GPCR CLASS (FAMILY)
SPECIES
G PROTEIN FAMILY
DATE
3D VIEW
Tertiary structure confidence
(pLDDT score) avg.: 84.5
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered
PTM Score: 0.8
iPTM Score: 0.8
PAE mean: 12.8
GPCR - G protein interface interactions
The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle
(Gα residues)
and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid,
hydrophobic - dashed,
ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.
GPCR-G protein backbone (bb) or sidechain (sc):
Structures
0 structures selected.
Sequence Color
Interaction frequency filter (%)
Gα,
GPCR
Interaction cut-off: strict (stick), loose (line)
Interaction type |
GPCR Segment |
AA |
Number |
Generic number |
Gα segment |
AA |
Number |
Generic number |
---|---|---|---|---|---|---|---|---|
Polar | H8 | N | 294 | 8x47 | G.H5 | E | 392 | G.H5.24 |
Hydrophobic | H8 | N | 294 | 8x47 | G.H5 | E | 392 | G.H5.24 |
Van-der-waals | H8 | N | 294 | 8x47 | G.H5 | E | 392 | G.H5.24 |
Hydrophobic | ICL2 | L | 130 | 34x51 | G.S3 | F | 219 | G.S3.03 |
Hydrophobic | ICL2 | P | 129 | 34x50 | G.H5 | H | 387 | G.H5.19 |
Hydrophobic | TM2 | M | 59 | 2x39 | G.H5 | Q | 390 | G.H5.22 |
Van-der-waals | TM2 | M | 59 | 2x39 | G.H5 | Q | 390 | G.H5.22 |
Hydrophobic | TM3 | C | 122 | 3x50 | G.H5 | L | 393 | G.H5.25 |
Van-der-waals | TM3 | C | 122 | 3x50 | G.H5 | L | 393 | G.H5.25 |
Hydrophobic | ICL2 | P | 129 | 34x50 | G.H5 | Q | 384 | G.H5.16 |
Polar | TM3 | D | 121 | 3x49 | G.H5 | Y | 391 | G.H5.23 |
Hydrophobic | TM3 | D | 121 | 3x49 | G.H5 | Y | 391 | G.H5.23 |
Van-der-waals | TM3 | D | 121 | 3x49 | G.H5 | Y | 391 | G.H5.23 |
Polar | TM6 | T | 240 | 6x36 | G.H5 | L | 393 | G.H5.25 |
Hydrophobic | TM6 | T | 240 | 6x36 | G.H5 | L | 393 | G.H5.25 |
Van-der-waals | TM6 | T | 240 | 6x36 | G.H5 | L | 393 | G.H5.25 |
Polar | ICL2 | L | 130 | 34x51 | G.S1 | H | 41 | G.S1.02 |
Hydrophobic | ICL2 | L | 130 | 34x51 | G.S1 | H | 41 | G.S1.02 |
Van-der-waals | ICL2 | L | 130 | 34x51 | G.S1 | H | 41 | G.S1.02 |
Hydrophobic | TM3 | I | 126 | 3x54 | G.H5 | L | 388 | G.H5.20 |
Hydrophobic | TM5 | I | 225 | 5x65 | G.H5 | L | 388 | G.H5.20 |
Hydrophobic | TM6 | K | 236 | 6x32 | G.H5 | L | 394 | G.H5.26 |
Van-der-waals | TM6 | K | 236 | 6x32 | G.H5 | L | 394 | G.H5.26 |
Hydrophobic | TM3 | A | 125 | 3x53 | G.H5 | Y | 391 | G.H5.23 |
