Gi2 - OR1A1 complex model

GPCR CLASS (FAMILY)

O2 (tetrapod specific odorant)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gi/o

DATE

2023-09-15

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

(pLDDT score) avg.: 84.4

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.6
iPTM Score: 0.3
PAE mean: 21.4


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic TM2 M 59 2x39 G.H5 L 354 G.H5.25
Van-der-waals TM2 M 59 2x39 G.H5 L 354 G.H5.25
Hydrophobic ICL2 L 130 34x51 G.S1 V 34 G.S1.02
Van-der-waals ICL2 L 130 34x51 G.S1 V 34 G.S1.02
Polar TM2 N 57 2x37 G.H5 D 351 G.H5.22
Hydrophobic TM2 N 57 2x37 G.H5 D 351 G.H5.22
Van-der-waals TM2 N 57 2x37 G.H5 D 351 G.H5.22
Hydrophobic H8 N 292 8x47 G.H5 L 354 G.H5.25
Van-der-waals H8 N 292 8x47 G.H5 L 354 G.H5.25
Hydrophobic TM6 K 235 6x32 G.H5 K 346 G.H5.17
Van-der-waals TM6 K 235 6x32 G.H5 K 346 G.H5.17
Hydrophobic TM3 R 128 3x56 G.hns1 R 32 G.hns1.03
Van-der-waals TM3 R 128 3x56 G.hns1 R 32 G.hns1.03
Hydrophobic TM3 R 122 3x50 G.H5 L 354 G.H5.25
Van-der-waals TM3 R 122 3x50 G.H5 L 354 G.H5.25
Hydrophobic ICL2 L 130 34x51 G.H5 I 345 G.H5.16
Van-der-waals TM6 K 235 6x32 G.H5 K 350 G.H5.21
Hydrophobic TM6 T 239 6x36 G.H5 F 355 G.H5.26
Van-der-waals TM6 T 239 6x36 G.H5 F 355 G.H5.26
Hydrophobic TM7 Y 288 7x53 G.H5 L 354 G.H5.25
Van-der-waals TM7 Y 288 7x53 G.H5 L 354 G.H5.25
Polar ICL2 P 129 34x50 G.H5 N 348 G.H5.19
Hydrophobic ICL2 P 129 34x50 G.H5 N 348 G.H5.19
Van-der-waals ICL2 P 129 34x50 G.H5 N 348 G.H5.19
Hydrophobic ICL1 R 54 12x49 G.h4s6 T 317 G.h4s6.10
Van-der-waals ICL1 R 54 12x49 G.h4s6 T 317 G.h4s6.10
Polar ICL2 T 134 34x55 G.hns1 A 30 G.hns1.01
Hydrophobic ICL2 T 134 34x55 G.hns1 A 30 G.hns1.01
Hydrophobic TM3 I 126 3x54 G.H5 L 349 G.H5.20
Van-der-waals TM3 I 126 3x54 G.H5 L 349 G.H5.20
Hydrophobic ICL2 L 130 34x51 G.H5 I 344 G.H5.15
Van-der-waals ICL2 L 130 34x51 G.H5 I 344 G.H5.15
Ionic TM3 R 128 3x56 G.HN E 28 G.HN.52
Hydrophobic TM3 A 125 3x53 G.H5 C 352 G.H5.23
Van-der-waals TM3 A 125 3x53 G.H5 C 352 G.H5.23
Hydrophobic TM2 L 63 2x43 G.H5 L 354 G.H5.25
Hydrophobic ICL2 I 135 34x56 G.hns1 A 31 G.hns1.02
Van-der-waals ICL2 I 135 34x56 G.hns1 A 31 G.hns1.02
