GPCR CLASS (FAMILY)
SPECIES
G PROTEIN FAMILY
DATE
3D VIEW
Tertiary structure confidence
(pLDDT score) avg.: 84.0
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered
PTM Score: 0.6
iPTM Score: 0.6
PAE mean: 22.2
GPCR - G protein interface interactions
The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle
(Gα residues)
and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid,
hydrophobic - dashed,
ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.
GPCR-G protein backbone (bb) or sidechain (sc):
Structures
0 structures selected.
Sequence Color
Interaction frequency filter (%)
Gα,
Gβ,
Gγ,
GPCR
Interaction cut-off: strict (stick), loose (line)
Interaction type |
GPCR Segment |
AA |
Number |
Generic number |
Gα segment |
AA |
Number |
Generic number |
---|---|---|---|---|---|---|---|---|
Polar | C-term | S | 339 | - | G.HN | L | 33 | G.HN.48 |
Hydrophobic | C-term | S | 339 | - | G.HN | L | 33 | G.HN.48 |
Polar | C-term | S | 339 | - | G.HN | K | 37 | G.HN.52 |
Hydrophobic | C-term | S | 339 | - | G.HN | K | 37 | G.HN.52 |
Van-der-waals | C-term | S | 339 | - | G.HN | K | 37 | G.HN.52 |
Hydrophobic | C-term | S | 338 | - | G.HN | K | 37 | G.HN.52 |
Polar | TM6 | T | 236 | 6x25 | G.h4s6 | R | 338 | G.h4s6.20 |
Hydrophobic | TM5 | V | 227 | 5x68 | G.H5 | L | 364 | G.H5.16 |
Van-der-waals | TM5 | V | 227 | 5x68 | G.H5 | L | 364 | G.H5.16 |
Hydrophobic | TM5 | L | 224 | 5x65 | G.H5 | L | 368 | G.H5.20 |
Van-der-waals | TM5 | L | 224 | 5x65 | G.H5 | L | 368 | G.H5.20 |
Hydrophobic | TM3 | V | 132 | 3x53 | G.H5 | I | 371 | G.H5.23 |
Polar | ICL2 | R | 141 | 34x55 | G.hns1 | R | 40 | G.hns1.02 |
Hydrophobic | ICL2 | R | 141 | 34x55 | G.hns1 | R | 40 | G.hns1.02 |
Van-der-waals | ICL2 | R | 141 | 34x55 | G.hns1 | R | 40 | G.hns1.02 |
Hydrophobic | TM3 | I | 133 | 3x54 | G.H5 | I | 371 | G.H5.23 |
Van-der-waals | TM3 | I | 133 | 3x54 | G.H5 | I | 371 | G.H5.23 |
Polar | C-term | S | 335 | - | G.hns1 | R | 40 | G.hns1.02 |
Hydrophobic | C-term | S | 335 | - | G.hns1 | R | 40 | G.hns1.02 |
Van-der-waals | C-term | S | 335 | - | G.hns1 | R | 40 | G.hns1.02 |
Polar | H8 | N | 304 | 8x47 | G.H5 | N | 372 | G.H5.24 |
Hydrophobic | H8 | N | 304 | 8x47 | G.H5 | N | 372 | G.H5.24 |
Van-der-waals | H8 | N | 304 | 8x47 | G.H5 | N | 372 | G.H5.24 |
Polar | TM5 | Q | 230 | 5x71 | G.H5 | R | 360 | G.H5.12 |
Van-der-waals | TM5 | Q | 230 | 5x71 | G.H5 | R | 360 | G.H5.12 |