Van-der-waals | TM3 | A | 125 | 3x53 | G.H5 | Y | 391 | G.H5.23 |
Hydrophobic | ICL2 | L | 130 | 34x51 | G.H5 | F | 376 | G.H5.08 |
Van-der-waals | ICL2 | L | 130 | 34x51 | G.H5 | F | 376 | G.H5.08 |
Van-der-waals | TM4 | S | 137 | 4x38 | G.HN | Q | 35 | G.HN.52 |
Hydrophobic | ICL2 | L | 130 | 34x51 | G.S3 | V | 217 | G.S3.01 |
Polar | ICL2 | Y | 132 | 34x53 | G.H5 | Y | 391 | G.H5.23 |
Van-der-waals | ICL2 | Y | 132 | 34x53 | G.H5 | Y | 391 | G.H5.23 |
Hydrophobic | TM5 | T | 224 | 5x64 | G.H5 | Q | 384 | G.H5.16 |
Van-der-waals | TM5 | T | 224 | 5x64 | G.H5 | Q | 384 | G.H5.16 |
Aromatic | ICL2 | Y | 132 | 34x53 | G.H5 | H | 387 | G.H5.19 |
Hydrophobic | ICL2 | Y | 132 | 34x53 | G.H5 | H | 387 | G.H5.19 |
Van-der-waals | ICL2 | Y | 132 | 34x53 | G.H5 | H | 387 | G.H5.19 |
Polar | TM3 | I | 126 | 3x54 | G.H5 | Q | 384 | G.H5.16 |
Hydrophobic | TM3 | I | 126 | 3x54 | G.H5 | Q | 384 | G.H5.16 |
Van-der-waals | TM3 | I | 126 | 3x54 | G.H5 | Q | 384 | G.H5.16 |
Hydrophobic | ICL2 | I | 133 | 34x54 | G.hns1 | A | 39 | G.hns1.03 |
Polar | TM3 | A | 125 | 3x53 | G.H5 | H | 387 | G.H5.19 |
Hydrophobic | TM3 | A | 125 | 3x53 | G.H5 | H | 387 | G.H5.19 |
Van-der-waals | TM3 | A | 125 | 3x53 | G.H5 | H | 387 | G.H5.19 |
Polar | H8 | E | 296 | 8x49 | G.H5 | Q | 390 | G.H5.22 |
Hydrophobic | H8 | E | 296 | 8x49 | G.H5 | Q | 390 | G.H5.22 |
Van-der-waals | H8 | E | 296 | 8x49 | G.H5 | Q | 390 | G.H5.22 |
Hydrophobic | TM4 | P | 138 | 4x39 | G.HN | Q | 35 | G.HN.52 |
Van-der-waals | TM4 | P | 138 | 4x39 | G.HN | Q | 35 | G.HN.52 |
Hydrophobic | TM6 | C | 241 | 6x37 | G.H5 | L | 393 | G.H5.25 |
Van-der-waals | TM6 | C | 241 | 6x37 | G.H5 | L | 393 | G.H5.25 |
Hydrophobic | TM7 | R | 293 | 7x56 | G.H5 | E | 392 | G.H5.24 |
Van-der-waals | TM7 | R | 293 | 7x56 | G.H5 | E | 392 | G.H5.24 |
Hydrophobic | ICL2 | L | 134 | 34x55 | G.hns1 | A | 39 | G.hns1.03 |
Hydrophobic | TM6 | G | 233 | 6x29 | G.H5 | L | 394 | G.H5.26 |
Hydrophobic | TM6 | T | 240 | 6x36 | G.H5 | Y | 391 | G.H5.23 |
Polar | ICL1 | H | 56 | 12x51 | G.hns1 | R | 38 | G.hns1.02 |
Hydrophobic | ICL1 | H | 56 | 12x51 | G.hns1 | R | 38 | G.hns1.02 |
Van-der-waals | ICL1 | H | 56 | 12x51 | G.hns1 | R | 38 | G.hns1.02 |
Hydrophobic | TM3 | C | 122 | 3x50 | G.H5 | Y | 391 | G.H5.23 |
Hydrophobic | ICL2 | L | 130 | 34x51 | G.H5 | I | 383 | G.H5.15 |
