Gs - OPN1LW complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gs

DATE

2023-09-15

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

(pLDDT score) avg.: 78.2

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.6
iPTM Score: 0.4
PAE mean: 20.4


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic TM3 V 154 3x53 G.H5 R 389 G.H5.21
Van-der-waals TM3 V 154 3x53 G.H5 R 389 G.H5.21
Polar C-term L 347 - G.H5 Q 384 G.H5.16
Hydrophobic C-term L 347 - G.H5 Q 384 G.H5.16
Van-der-waals C-term L 347 - G.H5 Q 384 G.H5.16
Polar C-term K 352 - G.S1 T 40 G.S1.01
Hydrophobic C-term K 352 - G.S1 T 40 G.S1.01
Van-der-waals C-term K 352 - G.S1 T 40 G.S1.01
Hydrophobic C-term V 358 - G.S2 E 209 G.S2.03
Hydrophobic TM5 Q 252 5x71 G.hns1 R 38 G.hns1.02
Van-der-waals TM5 Q 252 5x71 G.hns1 R 38 G.hns1.02
Hydrophobic TM5 V 242 5x61 G.H5 Y 391 G.H5.23
Hydrophobic ICL3 K 254 - G.HN Q 35 G.HN.52
Van-der-waals C-term K 352 - G.HN V 36 G.HN.53
Hydrophobic TM3 V 155 3x54 G.H5 Q 390 G.H5.22
Van-der-waals TM3 V 155 3x54 G.H5 Q 390 G.H5.22
Polar C-term E 346 - G.H5 Q 384 G.H5.16
Hydrophobic C-term E 346 - G.H5 Q 384 G.H5.16
Van-der-waals C-term E 346 - G.H5 Q 384 G.H5.16
Polar TM3 W 152 3x51 G.H5 E 392 G.H5.24
Hydrophobic TM3 W 152 3x51 G.H5 E 392 G.H5.24
Van-der-waals TM3 W 152 3x51 G.H5 E 392 G.H5.24
Hydrophobic TM3 V 154 3x53 G.H5 L 394 G.H5.26
Van-der-waals TM3 V 154 3x53 G.H5 L 394 G.H5.26
Hydrophobic TM6 V 266 6x33 G.H5 Y 391 G.H5.23
Van-der-waals TM6 V 266 6x33 G.H5 Y 391 G.H5.23
Polar TM5 I 246 5x65 G.H5 Y 391 G.H5.23
Hydrophobic TM5 I 246 5x65 G.H5 Y 391 G.H5.23
Van-der-waals TM5 I 246 5x65 G.H5 Y 391 G.H5.23
Hydrophobic C-term S 349 - G.S3 V 217 G.S3.01
Van-der-waals C-term S 349 - G.S3 V 217 G.S3.01
Hydrophobic ICL2 N 161 34x53 G.h4s6 G 355 G.h4s6.11
Van-der-waals ICL2 N 161 34x53 G.h4s6 G 355 G.h4s6.11
Hydrophobic ICL3 E 255 - G.HN Q 35 G.HN.52
Van-der-waals ICL3 E 255 - G.HN Q 35 G.HN.52
Polar C-term S 348 - G.H5 R 380 G.H5.12
Hydrophobic C-term S 348 - G.H5 R 380 G.H5.12
Van-der-waals C-term S 348 - G.H5 R 380 G.H5.12
Polar TM5 K 251 5x70 G.hns1 R 38 G.hns1.02
Hydrophobic TM5 K 251 5x70 G.hns1 R 38 G.hns1.02
Van-der-waals TM5 K 251 5x70 G.hns1 R 38 G.hns1.02
Polar C-term T 353 - G.S1 T 40 G.S1.01
Hydrophobic C-term T 353 - G.S1 T 40 G.S1.01
Van-der-waals C-term T 353 - G.S1 T 40 G.S1.01
Polar C-term S 356 - G.S2 K 211 G.S2.05
Hydrophobic C-term S 356 - G.S2 K 211 G.S2.05
Van-der-waals C-term S 356 - G.S2 K 211 G.S2.05
Hydrophobic C-term E 354 - G.S3 N 218 G.S3.02
Van-der-waals C-term E 354 - G.S3 N 218 G.S3.02
Hydrophobic ICL3 E 255 - G.hns1 A 39 G.hns1.03
Van-der-waals ICL3 E 255 - G.hns1 A 39 G.hns1.03
Hydrophobic C-term K 352 - G.s2s3 K 216 G.s2s3.02
Van-der-waals C-term K 352 - G.s2s3 K 216 G.s2s3.02
Hydrophobic TM5 Q 253 5x72 G.H5 I 383 G.H5.15
Hydrophobic C-term S 349 - G.H5 F 376 G.H5.08
Polar C-term S 351 - G.S1 H 41 G.S1.02
