GPCR CLASS (FAMILY)
SPECIES
G PROTEIN FAMILY
DATE
3D VIEW
Tertiary structure confidence
(pLDDT score) avg.: 77.6
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered
PTM Score: 0.5
iPTM Score: 0.3
PAE mean: 23.9
GPCR - G protein interface interactions
The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle
(Gα residues)
and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid,
hydrophobic - dashed,
ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.
GPCR-G protein backbone (bb) or sidechain (sc):
Structures
0 structures selected.
Sequence Color
Interaction frequency filter (%)
Gα,
GPCR
Interaction cut-off: strict (stick), loose (line)
Interaction type |
GPCR Segment |
AA |
Number |
Generic number |
Gα segment |
AA |
Number |
Generic number |
---|---|---|---|---|---|---|---|---|
Polar | ICL2 | G | 160 | 34x52 | G.HN | K | 36 | G.HN.51 |
Hydrophobic | ICL2 | G | 160 | 34x52 | G.HN | K | 36 | G.HN.51 |
Van-der-waals | ICL2 | G | 160 | 34x52 | G.HN | K | 36 | G.HN.51 |
Polar | C-term | T | 353 | - | G.S6 | H | 342 | G.S6.04 |
Hydrophobic | TM3 | R | 151 | 3x50 | G.H5 | L | 373 | G.H5.25 |
Polar | H8 | Q | 335 | 8x56 | G.h4s6 | K | 332 | G.h4s6.14 |
Polar | ICL2 | R | 163 | 34x55 | G.hns1 | R | 40 | G.hns1.02 |
Polar | H8 | Q | 328 | 8x49 | G.H5 | N | 372 | G.H5.24 |
Hydrophobic | H8 | Q | 328 | 8x49 | G.H5 | N | 372 | G.H5.24 |
Van-der-waals | H8 | Q | 328 | 8x49 | G.H5 | N | 372 | G.H5.24 |
Hydrophobic | TM3 | K | 157 | 3x56 | G.h2s4 | I | 227 | G.h2s4.05 |
Van-der-waals | TM3 | K | 157 | 3x56 | G.h2s4 | I | 227 | G.h2s4.05 |
Hydrophobic | TM5 | V | 249 | 5x68 | G.H5 | L | 364 | G.H5.16 |
Van-der-waals | TM5 | V | 249 | 5x68 | G.H5 | L | 364 | G.H5.16 |
Polar | H8 | R | 327 | 8x48 | G.H5 | L | 374 | G.H5.26 |
Hydrophobic | H8 | R | 327 | 8x48 | G.H5 | L | 374 | G.H5.26 |
Van-der-waals | H8 | R | 327 | 8x48 | G.H5 | L | 374 | G.H5.26 |
Polar | H8 | N | 326 | 8x47 | G.H5 | N | 372 | G.H5.24 |
Hydrophobic | H8 | N | 326 | 8x47 | G.H5 | N | 372 | G.H5.24 |
Van-der-waals | H8 | N | 326 | 8x47 | G.H5 | N | 372 | G.H5.24 |
Polar | TM5 | Q | 253 | 5x72 | G.H5 | R | 360 | G.H5.12 |
Hydrophobic | TM5 | Q | 253 | 5x72 | G.H5 | R | 360 | G.H5.12 |
Van-der-waals | TM5 | Q | 253 | 5x72 | G.H5 | R | 360 | G.H5.12 |
Polar | TM6 | S | 258 | 6x25 | G.H5 | D | 361 | G.H5.13 |
Van-der-waals | TM6 | S | 258 | 6x25 | G.H5 | D | 361 | G.H5.13 |
Polar | TM3 | V | 154 | 3x53 | G.H5 | Y | 367 | G.H5.19 |
Van-der-waals | TM3 | V | 154 | 3x53 | G.H5 | Y | 367 | G.H5.19 |
Polar | ICL2 | G | 160 | 34x52 | G.HN | K | 37 | G.HN.52 |
Hydrophobic | ICL2 | G | 160 | 34x52 | G.HN | K | 37 | G.HN.52 |
Van-der-waals | ICL2 | G | 160 | 34x52 | G.HN | K | 37 | G.HN.52 |
