G12 - δ receptor complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

G12/13

DATE

2023-09-15

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

(pLDDT score) avg.: 84.7

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.8
iPTM Score: 0.7
PAE mean: 14.0


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Ionic C-term E 355 - G.H3 K 284 G.H3.16
Polar C-term E 355 - G.H3 K 284 G.H3.16
Hydrophobic C-term E 355 - G.H3 K 284 G.H3.16
Van-der-waals C-term E 355 - G.H3 K 284 G.H3.16
Hydrophobic H8 D 322 8x47 G.H5 L 380 G.H5.25
Van-der-waals H8 D 322 8x47 G.H5 L 380 G.H5.25
Hydrophobic ICL3 L 246 - G.H5 H 364 G.H5.09
Hydrophobic TM2 I 88 2x43 G.H5 L 380 G.H5.25
Van-der-waals TM2 I 88 2x43 G.H5 L 380 G.H5.25
Polar TM4 T 161 4x38 G.hns1 R 55 G.hns1.02
Hydrophobic TM4 T 161 4x38 G.hns1 R 55 G.hns1.02
Van-der-waals TM4 T 161 4x38 G.hns1 R 55 G.hns1.02
Hydrophobic TM6 K 252 6x26 G.h4s6 P 345 G.h4s6.20
Polar C-term T 352 - G.H3 K 284 G.H3.16
Van-der-waals C-term T 352 - G.H3 K 284 G.H3.16
Hydrophobic TM3 V 150 3x54 G.H5 L 375 G.H5.20
Hydrophobic TM3 R 146 3x50 G.H5 I 378 G.H5.23
Van-der-waals TM3 R 146 3x50 G.H5 I 378 G.H5.23
Hydrophobic ICL2 P 153 34x50 G.H5 L 371 G.H5.16
Hydrophobic TM2 T 84 2x39 G.H5 L 380 G.H5.25
Hydrophobic ICL2 L 157 34x54 G.H5 I 370 G.H5.15
Hydrophobic TM6 L 256 6x30 G.H5 L 375 G.H5.20
Hydrophobic TM6 I 259 6x33 G.H5 M 379 G.H5.24
Van-der-waals TM6 I 259 6x33 G.H5 M 379 G.H5.24
Hydrophobic ICL2 A 156 34x53 G.H5 N 374 G.H5.19
Van-der-waals ICL2 A 156 34x53 G.H5 N 374 G.H5.19
Hydrophobic TM6 M 262 6x36 G.H5 M 379 G.H5.24
Polar ICL2 R 160 34x57 G.H5 N 374 G.H5.19
Van-der-waals ICL2 R 160 34x57 G.H5 N 374 G.H5.19
Hydrophobic TM6 K 252 6x26 G.H5 Q 372 G.H5.17
Van-der-waals TM6 K 252 6x26 G.H5 Q 372 G.H5.17
Hydrophobic TM2 N 85 2x40 G.H5 L 380 G.H5.25
Van-der-waals TM2 N 85 2x40 G.H5 L 380 G.H5.25
Hydrophobic TM3 A 149 3x53 G.H5 I 378 G.H5.23
Van-der-waals TM3 A 149 3x53 G.H5 I 378 G.H5.23
Ionic TM6 K 252 6x26 G.H5 D 368 G.H5.13
Polar TM6 K 252 6x26 G.H5 D 368 G.H5.13
Hydrophobic TM6 K 252 6x26 G.H5 D 368 G.H5.13
Van-der-waals TM6 K 252 6x26 G.H5 D 368 G.H5.13
Hydrophobic ICL2 V 154 34x51 G.S3 I 221 G.S3.01
Van-der-waals ICL2 V 154 34x51 G.S3 I 221 G.S3.01
Ionic ICL2 D 158 34x55 G.hns1 R 56 G.hns1.03
Polar ICL2 D 158 34x55 G.hns1 R 56 G.hns1.03
Hydrophobic ICL2 D 158 34x55 G.hns1 R 56 G.hns1.03
Van-der-waals ICL2 D 158 34x55 G.hns1 R 56 G.hns1.03
Hydrophobic TM6 V 263 6x37 G.H5 I 378 G.H5.23
Hydrophobic TM6 I 259 6x33 G.H5 L 375 G.H5.20
Van-der-waals TM6 I 259 6x33 G.H5 L 375 G.H5.20
Hydrophobic TM3 V 150 3x54 G.H5 L 371 G.H5.16
Van-der-waals TM3 V 150 3x54 G.H5 L 371 G.H5.16
Hydrophobic ICL2 P 153 34x50 G.H5 I 370 G.H5.15
Van-der-waals ICL2 P 153 34x50 G.H5 I 370 G.H5.15
Hydrophobic TM6 E 251 6x25 G.h4s6 S 343 G.h4s6.12
Ionic ICL2 R 160 34x57 G.H5 D 377 G.H5.22
Polar ICL2 R 160 34x57 G.H5 D 377 G.H5.22
Hydrophobic ICL2 R 160 34x57 G.H5 D 377 G.H5.22
Van-der-waals ICL2 R 160 34x57 G.H5 D 377 G.H5.22
Polar TM2 T 82 2x37 G.H5 D 377 G.H5.22
Hydrophobic TM2 T 82 2x37 G.H5 D 377 G.H5.22
Van-der-waals TM2 T 82 2x37 G.H5 D 377 G.H5.22
Polar TM2 T 84 2x39 G.H5 D 377 G.H5.22
Polar ICL2 P 153 34x50 G.H5 N 374 G.H5.19
Hydrophobic ICL2 V 154 34x51 G.H5 K 367 G.H5.12
Hydrophobic TM5 L 240 5x65 G.H5 L 375 G.H5.20
Hydrophobic ICL2 R 160 34x57 G.H5 I 378 G.H5.23
Van-der-waals ICL2 L 157 34x54 G.hns1 R 55 G.hns1.02
Hydrophobic TM6 M 262 6x36 G.H5 I 378 G.H5.23
Van-der-waals TM6 M 262 6x36 G.H5 I 378 G.H5.23
Hydrophobic TM5 V 243 5x68 G.H5 L 371 G.H5.16
Hydrophobic ICL2 V 154 34x51 G.H5 I 370 G.H5.15
Polar C-term A 351 - G.H3 K 284 G.H3.16
Van-der-waals C-term A 351 - G.H3 K 284 G.H3.16
Hydrophobic TM3 V 150 3x54 G.H5 I 378 G.H5.23
Polar TM3 A 149 3x53 G.H5 N 374 G.H5.19
Hydrophobic TM3 A 149 3x53 G.H5 N 374 G.H5.19
Van-der-waals TM3 A 149 3x53 G.H5 N 374 G.H5.19
Hydrophobic H8 F 325 8x50 G.H5 L 380 G.H5.25