 Q 350 G.H5.17
Van-der-waals TM6 L 246 6x29 G.H5 Q 350 G.H5.17
Hydrophobic TM6 R 239 6x22 G.H4 L 310 G.H4.12
Van-der-waals TM6 R 239 6x22 G.H4 L 310 G.H4.12
Aromatic C-term F 332 - G.H3 Y 261 G.H3.15
Hydrophobic C-term F 332 - G.H3 Y 261 G.H3.15
Van-der-waals C-term F 332 - G.H3 Y 261 G.H3.15
Hydrophobic TM4 K 145 4x38 G.HN R 34 G.HN.52
Van-der-waals TM4 K 145 4x38 G.HN R 34 G.HN.52
Hydrophobic ICL2 V 142 34x54 G.hns1 R 37 G.hns1.02
Van-der-waals ICL2 V 142 34x54 G.hns1 R 37 G.hns1.02
Hydrophobic TM6 L 246 6x29 G.H5 V 359 G.H5.26
Van-der-waals TM6 L 246 6x29 G.H5 V 359 G.H5.26
Hydrophobic C-term K 325 - G.H3 W 263 G.H3.17
Van-der-waals C-term K 325 - G.H3 W 263 G.H3.17
Polar TM6 L 250 6x33 G.H5 L 358 G.H5.25
Hydrophobic TM6 L 250 6x33 G.H5 L 358 G.H5.25
Van-der-waals TM6 L 250 6x33 G.H5 L 358 G.H5.25
Hydrophobic C-term S 328 - G.H3 P 262 G.H3.16
Hydrophobic TM3 R 131 3x50 G.H5 L 358 G.H5.25
Hydrophobic ICL2 L 138 34x50 G.S1 L 40 G.S1.02
Polar TM5 S 229 5x68 G.H5 D 346 G.H5.13
Hydrophobic TM5 S 229 5x68 G.H5 D 346 G.H5.13
Van-der-waals TM5 S 229 5x68 G.H5 D 346 G.H5.13
Hydrophobic C-term T 339 - G.H2 R 214 G.H2.05
Van-der-waals C-term T 339 - G.H2 R 214 G.H2.05
Hydrophobic TM6 V 253 6x36 G.H5 L 358 G.H5.25
Polar H8 D 310 8x47 G.H5 N 357 G.H5.24
Hydrophobic H8 D 310 8x47 G.H5 N 357 G.H5.24
Van-der-waals H8 D 310 8x47 G.H5 N 357 G.H5.24
Polar TM3 K 134 3x53 G.H5 Y 356 G.H5.23
Hydrophobic TM3 K 134 3x53 G.H5 Y 356 G.H5.23
Van-der-waals TM3 K 134 3x53 G.H5 Y 356 G.H5.23
Hydrophobic TM6 I 240 6x23 G.S6 Y 325 G.S6.02
Van-der-waals TM6 I 240 6x23 G.S6 Y 325 G.S6.02
Hydrophobic TM6 L 250 6x33 G.H5 V 359 G.H5.26
Hydrophobic TM5 V 233 5x72 G.S6 Y 325 G.S6.02
Van-der-waals TM5 V 233 5x72 G.S6 Y 325 G.S6.02
Hydrophobic TM2 A 68 2x39 G.H5 Y 356 G.H5.23
Van-der-waals TM2 A 68 2x39 G.H5 Y 356 G.H5.23
Hydrophobic TM5 V 226 5x65 G.H5 L 353 G.H5.20
Hydrophobic ICL3 F 236 - G.S6 H 327 G.S6.04
Hydrophobic ICL2 L 138 34x50 G.S3 V 199 G.S3.01
Ionic ICL1 R 66 12x51 G.H5 E 355 G.H5.22
Polar ICL1 R 66 12x51 G.H5 E 355 G.H5.22
Hydrophobic ICL1 R 66 12x51 G.H5 E 355 G.H5.22
Van-der-waals ICL1 R 66 12x51 G.H5 E 355 G.H5.22
Hydrophobic TM6 I 240 6x23 G.h4s6 I 323 G.h4s6.20
Ionic TM3 K 134 3x53 G.H5 E 355 G.H5.22
Polar TM3 K 134 3x53 G.H5 E 355 G.H5.22
Hydrophobic TM3 K 134 3x53 G.H5 E 355 G.H5.22
Van-der-waals TM3 K 134 3x53 G.H5 E 355 G.H5.22