Gi1 -
OX1 receptor complex model
GPCR CLASS (FAMILY)
SPECIES
G PROTEIN FAMILY
DATE
3D VIEW
Tertiary structure confidence
(pLDDT score) avg.: 80.4
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered
PTM Score: 0.7
iPTM Score: 0.7
PAE mean: 13.4
GPCR - G protein interface interactions
The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle
(Gα residues)
and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid,
hydrophobic - dashed,
ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.
GPCR-G protein backbone (bb) or sidechain (sc):
Structures
0 structures selected.
Sequence Color
Interaction frequency filter (%)
Gα,
GPCR
Interaction cut-off: strict (stick), loose (line)
Interaction type |
GPCR Segment |
AA |
Number |
Generic number |
Gα segment |
AA |
Number |
Generic number |
---|---|---|---|---|---|---|---|---|
Hydrophobic | TM6 | M | 299 | 6x36 | G.H5 | L | 353 | G.H5.25 |
Van-der-waals | TM6 | M | 299 | 6x36 | G.H5 | L | 353 | G.H5.25 |
Hydrophobic | C-term | V | 420 | - | G.S2 | E | 186 | G.S2.03 |
Van-der-waals | C-term | V | 420 | - | G.S2 | E | 186 | G.S2.03 |
Hydrophobic | TM5 | P | 248 | 5x71 | G.H5 | D | 341 | G.H5.13 |
Polar | TM3 | A | 147 | 3x53 | G.H5 | N | 347 | G.H5.19 |
Hydrophobic | TM3 | A | 147 | 3x53 | G.H5 | N | 347 | G.H5.19 |
Van-der-waals | TM3 | A | 147 | 3x53 | G.H5 | N | 347 | G.H5.19 |
Polar | C-term | V | 416 | - | G.S2 | T | 190 | G.S2.07 |
Hydrophobic | C-term | V | 416 | - | G.S2 | T | 190 | G.S2.07 |
Van-der-waals | C-term | V | 416 | - | G.S2 | T | 190 | G.S2.07 |
Hydrophobic | TM5 | R | 245 | 5x68 | G.H5 | T | 340 | G.H5.12 |
Polar | C-term | V | 415 | - | G.H1 | H | 57 | G.H1.12 |
Hydrophobic | C-term | V | 415 | - | G.H1 | H | 57 | G.H1.12 |
Van-der-waals | C-term | V | 415 | - | G.H1 | H | 57 | G.H1.12 |
Ionic | TM6 | K | 288 | 6x25 | G.h4s6 | D | 315 | G.h4s6.09 |
Polar | TM6 | K | 288 | 6x25 | G.h4s6 | D | 315 | G.h4s6.09 |
Hydrophobic | TM6 | K | 288 | 6x25 | G.h4s6 | D | 315 | G.h4s6.09 |
Van-der-waals | TM6 | K | 288 | 6x25 | G.h4s6 | D | 315 | G.h4s6.09 |
Hydrophobic | C-term | L | 417 | - | G.H1 | M | 53 | G.H1.08 |
Van-der-waals | C-term | L | 417 | - | G.H1 | M | 53 | G.H1.08 |
Polar | C-term | T | 418 | - | G.h1ha | E | 58 | G.h1ha.01 |
Hydrophobic | TM3 | I | 148 | 3x54 | G.H5 | I | 344 | G.H5.16 |
Hydrophobic | TM3 | A | 147 | 3x53 | G.H5 | C | 351 | G.H5.23 |
Hydrophobic | C-term | L | 424 | - | G.hfs2 | G | 183 | G.hfs2.07 |
Van-der-waals | C-term | L | 424 | - | G.hfs2 | G | 183 | G.hfs2.07 |
Hydrophobic | C-term | L | 424 | - | G.H2 | H | 213 | G.H2.09 |
