G12 -
OX2 receptor complex model
GPCR CLASS (FAMILY)
SPECIES
G PROTEIN FAMILY
DATE
3D VIEW
Tertiary structure confidence
(pLDDT score) avg.: 83.9
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered
PTM Score: 0.8
iPTM Score: 0.8
PAE mean: 12.9
GPCR - G protein interface interactions
The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle
(Gα residues)
and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid,
hydrophobic - dashed,
ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.
GPCR-G protein backbone (bb) or sidechain (sc):
Structures
0 structures selected.
Sequence Color
Interaction frequency filter (%)
Gα,
Gβ,
Gγ,
GPCR
Interaction cut-off: strict (stick), loose (line)
Interaction type |
GPCR Segment |
AA |
Number |
Generic number |
Gα segment |
AA |
Number |
Generic number |
---|---|---|---|---|---|---|---|---|
Hydrophobic | TM6 | T | 302 | 6x33 | G.H5 | L | 375 | G.H5.20 |
Polar | TM3 | R | 152 | 3x50 | G.H5 | I | 378 | G.H5.23 |
Hydrophobic | TM3 | R | 152 | 3x50 | G.H5 | I | 378 | G.H5.23 |
Van-der-waals | TM3 | R | 152 | 3x50 | G.H5 | I | 378 | G.H5.23 |
Hydrophobic | ICL2 | P | 159 | 34x50 | G.H5 | K | 367 | G.H5.12 |
Hydrophobic | TM6 | Q | 295 | 6x26 | G.h4s6 | P | 345 | G.h4s6.20 |
Van-der-waals | TM6 | Q | 295 | 6x26 | G.h4s6 | P | 345 | G.h4s6.20 |
Polar | C-term | V | 425 | - | G.s4h3 | R | 265 | G.s4h3.12 |
Hydrophobic | C-term | V | 425 | - | G.s4h3 | R | 265 | G.s4h3.12 |
Van-der-waals | C-term | V | 425 | - | G.s4h3 | R | 265 | G.s4h3.12 |
Polar | C-term | T | 427 | - | H.HD | E | 172 | H.HD.12 |
Hydrophobic | C-term | T | 427 | - | H.HD | E | 172 | H.HD.12 |
Van-der-waals | C-term | T | 427 | - | H.HD | E | 172 | H.HD.12 |
Polar | C-term | D | 415 | - | G.H2 | S | 233 | G.H2.02 |
Hydrophobic | C-term | D | 415 | - | G.H2 | S | 233 | G.H2.02 |
Van-der-waals | C-term | D | 415 | - | G.H2 | S | 233 | G.H2.02 |
Hydrophobic | TM6 | A | 291 | 6x22 | G.h4s6 | K | 344 | G.h4s6.19 |
Polar | H8 | G | 369 | 8x48 | G.H5 | L | 380 | G.H5.25 |
Hydrophobic | C-term | V | 424 | - | H.HA | V | 107 | H.HA.21 |
Van-der-waals | C-term | V | 424 | - | H.HA | V | 107 | H.HA.21 |
Polar | C-term | T | 408 | - | G.H2 | Q | 236 | G.H2.05 |
Hydrophobic | C-term | T | 408 | - | G.H2 | Q | 236 | G.H2.05 |
Hydrophobic | TM5 | P | 256 | 5x71 | G.S6 | F | 347 | G.S6.02 |