Polar | TM5 | Q | 253 | 5x72 | G.s2s3 | Q | 200 | G.s2s3.01 |
Hydrophobic | TM5 | Q | 253 | 5x72 | G.s2s3 | Q | 200 | G.s2s3.01 |
Van-der-waals | TM5 | Q | 253 | 5x72 | G.s2s3 | Q | 200 | G.s2s3.01 |
Hydrophobic | C-term | S | 345 | - | G.h4s6 | R | 338 | G.h4s6.20 |
Ionic | H8 | R | 327 | 8x48 | G.H5 | D | 369 | G.H5.21 |
Polar | H8 | R | 327 | 8x48 | G.H5 | D | 369 | G.H5.21 |
Van-der-waals | H8 | R | 327 | 8x48 | G.H5 | D | 369 | G.H5.21 |
Van-der-waals | TM5 | V | 249 | 5x68 | G.S3 | T | 202 | G.S3.01 |
Van-der-waals | TM5 | Q | 253 | 5x72 | G.H5 | D | 361 | G.H5.13 |
Hydrophobic | TM3 | V | 154 | 3x53 | G.H5 | I | 371 | G.H5.23 |
Van-der-waals | TM3 | V | 154 | 3x53 | G.H5 | I | 371 | G.H5.23 |
Hydrophobic | ICL2 | V | 162 | 34x54 | G.HN | L | 33 | G.HN.48 |
Polar | TM6 | T | 259 | 6x26 | G.H5 | D | 361 | G.H5.13 |
Polar | ICL2 | N | 161 | 34x53 | G.hns1 | D | 39 | G.hns1.01 |
Hydrophobic | ICL2 | N | 161 | 34x53 | G.hns1 | D | 39 | G.hns1.01 |
Van-der-waals | ICL2 | N | 161 | 34x53 | G.hns1 | D | 39 | G.hns1.01 |
Hydrophobic | TM6 | V | 266 | 6x33 | G.H5 | L | 374 | G.H5.26 |
Polar | C-term | T | 353 | - | G.H5 | D | 358 | G.H5.10 |
Hydrophobic | C-term | T | 353 | - | G.H5 | D | 358 | G.H5.10 |
Van-der-waals | C-term | T | 353 | - | G.H5 | D | 358 | G.H5.10 |
Polar | ICL1 | K | 83 | 12x49 | G.h4s6 | K | 332 | G.h4s6.14 |
Hydrophobic | TM5 | Q | 253 | 5x72 | G.H5 | L | 364 | G.H5.16 |
Van-der-waals | TM5 | Q | 253 | 5x72 | G.H5 | L | 364 | G.H5.16 |
Polar | TM2 | N | 89 | 2x40 | G.H5 | N | 372 | G.H5.24 |
Van-der-waals | TM2 | N | 89 | 2x40 | G.H5 | N | 372 | G.H5.24 |
Polar | ICL2 | N | 161 | 34x53 | G.HN | K | 36 | G.HN.51 |
Hydrophobic | ICL2 | N | 161 | 34x53 | G.HN | K | 36 | G.HN.51 |
Van-der-waals | ICL2 | N | 161 | 34x53 | G.HN | K | 36 | G.HN.51 |
Ionic | C-term | E | 346 | - | G.h4s6 | K | 332 | G.h4s6.14 |
Hydrophobic | C-term | S | 348 | - | G.h4s6 | R | 338 | G.h4s6.20 |
Hydrophobic | TM6 | E | 265 | 6x32 | G.H5 | L | 374 | G.H5.26 |
Van-der-waals | TM6 | E | 265 | 6x32 | G.H5 | L | 374 | G.H5.26 |
Polar | ICL2 | V | 162 | 34x54 | G.hns1 | R | 40 | G.hns1.02 |
Hydrophobic | ICL2 | V | 162 | 34x54 | G.hns1 | R | 40 | G.hns1.02 |
Van-der-waals | ICL2 | V | 162 | 34x54 | G.hns1 | R | 40 | G.hns1.02 |
Ionic | C-term | D | 342 | - | G.h4s6 | K | 332 | G.h4s6.14 |
Polar | C-term | D | 342 | - | G.h4s6 | K | 332 | G.h4s6.14 |
Van-der-waals | C-term | D | 342 | - | G.h4s6 | K | 332 | G.h4s6.14 |
Polar | ICL2 | R | 163 | 34x55 | G.h2s4 | N | 225 | G.h2s4.03 |
Hydrophobic | ICL2 | R | 163 | 34x55 | G.h2s4 | N | 225 | G.h2s4.03 |
Van-der-waals | ICL2 | R | 163 | 34x55 | G.h2s4 | N | 225 | G.h2s4.03 |
