Gq -
OX2 receptor complex model
GPCR CLASS (FAMILY)
SPECIES
G PROTEIN FAMILY
DATE
3D VIEW
Tertiary structure confidence
(pLDDT score) avg.: 84.2
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered
PTM Score: 0.7
iPTM Score: 0.7
PAE mean: 10.6
GPCR - G protein interface interactions
The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle
(Gα residues)
and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid,
hydrophobic - dashed,
ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.
GPCR-G protein backbone (bb) or sidechain (sc):
Structures
0 structures selected.
Sequence Color
Interaction frequency filter (%)
Gα,
Gβ,
Gγ,
GPCR
Interaction cut-off: strict (stick), loose (line)
Interaction type |
GPCR Segment |
AA |
Number |
Generic number |
Gα segment |
AA |
Number |
Generic number |
---|---|---|---|---|---|---|---|---|
Hydrophobic | TM6 | R | 299 | 6x30 | G.H5 | L | 353 | G.H5.20 |
Hydrophobic | ICL2 | F | 162 | 34x53 | G.H5 | I | 348 | G.H5.15 |
Hydrophobic | TM6 | Q | 295 | 6x26 | G.h4s6 | I | 323 | G.h4s6.20 |
Van-der-waals | TM6 | Q | 295 | 6x26 | G.h4s6 | I | 323 | G.h4s6.20 |
Hydrophobic | TM6 | R | 299 | 6x30 | G.H5 | L | 349 | G.H5.16 |
Hydrophobic | TM5 | I | 255 | 5x70 | G.h4s6 | I | 323 | G.h4s6.20 |
Polar | TM3 | A | 155 | 3x53 | G.H5 | N | 352 | G.H5.19 |
Hydrophobic | TM3 | A | 155 | 3x53 | G.H5 | N | 352 | G.H5.19 |
Van-der-waals | TM3 | A | 155 | 3x53 | G.H5 | N | 352 | G.H5.19 |
Polar | C-term | R | 404 | - | G.H2 | H | 218 | G.H2.09 |
Hydrophobic | ICL3 | A | 288 | - | G.H4 | V | 314 | G.H4.16 |
Van-der-waals | ICL3 | A | 288 | - | G.H4 | V | 314 | G.H4.16 |
Hydrophobic | TM3 | R | 152 | 3x50 | G.H5 | L | 358 | G.H5.25 |
Hydrophobic | ICL3 | V | 261 | - | G.H4 | L | 310 | G.H4.12 |
Polar | C-term | R | 404 | - | G.H2 | I | 217 | G.H2.08 |
Hydrophobic | C-term | R | 404 | - | G.H2 | I | 217 | G.H2.08 |
Van-der-waals | C-term | R | 404 | - | G.H2 | I | 217 | G.H2.08 |
Polar | ICL3 | T | 282 | - | G.H4 | E | 307 | G.H4.09 |
Hydrophobic | ICL3 | T | 282 | - | G.H4 | E | 307 | G.H4.09 |
Van-der-waals | ICL3 | T | 282 | - | G.H4 | E | 307 | G.H4.09 |
Hydrophobic | TM2 | T | 89 | 2x39 | G.H5 | Y | 356 | G.H5.23 |
Van-der-waals | TM2 | T | 89 | 2x39 | G.H5 | Y | 356 | G.H5.23 |
Hydrophobic | TM5 | P | 256 | 5x71 | G.H5 | A | 343 | G.H5.10 |
Hydrophobic | ICL2 | L | 160 | 34x51 | G.H5 | F | 341 | G.H5.08 |
Van-der-waals | ICL2 | L | 160 | 34x51 | G.H5 | F | 341 | G.H5.08 |
Polar | H8 | S | 368 | 8x47 | G.H5 | N | 357 | G.H5.24 |
Hydrophobic | H8 | S | 368 | 8x47 | G.H5 | N | 357 | G.H5.24 |
Van-der-waals | H8 | S | 368 | 8x47 | G.H5 | N | 357 | G.H5.24 |
Polar | H8 | K | 370 | 8x49 | G.H5 | K | 354 | G.H5.21 |
Hydrophobic | H8 | K | 370 | 8x49 | G.H5 | K | 354 | G.H5.21 |
Van-der-waals | H8 | K | 370 | 8x49 | G.H5 | K | 354 | G.H5.21 |
Polar | TM6 | T | 302 | 6x33 | G.H5 | L | 358 | G.H5.25 |
Hydrophobic | TM6 | T | 302 | 6x33 | G.H5 | L | 358 | G.H5.25 |
