Go - NOP receptor complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gi/o

DATE

2023-09-15

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

(pLDDT score) avg.: 86.4

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.8
iPTM Score: 0.8
PAE mean: 12.5


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Polar TM3 R 148 3x50 G.H5 C 351 G.H5.23
Hydrophobic TM3 R 148 3x50 G.H5 C 351 G.H5.23
Van-der-waals TM3 R 148 3x50 G.H5 C 351 G.H5.23
Hydrophobic TM5 L 242 5x65 G.H5 I 344 G.H5.16
Hydrophobic ICL2 I 156 34x51 G.s2s3 N 194 G.s2s3.02
Van-der-waals ICL2 I 156 34x51 G.s2s3 N 194 G.s2s3.02
Van-der-waals ICL2 I 156 34x51 G.s2s3 K 193 G.s2s3.01
Polar ICL3 L 247 - G.H5 D 341 G.H5.13
Hydrophobic ICL3 L 247 - G.H5 D 341 G.H5.13
Van-der-waals ICL3 L 247 - G.H5 D 341 G.H5.13
Polar TM2 T 86 2x39 G.H5 C 351 G.H5.23
Hydrophobic TM2 T 86 2x39 G.H5 C 351 G.H5.23
Hydrophobic TM3 I 152 3x54 G.H5 L 353 G.H5.25
Ionic C-term R 368 - G.H2 E 208 G.H2.03
Polar C-term R 368 - G.H2 E 208 G.H2.03
Hydrophobic TM6 I 261 6x33 G.H5 L 348 G.H5.20
Hydrophobic ICL2 P 155 34x50 G.H5 I 344 G.H5.16
Polar C-term A 370 - G.s4h3 E 237 G.s4h3.10
Hydrophobic C-term A 370 - G.s4h3 E 237 G.s4h3.10
Van-der-waals C-term A 370 - G.s4h3 E 237 G.s4h3.10
Hydrophobic TM6 I 261 6x33 G.H5 L 353 G.H5.25
Van-der-waals TM6 I 261 6x33 G.H5 L 353 G.H5.25
Polar ICL2 R 162 34x57 G.H5 N 347 G.H5.19
Van-der-waals ICL2 R 162 34x57 G.H5 N 347 G.H5.19
Van-der-waals TM6 L 264 6x36 G.H5 G 352 G.H5.24
Hydrophobic TM5 R 241 5x64 G.H5 I 344 G.H5.16
Hydrophobic ICL2 I 156 34x51 G.H5 F 336 G.H5.08
Hydrophobic ICL2 L 159 34x54 G.hns1 K 32 G.hns1.03
Hydrophobic ICL3 L 247 - G.H5 Y 354 G.H5.26
Hydrophobic ICL2 L 159 34x54 G.S3 L 195 G.S3.01
Van-der-waals ICL2 L 159 34x54 G.S3 L 195 G.S3.01
Hydrophobic TM6 I 261 6x33 G.H5 Y 354 G.H5.26
Van-der-waals TM6 I 261 6x33 G.H5 Y 354 G.H5.26
Hydrophobic TM5 V 245 5x68 G.H5 I 344 G.H5.16
Hydrophobic TM5 L 242 5x65 G.H5 L 348 G.H5.20
Hydrophobic ICL2 P 155 34x50 G.H5 T 340 G.H5.12
Van-der-waals ICL2 P 155 34x50 G.H5 T 340 G.H5.12
Hydrophobic TM3 I 152 3x54 G.H5 I 344 G.H5.16
Hydrophobic TM6 V 265 6x37 G.H5 L 353 G.H5.25
Van-der-waals TM6 V 265 6x37 G.H5 L 353 G.H5.25
Hydrophobic ICL2 L 159 34x54 G.H5 I 343 G.H5.15
Polar ICL2 R 162 34x57 G.H5 C 351 G.H5.23
Hydrophobic ICL2 R 162 34x57 G.H5 C 351 G.H5.23
Van-der-waals ICL2 R 162 34x57 G.H5 C 351 G.H5.23
Polar TM4 S 165 4x40 G.HN K 24 G.HN.48
Van-der-waals TM4 S 165 4x40 G.HN K 24 G.HN.48
Hydrophobic ICL3 L 247 - G.h4s6 E 318 G.h4s6.12
Van-der-waals ICL3 L 247 - G.h4s6 E 318 G.h4s6.12
Hydrophobic TM6 L 264 6x36 G.H5 L 353 G.H5.25
Ionic TM6 K 254 6x26 G.h4s6 E 318 G.h4s6.12
Polar TM6 K 254 6x26 G.h4s6 E 318 G.h4s6.12
Hydrophobic TM6 K 254 6x26 G.h4s6 E 318 G.h4s6.12
Van-der-waals TM6 K 254 6x26 G.h4s6 E 318 G.h4s6.12
Hydrophobic ICL3 L 248 - G.H5 L 348 G.H5.20
Hydrophobic TM5 M 238 5x61 G.H5 L 353 G.H5.25
Polar C-term A 370 - G.H2 R 206 G.H2.01
Hydrophobic C-term A 370 - G.H2 R 206 G.H2.01
Van-der-waals C-term A 370 - G.H2 R 206 G.H2.01
Polar TM3 A 151 3x53 G.H5 N 347 G.H5.19
Hydrophobic TM3 A 151 3x53 G.H5 N 347 G.H5.19
Van-der-waals TM3 A 151 3x53 G.H5 N 347 G.H5.19
Polar TM3 R 148 3x50 G.H5 G 352 G.H5.24
Polar TM6 N 257 6x29 G.H5 Y 354 G.H5.26
Hydrophobic ICL3 L 247 - G.H5 A 345 G.H5.17
Hydrophobic ICL3 L 248 - G.H5 Y 354 G.H5.26
Polar TM2 T 86 2x39 G.H5 G 350 G.H5.22
Hydrophobic ICL2 P 155 34x50 G.H5 I 343 G.H5.15
Hydrophobic TM5 V 245 5x68 G.H5 D 341 G.H5.13
Van-der-waals TM5 V 245 5x68 G.H5 D 341 G.H5.13
Hydrophobic ICL2 I 156 34x51 G.S3 L 195 G.S3.01
Ionic C-term D 355 - G.H3 K 258 G.H3.16
Polar C-term D 355 - G.H3 K 258 G.H3.16
Hydrophobic C-term D 355 - G.H3 K 258 G.H3.16
Van-der-waals C-term D 355 - G.H3 K 258 G.H3.16
Hydrophobic ICL3 L 247 - G.S6 Y 320 G.S6.02
Van-der-waals ICL3 L 247 - G.S6 Y 320 G.S6.02
Hydrophobic TM3 I 152 3x54 G.H5 L 348 G.H5.20
Van-der-waals TM3 I 152 3x54 G.H5 L 348 G.H5.20
Polar ICL3 R 246 - G.H5 D 341 G.H5.13
Van-der-waals ICL3 R 246 - G.H5 D 341 G.H5.13
Hydrophobic TM3 R 148 3x50 G.H5 L 353 G.H5.25
Van-der-waals TM3 R 148 3x50 G.H5 L 353 G.H5.25
Ionic ICL2 D 160 34x55 G.hns1 K 32 G.hns1.03
Polar ICL2 D 160 34x55 G.hns1 K 32 G.hns1.03
Hydrophobic ICL2 D 160 34x55 G.hns1 K 32 G.hns1.03
Van-der-waals ICL2 D 160 34x55 G.hns1 K 32 G.hns1.03