Polar | TM3 | K | 157 | 3x56 | G.hns1 | G | 41 | G.hns1.03 |
Hydrophobic | TM3 | K | 157 | 3x56 | G.hns1 | G | 41 | G.hns1.03 |
Van-der-waals | TM3 | K | 157 | 3x56 | G.hns1 | G | 41 | G.hns1.03 |
Polar | C-term | S | 356 | - | G.H5 | K | 354 | G.H5.06 |
Hydrophobic | C-term | T | 353 | - | G.H5 | K | 354 | G.H5.06 |
Hydrophobic | TM6 | V | 266 | 6x33 | G.H5 | L | 373 | G.H5.25 |
Polar | C-term | S | 345 | - | G.h4s6 | S | 336 | G.h4s6.18 |
Hydrophobic | C-term | S | 345 | - | G.h4s6 | S | 336 | G.h4s6.18 |
Van-der-waals | C-term | S | 345 | - | G.h4s6 | S | 336 | G.h4s6.18 |
Polar | C-term | G | 344 | - | G.h4s6 | R | 338 | G.h4s6.20 |
Van-der-waals | C-term | G | 344 | - | G.h4s6 | R | 338 | G.h4s6.20 |
Polar | ICL2 | N | 161 | 34x53 | G.h2s4 | N | 225 | G.h2s4.03 |
Hydrophobic | ICL2 | N | 161 | 34x53 | G.h2s4 | N | 225 | G.h2s4.03 |
Van-der-waals | ICL2 | N | 161 | 34x53 | G.h2s4 | N | 225 | G.h2s4.03 |
Polar | TM3 | K | 157 | 3x56 | G.hns1 | R | 40 | G.hns1.02 |
Hydrophobic | TM3 | K | 157 | 3x56 | G.hns1 | R | 40 | G.hns1.02 |
Van-der-waals | TM3 | K | 157 | 3x56 | G.hns1 | R | 40 | G.hns1.02 |
Hydrophobic | TM3 | K | 157 | 3x56 | G.S1 | L | 43 | G.S1.02 |
Polar | ICL2 | F | 159 | 34x51 | G.HN | K | 37 | G.HN.52 |
Hydrophobic | ICL2 | F | 159 | 34x51 | G.HN | K | 37 | G.HN.52 |
Van-der-waals | ICL2 | F | 159 | 34x51 | G.HN | K | 37 | G.HN.52 |
Hydrophobic | ICL2 | P | 158 | 34x50 | G.HN | K | 37 | G.HN.52 |
Van-der-waals | ICL2 | P | 158 | 34x50 | G.HN | K | 37 | G.HN.52 |
Hydrophobic | TM5 | I | 246 | 5x65 | G.H5 | L | 373 | G.H5.25 |
Van-der-waals | TM5 | I | 246 | 5x65 | G.H5 | L | 373 | G.H5.25 |
Polar | TM6 | S | 256 | 6x23 | G.H5 | D | 361 | G.H5.13 |
Hydrophobic | TM6 | S | 256 | 6x23 | G.H5 | D | 361 | G.H5.13 |
Van-der-waals | TM6 | S | 256 | 6x23 | G.H5 | D | 361 | G.H5.13 |
Van-der-waals | C-term | D | 343 | - | G.h4s6 | K | 332 | G.h4s6.14 |
Polar | ICL2 | F | 159 | 34x51 | G.hns1 | R | 40 | G.hns1.02 |
Hydrophobic | ICL2 | F | 159 | 34x51 | G.hns1 | R | 40 | G.hns1.02 |
Van-der-waals | ICL2 | F | 159 | 34x51 | G.hns1 | R | 40 | G.hns1.02 |
Polar | ICL1 | K | 83 | 12x49 | G.h4s6 | G | 333 | G.h4s6.15 |
Hydrophobic | ICL1 | K | 83 | 12x49 | G.h4s6 | G | 333 | G.h4s6.15 |
Van-der-waals | ICL1 | K | 83 | 12x49 | G.h4s6 | G | 333 | G.h4s6.15 |
Hydrophobic | TM3 | V | 155 | 3x54 | G.H5 | L | 373 | G.H5.25 |
Van-der-waals | TM3 | V | 155 | 3x54 | G.H5 | L | 373 | G.H5.25 |
Hydrophobic | ICL1 | K | 83 | 12x49 | G.h4s6 | A | 334 | G.h4s6.16 |
Polar | TM3 | K | 157 | 3x56 | G.S1 | E | 42 | G.S1.01 |
Van-der-waals | TM3 | K | 157 | 3x56 | G.S1 | E | 42 | G.S1.01 |
Polar | ICL2 | N | 161 | 34x53 | G.hns1 | R | 40 | G.hns1.02 |