Van-der-waals | TM6 | T | 302 | 6x33 | G.H5 | L | 358 | G.H5.25 |
Polar | H8 | K | 370 | 8x49 | G.H5 | N | 357 | G.H5.24 |
Van-der-waals | H8 | K | 370 | 8x49 | G.H5 | N | 357 | G.H5.24 |
Hydrophobic | C-term | F | 414 | - | G.H2 | R | 213 | G.H2.04 |
Hydrophobic | TM3 | I | 156 | 3x54 | G.H5 | L | 349 | G.H5.16 |
Van-der-waals | TM3 | I | 156 | 3x54 | G.H5 | L | 349 | G.H5.16 |
Hydrophobic | C-term | S | 418 | - | G.H2 | R | 210 | G.H2.01 |
Polar | ICL3 | S | 287 | - | G.H4 | D | 315 | G.H4.17 |
Van-der-waals | ICL3 | S | 287 | - | G.H4 | D | 315 | G.H4.17 |
Hydrophobic | ICL2 | F | 162 | 34x53 | G.S3 | V | 199 | G.S3.01 |
Polar | C-term | E | 402 | - | G.H3 | W | 263 | G.H3.17 |
Hydrophobic | TM6 | T | 302 | 6x33 | G.H5 | L | 353 | G.H5.20 |
Polar | TM3 | D | 151 | 3x49 | G.H5 | Y | 356 | G.H5.23 |
Hydrophobic | TM3 | D | 151 | 3x49 | G.H5 | Y | 356 | G.H5.23 |
Van-der-waals | TM3 | D | 151 | 3x49 | G.H5 | Y | 356 | G.H5.23 |
Hydrophobic | TM5 | P | 256 | 5x71 | G.H5 | F | 339 | G.H5.06 |
Polar | TM2 | N | 90 | 2x40 | G.H5 | N | 357 | G.H5.24 |
Hydrophobic | TM3 | A | 155 | 3x53 | G.H5 | Y | 356 | G.H5.23 |
Van-der-waals | TM3 | A | 155 | 3x53 | G.H5 | Y | 356 | G.H5.23 |
Hydrophobic | ICL2 | L | 160 | 34x51 | G.H5 | K | 345 | G.H5.12 |
Hydrophobic | TM5 | I | 255 | 5x70 | G.S6 | Y | 325 | G.S6.02 |
Van-der-waals | TM5 | I | 255 | 5x70 | G.S6 | Y | 325 | G.S6.02 |
Hydrophobic | C-term | F | 414 | - | G.H3 | I | 258 | G.H3.12 |
Hydrophobic | C-term | I | 411 | - | G.H2 | I | 217 | G.H2.08 |
Hydrophobic | ICL2 | F | 162 | 34x53 | G.S1 | L | 40 | G.S1.02 |
Hydrophobic | ICL3 | G | 257 | - | G.H5 | F | 339 | G.H5.06 |
Hydrophobic | C-term | I | 411 | - | G.H2 | R | 214 | G.H2.05 |
Van-der-waals | C-term | I | 411 | - | G.H2 | R | 214 | G.H2.05 |
Hydrophobic | TM6 | L | 306 | 6x37 | G.H5 | L | 358 | G.H5.25 |
Hydrophobic | TM6 | A | 291 | 6x22 | G.h4s6 | S | 320 | G.h4s6.11 |
Van-der-waals | TM6 | A | 291 | 6x22 | G.h4s6 | S | 320 | G.h4s6.11 |
Hydrophobic | ICL2 | P | 159 | 34x50 | G.H5 | K | 345 | G.H5.12 |
Hydrophobic | TM5 | P | 256 | 5x71 | G.H5 | D | 346 | G.H5.13 |
Hydrophobic | C-term | L | 407 | - | G.H3 | W | 263 | G.H3.17 |
Hydrophobic | TM3 | R | 152 | 3x50 | G.H5 | Y | 356 | G.H5.23 |
Van-der-waals | TM3 | R | 152 | 3x50 | G.H5 | Y | 356 | G.H5.23 |
Hydrophobic | ICL3 | M | 286 | - | G.H4 | V | 314 | G.H4.16 |
Hydrophobic | ICL2 | L | 160 | 34x51 | G.S3 | V | 199 | G.S3.01 |
Polar | ICL2 | S | 164 | - | G.H5 | Y | 356 | G.H5.23 |
Van-der-waals | ICL2 | S | 164 | - | G.H5 | Y | 356 | G.H5.23 |
Ionic | TM6 | R | 299 | 6x30 | G.H5 | D | 346 | G.H5.13 |
Polar | TM6 | R | 299 | 6x30 | G.H5 | D | 346 | G.H5.13 |
Hydrophobic | TM6 | R | 299 | 6x30 | G.H5 | D | 346 | G.H5.13 |
Van-der-waals | TM6 | R | 299 | 6x30 | G.H5 | D | 346 | G.H5.13 |
Polar | TM6 | R | 299 | 6x30 | G.H5 | Q | 350 | G.H5.17 |
