Gs - δ receptor complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gs

DATE

2023-09-15

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

(pLDDT score) avg.: 84.0

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.8
iPTM Score: 0.7
PAE mean: 16.2


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic TM6 L 256 6x30 G.H5 L 388 G.H5.20
Hydrophobic ICL2 V 154 34x51 G.H5 R 380 G.H5.12
Polar ICL3 S 247 - G.H5 R 385 G.H5.17
Hydrophobic ICL3 S 247 - G.H5 R 385 G.H5.17
Van-der-waals ICL3 S 247 - G.H5 R 385 G.H5.17
Hydrophobic ICL2 V 154 34x51 G.S1 H 41 G.S1.02
Hydrophobic H8 D 322 8x47 G.H5 E 392 G.H5.24
Van-der-waals H8 D 322 8x47 G.H5 E 392 G.H5.24
Polar ICL2 P 153 34x50 G.H5 H 387 G.H5.19
Hydrophobic ICL2 P 153 34x50 G.H5 H 387 G.H5.19
Van-der-waals ICL2 P 153 34x50 G.H5 H 387 G.H5.19
Hydrophobic ICL2 L 157 34x54 G.H5 I 383 G.H5.15
Van-der-waals TM7 L 321 7x56 G.H5 E 392 G.H5.24
Polar TM3 R 146 3x50 G.H5 Y 391 G.H5.23
Hydrophobic TM3 R 146 3x50 G.H5 Y 391 G.H5.23
Polar ICL2 R 160 34x57 G.H5 Y 391 G.H5.23
Hydrophobic ICL2 R 160 34x57 G.H5 Y 391 G.H5.23
Van-der-waals ICL2 R 160 34x57 G.H5 Y 391 G.H5.23
Polar TM6 S 255 6x29 G.H5 L 393 G.H5.25
Hydrophobic TM6 K 252 6x26 G.h4s6 Y 358 G.h4s6.20
Van-der-waals TM6 K 252 6x26 G.h4s6 Y 358 G.h4s6.20
Van-der-waals TM5 V 243 5x68 G.H5 D 381 G.H5.13
Hydrophobic TM6 M 262 6x36 G.H5 E 392 G.H5.24
Polar TM5 R 239 5x64 G.H5 Q 384 G.H5.16
Van-der-waals TM5 R 239 5x64 G.H5 Q 384 G.H5.16
Hydrophobic ICL2 A 156 34x53 G.H5 H 387 G.H5.19
Van-der-waals ICL2 A 156 34x53 G.H5 H 387 G.H5.19
Polar ICL2 R 160 34x57 G.H5 H 387 G.H5.19
Aromatic ICL2 R 160 34x57 G.H5 H 387 G.H5.19
Van-der-waals ICL2 R 160 34x57 G.H5 H 387 G.H5.19
Hydrophobic ICL2 L 157 34x54 G.H5 M 386 G.H5.18
Hydrophobic TM6 I 259 6x33 G.H5 L 394 G.H5.26
Van-der-waals TM6 I 259 6x33 G.H5 L 394 G.H5.26
Polar TM3 V 150 3x54 G.H5 Q 384 G.H5.16
Hydrophobic TM3 V 150 3x54 G.H5 Q 384 G.H5.16
Van-der-waals TM3 V 150 3x54 G.H5 Q 384 G.H5.16
Hydrophobic TM6 V 263 6x37 G.H5 L 393 G.H5.25
Van-der-waals TM6 V 263 6x37 G.H5 L 393 G.H5.25
Hydrophobic ICL2 V 154 34x51 G.H5 I 383 G.H5.15
Hydrophobic ICL2 P 153 34x50 G.H5 R 380 G.H5.12
Van-der-waals ICL2 P 153 34x50 G.H5 R 380 G.H5.12
Hydrophobic TM2 T 84 2x39 G.H5 Y 391 G.H5.23
Van-der-waals TM2 T 84 2x39 G.H5 Y 391 G.H5.23
Hydrophobic TM5 V 243 5x68 G.H5 Q 384 G.H5.16
Van-der-waals TM5 V 243 5x68 G.H5 Q 384 G.H5.16
Hydrophobic ICL2 P 153 34x50 G.H5 I 383 G.H5.15
Van-der-waals ICL2 P 153 34x50 G.H5 I 383 G.H5.15
Hydrophobic ICL2 L 157 34x54 G.H5 H 387 G.H5.19
Hydrophobic ICL2 L 157 34x54 G.S1 H 41 G.S1.02
Van-der-waals ICL2 L 157 34x54 G.S1 H 41 G.S1.02
Hydrophobic TM5 L 240 5x65 G.H5 L 388 G.H5.20
Hydrophobic TM6 M 262 6x36 G.H5 L 393 G.H5.25
Van-der-waals TM6 M 262 6x36 G.H5 L 393 G.H5.25
Hydrophobic ICL2 V 154 34x51 G.S3 V 217 G.S3.01
Van-der-waals ICL2 V 154 34x51 G.S3 V 217 G.S3.01
Hydrophobic TM6 I 259 6x33 G.H5 L 393 G.H5.25
Van-der-waals TM6 I 259 6x33 G.H5 L 393 G.H5.25
Hydrophobic ICL2 P 153 34x50 G.H5 Q 384 G.H5.16
Ionic C-term E 355 - G.h3s5 R 283 G.h3s5.01
Polar C-term E 355 - G.h3s5 R 283 G.h3s5.01
Hydrophobic C-term E 355 - G.h3s5 R 283 G.h3s5.01
Van-der-waals C-term E 355 - G.h3s5 R 283 G.h3s5.01
Hydrophobic TM6 I 259 6x33 G.H5 L 388 G.H5.20
Ionic C-term E 355 - G.h4s6 R 356 G.h4s6.12
Polar C-term E 355 - G.h4s6 R 356 G.h4s6.12
Van-der-waals C-term E 355 - G.h4s6 R 356 G.h4s6.12
Polar H8 E 323 8x48 G.H5 E 392 G.H5.24
Hydrophobic H8 E 323 8x48 G.H5 E 392 G.H5.24
Van-der-waals H8 E 323 8x48 G.H5 E 392 G.H5.24
Hydrophobic TM6 K 252 6x26 G.H5 R 385 G.H5.17
Van-der-waals TM6 K 252 6x26 G.H5 R 385 G.H5.17
Polar TM3 D 145 3x49 G.H5 Y 391 G.H5.23
Hydrophobic TM3 D 145 3x49 G.H5 Y 391 G.H5.23
Van-der-waals TM3 D 145 3x49 G.H5 Y 391 G.H5.23
Polar H8 N 324 8x49 G.H5 E 392 G.H5.24
Van-der-waals H8 N 324 8x49 G.H5 E 392 G.H5.24
Hydrophobic TM6 S 255 6x29 G.H5 L 394 G.H5.26
Van-der-waals TM6 S 255 6x29 G.H5 L 394 G.H5.26
Hydrophobic TM3 V 150 3x54 G.H5 L 388 G.H5.20
Van-der-waals TM3 V 150 3x54 G.H5 L 388 G.H5.20
Polar TM3 A 149 3x53 G.H5 H 387 G.H5.19
Hydrophobic TM3 A 149 3x53 G.H5 H 387 G.H5.19
Van-der-waals TM3 A 149 3x53 G.H5 H 387 G.H5.19
Polar ICL2 R 160 34x57 G.H5 Q 390 G.H5.22
Hydrophobic TM3 A 149 3x53 G.H5 Y 391 G.H5.23
Van-der-waals TM3 A 149 3x53 G.H5 Y 391 G.H5.23