Hydrophobic | ICL2 | N | 161 | 34x53 | G.hns1 | R | 40 | G.hns1.02 |
Van-der-waals | ICL2 | N | 161 | 34x53 | G.hns1 | R | 40 | G.hns1.02 |
Hydrophobic | TM5 | A | 248 | 5x67 | G.s2s3 | K | 201 | G.s2s3.02 |
Polar | TM5 | Q | 252 | 5x71 | G.s2s3 | Q | 200 | G.s2s3.01 |
Hydrophobic | TM5 | Q | 252 | 5x71 | G.s2s3 | Q | 200 | G.s2s3.01 |
Van-der-waals | TM5 | Q | 252 | 5x71 | G.s2s3 | Q | 200 | G.s2s3.01 |
Hydrophobic | TM6 | A | 262 | 6x29 | G.H5 | L | 374 | G.H5.26 |
Polar | H8 | Q | 328 | 8x49 | G.h4s6 | R | 335 | G.h4s6.17 |
Hydrophobic | ICL2 | V | 162 | 34x54 | G.HN | K | 36 | G.HN.51 |
Van-der-waals | ICL2 | V | 162 | 34x54 | G.HN | K | 36 | G.HN.51 |
Polar | TM3 | R | 151 | 3x50 | G.H5 | N | 372 | G.H5.24 |
Hydrophobic | TM3 | R | 151 | 3x50 | G.H5 | N | 372 | G.H5.24 |
Van-der-waals | TM3 | R | 151 | 3x50 | G.H5 | N | 372 | G.H5.24 |
Hydrophobic | TM5 | I | 246 | 5x65 | G.H5 | L | 368 | G.H5.20 |
Polar | TM3 | R | 151 | 3x50 | G.H5 | I | 371 | G.H5.23 |
Hydrophobic | TM3 | R | 151 | 3x50 | G.H5 | I | 371 | G.H5.23 |
Van-der-waals | TM3 | R | 151 | 3x50 | G.H5 | I | 371 | G.H5.23 |
Hydrophobic | TM6 | S | 258 | 6x25 | G.H5 | A | 365 | G.H5.17 |
Hydrophobic | TM5 | V | 242 | 5x61 | G.H5 | L | 373 | G.H5.25 |
Polar | TM3 | K | 157 | 3x56 | G.H5 | Y | 367 | G.H5.19 |
Hydrophobic | TM3 | K | 157 | 3x56 | G.H5 | Y | 367 | G.H5.19 |
Van-der-waals | TM3 | K | 157 | 3x56 | G.H5 | Y | 367 | G.H5.19 |
Hydrophobic | TM3 | V | 155 | 3x54 | G.H5 | I | 371 | G.H5.23 |
Van-der-waals | TM3 | V | 155 | 3x54 | G.H5 | I | 371 | G.H5.23 |
Polar | ICL2 | G | 160 | 34x52 | G.hns1 | R | 40 | G.hns1.02 |
Hydrophobic | ICL2 | G | 160 | 34x52 | G.hns1 | R | 40 | G.hns1.02 |
Van-der-waals | ICL2 | G | 160 | 34x52 | G.hns1 | R | 40 | G.hns1.02 |
Ionic | ICL3 | E | 255 | - | G.H5 | K | 357 | G.H5.09 |
Polar | ICL3 | E | 255 | - | G.H5 | K | 357 | G.H5.09 |
Hydrophobic | ICL3 | E | 255 | - | G.H5 | K | 357 | G.H5.09 |
Van-der-waals | ICL3 | E | 255 | - | G.H5 | K | 357 | G.H5.09 |
Hydrophobic | TM6 | A | 262 | 6x29 | G.H5 | L | 368 | G.H5.20 |
Van-der-waals | TM6 | A | 262 | 6x29 | G.H5 | L | 368 | G.H5.20 |
Polar | C-term | E | 354 | - | G.H5 | K | 354 | G.H5.06 |
Polar | TM5 | Q | 252 | 5x71 | G.s2s3 | K | 201 | G.s2s3.02 |
Hydrophobic | TM5 | Q | 252 | 5x71 | G.s2s3 | K | 201 | G.s2s3.02 |
Van-der-waals | TM5 | Q | 252 | 5x71 | G.s2s3 | K | 201 | G.s2s3.02 |
Hydrophobic | TM6 | M | 269 | 6x36 | G.H5 | L | 373 | G.H5.25 |
Van-der-waals | TM6 | M | 269 | 6x36 | G.H5 | L | 373 | G.H5.25 |
Polar | TM3 | M | 153 | 3x52 | G.hns1 | R | 40 | G.hns1.02 |
Hydrophobic | TM3 | M | 153 | 3x52 | G.hns1 | R | 40 | G.hns1.02 |
Van-der-waals | TM3 | M | 153 | 3x52 | G.hns1 | R | 40 | G.hns1.02 |