Gs - OX1 receptor complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gs

DATE

2023-09-15

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

(pLDDT score) avg.: 79.9

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.7
iPTM Score: 0.7
PAE mean: 13.4


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic TM6 M 299 6x36 G.H5 L 393 G.H5.25
Van-der-waals TM6 M 299 6x36 G.H5 L 393 G.H5.25
Polar TM6 R 293 6x30 G.H5 Q 384 G.H5.16
Polar TM3 D 143 3x49 G.H5 Y 391 G.H5.23
Hydrophobic TM3 D 143 3x49 G.H5 Y 391 G.H5.23
Van-der-waals TM3 D 143 3x49 G.H5 Y 391 G.H5.23
Hydrophobic TM3 I 148 3x54 G.H5 L 388 G.H5.20
Van-der-waals TM3 I 148 3x54 G.H5 L 388 G.H5.20
Hydrophobic ICL2 L 153 34x52 G.s2s3 K 216 G.s2s3.02
Hydrophobic TM5 I 247 5x70 G.H5 R 385 G.H5.17
Van-der-waals TM5 I 247 5x70 G.H5 R 385 G.H5.17
Hydrophobic ICL3 A 282 - G.h4s6 T 350 G.h4s6.03
Van-der-waals ICL3 A 282 - G.h4s6 T 350 G.h4s6.03
Ionic ICL3 R 279 - G.H4 D 343 G.H4.13
Polar ICL3 R 279 - G.H4 D 343 G.H4.13
Hydrophobic ICL3 R 279 - G.H4 D 343 G.H4.13
Van-der-waals ICL3 R 279 - G.H4 D 343 G.H4.13
Hydrophobic TM5 R 245 5x68 G.H5 R 380 G.H5.12
Van-der-waals TM5 R 245 5x68 G.H5 R 380 G.H5.12
Hydrophobic ICL2 P 151 34x50 G.H5 R 380 G.H5.12
Van-der-waals ICL2 P 151 34x50 G.H5 R 380 G.H5.12
Hydrophobic H8 F 365 8x50 G.H5 E 392 G.H5.24
Van-der-waals H8 F 365 8x50 G.H5 E 392 G.H5.24
Hydrophobic ICL2 P 151 34x50 G.H5 I 383 G.H5.15
Polar ICL2 L 152 34x51 G.S1 H 41 G.S1.02
Hydrophobic ICL2 L 152 34x51 G.S1 H 41 G.S1.02
Van-der-waals ICL2 L 152 34x51 G.S1 H 41 G.S1.02
Hydrophobic ICL2 K 155 - G.hns1 A 39 G.hns1.03
Van-der-waals ICL2 K 155 - G.hns1 A 39 G.hns1.03
Hydrophobic ICL3 V 255 - G.hgh4 D 323 G.hgh4.13
Van-der-waals ICL3 V 255 - G.hgh4 D 323 G.hgh4.13
Hydrophobic TM6 A 292 6x29 G.H5 L 394 G.H5.26
Hydrophobic ICL2 L 152 34x51 G.H5 F 376 G.H5.08
Van-der-waals ICL2 L 152 34x51 G.H5 F 376 G.H5.08
Hydrophobic ICL3 G 249 - G.S6 P 361 G.S6.03
Polar TM6 Q 289 6x26 G.H5 R 385 G.H5.17
Hydrophobic TM6 Q 289 6x26 G.H5 R 385 G.H5.17
Van-der-waals TM6 Q 289 6x26 G.H5 R 385 G.H5.17
Polar H8 S 362 8x47 G.H5 E 392 G.H5.24
Hydrophobic H8 S 362 8x47 G.H5 E 392 G.H5.24
Van-der-waals H8 S 362 8x47 G.H5 E 392 G.H5.24
Hydrophobic TM5 L 242 5x65 G.H5 Q 384 G.H5.16
Hydrophobic ICL2 L 152 34x51 G.S3 V 217 G.S3.01
Van-der-waals ICL2 L 152 34x51 G.S3 V 217 G.S3.01
Hydrophobic ICL3 R 279 - G.hgh4 P 321 G.hgh4.11
Van-der-waals ICL3 R 279 - G.hgh4 P 321 G.hgh4.11
Hydrophobic TM5 P 248 5x71 G.H5 D 378 G.H5.10
Van-der-waals TM5 P 248 5x71 G.H5 D 378 G.H5.10
Van-der-waals TM6 R 293 6x30 G.H5 R 385 G.H5.17
Ionic TM6 R 293 6x30 G.H5 D 381 G.H5.13
Polar TM6 R 293 6x30 G.H5 D 381 G.H5.13
Hydrophobic TM6 R 293 6x30 G.H5 D 381 G.H5.13
Van-der-waals TM6 R 293 6x30 G.H5 D 381 G.H5.13
Polar TM2 T 81 2x39 G.H5 Y 391 G.H5.23
Hydrophobic TM2 T 81 2x39 G.H5 Y 391 G.H5.23
Van-der-waals TM2 T 81 2x39 G.H5 Y 391 G.H5.23
Hydrophobic TM5 L 242 5x65 G.H5 L 388 G.H5.20
Van-der-waals TM5 L 242 5x65 G.H5 L 388 G.H5.20
Van-der-waals TM5 K 241 5x64 G.H5 Q 384 G.H5.16
Polar ICL3 T 251 - G.H4 R 342 G.H4.12
