G12 - OX1 receptor complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

G12/13

DATE

2023-09-15

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

(pLDDT score) avg.: 78.1

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.7
iPTM Score: 0.6
PAE mean: 15.1


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic ICL3 R 279 - G.H4 R 337 G.H4.17
Van-der-waals ICL3 R 279 - G.H4 R 337 G.H4.17
Polar ICL3 L 254 - G.H4 R 329 G.H4.09
Hydrophobic TM5 K 241 5x64 G.H5 K 367 G.H5.12
Polar ICL3 R 279 - G.H4 Q 333 G.H4.13
Hydrophobic ICL3 R 279 - G.H4 Q 333 G.H4.13
Van-der-waals ICL3 R 279 - G.H4 Q 333 G.H4.13
Hydrophobic ICL2 L 152 34x51 G.S1 V 58 G.S1.02
Polar H8 F 365 8x50 G.H5 L 380 G.H5.25
Hydrophobic H8 F 365 8x50 G.H5 L 380 G.H5.25
Hydrophobic TM5 P 248 5x71 G.H5 H 364 G.H5.09
Hydrophobic TM6 Q 289 6x26 G.h4s6 P 345 G.h4s6.20
Van-der-waals TM6 Q 289 6x26 G.h4s6 P 345 G.h4s6.20
Hydrophobic TM5 P 248 5x71 G.H5 D 368 G.H5.13
Hydrophobic ICL2 L 152 34x51 G.H5 K 367 G.H5.12
Polar TM6 Q 289 6x26 G.H5 Q 372 G.H5.17
Hydrophobic TM6 Q 289 6x26 G.H5 Q 372 G.H5.17
Van-der-waals TM6 Q 289 6x26 G.H5 Q 372 G.H5.17
Ionic TM6 R 293 6x30 G.H5 D 368 G.H5.13
Polar TM6 R 293 6x30 G.H5 D 368 G.H5.13
Hydrophobic TM6 R 293 6x30 G.H5 D 368 G.H5.13
Van-der-waals TM6 R 293 6x30 G.H5 D 368 G.H5.13
Polar ICL2 L 153 34x52 G.hns1 R 56 G.hns1.03
Van-der-waals ICL2 L 153 34x52 G.hns1 R 56 G.hns1.03
Hydrophobic ICL3 L 254 - G.H4 E 325 G.H4.05
Polar H8 G 363 8x48 G.H5 L 380 G.H5.25
Van-der-waals H8 G 363 8x48 G.H5 L 380 G.H5.25
Hydrophobic ICL2 P 151 34x50 G.H5 I 370 G.H5.15
Hydrophobic TM5 R 245 5x68 G.H5 K 367 G.H5.12
Van-der-waals TM5 R 245 5x68 G.H5 K 367 G.H5.12
Polar H8 K 364 8x49 G.H5 L 380 G.H5.25
Hydrophobic H8 K 364 8x49 G.H5 L 380 G.H5.25
Van-der-waals H8 K 364 8x49 G.H5 L 380 G.H5.25
Hydrophobic TM5 P 248 5x71 G.H5 F 361 G.H5.06
Hydrophobic TM3 I 148 3x54 G.H5 L 371 G.H5.16
Hydrophobic TM6 R 293 6x30 G.H5 L 371 G.H5.16
Hydrophobic ICL3 P 276 - G.H4 R 329 G.H4.09
Van-der-waals ICL3 P 276 - G.H4 R 329 G.H4.09
Hydrophobic TM5 I 247 5x70 G.h4s6 P 345 G.h4s6.20
Hydrophobic H8 K 364 8x49 G.H5 Q 381 G.H5.26
Van-der-waals H8 K 364 8x49 G.H5 Q 381 G.H5.26
Hydrophobic ICL2 L 152 34x51 G.H5 V 366 G.H5.11
Hydrophobic TM6 A 292 6x29 G.H5 M 379 G.H5.24
Hydrophobic TM5 L 242 5x65 G.H5 L 375 G.H5.20
Van-der-waals TM5 L 242 5x65 G.H5 L 375 G.H5.20
Polar TM3 R 144 3x50 G.H5 I 378 G.H5.23
