Golf - OPN1SW complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gs

DATE

2023-09-15

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

(pLDDT score) avg.: 86.5

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.8
iPTM Score: 0.7
PAE mean: 17.2


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Polar H8 K 305 8x48 G.H5 L 381 G.H5.26
Van-der-waals H8 K 305 8x48 G.H5 L 381 G.H5.26
Hydrophobic TM6 T 236 6x25 G.h4s6 Y 345 G.h4s6.20
Van-der-waals TM6 T 236 6x25 G.h4s6 Y 345 G.h4s6.20
Ionic ICL3 E 233 - G.H4 R 329 G.H4.12
Polar ICL3 E 233 - G.H4 R 329 G.H4.12
Van-der-waals ICL3 E 233 - G.H4 R 329 G.H4.12
Polar ICL2 R 141 34x55 G.hns1 K 40 G.hns1.02
Hydrophobic ICL2 R 141 34x55 G.hns1 K 40 G.hns1.02
Van-der-waals ICL2 R 141 34x55 G.hns1 K 40 G.hns1.02
Hydrophobic C-term C 327 - G.h3s5 T 271 G.h3s5.02
Van-der-waals C-term C 327 - G.h3s5 T 271 G.h3s5.02
Polar TM3 R 129 3x50 G.H5 Y 378 G.H5.23
Hydrophobic TM3 R 129 3x50 G.H5 Y 378 G.H5.23
Van-der-waals TM3 R 129 3x50 G.H5 Y 378 G.H5.23
Hydrophobic TM3 K 135 3x56 G.H5 I 370 G.H5.15
Van-der-waals TM3 K 135 3x56 G.H5 I 370 G.H5.15
Polar TM3 I 133 3x54 G.H5 Q 371 G.H5.16
Van-der-waals TM3 I 133 3x54 G.H5 Q 371 G.H5.16
Polar TM3 V 132 3x53 G.H5 H 374 G.H5.19
Hydrophobic TM3 V 132 3x53 G.H5 H 374 G.H5.19
Van-der-waals TM3 V 132 3x53 G.H5 H 374 G.H5.19
Hydrophobic TM3 I 133 3x54 G.H5 Y 378 G.H5.23
Hydrophobic TM6 V 244 6x33 G.H5 L 380 G.H5.25
Van-der-waals TM6 V 244 6x33 G.H5 L 380 G.H5.25
Polar C-term Q 330 - G.H5 Q 377 G.H5.22
Van-der-waals C-term Q 330 - G.H5 Q 377 G.H5.22
Hydrophobic TM5 Q 231 5x72 G.S6 Y 347 G.S6.02
Van-der-waals TM5 Q 231 5x72 G.S6 Y 347 G.S6.02
Polar TM5 Q 231 5x72 G.H5 D 368 G.H5.13
Hydrophobic TM5 Q 231 5x72 G.H5 D 368 G.H5.13
Van-der-waals TM5 Q 231 5x72 G.H5 D 368 G.H5.13
Ionic H8 K 305 8x48 G.H5 E 379 G.H5.24
Hydrophobic H8 K 305 8x48 G.H5 E 379 G.H5.24
Van-der-waals H8 K 305 8x48 G.H5 E 379 G.H5.24
Polar H8 Q 306 8x49 G.H5 Q 377 G.H5.22
Polar C-term S 324 - G.h4s6 K 343 G.h4s6.12
Hydrophobic C-term S 324 - G.h4s6 K 343 G.h4s6.12
Van-der-waals C-term S 324 - G.h4s6 K 343 G.h4s6.12
Hydrophobic TM6 M 247 6x36 G.H5 L 380 G.H5.25
Van-der-waals TM6 M 247 6x36 G.H5 L 380 G.H5.25
Van-der-waals C-term K 331 - G.S1 R 44 G.S1.03
Polar ICL2 N 139 34x53 G.s2s3 K 203 G.s2s3.02
Van-der-waals ICL2 N 139 34x53 G.s2s3 K 203 G.s2s3.02
Polar C-term C 327 - G.h4s6 K 343 G.h4s6.12
Hydrophobic C-term C 327 - G.h4s6 K 343 G.h4s6.12
Van-der-waals C-term C 327 - G.h4s6 K 343 G.h4s6.12
Hydrophobic TM3 I 133 3x54 G.H5 L 380 G.H5.25
Hydrophobic TM2 L 66 2x39 G.H5 Q 377 G.H5.22
Hydrophobic TM5 L 224 5x65 G.H5 L 375 G.H5.20
Van-der-waals TM5 L 224 5x65 G.H5 L 375 G.H5.20
Polar TM6 S 234 6x23 G.H5 R 372 G.H5.17
Hydrophobic TM2 L 66 2x39 G.H5 Y 378 G.H5.23
Van-der-waals TM2 L 66 2x39 G.H5 Y 378 G.H5.23
Ionic C-term E 333 - G.hns1 K 40 G.hns1.02
Polar C-term E 333 - G.hns1 K 40 G.hns1.02
Van-der-waals C-term E 333 - G.hns1 K 40 G.hns1.02
Polar H8 Q 306 8x49 G.H5 E 379 G.H5.24
Hydrophobic H8 Q 306 8x49 G.H5 E 379 G.H5.24
Van-der-waals H8 Q 306 8x49 G.H5 E 379 G.H5.24
Hydrophobic ICL2 R 141 34x55 G.hns1 A 41 G.hns1.03
Hydrophobic TM3 V 132 3x53 G.H5 Y 378 G.H5.23
Van-der-waals TM3 V 132 3x53 G.H5 Y 378 G.H5.23
Hydrophobic TM3 I 133 3x54 G.H5 H 374 G.H5.19
Polar H8 N 304 8x47 G.H5 Y 378 G.H5.23
Hydrophobic TM5 V 227 5x68 G.H5 D 368 G.H5.13
Van-der-waals TM5 V 227 5x68 G.H5 D 368 G.H5.13
Hydrophobic TM3 K 135 3x56 G.H5 H 374 G.H5.19
Hydrophobic H8 N 304 8x47 G.H5 E 379 G.H5.24
Van-der-waals H8 N 304 8x47 G.H5 E 379 G.H5.24
Polar TM5 Q 231 5x72 G.H5 R 372 G.H5.17
Van-der-waals TM5 Q 231 5x72 G.H5 R 372 G.H5.17
Hydrophobic TM5 V 227 5x68 G.H5 Q 371 G.H5.16
Van-der-waals TM5 V 227 5x68 G.H5 Q 371 G.H5.16
Hydrophobic TM3 I 133 3x54 G.H5 L 375 G.H5.20
Van-der-waals TM3 I 133 3x54 G.H5 L 375 G.H5.20
Polar TM6 T 237 6x26 G.H5 R 372 G.H5.17
Hydrophobic TM6 T 237 6x26 G.H5 R 372 G.H5.17
Van-der-waals TM6 T 237 6x26 G.H5 R 372 G.H5.17
Polar TM3 E 128 3x49 G.H5 Y 378 G.H5.23
Van-der-waals TM3 E 128 3x49 G.H5 Y 378 G.H5.23
Hydrophobic TM6 A 240 6x29 G.H5 L 381 G.H5.26
Van-der-waals TM6 A 240 6x29 G.H5 L 381 G.H5.26