Van-der-waals | TM6 | R | 299 | 6x30 | G.H5 | Q | 350 | G.H5.17 |
Polar | TM6 | Q | 295 | 6x26 | G.H5 | Q | 350 | G.H5.17 |
Hydrophobic | TM6 | Q | 295 | 6x26 | G.H5 | Q | 350 | G.H5.17 |
Van-der-waals | TM6 | Q | 295 | 6x26 | G.H5 | Q | 350 | G.H5.17 |
Hydrophobic | TM6 | E | 292 | 6x23 | G.h4s6 | I | 323 | G.h4s6.20 |
Aromatic | C-term | R | 404 | - | G.H3 | W | 263 | G.H3.17 |
Hydrophobic | C-term | R | 404 | - | G.H3 | W | 263 | G.H3.17 |
Van-der-waals | C-term | R | 404 | - | G.H3 | W | 263 | G.H3.17 |
Hydrophobic | TM5 | P | 256 | 5x71 | G.S6 | Y | 325 | G.S6.02 |
Van-der-waals | TM5 | P | 256 | 5x71 | G.S6 | Y | 325 | G.S6.02 |
Hydrophobic | ICL2 | L | 160 | 34x51 | G.H5 | I | 348 | G.H5.15 |
Van-der-waals | ICL2 | L | 160 | 34x51 | G.H5 | I | 348 | G.H5.15 |
Hydrophobic | TM5 | L | 250 | 5x65 | G.H5 | L | 349 | G.H5.16 |
Ionic | C-term | D | 415 | - | G.H2 | R | 214 | G.H2.05 |
Polar | C-term | D | 415 | - | G.H2 | R | 214 | G.H2.05 |
Van-der-waals | C-term | D | 415 | - | G.H2 | R | 214 | G.H2.05 |
Hydrophobic | C-term | F | 414 | - | G.H3 | L | 254 | G.H3.08 |
Van-der-waals | C-term | F | 414 | - | G.H3 | L | 254 | G.H3.08 |
Hydrophobic | TM3 | I | 156 | 3x54 | G.H5 | L | 353 | G.H5.20 |
Hydrophobic | C-term | L | 407 | - | G.H2 | I | 217 | G.H2.08 |
Van-der-waals | C-term | L | 407 | - | G.H2 | I | 217 | G.H2.08 |
Hydrophobic | TM5 | L | 250 | 5x65 | G.H5 | L | 353 | G.H5.20 |
Hydrophobic | ICL2 | L | 160 | 34x51 | G.S1 | L | 40 | G.S1.02 |
Hydrophobic | C-term | I | 417 | - | G.H3 | A | 253 | G.H3.07 |
Ionic | TM6 | K | 294 | 6x25 | G.h4s6 | D | 321 | G.h4s6.12 |
Polar | TM6 | K | 294 | 6x25 | G.h4s6 | D | 321 | G.h4s6.12 |
Hydrophobic | TM6 | K | 294 | 6x25 | G.h4s6 | D | 321 | G.h4s6.12 |
Van-der-waals | TM6 | K | 294 | 6x25 | G.h4s6 | D | 321 | G.h4s6.12 |
Hydrophobic | C-term | F | 414 | - | G.H3 | Y | 261 | G.H3.15 |
Van-der-waals | C-term | F | 414 | - | G.H3 | Y | 261 | G.H3.15 |
Hydrophobic | C-term | F | 414 | - | G.H3 | T | 257 | G.H3.11 |
Van-der-waals | C-term | F | 414 | - | G.H3 | T | 257 | G.H3.11 |
Hydrophobic | TM5 | R | 253 | 5x68 | G.H5 | K | 345 | G.H5.12 |
Hydrophobic | TM5 | P | 256 | 5x71 | G.H5 | A | 342 | G.H5.09 |
Van-der-waals | TM5 | P | 256 | 5x71 | G.H5 | A | 342 | G.H5.09 |
Hydrophobic | ICL3 | M | 286 | - | G.H4 | K | 311 | G.H4.13 |
Van-der-waals | ICL3 | M | 286 | - | G.H4 | K | 311 | G.H4.13 |
Hydrophobic | TM3 | I | 156 | 3x54 | G.H5 | L | 358 | G.H5.25 |
Hydrophobic | ICL2 | P | 159 | 34x50 | G.H5 | I | 348 | G.H5.15 |
Van-der-waals | ICL2 | P | 159 | 34x50 | G.H5 | I | 348 | G.H5.15 |
Polar | C-term | S | 421 | - | G.s4h3 | E | 245 | G.s4h3.14 |
Hydrophobic | C-term | R | 404 | - | G.h2s4 | F | 220 | G.h2s4.01 |
Van-der-waals | C-term | R | 404 | - | G.h2s4 | F | 220 | G.h2s4.01 |
Hydrophobic | C-term | I | 417 | - | G.H3 | T | 257 | G.H3.11 |
Van-der-waals | C-term | I | 417 | - | G.H3 | T | 257 | G.H3.11 |