Hydrophobic | TM6 | V | 244 | 6x33 | G.H5 | L | 373 | G.H5.25 |
Van-der-waals | TM6 | V | 244 | 6x33 | G.H5 | L | 373 | G.H5.25 |
Polar | H8 | Q | 306 | 8x49 | G.H5 | E | 370 | G.H5.22 |
Hydrophobic | TM3 | V | 132 | 3x53 | G.H5 | Y | 367 | G.H5.19 |
Van-der-waals | TM3 | V | 132 | 3x53 | G.H5 | Y | 367 | G.H5.19 |
Ionic | TM6 | E | 243 | 6x32 | G.h4s6 | R | 335 | G.h4s6.17 |
Polar | TM6 | E | 243 | 6x32 | G.h4s6 | R | 335 | G.h4s6.17 |
Hydrophobic | TM5 | V | 227 | 5x68 | G.H5 | R | 360 | G.H5.12 |
Hydrophobic | TM6 | V | 244 | 6x33 | G.H5 | L | 368 | G.H5.20 |
Polar | C-term | S | 338 | - | G.HN | L | 33 | G.HN.48 |
Hydrophobic | C-term | S | 338 | - | G.HN | L | 33 | G.HN.48 |
Van-der-waals | C-term | S | 338 | - | G.HN | L | 33 | G.HN.48 |
Van-der-waals | C-term | T | 340 | - | G.HN | L | 33 | G.HN.48 |
Polar | C-term | V | 342 | - | G.HN | E | 34 | G.HN.49 |
Van-der-waals | C-term | V | 342 | - | G.HN | E | 34 | G.HN.49 |
Polar | C-term | E | 323 | - | G.h4s6 | S | 330 | G.h4s6.12 |
Hydrophobic | TM3 | K | 135 | 3x56 | G.H5 | Y | 367 | G.H5.19 |
Polar | C-term | T | 336 | - | G.hns1 | R | 40 | G.hns1.02 |
Hydrophobic | C-term | T | 336 | - | G.hns1 | R | 40 | G.hns1.02 |
Van-der-waals | C-term | T | 336 | - | G.hns1 | R | 40 | G.hns1.02 |
Polar | TM5 | Q | 230 | 5x71 | G.H5 | K | 357 | G.H5.09 |
Hydrophobic | TM5 | Q | 230 | 5x71 | G.H5 | K | 357 | G.H5.09 |
Van-der-waals | TM5 | Q | 230 | 5x71 | G.H5 | K | 357 | G.H5.09 |
Polar | H8 | K | 305 | 8x48 | G.H5 | L | 374 | G.H5.26 |
Hydrophobic | H8 | K | 305 | 8x48 | G.H5 | L | 374 | G.H5.26 |
Van-der-waals | H8 | K | 305 | 8x48 | G.H5 | L | 374 | G.H5.26 |
Polar | C-term | S | 338 | - | G.HN | E | 34 | G.HN.49 |
Hydrophobic | C-term | S | 338 | - | G.HN | E | 34 | G.HN.49 |
Hydrophobic | C-term | V | 337 | - | G.HN | K | 36 | G.HN.51 |
Van-der-waals | C-term | V | 337 | - | G.HN | K | 36 | G.HN.51 |
Hydrophobic | C-term | V | 337 | - | G.HN | L | 33 | G.HN.48 |
Van-der-waals | C-term | V | 337 | - | G.HN | L | 33 | G.HN.48 |
Polar | TM6 | T | 237 | 6x26 | G.h4s6 | R | 338 | G.h4s6.20 |
Hydrophobic | TM6 | T | 237 | 6x26 | G.h4s6 | R | 338 | G.h4s6.20 |
Van-der-waals | TM6 | T | 237 | 6x26 | G.h4s6 | R | 338 | G.h4s6.20 |
Hydrophobic | TM3 | I | 133 | 3x54 | G.H5 | L | 368 | G.H5.20 |
Hydrophobic | TM6 | A | 240 | 6x29 | G.H5 | L | 374 | G.H5.26 |
Van-der-waals | TM6 | A | 240 | 6x29 | G.H5 | L | 374 | G.H5.26 |
Hydrophobic | H8 | K | 305 | 8x48 | G.H5 | N | 372 | G.H5.24 |