Polar ICL2 H 131 34x52 G.hns1 A 31 G.hns1.02
Hydrophobic ICL2 H 131 34x52 G.hns1 A 31 G.hns1.02
Van-der-waals ICL2 H 131 34x52 G.hns1 A 31 G.hns1.02
Polar ICL2 Y 132 34x53 G.H5 C 352 G.H5.23
Hydrophobic ICL2 Y 132 34x53 G.H5 C 352 G.H5.23
Van-der-waals ICL2 Y 132 34x53 G.H5 C 352 G.H5.23
Hydrophobic TM6 T 239 6x36 G.H5 G 353 G.H5.24
Van-der-waals TM6 T 239 6x36 G.H5 G 353 G.H5.24
Hydrophobic ICL2 P 129 34x50 G.H5 L 349 G.H5.20
Hydrophobic TM6 S 242 6x39 G.H5 L 354 G.H5.25
Polar ICL2 Y 132 34x53 G.H5 D 351 G.H5.22
Hydrophobic ICL2 Y 132 34x53 G.H5 D 351 G.H5.22
Hydrophobic TM2 M 59 2x39 G.H5 G 353 G.H5.24
Hydrophobic ICL2 L 130 34x51 G.S3 L 195 G.S3.01
Van-der-waals ICL2 L 130 34x51 G.S3 L 195 G.S3.01
Hydrophobic TM3 D 121 3x49 G.H5 C 352 G.H5.23
Van-der-waals TM3 D 121 3x49 G.H5 C 352 G.H5.23
Polar H8 D 294 8x49 G.H5 F 355 G.H5.26
Polar H8 N 292 8x47 G.H5 F 355 G.H5.26
Hydrophobic H8 N 292 8x47 G.H5 F 355 G.H5.26
Van-der-waals H8 N 292 8x47 G.H5 F 355 G.H5.26
Aromatic TM6 K 235 6x32 G.H5 F 355 G.H5.26
Hydrophobic TM6 K 235 6x32 G.H5 F 355 G.H5.26
Van-der-waals TM6 K 235 6x32 G.H5 F 355 G.H5.26
Hydrophobic ICL2 T 134 34x55 G.hns1 A 31 G.hns1.02
Hydrophobic TM3 A 125 3x53 G.H5 L 349 G.H5.20
Van-der-waals TM3 A 125 3x53 G.H5 L 349 G.H5.20
Polar H8 R 293 8x48 G.H5 F 355 G.H5.26
Hydrophobic H8 R 293 8x48 G.H5 F 355 G.H5.26
Van-der-waals H8 R 293 8x48 G.H5 F 355 G.H5.26
Hydrophobic ICL2 H 131 34x52 G.S1 V 34 G.S1.02
Hydrophobic ICL2 L 130 34x51 G.H5 N 348 G.H5.19
Van-der-waals ICL2 L 130 34x51 G.H5 N 348 G.H5.19
Hydrophobic ICL2 L 130 34x51 G.h2s4 T 220 G.h2s4.05
Hydrophobic ICL2 H 131 34x52 G.S3 L 195 G.S3.01
Van-der-waals ICL2 H 131 34x52 G.S3 L 195 G.S3.01
Polar ICL2 H 131 34x52 G.S1 E 33 G.S1.01
Hydrophobic ICL2 H 131 34x52 G.S1 E 33 G.S1.01
Van-der-waals ICL2 H 131 34x52 G.S1 E 33 G.S1.01
Polar ICL2 H 131 34x52 G.hns1 A 30 G.hns1.01
Hydrophobic ICL2 P 129 34x50 G.H5 I 345 G.H5.16
Van-der-waals ICL2 P 129 34x50 G.H5 I 345 G.H5.16
Hydrophobic TM2 M 59 2x39 G.H5 C 352 G.H5.23
Van-der-waals TM2 M 59 2x39 G.H5 C 352 G.H5.23
Polar ICL2 H 131 34x52 G.hns1 R 32 G.hns1.03
Hydrophobic ICL2 H 131 34x52 G.hns1 R 32 G.hns1.03
Van-der-waals ICL2 H 131 34x52 G.hns1 R 32 G.hns1.03