Gz - Rhodopsin complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gi/o

DATE

2023-09-15

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

(pLDDT score) avg.: 86.1

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.7
iPTM Score: 0.7
PAE mean: 15.7


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Polar TM3 R 135 3x50 G.H5 G 353 G.H5.24
Hydrophobic TM3 V 139 3x54 G.H5 L 349 G.H5.20
Hydrophobic TM5 L 226 5x61 G.H5 L 354 G.H5.25
Polar H8 N 310 8x47 G.H5 G 353 G.H5.24
Hydrophobic H8 N 310 8x47 G.H5 G 353 G.H5.24
Polar C-term T 340 - G.H3 N 258 G.H3.16
Hydrophobic TM6 A 246 6x29 G.H5 L 349 G.H5.20
Hydrophobic TM5 Q 237 5x72 G.H5 I 345 G.H5.16
Polar TM5 Q 237 5x72 G.H5 D 338 G.H5.09
Hydrophobic TM5 Q 237 5x72 G.H5 D 338 G.H5.09
Van-der-waals TM5 Q 237 5x72 G.H5 D 338 G.H5.09
Polar ICL2 R 147 34x55 G.hns1 R 31 G.hns1.02
Hydrophobic ICL2 R 147 34x55 G.hns1 R 31 G.hns1.02
Van-der-waals ICL2 R 147 34x55 G.hns1 R 31 G.hns1.02
Hydrophobic C-term D 330 - G.h4s6 E 316 G.h4s6.09
Van-der-waals C-term D 330 - G.h4s6 E 316 G.h4s6.09
Hydrophobic TM2 L 72 2x39 G.H5 Y 351 G.H5.22
Van-der-waals TM2 L 72 2x39 G.H5 Y 351 G.H5.22
Hydrophobic TM5 A 233 5x68 G.H5 I 345 G.H5.16
Van-der-waals TM5 A 233 5x68 G.H5 I 345 G.H5.16
Hydrophobic TM3 V 139 3x54 G.H5 N 348 G.H5.19
Polar ICL3 S 240 - G.H5 D 342 G.H5.13
Hydrophobic ICL3 S 240 - G.H5 D 342 G.H5.13
Van-der-waals ICL3 S 240 - G.H5 D 342 G.H5.13
Hydrophobic TM3 R 135 3x50 G.H5 L 354 G.H5.25
Van-der-waals TM3 R 135 3x50 G.H5 L 354 G.H5.25
Hydrophobic TM6 V 250 6x33 G.H5 C 355 G.H5.26
Van-der-waals TM6 V 250 6x33 G.H5 C 355 G.H5.26
Hydrophobic TM6 V 250 6x33 G.H5 L 349 G.H5.20
Van-der-waals TM6 V 250 6x33 G.H5 L 349 G.H5.20
Polar H8 Q 312 8x49 G.H5 K 350 G.H5.21
Van-der-waals H8 Q 312 8x49 G.H5 K 350 G.H5.21
Hydrophobic TM3 V 138 3x53 G.H5 Y 351 G.H5.22
Hydrophobic TM5 L 226 5x61 G.H5 I 352 G.H5.23
Hydrophobic TM2 L 72 2x39 G.H5 I 352 G.H5.23
Van-der-waals TM2 L 72 2x39 G.H5 I 352 G.H5.23
Polar C-term S 338 - G.H3 N 258 G.H3.16
Hydrophobic C-term S 338 - G.H3 N 258 G.H3.16
Van-der-waals C-term S 338 - G.H3 N 258 G.H3.16
Hydrophobic TM5 Q 237 5x72 G.H5 T 341 G.H5.12
Van-der-waals TM5 Q 237 5x72 G.H5 T 341 G.H5.12
Polar ICL2 N 145 34x53 G.hns1 R 32 G.hns1.03
Hydrophobic ICL2 N 145 34x53 G.hns1 R 32 G.hns1.03
Van-der-waals ICL2 N 145 34x53 G.hns1 R 32 G.hns1.03
Polar ICL2 S 144 34x52 G.hns1 R 32 G.hns1.03
Hydrophobic ICL2 S 144 34x52 G.hns1 R 32 G.hns1.03
Van-der-waals ICL2 S 144 34x52 G.hns1 R 32 G.hns1.03
Hydrophobic TM5 V 230 5x65 G.H5 L 349 G.H5.20
Polar C-term D 331 - G.h4s6 E 316 G.h4s6.09
Hydrophobic TM6 A 246 6x29 G.H5 C 355 G.H5.26
Polar C-term E 332 - G.h4s6 E 316 G.h4s6.09
Hydrophobic ICL3 E 239 - G.H5 F 335 G.H5.06
Van-der-waals ICL3 E 239 - G.H5 F 335 G.H5.06
Hydrophobic TM6 A 246 6x29 G.H5 Q 346 G.H5.17
Van-der-waals TM6 A 246 6x29 G.H5 Q 346 G.H5.17
Polar ICL2 F 148 34x56 G.hns1 R 31 G.hns1.02
Hydrophobic TM6 M 253 6x36 G.H5 L 354 G.H5.25
Hydrophobic TM2 T 70 2x37 G.H5 Y 351 G.H5.22
Hydrophobic TM3 V 138 3x53 G.H5 I 352 G.H5.23
Van-der-waals TM3 V 138 3x53 G.H5 I 352 G.H5.23
Polar TM6 T 242 6x25 G.H5 Q 346 G.H5.17
Van-der-waals TM6 T 242 6x25 G.H5 Q 346 G.H5.17
Hydrophobic TM6 M 257 6x40 G.H5 L 354 G.H5.25
Hydrophobic ICL2 N 145 34x53 G.HN R 29 G.HN.53
Van-der-waals ICL2 N 145 34x53 G.HN R 29 G.HN.53
Hydrophobic TM3 V 139 3x54 G.H5 I 352 G.H5.23
Van-der-waals TM3 V 139 3x54 G.H5 I 352 G.H5.23
Polar TM3 R 135 3x50 G.H5 I 352 G.H5.23
Hydrophobic TM3 R 135 3x50 G.H5 I 352 G.H5.23
Van-der-waals TM3 R 135 3x50 G.H5 I 352 G.H5.23
Polar TM5 Q 237 5x72 G.H5 D 342 G.H5.13
Hydrophobic TM5 Q 237 5x72 G.H5 D 342 G.H5.13
Van-der-waals TM5 Q 237 5x72 G.H5 D 342 G.H5.13
Polar TM5 Q 236 5x71 G.s2s3 K 193 G.s2s3.01
Hydrophobic TM5 Q 236 5x71 G.s2s3 K 193 G.s2s3.01
Van-der-waals TM5 Q 236 5x71 G.s2s3 K 193 G.s2s3.01
Polar TM6 T 243 6x26 G.H5 D 342 G.H5.13
Hydrophobic TM6 T 243 6x26 G.H5 D 342 G.H5.13
Van-der-waals TM6 T 243 6x26 G.H5 D 342 G.H5.13
Hydrophobic TM6 E 249 6x32 G.H5 C 355 G.H5.26
Hydrophobic TM6 V 250 6x33 G.H5 L 354 G.H5.25
Hydrophobic ICL2 N 145 34x53 G.HN Q 28 G.HN.52
Van-der-waals ICL2 N 145 34x53 G.HN Q 28 G.HN.52
Hydrophobic TM3 K 141 3x56 G.S3 L 195 G.S3.01