Van-der-waals | TM5 | P | 256 | 5x71 | G.S6 | F | 347 | G.S6.02 |
Polar | TM2 | T | 89 | 2x39 | G.H5 | D | 377 | G.H5.22 |
Hydrophobic | ICL2 | L | 160 | 34x51 | G.H5 | I | 370 | G.H5.15 |
Van-der-waals | ICL2 | L | 160 | 34x51 | G.H5 | I | 370 | G.H5.15 |
Hydrophobic | ICL2 | F | 162 | 34x53 | G.hns1 | R | 56 | G.hns1.03 |
Hydrophobic | TM5 | I | 255 | 5x70 | G.S6 | F | 347 | G.S6.02 |
Van-der-waals | TM5 | I | 255 | 5x70 | G.S6 | F | 347 | G.S6.02 |
Hydrophobic | TM2 | N | 90 | 2x40 | G.H5 | L | 380 | G.H5.25 |
Hydrophobic | ICL3 | G | 257 | - | G.H5 | F | 361 | G.H5.06 |
Van-der-waals | ICL3 | G | 257 | - | G.H5 | F | 361 | G.H5.06 |
Hydrophobic | ICL3 | S | 284 | - | G.H4 | R | 329 | G.H4.09 |
Polar | C-term | T | 399 | - | G.H3 | K | 284 | G.H3.16 |
Hydrophobic | C-term | T | 399 | - | G.H3 | K | 284 | G.H3.16 |
Van-der-waals | C-term | T | 399 | - | G.H3 | K | 284 | G.H3.16 |
Hydrophobic | C-term | F | 414 | - | G.s4h3 | D | 264 | G.s4h3.11 |
Hydrophobic | TM6 | T | 302 | 6x33 | G.H5 | M | 379 | G.H5.24 |
Van-der-waals | TM6 | T | 302 | 6x33 | G.H5 | M | 379 | G.H5.24 |
Hydrophobic | ICL3 | M | 286 | - | G.H4 | D | 336 | G.H4.16 |
Hydrophobic | TM5 | P | 256 | 5x71 | G.H5 | A | 365 | G.H5.10 |
Polar | TM6 | R | 299 | 6x30 | G.H5 | Q | 372 | G.H5.17 |
Van-der-waals | TM6 | R | 299 | 6x30 | G.H5 | Q | 372 | G.H5.17 |
Hydrophobic | ICL2 | P | 159 | 34x50 | G.H5 | I | 370 | G.H5.15 |
Ionic | H8 | K | 370 | 8x49 | G.H5 | D | 377 | G.H5.22 |
Polar | H8 | K | 370 | 8x49 | G.H5 | D | 377 | G.H5.22 |
Polar | C-term | T | 427 | - | H.HD | S | 171 | H.HD.11 |
Polar | C-term | V | 424 | - | H.HA | D | 110 | H.HA.24 |
Hydrophobic | C-term | V | 424 | - | H.HA | D | 110 | H.HA.24 |
Van-der-waals | C-term | V | 424 | - | H.HA | D | 110 | H.HA.24 |
Hydrophobic | ICL2 | L | 160 | 34x51 | G.H5 | K | 367 | G.H5.12 |
Ionic | C-term | E | 402 | - | G.H3 | K | 284 | G.H3.16 |
Hydrophobic | TM4 | T | 165 | 4x38 | G.hns1 | R | 55 | G.hns1.02 |
Van-der-waals | TM4 | T | 165 | 4x38 | G.hns1 | R | 55 | G.hns1.02 |
Polar | C-term | S | 400 | - | G.H2 | Q | 240 | G.H2.09 |
Van-der-waals | C-term | S | 400 | - | G.H2 | Q | 240 | G.H2.09 |
Hydrophobic | ICL3 | A | 288 | - | G.S6 | L | 346 | G.S6.01 |
Hydrophobic | TM5 | P | 256 | 5x71 | G.H5 | H | 364 | G.H5.09 |
Van-der-waals | TM5 | P | 256 | 5x71 | G.H5 | H | 364 | G.H5.09 |