Hydrophobic | C-term | V | 415 | - | G.S2 | F | 189 | G.S2.06 |
Van-der-waals | C-term | V | 415 | - | G.S2 | F | 189 | G.S2.06 |
Polar | C-term | T | 418 | - | G.S2 | F | 189 | G.S2.06 |
Hydrophobic | ICL2 | L | 152 | 34x51 | G.H5 | I | 343 | G.H5.15 |
Hydrophobic | TM5 | P | 248 | 5x71 | G.H5 | D | 337 | G.H5.09 |
Van-der-waals | TM5 | P | 248 | 5x71 | G.H5 | D | 337 | G.H5.09 |
Hydrophobic | ICL3 | S | 252 | - | G.S6 | F | 323 | G.S6.05 |
Hydrophobic | C-term | E | 413 | - | G.S2 | F | 191 | G.S2.08 |
Van-der-waals | C-term | E | 413 | - | G.S2 | F | 191 | G.S2.08 |
Hydrophobic | ICL3 | V | 255 | - | G.H4 | A | 301 | G.H4.08 |
Hydrophobic | C-term | L | 417 | - | G.S2 | T | 187 | G.S2.04 |
Van-der-waals | C-term | L | 417 | - | G.S2 | T | 187 | G.S2.04 |
Hydrophobic | C-term | V | 423 | - | G.S2 | E | 186 | G.S2.03 |
Van-der-waals | C-term | V | 423 | - | G.S2 | E | 186 | G.S2.03 |
Hydrophobic | C-term | V | 415 | - | G.H5 | V | 332 | G.H5.04 |
Hydrophobic | C-term | V | 415 | - | G.S2 | T | 190 | G.S2.07 |
Van-der-waals | C-term | V | 415 | - | G.S2 | T | 190 | G.S2.07 |
Polar | C-term | L | 417 | - | G.H1 | H | 57 | G.H1.12 |
Hydrophobic | C-term | L | 417 | - | G.H1 | H | 57 | G.H1.12 |
Van-der-waals | C-term | L | 417 | - | G.H1 | H | 57 | G.H1.12 |
Ionic | C-term | E | 413 | - | G.s2s3 | K | 192 | G.s2s3.01 |
Polar | C-term | E | 413 | - | G.s2s3 | K | 192 | G.s2s3.01 |
Hydrophobic | C-term | E | 413 | - | G.s2s3 | K | 192 | G.s2s3.01 |
Van-der-waals | C-term | E | 413 | - | G.s2s3 | K | 192 | G.s2s3.01 |
Hydrophobic | C-term | P | 425 | - | G.hfs2 | G | 183 | G.hfs2.07 |
Van-der-waals | C-term | P | 425 | - | G.hfs2 | G | 183 | G.hfs2.07 |
Polar | C-term | V | 416 | - | G.H1 | H | 57 | G.H1.12 |
Hydrophobic | C-term | V | 416 | - | G.H1 | H | 57 | G.H1.12 |
Van-der-waals | C-term | V | 416 | - | G.H1 | H | 57 | G.H1.12 |
Polar | C-term | L | 424 | - | G.S2 | I | 184 | G.S2.01 |
Hydrophobic | C-term | L | 424 | - | G.S2 | I | 184 | G.S2.01 |
Van-der-waals | C-term | L | 424 | - | G.S2 | I | 184 | G.S2.01 |
Hydrophobic | C-term | L | 417 | - | G.S2 | F | 189 | G.S2.06 |
Van-der-waals | C-term | L | 417 | - | G.S2 | F | 189 | G.S2.06 |
Ionic | ICL2 | K | 155 | - | G.HN | E | 28 | G.HN.52 |
Polar | ICL2 | K | 155 | - | G.HN | E | 28 | G.HN.52 |
Hydrophobic | ICL2 | K | 155 | - | G.HN | E | 28 | G.HN.52 |
Van-der-waals | ICL2 | K | 155 | - | G.HN | E | 28 | G.HN.52 |
Ionic | TM6 | R | 293 | 6x30 | G.H5 | D | 341 | G.H5.13 |
Polar | TM6 | R | 293 | 6x30 | G.H5 | D | 341 | G.H5.13 |
Hydrophobic | TM6 | R | 293 | 6x30 | G.H5 | D | 341 | G.H5.13 |