Hydrophobic TM3 R 144 3x50 G.H5 I 378 G.H5.23
Van-der-waals TM3 R 144 3x50 G.H5 I 378 G.H5.23
Hydrophobic TM5 P 248 5x71 G.S6 F 347 G.S6.02
Van-der-waals TM5 P 248 5x71 G.S6 F 347 G.S6.02
Polar TM4 T 157 4x38 G.hns1 R 55 G.hns1.02
Hydrophobic TM4 T 157 4x38 G.hns1 R 55 G.hns1.02
Van-der-waals TM4 T 157 4x38 G.hns1 R 55 G.hns1.02
Ionic H8 K 364 8x49 G.H5 D 377 G.H5.22
Polar H8 K 364 8x49 G.H5 D 377 G.H5.22
Van-der-waals H8 K 364 8x49 G.H5 D 377 G.H5.22
Polar H8 S 362 8x47 G.H5 M 379 G.H5.24
Hydrophobic H8 S 362 8x47 G.H5 M 379 G.H5.24
Van-der-waals H8 S 362 8x47 G.H5 M 379 G.H5.24
Hydrophobic TM6 T 296 6x33 G.H5 L 375 G.H5.20
Hydrophobic TM2 I 85 2x43 G.H5 L 380 G.H5.25
Hydrophobic ICL2 L 152 34x51 G.H5 F 363 G.H5.08
Van-der-waals ICL2 L 152 34x51 G.H5 F 363 G.H5.08
Hydrophobic ICL3 G 249 - G.H5 F 361 G.H5.06
Van-der-waals ICL3 G 249 - G.H5 F 361 G.H5.06
Hydrophobic TM5 L 242 5x65 G.H5 L 371 G.H5.16
Hydrophobic TM6 R 293 6x30 G.H5 L 375 G.H5.20
Hydrophobic ICL2 L 152 34x51 G.S3 I 221 G.S3.01
Van-der-waals ICL2 L 152 34x51 G.S3 I 221 G.S3.01
Hydrophobic ICL2 L 152 34x51 G.H5 I 370 G.H5.15
Van-der-waals ICL2 L 152 34x51 G.H5 I 370 G.H5.15
Polar TM3 A 147 3x53 G.H5 N 374 G.H5.19
Hydrophobic TM3 A 147 3x53 G.H5 N 374 G.H5.19
Van-der-waals TM3 A 147 3x53 G.H5 N 374 G.H5.19
Hydrophobic TM3 I 148 3x54 G.H5 I 378 G.H5.23
Hydrophobic TM3 A 147 3x53 G.H5 I 378 G.H5.23
Van-der-waals TM3 A 147 3x53 G.H5 I 378 G.H5.23
Hydrophobic ICL2 P 151 34x50 G.H5 K 367 G.H5.12
Hydrophobic TM5 P 248 5x71 G.H5 A 365 G.H5.10
Van-der-waals TM5 P 248 5x71 G.H5 A 365 G.H5.10
Polar ICL2 K 155 - G.hns1 R 55 G.hns1.02
Hydrophobic ICL2 K 155 - G.hns1 R 55 G.hns1.02
Van-der-waals ICL2 K 155 - G.hns1 R 55 G.hns1.02
Hydrophobic TM3 I 148 3x54 G.H5 L 375 G.H5.20
Hydrophobic ICL3 V 255 - G.H4 R 329 G.H4.09
Van-der-waals ICL3 V 255 - G.H4 R 329 G.H4.09
Polar TM6 R 293 6x30 G.H5 Q 372 G.H5.17
Hydrophobic TM6 R 293 6x30 G.H5 Q 372 G.H5.17
Van-der-waals TM6 R 293 6x30 G.H5 Q 372 G.H5.17
Hydrophobic TM6 T 296 6x33 G.H5 M 379 G.H5.24
Van-der-waals TM6 T 296 6x33 G.H5 M 379 G.H5.24
Polar H8 S 362 8x47 G.H5 L 380 G.H5.25
Hydrophobic H8 S 362 8x47 G.H5 L 380 G.H5.25
Van-der-waals H8 S 362 8x47 G.H5 L 380 G.H5.25
Polar TM6 Q 289 6x26 G.H5 D 368 G.H5.13
Hydrophobic TM2 N 82 2x40 G.H5 L 380 G.H5.25
Hydrophobic TM5 I 247 5x70 G.S6 F 347 G.S6.02
Van-der-waals TM5 I 247 5x70 G.S6 F 347 G.S6.02