Hydrophobic | TM6 | A | 291 | 6x22 | G.h4s6 | P | 345 | G.h4s6.20 |
Hydrophobic | TM2 | I | 93 | 2x43 | G.H5 | L | 380 | G.H5.25 |
Hydrophobic | ICL2 | L | 160 | 34x51 | G.H5 | F | 363 | G.H5.08 |
Van-der-waals | ICL2 | L | 160 | 34x51 | G.H5 | F | 363 | G.H5.08 |
Hydrophobic | TM5 | L | 250 | 5x65 | G.H5 | L | 375 | G.H5.20 |
Van-der-waals | TM5 | L | 250 | 5x65 | G.H5 | L | 375 | G.H5.20 |
Hydrophobic | C-term | S | 406 | - | G.H2 | K | 237 | G.H2.06 |
Hydrophobic | TM6 | A | 291 | 6x22 | G.h4s6 | S | 343 | G.h4s6.12 |
Hydrophobic | C-term | T | 427 | - | G.s4h3 | R | 265 | G.s4h3.12 |
Van-der-waals | C-term | T | 427 | - | G.s4h3 | R | 265 | G.s4h3.12 |
Polar | H8 | F | 371 | 8x50 | G.H5 | L | 380 | G.H5.25 |
Hydrophobic | H8 | F | 371 | 8x50 | G.H5 | L | 380 | G.H5.25 |
Hydrophobic | C-term | S | 403 | - | G.H3 | L | 285 | G.H3.17 |
Van-der-waals | C-term | S | 403 | - | G.H3 | L | 285 | G.H3.17 |
Hydrophobic | C-term | I | 417 | - | G.s4h3 | E | 263 | G.s4h3.10 |
Van-der-waals | C-term | I | 417 | - | G.s4h3 | E | 263 | G.s4h3.10 |
Polar | TM6 | T | 302 | 6x33 | G.H5 | Q | 381 | G.H5.26 |
Polar | H8 | S | 368 | 8x47 | G.H5 | L | 380 | G.H5.25 |
Hydrophobic | H8 | S | 368 | 8x47 | G.H5 | L | 380 | G.H5.25 |
Van-der-waals | H8 | S | 368 | 8x47 | G.H5 | L | 380 | G.H5.25 |
Hydrophobic | C-term | D | 415 | - | G.H2 | R | 232 | G.H2.01 |
Van-der-waals | C-term | D | 415 | - | G.H2 | R | 232 | G.H2.01 |
Hydrophobic | TM5 | P | 256 | 5x71 | G.H5 | D | 368 | G.H5.13 |
Polar | ICL2 | S | 164 | - | G.hns1 | R | 55 | G.hns1.02 |
Hydrophobic | ICL2 | S | 164 | - | G.hns1 | R | 55 | G.hns1.02 |
Van-der-waals | ICL2 | S | 164 | - | G.hns1 | R | 55 | G.hns1.02 |
Hydrophobic | H8 | K | 370 | 8x49 | G.H5 | Q | 381 | G.H5.26 |
Polar | TM6 | Q | 295 | 6x26 | G.H5 | Q | 372 | G.H5.17 |
Hydrophobic | TM6 | Q | 295 | 6x26 | G.H5 | Q | 372 | G.H5.17 |
Van-der-waals | TM6 | Q | 295 | 6x26 | G.H5 | Q | 372 | G.H5.17 |
Ionic | TM6 | R | 299 | 6x30 | G.H5 | D | 368 | G.H5.13 |
Polar | TM6 | R | 299 | 6x30 | G.H5 | D | 368 | G.H5.13 |
Hydrophobic | TM6 | R | 299 | 6x30 | G.H5 | D | 368 | G.H5.13 |
Van-der-waals | TM6 | R | 299 | 6x30 | G.H5 | D | 368 | G.H5.13 |
Hydrophobic | C-term | T | 427 | - | G.s4h3 | V | 260 | G.s4h3.07 |
Van-der-waals | C-term | T | 427 | - | G.s4h3 | V | 260 | G.s4h3.07 |