Van-der-waals | TM6 | R | 293 | 6x30 | G.H5 | D | 341 | G.H5.13 |
Hydrophobic | C-term | H | 414 | - | G.S2 | F | 191 | G.S2.08 |
Hydrophobic | TM6 | T | 296 | 6x33 | G.H5 | L | 348 | G.H5.20 |
Hydrophobic | ICL2 | P | 151 | 34x50 | G.H5 | I | 344 | G.H5.16 |
Polar | TM2 | T | 81 | 2x39 | G.H5 | C | 351 | G.H5.23 |
Hydrophobic | TM2 | T | 81 | 2x39 | G.H5 | C | 351 | G.H5.23 |
Polar | H8 | S | 362 | 8x47 | G.H5 | F | 354 | G.H5.26 |
Hydrophobic | TM5 | K | 241 | 5x64 | G.H5 | I | 344 | G.H5.16 |
Van-der-waals | TM5 | K | 241 | 5x64 | G.H5 | I | 344 | G.H5.16 |
Hydrophobic | TM5 | P | 248 | 5x71 | G.S6 | Y | 320 | G.S6.02 |
Hydrophobic | ICL2 | L | 152 | 34x51 | G.H5 | F | 336 | G.H5.08 |
Van-der-waals | ICL2 | L | 152 | 34x51 | G.H5 | F | 336 | G.H5.08 |
Hydrophobic | C-term | V | 416 | - | G.S2 | F | 189 | G.S2.06 |
Van-der-waals | C-term | V | 416 | - | G.S2 | F | 189 | G.S2.06 |
Hydrophobic | ICL2 | K | 155 | - | G.hns1 | R | 32 | G.hns1.03 |
Hydrophobic | C-term | P | 425 | - | G.hfs2 | T | 182 | G.hfs2.06 |
Van-der-waals | C-term | P | 425 | - | G.hfs2 | T | 182 | G.hfs2.06 |
Hydrophobic | C-term | L | 417 | - | G.S2 | H | 188 | G.S2.05 |
Van-der-waals | C-term | L | 417 | - | G.S2 | H | 188 | G.S2.05 |
Polar | TM6 | T | 296 | 6x33 | G.H5 | L | 353 | G.H5.25 |
Hydrophobic | TM6 | T | 296 | 6x33 | G.H5 | L | 353 | G.H5.25 |
Van-der-waals | TM6 | T | 296 | 6x33 | G.H5 | L | 353 | G.H5.25 |
Hydrophobic | C-term | T | 422 | - | G.S2 | I | 184 | G.S2.01 |
Van-der-waals | C-term | T | 422 | - | G.S2 | I | 184 | G.S2.01 |
Polar | C-term | V | 423 | - | G.S2 | I | 184 | G.S2.01 |
Hydrophobic | C-term | V | 423 | - | G.S2 | I | 184 | G.S2.01 |
Van-der-waals | C-term | V | 423 | - | G.S2 | I | 184 | G.S2.01 |
Polar | C-term | P | 425 | - | G.H2 | K | 210 | G.H2.06 |
Hydrophobic | C-term | P | 425 | - | G.H2 | K | 210 | G.H2.06 |
Van-der-waals | C-term | P | 425 | - | G.H2 | K | 210 | G.H2.06 |
Hydrophobic | ICL3 | G | 249 | - | G.H5 | F | 334 | G.H5.06 |
Van-der-waals | ICL3 | G | 249 | - | G.H5 | F | 334 | G.H5.06 |
Hydrophobic | C-term | V | 420 | - | G.S2 | T | 187 | G.S2.04 |
Polar | ICL3 | R | 279 | - | G.H4 | Q | 304 | G.H4.12 |
Van-der-waals | ICL3 | R | 279 | - | G.H4 | Q | 304 | G.H4.12 |
Hydrophobic | TM6 | L | 300 | 6x37 | G.H5 | L | 353 | G.H5.25 |
Van-der-waals | TM6 | L | 300 | 6x37 | G.H5 | L | 353 | G.H5.25 |
Hydrophobic | TM6 | A | 285 | 6x22 | G.h4s6 | K | 314 | G.h4s6.08 |
Van-der-waals | TM6 | A | 285 | 6x22 | G.h4s6 | K | 314 | G.h4s6.08 |
Polar | H8 | G | 363 | 8x48 | G.H5 | F | 354 | G.H5.26 |
