G12 - μ receptor complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

G12/13

DATE

2023-09-15

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

(pLDDT score) avg.: 82.2

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.7
iPTM Score: 0.7
PAE mean: 14.7


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Polar ICL2 P 174 34x50 G.H5 N 374 G.H5.19
Hydrophobic TM5 V 264 5x68 G.H5 D 368 G.H5.13
Hydrophobic TM3 V 171 3x54 G.H5 I 378 G.H5.23
Hydrophobic TM3 R 167 3x50 G.H5 L 380 G.H5.25
Polar TM3 R 167 3x50 G.H5 I 378 G.H5.23
Hydrophobic TM3 R 167 3x50 G.H5 I 378 G.H5.23
Van-der-waals TM3 R 167 3x50 G.H5 I 378 G.H5.23
Hydrophobic ICL3 M 266 - G.S6 F 347 G.S6.02
Van-der-waals ICL3 M 266 - G.S6 F 347 G.S6.02
Ionic ICL2 R 181 34x57 G.H5 D 377 G.H5.22
Polar ICL2 R 181 34x57 G.H5 D 377 G.H5.22
Hydrophobic ICL2 R 181 34x57 G.H5 D 377 G.H5.22
Van-der-waals ICL2 R 181 34x57 G.H5 D 377 G.H5.22
Hydrophobic TM3 V 171 3x54 G.H5 L 371 G.H5.16
Van-der-waals TM3 V 171 3x54 G.H5 L 371 G.H5.16
Hydrophobic ICL3 L 267 - G.H5 L 375 G.H5.20
Hydrophobic TM2 I 109 2x43 G.H5 M 379 G.H5.24
Van-der-waals TM2 I 109 2x43 G.H5 M 379 G.H5.24
Hydrophobic H8 D 342 8x47 G.H5 M 379 G.H5.24
Van-der-waals H8 D 342 8x47 G.H5 M 379 G.H5.24
Hydrophobic TM6 M 283 6x36 G.H5 L 380 G.H5.25
Van-der-waals TM6 M 283 6x36 G.H5 L 380 G.H5.25
Hydrophobic TM5 M 257 5x61 G.H5 L 380 G.H5.25
Van-der-waals TM5 M 257 5x61 G.H5 L 380 G.H5.25
Hydrophobic ICL2 V 175 34x51 G.S3 I 221 G.S3.01
Van-der-waals ICL2 V 175 34x51 G.S3 I 221 G.S3.01
Ionic ICL2 D 179 34x55 G.hns1 R 56 G.hns1.03
Polar ICL2 D 179 34x55 G.hns1 R 56 G.hns1.03
Hydrophobic ICL2 D 179 34x55 G.hns1 R 56 G.hns1.03
Van-der-waals ICL2 D 179 34x55 G.hns1 R 56 G.hns1.03
Polar TM3 R 167 3x50 G.H5 M 379 G.H5.24
Hydrophobic ICL2 R 181 34x57 G.H5 I 378 G.H5.23
Van-der-waals ICL2 R 181 34x57 G.H5 I 378 G.H5.23
Hydrophobic TM2 T 105 2x39 G.H5 M 379 G.H5.24
Hydrophobic TM6 V 284 6x37 G.H5 L 380 G.H5.25
Van-der-waals TM6 R 279 6x32 G.H5 Q 381 G.H5.26
Hydrophobic ICL2 P 174 34x50 G.H5 L 371 G.H5.16
Hydrophobic ICL2 A 177 34x53 G.H5 N 374 G.H5.19
Van-der-waals ICL2 A 177 34x53 G.H5 N 374 G.H5.19
Hydrophobic H8 F 345 8x50 G.H5 M 379 G.H5.24
Hydrophobic TM2 T 105 2x39 G.H5 I 378 G.H5.23
Hydrophobic TM2 N 106 2x40 G.H5 M 379 G.H5.24
Hydrophobic ICL3 M 266 - G.H5 Q 372 G.H5.17
Van-der-waals ICL3 M 266 - G.H5 Q 372 G.H5.17
Hydrophobic ICL3 M 266 - G.h4s6 P 345 G.h4s6.20
Hydrophobic TM6 M 283 6x36 G.H5 M 379 G.H5.24
Van-der-waals TM6 M 283 6x36 G.H5 M 379 G.H5.24
Polar H8 N 344 8x49 G.H5 K 376 G.H5.21
Hydrophobic TM6 I 280 6x33 G.H5 L 380 G.H5.25
Van-der-waals TM6 I 280 6x33 G.H5 L 380 G.H5.25
Hydrophobic ICL2 L 178 34x54 G.H5 I 370 G.H5.15
Hydrophobic ICL2 V 175 34x51 G.H5 K 367 G.H5.12
Ionic TM5 R 260 5x64 G.H5 D 368 G.H5.13
Polar ICL3 M 266 - G.H5 D 368 G.H5.13
Hydrophobic ICL3 M 266 - G.H5 D 368 G.H5.13
Van-der-waals ICL3 M 266 - G.H5 D 368 G.H5.13
Hydrophobic TM5 V 264 5x68 G.H5 L 371 G.H5.16
Van-der-waals TM5 V 264 5x68 G.H5 L 371 G.H5.16
Polar ICL2 R 181 34x57 G.H5 N 374 G.H5.19
Van-der-waals ICL2 R 181 34x57 G.H5 N 374 G.H5.19
Hydrophobic TM4 T 182 4x38 G.hns1 R 55 G.hns1.02
Van-der-waals TM4 T 182 4x38 G.hns1 R 55 G.hns1.02
Polar TM3 A 170 3x53 G.H5 N 374 G.H5.19
Hydrophobic TM3 A 170 3x53 G.H5 N 374 G.H5.19
Van-der-waals TM3 A 170 3x53 G.H5 N 374 G.H5.19
Hydrophobic TM3 A 170 3x53 G.H5 I 378 G.H5.23
Van-der-waals TM3 A 170 3x53 G.H5 I 378 G.H5.23
Hydrophobic ICL2 P 174 34x50 G.H5 I 370 G.H5.15
Van-der-waals ICL2 P 174 34x50 G.H5 I 370 G.H5.15
Van-der-waals TM4 R 184 4x40 G.HN R 52 G.HN.52
Polar TM2 T 105 2x39 G.H5 D 377 G.H5.22
Van-der-waals TM2 T 105 2x39 G.H5 D 377 G.H5.22
Hydrophobic H8 E 343 8x48 G.H5 Q 381 G.H5.26
Van-der-waals H8 E 343 8x48 G.H5 Q 381 G.H5.26
Hydrophobic TM5 L 261 5x65 G.H5 L 375 G.H5.20
Hydrophobic TM6 I 280 6x33 G.H5 Q 381 G.H5.26
Hydrophobic TM3 V 171 3x54 G.H5 L 375 G.H5.20