Hydrophobic | C-term | V | 342 | - | G.HN | I | 31 | G.HN.46 |
Van-der-waals | C-term | V | 342 | - | G.HN | I | 31 | G.HN.46 |
Polar | TM5 | Q | 231 | 5x72 | G.h4s6 | R | 338 | G.h4s6.20 |
Van-der-waals | TM5 | Q | 231 | 5x72 | G.h4s6 | R | 338 | G.h4s6.20 |
Hydrophobic | TM3 | I | 133 | 3x54 | G.H5 | L | 373 | G.H5.25 |
Polar | C-term | T | 340 | - | G.HN | R | 30 | G.HN.45 |
Hydrophobic | C-term | T | 340 | - | G.HN | R | 30 | G.HN.45 |
Van-der-waals | C-term | T | 340 | - | G.HN | R | 30 | G.HN.45 |
Hydrophobic | TM5 | V | 227 | 5x68 | G.H5 | D | 361 | G.H5.13 |
Polar | C-term | V | 334 | - | G.hns1 | R | 40 | G.hns1.02 |
Hydrophobic | C-term | V | 334 | - | G.hns1 | R | 40 | G.hns1.02 |
Van-der-waals | C-term | V | 334 | - | G.hns1 | R | 40 | G.hns1.02 |
Hydrophobic | C-term | S | 339 | - | G.HN | E | 34 | G.HN.49 |
Van-der-waals | C-term | S | 339 | - | G.HN | E | 34 | G.HN.49 |
Polar | C-term | S | 335 | - | G.HN | K | 36 | G.HN.51 |
Hydrophobic | C-term | S | 335 | - | G.HN | K | 36 | G.HN.51 |
Van-der-waals | C-term | S | 335 | - | G.HN | K | 36 | G.HN.51 |
Hydrophobic | H8 | Q | 306 | 8x49 | G.H5 | N | 372 | G.H5.24 |
Van-der-waals | H8 | Q | 306 | 8x49 | G.H5 | N | 372 | G.H5.24 |
Hydrophobic | C-term | T | 340 | - | G.HN | E | 34 | G.HN.49 |
Van-der-waals | C-term | T | 340 | - | G.HN | E | 34 | G.HN.49 |
Polar | C-term | Q | 341 | - | G.HN | E | 34 | G.HN.49 |
Hydrophobic | C-term | Q | 341 | - | G.HN | E | 34 | G.HN.49 |
Van-der-waals | C-term | Q | 341 | - | G.HN | E | 34 | G.HN.49 |
Polar | C-term | V | 337 | - | G.HN | K | 37 | G.HN.52 |
Van-der-waals | C-term | V | 337 | - | G.HN | K | 37 | G.HN.52 |
Hydrophobic | TM3 | I | 133 | 3x54 | G.H5 | L | 364 | G.H5.16 |
Ionic | C-term | D | 322 | - | G.h4s6 | K | 332 | G.h4s6.14 |
Polar | C-term | D | 322 | - | G.h4s6 | K | 332 | G.h4s6.14 |
Hydrophobic | C-term | D | 322 | - | G.h4s6 | K | 332 | G.h4s6.14 |
Van-der-waals | C-term | D | 322 | - | G.h4s6 | K | 332 | G.h4s6.14 |
Hydrophobic | TM6 | M | 247 | 6x36 | G.H5 | L | 373 | G.H5.25 |
Hydrophobic | TM3 | R | 129 | 3x50 | G.H5 | I | 371 | G.H5.23 |
Hydrophobic | C-term | V | 337 | - | G.HN | L | 32 | G.HN.47 |
Van-der-waals | C-term | V | 337 | - | G.HN | L | 32 | G.HN.47 |
Polar | TM5 | Q | 231 | 5x72 | G.H5 | D | 361 | G.H5.13 |
Hydrophobic | TM5 | Q | 231 | 5x72 | G.H5 | D | 361 | G.H5.13 |
Van-der-waals | TM5 | Q | 231 | 5x72 | G.H5 | D | 361 | G.H5.13 |