Hydrophobic | ICL3 | V | 255 | - | G.H4 | E | 298 | G.H4.05 |
Polar | H8 | K | 364 | 8x49 | G.H5 | F | 354 | G.H5.26 |
Hydrophobic | C-term | V | 420 | - | G.S2 | V | 185 | G.S2.02 |
Van-der-waals | C-term | V | 420 | - | G.S2 | V | 185 | G.S2.02 |
Hydrophobic | TM5 | P | 248 | 5x71 | G.H5 | A | 338 | G.H5.10 |
Hydrophobic | TM5 | P | 248 | 5x71 | G.H5 | F | 334 | G.H5.06 |
Van-der-waals | TM5 | P | 248 | 5x71 | G.H5 | F | 334 | G.H5.06 |
Hydrophobic | ICL3 | A | 282 | - | G.H4 | E | 308 | G.H4.16 |
Van-der-waals | ICL3 | A | 282 | - | G.H4 | E | 308 | G.H4.16 |
Polar | C-term | T | 421 | - | G.S2 | E | 186 | G.S2.03 |
Hydrophobic | C-term | T | 421 | - | G.S2 | E | 186 | G.S2.03 |
Van-der-waals | C-term | T | 421 | - | G.S2 | E | 186 | G.S2.03 |
Ionic | TM6 | R | 293 | 6x30 | G.h4s6 | E | 318 | G.h4s6.12 |
Polar | TM6 | R | 293 | 6x30 | G.h4s6 | E | 318 | G.h4s6.12 |
Hydrophobic | TM5 | I | 247 | 5x70 | G.h4s6 | E | 318 | G.h4s6.12 |
Van-der-waals | TM5 | I | 247 | 5x70 | G.h4s6 | E | 318 | G.h4s6.12 |
Polar | TM6 | Q | 289 | 6x26 | G.h4s6 | E | 318 | G.h4s6.12 |
Hydrophobic | TM6 | Q | 289 | 6x26 | G.h4s6 | E | 318 | G.h4s6.12 |
Van-der-waals | TM6 | Q | 289 | 6x26 | G.h4s6 | E | 318 | G.h4s6.12 |
Polar | TM4 | T | 157 | 4x38 | G.HN | R | 24 | G.HN.48 |
Van-der-waals | TM4 | T | 157 | 4x38 | G.HN | R | 24 | G.HN.48 |
Hydrophobic | ICL3 | R | 279 | - | G.H4 | C | 305 | G.H4.13 |
Van-der-waals | ICL3 | R | 279 | - | G.H4 | C | 305 | G.H4.13 |
Hydrophobic | ICL3 | R | 279 | - | G.H4 | A | 301 | G.H4.08 |
Van-der-waals | ICL3 | R | 279 | - | G.H4 | A | 301 | G.H4.08 |
Polar | ICL2 | L | 152 | 34x51 | G.hns1 | R | 32 | G.hns1.03 |
Hydrophobic | ICL2 | F | 154 | 34x53 | G.H5 | N | 347 | G.H5.19 |
Hydrophobic | TM3 | I | 148 | 3x54 | G.H5 | L | 348 | G.H5.20 |
Van-der-waals | TM3 | I | 148 | 3x54 | G.H5 | L | 348 | G.H5.20 |
Hydrophobic | ICL2 | L | 153 | 34x52 | G.hns1 | R | 32 | G.hns1.03 |
Hydrophobic | TM5 | L | 242 | 5x65 | G.H5 | I | 344 | G.H5.16 |
Hydrophobic | ICL2 | P | 151 | 34x50 | G.H5 | T | 340 | G.H5.12 |
Van-der-waals | ICL3 | G | 249 | - | G.S6 | T | 321 | G.S6.03 |
Hydrophobic | ICL2 | P | 151 | 34x50 | G.H5 | I | 343 | G.H5.15 |
Van-der-waals | ICL2 | P | 151 | 34x50 | G.H5 | I | 343 | G.H5.15 |
Ionic | H8 | K | 364 | 8x49 | G.H5 | D | 350 | G.H5.22 |
Polar | H8 | K | 364 | 8x49 | G.H5 | D | 350 | G.H5.22 |
Van-der-waals | H8 | K | 364 | 8x49 | G.H5 | D | 350 | G.H5.22 |
Polar | TM3 | R | 144 | 3x50 | G.H5 | C | 351 | G.H5.23 |
Hydrophobic | TM3 | R | 144 | 3x50 | G.H5 | C | 351 | G.H5.23 |