Hydrophobic C-term S 351 - G.S1 H 41 G.S1.02
Van-der-waals C-term S 351 - G.S1 H 41 G.S1.02
Polar ICL2 N 161 34x53 G.h4s6 D 354 G.h4s6.10
Hydrophobic ICL2 N 161 34x53 G.h4s6 D 354 G.h4s6.10
Van-der-waals ICL2 N 161 34x53 G.h4s6 D 354 G.h4s6.10
Van-der-waals TM3 S 148 3x47 G.H5 E 392 G.H5.24
Hydrophobic TM6 V 266 6x33 G.H5 L 393 G.H5.25
Polar C-term K 352 - G.hns1 A 39 G.hns1.03
Hydrophobic C-term K 352 - G.hns1 A 39 G.hns1.03
Van-der-waals C-term K 352 - G.hns1 A 39 G.hns1.03
Polar C-term S 348 - G.H5 Q 384 G.H5.16
Hydrophobic C-term S 348 - G.H5 Q 384 G.H5.16
Van-der-waals C-term S 348 - G.H5 Q 384 G.H5.16
Polar C-term S 351 - G.hns1 R 38 G.hns1.02
Van-der-waals C-term S 351 - G.hns1 R 38 G.hns1.02
Polar TM5 I 246 5x65 G.H5 Q 390 G.H5.22
Hydrophobic TM5 I 246 5x65 G.H5 Q 390 G.H5.22
Van-der-waals TM5 I 246 5x65 G.H5 Q 390 G.H5.22
Polar C-term S 345 - G.H5 Q 384 G.H5.16
Hydrophobic C-term S 345 - G.H5 Q 384 G.H5.16
Van-der-waals C-term S 345 - G.H5 Q 384 G.H5.16
Polar C-term T 353 - G.S3 N 218 G.S3.02
Hydrophobic C-term T 353 - G.S3 N 218 G.S3.02
Van-der-waals C-term T 353 - G.S3 N 218 G.S3.02
Polar TM3 K 157 3x56 G.h4s6 G 355 G.h4s6.11
Polar ICL2 R 163 34x55 G.h4s6 G 353 G.h4s6.09
Van-der-waals ICL2 R 163 34x55 G.h4s6 G 353 G.h4s6.09
Ionic C-term E 346 - G.H5 R 380 G.H5.12
Polar C-term E 346 - G.H5 R 380 G.H5.12
Hydrophobic C-term E 346 - G.H5 R 380 G.H5.12
Van-der-waals C-term E 346 - G.H5 R 380 G.H5.12
Hydrophobic TM5 V 249 5x68 G.H5 H 387 G.H5.19
Van-der-waals TM5 V 249 5x68 G.H5 H 387 G.H5.19
Polar C-term T 353 - G.S3 F 219 G.S3.03
Hydrophobic C-term T 353 - G.S3 F 219 G.S3.03
Van-der-waals C-term T 353 - G.S3 F 219 G.S3.03
Hydrophobic TM5 V 242 5x61 G.H5 E 392 G.H5.24
Van-der-waals TM5 V 242 5x61 G.H5 E 392 G.H5.24
Polar TM6 T 259 6x26 G.H5 Y 391 G.H5.23
Hydrophobic C-term V 355 - G.S3 F 219 G.S3.03
Van-der-waals C-term V 355 - G.S3 F 219 G.S3.03
Polar ICL2 N 161 34x53 G.h4s6 R 356 G.h4s6.12
Hydrophobic ICL2 N 161 34x53 G.h4s6 R 356 G.h4s6.12
Van-der-waals ICL2 N 161 34x53 G.h4s6 R 356 G.h4s6.12
Polar C-term E 354 - G.HN V 36 G.HN.53
Hydrophobic C-term E 354 - G.HN V 36 G.HN.53
Van-der-waals C-term E 354 - G.HN V 36 G.HN.53
Polar ICL3 E 255 - G.HN V 36 G.HN.53
Hydrophobic ICL3 E 255 - G.HN V 36 G.HN.53
Van-der-waals ICL3 E 255 - G.HN V 36 G.HN.53
Hydrophobic ICL2 R 163 34x55 G.h4s6 Y 358 G.h4s6.20
Polar C-term S 348 - G.H5 D 381 G.H5.13
Hydrophobic C-term S 348 - G.H5 D 381 G.H5.13
Van-der-waals C-term S 348 - G.H5 D 381 G.H5.13
Polar TM5 Q 253 5x72 G.H5 H 387 G.H5.19
Hydrophobic TM5 Q 253 5x72 G.H5 H 387 G.H5.19
Van-der-waals TM5 Q 253 5x72 G.H5 H 387 G.H5.19
Hydrophobic TM3 V 155 3x54 G.H5 L 388 G.H5.20
Van-der-waals TM3 V 155 3x54 G.H5 L 388 G.H5.20
Polar ICL2 G 160 34x52 G.h4s6 R 356 G.h4s6.12
Hydrophobic ICL2 G 160 34x52 G.h4s6 R 356 G.h4s6.12
Van-der-waals ICL2 G 160 34x52 G.h4s6 R 356 G.h4s6.12
Hydrophobic TM3 V 155 3x54 G.H5 Y 391 G.H5.23