Hydrophobic TM6 L 300 6x37 G.H5 L 393 G.H5.25
Polar TM3 I 148 3x54 G.H5 Q 384 G.H5.16
Hydrophobic TM3 I 148 3x54 G.H5 Q 384 G.H5.16
Van-der-waals TM3 I 148 3x54 G.H5 Q 384 G.H5.16
Hydrophobic ICL3 V 255 - G.hgh4 P 321 G.hgh4.11
Van-der-waals ICL3 V 255 - G.hgh4 P 321 G.hgh4.11
Hydrophobic ICL2 P 151 34x50 G.H5 H 387 G.H5.19
Van-der-waals ICL2 P 151 34x50 G.H5 H 387 G.H5.19
Hydrophobic TM3 I 148 3x54 G.H5 L 393 G.H5.25
Hydrophobic ICL2 L 152 34x51 G.H5 I 383 G.H5.15
Van-der-waals ICL2 L 152 34x51 G.H5 I 383 G.H5.15
Polar ICL2 S 156 - G.H5 Y 391 G.H5.23
Hydrophobic TM5 P 248 5x71 G.H5 D 381 G.H5.13
Van-der-waals TM5 P 248 5x71 G.H5 D 381 G.H5.13
Hydrophobic ICL3 R 281 - G.h4s6 T 350 G.h4s6.03
Hydrophobic ICL3 S 252 - G.hgh4 D 323 G.hgh4.13
Ionic H8 K 364 8x49 G.H5 E 392 G.H5.24
Polar H8 K 364 8x49 G.H5 E 392 G.H5.24
Hydrophobic H8 K 364 8x49 G.H5 E 392 G.H5.24
Van-der-waals H8 K 364 8x49 G.H5 E 392 G.H5.24
Hydrophobic ICL2 P 151 34x50 G.H5 Q 384 G.H5.16
Hydrophobic TM5 P 248 5x71 G.S6 Y 360 G.S6.02
Van-der-waals TM5 P 248 5x71 G.S6 Y 360 G.S6.02
Hydrophobic ICL3 G 249 - G.S6 H 362 G.S6.04
Hydrophobic ICL2 L 153 34x52 G.S3 V 217 G.S3.01
Hydrophobic ICL3 A 253 - G.hgh4 E 322 G.hgh4.12
Van-der-waals ICL3 A 253 - G.hgh4 E 322 G.hgh4.12
Hydrophobic ICL2 L 152 34x51 G.H5 R 380 G.H5.12
Ionic ICL3 R 279 - G.hgh4 D 323 G.hgh4.13
Polar ICL3 R 279 - G.hgh4 D 323 G.hgh4.13
Hydrophobic ICL3 R 279 - G.hgh4 D 323 G.hgh4.13
Van-der-waals ICL3 R 279 - G.hgh4 D 323 G.hgh4.13
Polar ICL3 T 251 - G.hgh4 D 323 G.hgh4.13
Hydrophobic ICL3 T 251 - G.hgh4 D 323 G.hgh4.13
Van-der-waals ICL3 T 251 - G.hgh4 D 323 G.hgh4.13
Hydrophobic TM5 I 247 5x70 G.S6 Y 360 G.S6.02
Hydrophobic TM6 R 293 6x30 G.H5 L 394 G.H5.26
Hydrophobic TM6 Q 289 6x26 G.h4s6 Y 358 G.h4s6.20
Van-der-waals ICL3 L 254 - G.hgh4 E 322 G.hgh4.12
Hydrophobic TM6 T 296 6x33 G.H5 L 388 G.H5.20
Polar H8 K 364 8x49 G.H5 R 389 G.H5.21
Hydrophobic ICL2 L 152 34x51 G.H5 C 379 G.H5.11
Hydrophobic ICL3 V 255 - G.hgh4 E 322 G.hgh4.12
Hydrophobic TM3 R 144 3x50 G.H5 Y 391 G.H5.23
Hydrophobic ICL3 R 279 - G.H4 R 342 G.H4.12
Van-der-waals ICL3 R 279 - G.H4 R 342 G.H4.12
Aromatic ICL2 F 154 34x53 G.H5 H 387 G.H5.19
Hydrophobic ICL2 F 154 34x53 G.H5 H 387 G.H5.19
Van-der-waals ICL2 F 154 34x53 G.H5 H 387 G.H5.19
Hydrophobic TM5 P 248 5x71 G.H5 N 377 G.H5.09
Polar TM6 T 296 6x33 G.H5 L 393 G.H5.25
Hydrophobic TM6 T 296 6x33 G.H5 L 393 G.H5.25
Van-der-waals TM6 T 296 6x33 G.H5 L 393 G.H5.25
Hydrophobic ICL2 F 154 34x53 G.H5 Y 391 G.H5.23
Van-der-waals ICL2 F 154 34x53 G.H5 Y 391 G.H5.23
Polar ICL3 R 279 - G.hgh4 Y 318 G.hgh4.08
Hydrophobic TM3 R 144 3x50 G.H5 L 393 G.H5.25
Hydrophobic ICL3 A 253 - G.hgh4 D 323 G.hgh4.13
Van-der-waals ICL3 A 253 - G.hgh4 D 323 G.hgh4.13
Polar TM3 A 147 3x53 G.H5 H 387 G.H5.19
Hydrophobic TM3 A 147 3x53 G.H5 H 387 G.H5.19
Van-der-waals TM3 A 147 3x53 G.H5 H 387 G.H5.19
Hydrophobic ICL3 T 251 - G.hgh4 T 325 G.hgh4.15
Van-der-waals ICL3 T 251 - G.hgh4 T 325 G.hgh4.15
Hydrophobic TM3 A 147 3x53 G.H5 Y 391 G.H5.23
Van-der-waals TM3 A 147 3x53 G.H5 Y 391 G.H5.23