Van-der-waals | ICL2 | L | 130 | 34x51 | G.H5 | I | 383 | G.H5.15 |
Hydrophobic | TM3 | I | 126 | 3x54 | G.H5 | L | 393 | G.H5.25 |
Van-der-waals | TM3 | I | 126 | 3x54 | G.H5 | L | 393 | G.H5.25 |
Hydrophobic | ICL2 | P | 129 | 34x50 | G.H5 | R | 380 | G.H5.12 |
Van-der-waals | ICL2 | P | 129 | 34x50 | G.H5 | R | 380 | G.H5.12 |
Hydrophobic | ICL2 | L | 130 | 34x51 | G.H5 | R | 380 | G.H5.12 |
Hydrophobic | ICL3 | I | 228 | - | G.H5 | Q | 384 | G.H5.16 |
Van-der-waals | ICL3 | I | 228 | - | G.H5 | Q | 384 | G.H5.16 |
Polar | H8 | N | 294 | 8x47 | G.H5 | Q | 390 | G.H5.22 |
Van-der-waals | H8 | N | 294 | 8x47 | G.H5 | Q | 390 | G.H5.22 |
Hydrophobic | TM2 | M | 59 | 2x39 | G.H5 | Y | 391 | G.H5.23 |
Van-der-waals | TM2 | M | 59 | 2x39 | G.H5 | Y | 391 | G.H5.23 |
Hydrophobic | ICL2 | P | 129 | 34x50 | G.H5 | I | 383 | G.H5.15 |
Van-der-waals | ICL2 | P | 129 | 34x50 | G.H5 | I | 383 | G.H5.15 |
Polar | TM6 | S | 230 | 6x26 | G.H5 | R | 385 | G.H5.17 |
Hydrophobic | ICL2 | I | 133 | 34x54 | G.hns1 | R | 38 | G.hns1.02 |
Van-der-waals | ICL2 | I | 133 | 34x54 | G.hns1 | R | 38 | G.hns1.02 |
Polar | ICL2 | H | 131 | 34x52 | G.s2s3 | D | 215 | G.s2s3.01 |
Van-der-waals | ICL2 | H | 131 | 34x52 | G.s2s3 | D | 215 | G.s2s3.01 |
Polar | TM6 | A | 237 | 6x33 | G.H5 | L | 393 | G.H5.25 |
Hydrophobic | TM6 | A | 237 | 6x33 | G.H5 | L | 393 | G.H5.25 |
Van-der-waals | TM6 | A | 237 | 6x33 | G.H5 | L | 393 | G.H5.25 |
Hydrophobic | ICL2 | L | 130 | 34x51 | G.H5 | C | 379 | G.H5.11 |
Hydrophobic | ICL2 | H | 131 | 34x52 | G.S3 | V | 217 | G.S3.01 |
Van-der-waals | ICL2 | H | 131 | 34x52 | G.S3 | V | 217 | G.S3.01 |
Polar | ICL1 | T | 53 | 12x48 | G.hns1 | R | 38 | G.hns1.02 |
Hydrophobic | TM6 | A | 237 | 6x33 | G.H5 | L | 388 | G.H5.20 |
Hydrophobic | ICL2 | L | 134 | 34x55 | G.s2s3 | K | 216 | G.s2s3.02 |
Van-der-waals | ICL2 | L | 134 | 34x55 | G.s2s3 | K | 216 | G.s2s3.02 |
Hydrophobic | ICL3 | I | 228 | - | G.H5 | L | 388 | G.H5.20 |
Van-der-waals | ICL3 | I | 228 | - | G.H5 | L | 388 | G.H5.20 |
Polar | TM6 | T | 240 | 6x36 | G.H5 | E | 392 | G.H5.24 |
Hydrophobic | TM6 | T | 240 | 6x36 | G.H5 | E | 392 | G.H5.24 |
Van-der-waals | TM6 | T | 240 | 6x36 | G.H5 | E | 392 | G.H5.24 |
Hydrophobic | TM6 | K | 236 | 6x32 | G.H5 | L | 393 | G.H5.25 |
Van-der-waals | TM6 | K | 236 | 6x32 | G.H5 | L | 393 | G.H5.25 |