G13 - OPN1SW complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

G12/13

DATE

2023-09-15

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

(pLDDT score) avg.: 85.6

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.8
iPTM Score: 0.7
PAE mean: 16.3


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic TM1 L 57 1x58 G.HN M 1 G.HN.01
Van-der-waals TM1 L 57 1x58 G.HN M 1 G.HN.01
Polar H8 K 305 8x48 G.H5 Q 377 G.H5.26
Hydrophobic H8 K 305 8x48 G.H5 Q 377 G.H5.26
Van-der-waals H8 K 305 8x48 G.H5 Q 377 G.H5.26
Polar C-term Q 330 - G.H3 R 279 G.H3.16
Hydrophobic C-term Q 330 - G.H3 R 279 G.H3.16
Van-der-waals C-term Q 330 - G.H3 R 279 G.H3.16
Hydrophobic TM3 K 135 3x56 G.H5 I 366 G.H5.15
Van-der-waals TM3 K 135 3x56 G.H5 I 366 G.H5.15
Hydrophobic TM5 V 227 5x68 G.H5 D 364 G.H5.13
Van-der-waals TM5 V 227 5x68 G.H5 D 364 G.H5.13
Polar H8 K 305 8x48 G.H5 L 376 G.H5.25
Hydrophobic H8 K 305 8x48 G.H5 L 376 G.H5.25
Van-der-waals H8 K 305 8x48 G.H5 L 376 G.H5.25
Hydrophobic ICL1 R 63 12x51 G.HN F 4 G.HN.04
Van-der-waals ICL1 R 63 12x51 G.HN F 4 G.HN.04
Polar TM5 Q 231 5x72 G.H5 D 364 G.H5.13
Hydrophobic TM5 Q 231 5x72 G.H5 D 364 G.H5.13
Van-der-waals TM5 Q 231 5x72 G.H5 D 364 G.H5.13
Hydrophobic TM3 I 133 3x54 G.H5 L 371 G.H5.20
Hydrophobic TM2 L 66 2x39 G.H5 L 374 G.H5.23
Van-der-waals TM2 L 66 2x39 G.H5 L 374 G.H5.23
Polar H8 N 304 8x47 G.H5 Q 377 G.H5.26
Hydrophobic H8 N 304 8x47 G.H5 Q 377 G.H5.26
Van-der-waals H8 N 304 8x47 G.H5 Q 377 G.H5.26
Hydrophobic TM3 V 132 3x53 G.H5 L 374 G.H5.23
Van-der-waals TM3 V 132 3x53 G.H5 L 374 G.H5.23
Hydrophobic TM6 E 243 6x32 G.H5 L 376 G.H5.25
Van-der-waals TM6 E 243 6x32 G.H5 L 376 G.H5.25
Hydrophobic H8 Q 306 8x49 G.H5 Q 377 G.H5.26
Van-der-waals H8 Q 306 8x49 G.H5 Q 377 G.H5.26
Hydrophobic TM6 V 244 6x33 G.H5 L 376 G.H5.25
Hydrophobic C-term S 324 - G.h4s6 Q 339 G.h4s6.13
Polar C-term N 345 - G.s4h3 E 258 G.s4h3.10
Van-der-waals C-term N 345 - G.s4h3 E 258 G.s4h3.10
Hydrophobic TM6 V 244 6x33 G.H5 M 375 G.H5.24
Polar TM3 V 132 3x53 G.H5 N 370 G.H5.19
Hydrophobic TM3 V 132 3x53 G.H5 N 370 G.H5.19
Van-der-waals TM3 V 132 3x53 G.H5 N 370 G.H5.19
Hydrophobic TM6 A 240 6x29 G.H5 L 376 G.H5.25
Polar TM3 R 129 3x50 G.H5 L 374 G.H5.23
Hydrophobic TM3 R 129 3x50 G.H5 L 374 G.H5.23
Van-der-waals TM3 R 129 3x50 G.H5 L 374 G.H5.23
Hydrophobic TM3 I 133 3x54 G.H5 N 370 G.H5.19
Hydrophobic TM6 V 248 6x37 G.H5 M 375 G.H5.24
Hydrophobic TM6 M 247 6x36 G.H5 M 375 G.H5.24
Van-der-waals TM6 M 247 6x36 G.H5 M 375 G.H5.24
Polar ICL2 R 141 34x55 G.hns1 K 46 G.hns1.02
Hydrophobic ICL2 R 141 34x55 G.hns1 K 46 G.hns1.02
Van-der-waals ICL2 R 141 34x55 G.hns1 K 46 G.hns1.02
Hydrophobic ICL1 K 60 12x48 G.HN F 4 G.HN.04
Hydrophobic TM1 R 58 1x59 G.HN M 1 G.HN.01
Hydrophobic TM5 L 224 5x65 G.H5 L 371 G.H5.20
Van-der-waals TM5 L 224 5x65 G.H5 L 371 G.H5.20
Hydrophobic TM6 A 240 6x29 G.H5 H 368 G.H5.17
Hydrophobic TM6 V 244 6x33 G.H5 L 371 G.H5.20
Polar C-term S 335 - G.H2 K 231 G.H2.05
Van-der-waals C-term S 335 - G.H2 K 231 G.H2.05
Hydrophobic TM3 I 133 3x54 G.H5 L 367 G.H5.16
Van-der-waals TM3 I 133 3x54 G.H5 L 367 G.H5.16
Hydrophobic TM3 I 133 3x54 G.H5 L 374 G.H5.23
Van-der-waals TM3 I 133 3x54 G.H5 L 374 G.H5.23
Hydrophobic TM3 R 129 3x50 G.H5 M 375 G.H5.24
Van-der-waals TM3 R 129 3x50 G.H5 M 375 G.H5.24
Hydrophobic TM5 V 227 5x68 G.H5 L 367 G.H5.16
Van-der-waals TM5 V 227 5x68 G.H5 L 367 G.H5.16
Polar C-term S 328 - G.H3 R 279 G.H3.16
Van-der-waals C-term S 328 - G.H3 R 279 G.H3.16
Hydrophobic TM3 I 133 3x54 G.H5 M 375 G.H5.24