Polar | C-term | L | 407 | - | G.H2 | Q | 236 | G.H2.05 |
Hydrophobic | C-term | L | 407 | - | G.H2 | Q | 236 | G.H2.05 |
Van-der-waals | C-term | L | 407 | - | G.H2 | Q | 236 | G.H2.05 |
Hydrophobic | C-term | V | 424 | - | H.hdhe | F | 173 | H.hdhe.01 |
Van-der-waals | C-term | V | 424 | - | H.hdhe | F | 173 | H.hdhe.01 |
Hydrophobic | ICL3 | M | 286 | - | G.H4 | V | 332 | G.H4.12 |
Hydrophobic | TM5 | P | 256 | 5x71 | G.H5 | F | 361 | G.H5.06 |
Polar | C-term | R | 404 | - | G.H2 | K | 237 | G.H2.06 |
Van-der-waals | C-term | R | 404 | - | G.H2 | K | 237 | G.H2.06 |
Polar | C-term | T | 427 | - | H.hdhe | F | 173 | H.hdhe.01 |
Hydrophobic | TM3 | A | 155 | 3x53 | G.H5 | I | 378 | G.H5.23 |
Van-der-waals | TM3 | A | 155 | 3x53 | G.H5 | I | 378 | G.H5.23 |
Hydrophobic | TM6 | A | 291 | 6x22 | G.h4s6 | R | 342 | G.h4s6.11 |
Van-der-waals | TM6 | A | 291 | 6x22 | G.h4s6 | R | 342 | G.h4s6.11 |
Hydrophobic | ICL2 | L | 160 | 34x51 | G.S3 | I | 221 | G.S3.01 |
Van-der-waals | ICL2 | L | 160 | 34x51 | G.S3 | I | 221 | G.S3.01 |
Hydrophobic | TM5 | K | 249 | 5x64 | G.H5 | L | 371 | G.H5.16 |
Polar | C-term | V | 424 | - | H.HA | K | 114 | H.HA.28 |
Hydrophobic | C-term | V | 424 | - | H.HA | K | 114 | H.HA.28 |
Van-der-waals | C-term | V | 424 | - | H.HA | K | 114 | H.HA.28 |
Hydrophobic | ICL3 | M | 286 | - | G.H4 | Q | 333 | G.H4.13 |
Van-der-waals | ICL3 | M | 286 | - | G.H4 | Q | 333 | G.H4.13 |
Hydrophobic | ICL2 | F | 162 | 34x53 | G.H5 | I | 370 | G.H5.15 |
Hydrophobic | TM3 | I | 156 | 3x54 | G.H5 | L | 375 | G.H5.20 |
Hydrophobic | TM6 | R | 299 | 6x30 | G.H5 | L | 375 | G.H5.20 |
Polar | ICL3 | S | 287 | - | G.h4s6 | R | 342 | G.h4s6.11 |
Hydrophobic | ICL3 | S | 287 | - | G.h4s6 | R | 342 | G.h4s6.11 |
Van-der-waals | ICL3 | S | 287 | - | G.h4s6 | R | 342 | G.h4s6.11 |
Polar | C-term | Q | 423 | - | G.s4h3 | R | 265 | G.s4h3.12 |
Van-der-waals | C-term | Q | 423 | - | G.s4h3 | R | 265 | G.s4h3.12 |
Polar | ICL3 | T | 282 | - | G.H4 | R | 329 | G.H4.09 |
Polar | ICL3 | A | 288 | - | G.H4 | D | 336 | G.H4.16 |
Hydrophobic | ICL3 | A | 288 | - | G.H4 | D | 336 | G.H4.16 |
Van-der-waals | ICL3 | A | 288 | - | G.H4 | D | 336 | G.H4.16 |
Hydrophobic | TM6 | M | 305 | 6x36 | G.H5 | M | 379 | G.H5.24 |
Van-der-waals | TM6 | M | 305 | 6x36 | G.H5 | M | 379 | G.H5.24 |
Polar | C-term | S | 406 | - | G.H2 | Q | 236 | G.H2.05 |