Van-der-waals TM3 V 155 3x54 G.H5 Y 391 G.H5.23
Hydrophobic C-term K 352 - G.S3 V 217 G.S3.01
Polar ICL2 F 159 34x51 G.h4s6 R 356 G.h4s6.12
Hydrophobic C-term A 350 - G.S3 V 217 G.S3.01
Hydrophobic C-term V 358 - G.S2 K 211 G.S2.05
Van-der-waals C-term V 358 - G.S2 K 211 G.S2.05
Polar TM6 E 263 6x30 G.H5 Y 391 G.H5.23
Hydrophobic TM6 E 263 6x30 G.H5 Y 391 G.H5.23
Van-der-waals TM6 E 263 6x30 G.H5 Y 391 G.H5.23
Hydrophobic C-term T 353 - G.S3 H 220 G.S3.04
Van-der-waals C-term T 353 - G.S3 H 220 G.S3.04
Hydrophobic ICL2 R 163 34x55 G.h4s6 G 355 G.h4s6.11
Van-der-waals ICL2 R 163 34x55 G.h4s6 G 355 G.h4s6.11
Polar ICL2 R 163 34x55 G.h4s6 D 354 G.h4s6.10
Hydrophobic ICL2 R 163 34x55 G.h4s6 D 354 G.h4s6.10
Van-der-waals ICL2 R 163 34x55 G.h4s6 D 354 G.h4s6.10
Hydrophobic TM3 K 157 3x56 G.H5 R 389 G.H5.21
Van-der-waals TM3 K 157 3x56 G.H5 R 389 G.H5.21
Hydrophobic C-term V 355 - G.S2 K 211 G.S2.05
Van-der-waals C-term V 355 - G.S2 K 211 G.S2.05
Polar TM3 R 151 3x50 G.H5 L 393 G.H5.25
Hydrophobic TM3 R 151 3x50 G.H5 L 393 G.H5.25
Van-der-waals TM3 R 151 3x50 G.H5 L 393 G.H5.25
Hydrophobic TM6 A 262 6x29 G.H5 Y 391 G.H5.23
Van-der-waals TM6 A 262 6x29 G.H5 Y 391 G.H5.23
Polar C-term S 349 - G.S1 H 41 G.S1.02
Hydrophobic TM5 V 249 5x68 G.H5 Q 390 G.H5.22
Van-der-waals TM5 V 249 5x68 G.H5 Q 390 G.H5.22
Hydrophobic C-term S 349 - G.H5 R 380 G.H5.12
Polar TM3 R 151 3x50 G.H5 E 392 G.H5.24
Hydrophobic TM3 R 151 3x50 G.H5 E 392 G.H5.24
Van-der-waals TM3 R 151 3x50 G.H5 E 392 G.H5.24
Polar TM3 K 157 3x56 G.h4s6 R 356 G.h4s6.12
Van-der-waals TM3 K 157 3x56 G.h4s6 R 356 G.h4s6.12
Hydrophobic C-term S 348 - G.H5 I 383 G.H5.15
Polar TM6 T 259 6x26 G.H5 H 387 G.H5.19
Hydrophobic TM6 T 259 6x26 G.H5 H 387 G.H5.19
Van-der-waals TM6 T 259 6x26 G.H5 H 387 G.H5.19
Hydrophobic TM3 V 155 3x54 G.H5 R 389 G.H5.21
Van-der-waals TM3 V 155 3x54 G.H5 R 389 G.H5.21
Polar C-term E 354 - G.S1 T 40 G.S1.01
Van-der-waals C-term E 354 - G.S1 T 40 G.S1.01
Hydrophobic TM3 V 155 3x54 G.H5 E 392 G.H5.24
Van-der-waals TM3 V 155 3x54 G.H5 E 392 G.H5.24
Hydrophobic C-term V 355 - G.S3 N 218 G.S3.02
Polar C-term T 353 - G.hns1 A 39 G.hns1.03
Hydrophobic C-term T 353 - G.hns1 A 39 G.hns1.03
Van-der-waals C-term T 353 - G.hns1 A 39 G.hns1.03
Hydrophobic C-term S 351 - G.S3 V 217 G.S3.01
Van-der-waals C-term S 351 - G.S3 V 217 G.S3.01
Polar C-term S 351 - G.hns1 A 39 G.hns1.03
Hydrophobic C-term S 351 - G.hns1 A 39 G.hns1.03
Van-der-waals C-term S 351 - G.hns1 A 39 G.hns1.03
Polar C-term K 352 - G.S3 N 218 G.S3.02
Hydrophobic C-term K 352 - G.S3 N 218 G.S3.02
Van-der-waals C-term K 352 - G.S3 N 218 G.S3.02
Hydrophobic C-term V 355 - G.S3 H 220 G.S3.04
Polar TM5 A 245 5x64 G.H5 Q 390 G.H5.22
Hydrophobic TM5 A 245 5x64 G.H5 Q 390 G.H5.22
Van-der-waals TM5 A 245 5x64 G.H5 Q 390 G.H5.22
Polar C-term T 353 - G.S1 H 41 G.S1.02
Hydrophobic C-term T 353 - G.S1 H 41 G.S1.02
Van-der-waals C-term T 353 - G.S1 H 41 G.S1.02