Hydrophobic | TM4 | R | 159 | 4x40 | G.HN | R | 24 | G.HN.48 |
Van-der-waals | TM4 | R | 159 | 4x40 | G.HN | R | 24 | G.HN.48 |
Hydrophobic | C-term | T | 422 | - | G.S2 | V | 185 | G.S2.02 |
Polar | C-term | L | 417 | - | G.h1ha | E | 58 | G.h1ha.01 |
Hydrophobic | C-term | L | 417 | - | G.h1ha | E | 58 | G.h1ha.01 |
Van-der-waals | C-term | L | 417 | - | G.h1ha | E | 58 | G.h1ha.01 |
Hydrophobic | ICL3 | V | 255 | - | G.H4 | E | 297 | G.H4.04 |
Polar | H8 | S | 362 | 8x47 | G.H5 | G | 352 | G.H5.24 |
Hydrophobic | H8 | S | 362 | 8x47 | G.H5 | G | 352 | G.H5.24 |
Van-der-waals | H8 | S | 362 | 8x47 | G.H5 | G | 352 | G.H5.24 |
Hydrophobic | TM5 | R | 245 | 5x68 | G.H5 | I | 344 | G.H5.16 |
Van-der-waals | TM5 | R | 245 | 5x68 | G.H5 | I | 344 | G.H5.16 |
Hydrophobic | TM5 | L | 242 | 5x65 | G.H5 | L | 348 | G.H5.20 |
Hydrophobic | C-term | S | 419 | - | G.S2 | T | 187 | G.S2.04 |
Van-der-waals | C-term | S | 419 | - | G.S2 | T | 187 | G.S2.04 |
Polar | TM6 | Q | 289 | 6x26 | G.H5 | K | 345 | G.H5.17 |
Hydrophobic | TM6 | Q | 289 | 6x26 | G.H5 | K | 345 | G.H5.17 |
Van-der-waals | TM6 | Q | 289 | 6x26 | G.H5 | K | 345 | G.H5.17 |
Hydrophobic | C-term | V | 415 | - | G.S2 | F | 191 | G.S2.08 |
Van-der-waals | C-term | V | 415 | - | G.S2 | F | 191 | G.S2.08 |
Hydrophobic | ICL3 | R | 281 | - | G.h4s6 | K | 314 | G.h4s6.08 |
Van-der-waals | ICL3 | R | 281 | - | G.h4s6 | K | 314 | G.h4s6.08 |
Polar | C-term | S | 419 | - | G.S2 | H | 188 | G.S2.05 |
Van-der-waals | C-term | S | 419 | - | G.S2 | H | 188 | G.S2.05 |
Hydrophobic | ICL2 | L | 152 | 34x51 | G.S3 | L | 194 | G.S3.01 |
Van-der-waals | ICL2 | L | 152 | 34x51 | G.S3 | L | 194 | G.S3.01 |
Hydrophobic | TM3 | R | 144 | 3x50 | G.H5 | L | 353 | G.H5.25 |
Van-der-waals | TM3 | R | 144 | 3x50 | G.H5 | L | 353 | G.H5.25 |
Polar | H8 | K | 364 | 8x49 | G.H5 | K | 349 | G.H5.21 |
Hydrophobic | H8 | K | 364 | 8x49 | G.H5 | K | 349 | G.H5.21 |
Van-der-waals | H8 | K | 364 | 8x49 | G.H5 | K | 349 | G.H5.21 |
Hydrophobic | C-term | L | 417 | - | G.H1 | K | 54 | G.H1.09 |
Van-der-waals | C-term | L | 417 | - | G.H1 | K | 54 | G.H1.09 |
Polar | C-term | T | 418 | - | G.S2 | H | 188 | G.S2.05 |
Hydrophobic | C-term | T | 418 | - | G.S2 | H | 188 | G.S2.05 |
Van-der-waals | C-term | T | 418 | - | G.S2 | H | 188 | G.S2.05 |
Hydrophobic | TM5 | I | 247 | 5x70 | G.S6 | Y | 320 | G.S6.02 |
Van-der-waals | TM5 | I | 247 | 5x70 | G.S6 | Y | 320 | G.S6.02 |
Van-der-waals | TM4 | R | 160 | 4x41 | G.HN | R | 24 | G.HN.48 |
Hydrophobic | TM3 | I | 148 | 3x54 | G.H5 | L | 353 | G.H5.25 |