Van-der-waals | C-term | S | 406 | - | G.H2 | Q | 236 | G.H2.05 |
Hydrophobic | C-term | I | 429 | - | G.s4h3 | V | 260 | G.s4h3.07 |
Polar | TM3 | A | 155 | 3x53 | G.H5 | N | 374 | G.H5.19 |
Hydrophobic | TM3 | A | 155 | 3x53 | G.H5 | N | 374 | G.H5.19 |
Van-der-waals | TM3 | A | 155 | 3x53 | G.H5 | N | 374 | G.H5.19 |
Hydrophobic | H8 | S | 368 | 8x47 | G.H5 | M | 379 | G.H5.24 |
Van-der-waals | H8 | S | 368 | 8x47 | G.H5 | M | 379 | G.H5.24 |
Ionic | C-term | E | 422 | - | H.HA | R | 106 | H.HA.20 |
Polar | C-term | E | 422 | - | H.HA | R | 106 | H.HA.20 |
Van-der-waals | C-term | E | 422 | - | H.HA | R | 106 | H.HA.20 |
Hydrophobic | TM3 | I | 156 | 3x54 | G.H5 | L | 371 | G.H5.16 |
Van-der-waals | TM3 | I | 156 | 3x54 | G.H5 | L | 371 | G.H5.16 |
Polar | ICL3 | S | 284 | - | G.H4 | Q | 333 | G.H4.13 |
Polar | C-term | R | 404 | - | G.H2 | Q | 240 | G.H2.09 |
Hydrophobic | C-term | R | 404 | - | G.H2 | Q | 240 | G.H2.09 |
Van-der-waals | C-term | R | 404 | - | G.H2 | Q | 240 | G.H2.09 |
Hydrophobic | TM6 | L | 306 | 6x37 | G.H5 | M | 379 | G.H5.24 |
Polar | H8 | K | 370 | 8x49 | G.H5 | L | 380 | G.H5.25 |
Hydrophobic | H8 | K | 370 | 8x49 | G.H5 | L | 380 | G.H5.25 |
Van-der-waals | H8 | K | 370 | 8x49 | G.H5 | L | 380 | G.H5.25 |
Hydrophobic | TM2 | T | 89 | 2x39 | G.H5 | I | 378 | G.H5.23 |
Ionic | C-term | E | 422 | - | H.HA | K | 103 | H.HA.17 |
Hydrophobic | C-term | E | 422 | - | H.HA | K | 103 | H.HA.17 |
Van-der-waals | C-term | E | 422 | - | H.HA | K | 103 | H.HA.17 |
Hydrophobic | TM3 | R | 152 | 3x50 | G.H5 | M | 379 | G.H5.24 |
Hydrophobic | C-term | V | 424 | - | H.HA | A | 111 | H.HA.25 |
Polar | ICL3 | S | 287 | - | G.H4 | D | 336 | G.H4.16 |
Van-der-waals | ICL3 | S | 287 | - | G.H4 | D | 336 | G.H4.16 |
Hydrophobic | C-term | L | 426 | - | H.HA | L | 115 | H.HA.29 |
Van-der-waals | C-term | L | 426 | - | H.HA | L | 115 | H.HA.29 |
Hydrophobic | ICL2 | P | 159 | 34x50 | G.H5 | L | 371 | G.H5.16 |
Hydrophobic | ICL3 | M | 286 | - | G.H4 | R | 329 | G.H4.09 |
Hydrophobic | C-term | L | 426 | - | H.HA | K | 114 | H.HA.28 |
Van-der-waals | C-term | L | 426 | - | H.HA | K | 114 | H.HA.28 |
Polar | C-term | S | 403 | - | G.H2 | Q | 240 | G.H2.09 |
Hydrophobic | C-term | S | 403 | - | G.H2 | Q | 240 | G.H2.09 |
Van-der-waals | C-term | S | 403 | - | G.H2 | Q | 240 | G.H2.09 |